12 research outputs found
Forged paintings as a form of art crime and experts in Slovenia
No full textPreiskovanje ponarejanja umetnin je zapleteno saj zahteva dobro načrtovanje, organiziranje dela in povezovanje s strokovnjaki, ki delujejo na področju poznavanja podpisov, materialov, tehnik nanosa, obdobij umetnoste zgodovine oziroma stilov in drugo. Le multidisciplinarno delovanje omogoča uspešno preiskovanje primerov kaznivih dejanj zoper umetnine.
Zaključno delo se osredotoča na preiskovanje ponaredkov slik, medresorsko sodelovanje različnih subjektov ter na tehnike preiskave, ki so ključne za avtentikacijo umetnine. Z metodo analize vsebine pisnih virov smo pregledali domačo in tujo strokovno literaturo. Na podlagi pregleda smo oblikovali teoretična izhodišča glede pristopov k preiskovanju tovrstne kriminalitete in vlogi multidisciplinarnega sodelovanja pri preiskovanju ponaredkov umetnin. Empirično tonirano podlago za ovrednotenje izhodišč smo pridobili iz analize delno strukturiranih intervjujev, ki smo jih naredili s predstavniki policije, strokovnjakov s področja umetnostne zgodovine oziroma cenilstva in s področja podpisov. Ugotavljamo, da je za uspešno preiskovanje kaznivega dejanja ponarejanja slik potrebna kohezija med številnimi subjekti, ki se morajo povezovati v multidisciplinirano ekipo. Za uspešno stilistično in zgodovinsko analizo ter posledično odkrivanja lastnosti slike, avtorja in obdobja, je sodelovanje z izvedenci s področja umetnostne zgodovine primarnega pomena. Ključnega pomena je tudi sodelovanje s strokovnjaki s področja podpisov, saj lahko le ti že v začetni fazi pripomorejo k odkrivanju informacij o pisalnih značilnostih in o pristnosti podpisa. Preiskovanje kaznivih dejanj zoper umetnine bi moralo potekati znotraj okvirjev institucije, ustanovljene na nacionalni ravni, ki bi se izključno ukvarjala s kriminaliteto zoper umetnine in kulturno dediščino, vsak posameznik pa bi moral pred nakupom umetnine, obvezno preveriti avtentičnost slike, saj bi s tem bistveno pripomogel k zmanjšanju ponaredkov na trgu.Investigating the forgery of paintings is a complex process as it requires good planning, organization of work, and liaison with experts working in the field of knowledge of signatures, materials, application techniques, periods of art history or styles, and more. Only multidisciplinary action enables the successful investigation of cases of art crime.
The final work focuses on the investigation of forgeries of paintings, interdepartmental cooperation of various subjects, and on investigation techniques that are crucial for the authentication of a work of art. Using the method of analyzing the content of written sources, we reviewed domestic and foreign professional literature. Based on the review, we formed theoretical starting points regarding approaches to the investigation of this type of crime and the role of multidisciplinary cooperation in the investigation of art crime. An empirically toned basis for evaluating the starting points was obtained from the analysis of partially structured interviews conducted with representatives of the police, experts in the field of art history and appraisal, and signatures. We find that a successful investigation of the crime of the falsification of the painting requires cohesion between a number of entities, which must unite in a multidisciplinary team. Cooperation with experts in the field of art history is of primary importance for successful stylistic and historical analysis and, consequently, the discovery of the characteristics of the painting, the author, and the period. Cooperation with signature experts is also crucial, as they can help to discover information about the writing characteristics and the authenticity of the signature at an early stage. The investigation of art crime should take place within the framework of an institution established at the national level, which would deal exclusively with art crime and cultural heritage. Furthermore, each individual should check the authenticity of the painting before buying the work of art to reduce counterfeiting in the art market
Rosa Nassif : una militante e intelectual del maoísmo argentino
No full textAproximación a la vida de Rosa Nassif (n. 1946), militante y dirigente de uno de los principales partidos maoístas en Argentina. El artículo empieza en la etapa de formación de Nassif para seguir con sus primeros años de militancia y llegar hasta su condición de intelectual partidaria enfocada en el análisis de la Revolución Cubana y los aportes del Che Guevara. Para tal aproximación biográfica, la autora se basa en una entrevista realizada a Nassif con la metodología de historia de vida y en el análisis de su libro El Che (1988); se acompaña además de literatura específica que permite poner al personaje estudiado en diálogo con la realidad socioeconómica y política del país. El presente trabajo contribuye a mostrar las condiciones de las mujeres militantes en las izquierdas latinoamericanas que se constituyeron en intelectuales de sus organizaciones.Presentation of the life of Rosa Nassif (b. 1946), militant and head of one of Argentina’s major Maoist parties. The paper first reviews Nassif’s training stage and then goes on to her first years of militancy before reaching the stage as an intellectual supporter focused on the analysis of Cuban Revolution and Che Guevara’s contributions. To support the biographic approach, the author uses an interview made to Nassif with the methodology known as life history, together with an analysis of her book El Che (1988); she also reviews specific literature that allows an exploration of the individual in dialogue with the country’s socioeconomic and political reality. This work further displays the conditions of Latin American left-militant women who were intellectuals within their organizations
Errata
No full textAt the request of Prof. Dr. Sandra Stefan Mikic, Ph. D., author of the paper
?ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF ACINETOBACTER SPP IN THE PERIOD
2012 - 2015?, published in the journal Medical Review, 3-4/2017, pages 99
- 106, we hereby provide the correct list of coauthors of this paper: Sandra
Stefan-Mikic, Sinisa Sevic, Ivana Hrnjakovic Cvjetkovic, Vesna Milosevic,
Vedrana Petric and Milica Rupar. Acknowledgment - This work was supported and
funded by the Ministry of Education, Science and Technological Development
of the Republic of Serbia (grant TR31084). Na molbu prof. dr Sandre Stefan
Mikic, autorke rada ?Ispitivanje osetljivosti Acinetobacter spp na
antimikrobne lekove u periodu 2012?2013. godine?, objavl?enog u dvobroju
3-4/2017, na stranama 99?106, objavl?ujemo ispravke koje se odnose na
koautore rada, a koji glasi: Sandra Stefan Mikic, Sinisa Sevic, Ivana
Hrnjakovic Cvjetkovic, Vesna Milosevic, Vedrana Petric i Milica Rupar, kao i
na Zahvalnicu koja je izostavl?ena, a treba da glasi: Acknowledgments - This
work was supported by project grants TR31084 funded by the Ministry of
Education, Science and Technological Development of the Republic of Serbia
**** At the request of Dr. Uros Milosevic, author of the article ?CENTRAL
PANCREATECTOMY IN SURGICAL TREATMENT OF PANCREATIC INSULINOMA?, published in
the journal Medical Review, 3 - 4/2017, pages 111 - 114, we hereby provide
the correct email address of the author: [email protected]. Na
molbu dr Urosa Milosevica, autora rada ?Centralna pankreatektomija u
hirurskom tretmanu insulinoma pankreasa - prikaz slucaja?, objavl?enog u
dvobroju 3-4/2017, na stranama 111?114. objavl?ujemo ispravku koja se odnosi
na imejl adresu autora, a koja bi trebalo da glasi
[email protected] <br><br><font color="red"><b> Link to the corrected article <u><a href="http://dx.doi.org/10.2298/MPNS1704099M">10.2298/MPNS1704099M</a></b></u>
<br><br><font color="red"><b> Link to the corrected article <u><a href="http://dx.doi.org/10.2298/MPNS1704111M">10.2298/MPNS1704111M</a></b></u></jats:p
Conjugated organoboron macrocycles
No full textOrganic π-conjugated systems continue to attract great interest in applications ranging from organic electronics to sensing and imaging. The introduction of main group elements to π-conjugated systems provides a means to further modify and fine-tune the electronic and optical properties of π-system. In particular, the incorporation of tricoordinate boron leads to novel optical and electronic properties due to the empty p-orbital on boron that overlaps with π-orbitals of attached aryl or other unsaturated groups. The central focus of this thesis is to investigate the incorporation of organoborane moieties into conjugated macrocycles. We developed a new boron-doped cyclophane, the hexabora[16]cyclophane, B6-FMes, in which six tricoordinate borane moieties alternate with short conjugated p-phenylene linkers. Exocyclic FMes groups provide not only good stability but make the boron centers highly electron deficient. The optical and electronic properties are compared with those of related linear oligomers and the electronic structure is further evaluated by computational methods. The studies show that B6-FMes has a low-lying and extensively delocalized LUMO and a wide HOMO–LUMO gap which could be of interest in optoelectronic applications that require wide-gap host materials.
We also isolated an ambipolar π-conjugated macrocycle, B4N2-FMes, having triarylamine donors paired with highly electron-deficient bis(boryl)fluorene units. The pendent FMes groups play an important role to increase the electron acceptor character of the boron centers, thereby to manipulate the intramolecular charge transfer character (ICT) of B4N2-FMes. The photophysical and electronic properties of B4N2-FMes are evaluated in comparison to previously reported ambipolar macrocycles. Attempts at isolating the phosphorous analog B4P2-FMes in which N is replaced by P are also described. While this macrocycle could not be isolated, computational studies provide information on the geometry and electronic structure of B4P2-FMes. They reveal a distinctly different structure for B4P2-FMes with possible formation of syn- and anti-isomers due to the pyramidal environment at P (by comparison the N atoms in B4N2-FMes adopt a trigonal planar geometry). The HOMO and LUMO levels of B4P2-FMes are slightly lower than those of B4N2-FMes, but overall they are of similar energy. The affinity of B4N2-FMes for small anions suggests potential utility in anion sensor applications.
Finally, we extended our studies to investigate polycationic organoboron macrocycles that contain multiple bipyridylboronium moieties. Macrocycle [B4N2-4bipy]4+ (MC1) was successfully isolated and fully characterized, but efforts at isolating the corresponding hexaboron macrocycles [B6Ar-4bipy]4+ (MC2 and MC3) have not been met with success. MC1 exhibits multi-step redox properties involving the reversible transfer of up to 10 electrons. These macrocycles are also expected to display potentially interesting stimuli-responsive and self-assembly properties.Ph.D.Includes bibliographical reference
Abstract 5071: Preclinical characterization of the potent and selective BET inhibitor INCB057643 in models of hematologic malignancies
No full textAbstract
Inhibitors of the Bromodomain and Extra-Terminal (BET) family of bromodomain containing proteins regulate expression of key cell fate, cell cycle, and survival genes including c-myc. In preclinical models, BET inhibitors have demonstrated significant efficacy in a variety of different oncology indications, including hematological malignancies. Here we describe the preclinical profile of the novel, orally bioavailable BET inhibitor INCB057643 in preclinical models of hematologic malignancies. INCB057643 inhibited binding of BRD2/BRD3/BRD4 to an acetylated histone H4 peptide in the low nM range, and was selective against other bromodomain containing proteins. In vitro analyses showed that INCB057643 inhibited proliferation of human AML, DLBCL, and multiple myeloma cell lines, with a corresponding decrease in MYC protein levels. Cell cycle analyses indicated that G1 arrest and a concentration-dependent increase in apoptosis were seen within 48 hours of treatment with INCB057643. BRD proteins also regulate the expression of many pro-inflammatory genes. Production of several cytokines, including IL-6, IL-10 and MIP-1α, was repressed by INCB057643 in human and mouse whole blood stimulated ex vivo with LPS. Consistent with these effects, analyses of gene expression in cells treated with INCB057643 revealed that pathways involved in cell cycle progression, apoptosis, and IL-6 were among the most significantly altered in vitro. Oral administration of INCB057643 resulted in significant anti-tumor efficacy in xenograft models of AML, myeloma, and DLBCL. Additionally, combining INCB057643 with standard of care agents used for the treatment of DLBCL including rituximab and bendamustine resulted in enhanced anti-tumor efficacy relative to that achieved with single agent therapies at doses that were well tolerated. In addition, many B cell malignancies are reliant on the PI3Kδ pathway for proliferation and survival, suggesting that the combination of INCB057643 with the clinical stage PI3Kδ specific inhibitor INCB050465 may be a rational therapeutic strategy for DLBCL. Compared with single agent BETi or PI3Kδi therapy, the combination significantly potentiated tumor growth inhibition in DLBCL models representative of the ABC subtype (HBL-1), and the double hit GCB subtype (WILL2). These data suggest that clinical exploration of INCB057643 as a monotherapy or in combination in hematologic malignancies is warranted.
Citation Format: Matthew C. Stubbs, Thomas Maduskuie, Timothy Burn, Sharon Diamond-Fosbenner, Nikoo Falahatpisheh, Alla Volgina, Nina Zolotarjova, Xiaoming Wen, Patricia Feldman, Mark Rupar, Robert Collins, Cindy Marando, Bruce Ruggeri, Maryanne Covington, Xuesong Mike Liu, Richard Wynn, Swamy Yeleswaram, Wenqing Yao, Reid Huber, Gregory Hollis, Peggy Scherle, Andrew P. Combs, Phillip C. Liu. Preclinical characterization of the potent and selective BET inhibitor INCB057643 in models of hematologic malignancies [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5071. doi:10.1158/1538-7445.AM2017-5071</jats:p
Sustainable citizenship as a key to sustainability: Establishing a common ground on technology use in New Zealand's dairy sector
No full textSustainability is a key issue in New Zealand’s dairy industry. Arguments are often made from either a purely economic or environmental perspective. The debate is dominated by polarised viewpoints characterised by hasty rejection or assertive support of production-focused biotechnological approaches. On the one hand is the biotechnology industry and on the other environmentalists and an anxious public. In the context of this divisive discussion, progress towards sustainable development is hard to achieve. By using the concept of sustainable citizenship as a theoretical framework, it is possible to incorporate economic, environmental, political and social approaches to sustainability. This thesis employs sustainable citizenship in order to find a common ground amongst the various points of view within the dairy sector. Shared values around farming methods and biotechnology are used to find a way to facilitate sustainable development in the industry, combining current interests of various stakeholders with the long-term interest of future generations
Biallelic <em>NDUFA13 </em>variants lead to a neurodevelopmental phenotype with gradual neurological impairment
No full text\ua9 The Author(s) 2024.Biallelic variants in NADH (nicotinamide adenine dinucleotide (NAD) + hydrogen (H))-ubiquinone oxidoreductase 1 alpha subcomplex 13 have been linked to mitochondrial complex I deficiency, nuclear type 28, based on three affected individuals from two families. With only two families reported, the clinical and molecular spectrum of NADH-ubiquinone oxidoreductase 1 alpha subcomplex 13–related diseases remains unclear. We report 10 additional affected individuals from nine independent families, identifying four missense variants (including recurrent c.170G > A) and three ultra-rare or novel predicted loss-of-function biallelic variants. Updated clinical–radiological data from previously reported families and a literature review compiling clinical features of all reported patients with isolated complex I deficiency caused by 43 genes encoding complex I subunits and assembly factors are also provided. Our cohort (mean age 7.8 \ub1 5.4 years; range 2.5–18) predominantly presented a moderate-to-severe neurodevelopmental syndrome with oculomotor abnormalities (84%), spasticity/hypertonia (83%), hypotonia (69%), cerebellar ataxia (66%), movement disorders (58%) and epilepsy (46%). Neuroimaging revealed bilateral symmetric T2 hyperintense substantia nigra lesions (91.6%) and optic nerve atrophy (66.6%). Protein modeling suggests missense variants destabilize a critical junction between the hydrophilic and membrane arms of complex I. Fibroblasts from two patients showed reduced complex I activity and compensatory complex IV activity increase. This study characterizes NADH-ubiquinone oxidoreductase 1 alpha subcomplex 13–related disease in 13 individuals, highlighting genotype–phenotype correlations
INCB040093 Is a Novel PI3K<i>δ</i>Inhibitor for the Treatment of B Cell Lymphoid Malignancies
No full text
