1,010 research outputs found
Déjà déjà visité : Mike Bayne, Jocelyne Purdie, Maayke Schurer
No full text"In this intimate field guide to Kingston’s contemporary artistic ecology, curator Sunny Kerr takes readers on a journey through the work of Mike Bayne, Jocelyn Purdie, and Maayke Schurer. A dynamic visual compendium follows Kerr's narrative adventure, challenging our perception of our physical environment and casting us as tourists confronting familiar, already-experienced situations coloured by a lens of estrangement" -- p. [4] of cover
The use of antiepileptic medication in adults with intellectual disabilities: a serious conundrum
No full textUntil the early 1990s, six major drugs existed in the treatment of epilepsy. By 2004, ten new antiepilepsy drugs (AEDs) were made available in the UK. Currently, the available number of AEDs has grown to over 20. There are a number of concerns posed by these medications, ranging from teratogenic concerns to negative impact upon cognitive function to worsening behavior, all which can have an effect upon quality of life of the person with epilepsy (PWE). While treatment guidelines have suggested that the newer AEDs tend to be better tolerated and affect cognitive functioning to a lesser degree than older AED options, the evidence base applied to people with intellectual disability (ID) has not been suitably explored. About 25 % of PWE also have an ID. This group has communication issues, premature mortality, more treatment resistance, difficulties in making informed choices, and greater risks of physical and mental health comorbidities. There is no specific prescribing guidance for this large, heterogeneous, and vulnerable group.
Identifying adverse effects to treatment is extremely challenging in PWE with an ID due to the presence of complex comorbidities and often profound communication barriers. This chapter looks to consolidate the current evidence and good practice needed to prescribe specifically in a PWE and ID. It takes into consideration and brings together a wide range of contextual good practice literature from both the ID research world, such as concepts of mental capacity, and the epilepsy world, such as the latest epilepsy medication and drug effects, thus helping straddle the diverse yet fast-developing nature of both the epilepsy and ID scientific worlds. To help present concepts and to highlight clinical complexity, ten case vignettes have been presented. It would be considered an essential read to any clinical practitioner who manages PWE and ID
A national survey of Rett syndrome : age, clinical characteristics, current abilities, and health
No full textAs part of a wider study to investigate the behavioral phenotype of a national sample of girls and women with Rett syndrome (RTT) in comparison to a well-chosen contrast group and its relationship to parental well-being, the development, clinical severity, current abilities and health of 91 participants were analyzed in relation to diagnostic, clinical and genetic mutation categories. Early truncating mutations or large deletions were associated with greater severity. Early regression was also associated with greater severity. All three were associated with lower current abilities. Epilepsy and weight, gastrointestinal and bowel problems were common co-morbidities. Participants with classic RTT had greater health problems than those with atypical RTT. A substantial minority of respondents reported fairly frequent signs of possible pain experienced by their relative with RTT. Overall, the study provides new data on the current abilities and general health of people with RTT and adds to the evidence that the severity of the condition and variation of subsequent disability, albeit generally within the profound range, may be related to gene mutation. The presence of certain co-morbidities represents a substantial ongoing need for better health. The experience of pain requires further investigation
Recession, International Trade and the Fallacies of Composition
No full textA truly global recession has not been manifest since the Great Depression of the 1930s. As a result, the multilateral institutions put in place at the end of the Second World War to ensure that a major depression never happened again have not been tested. One of the lessons of the Great Depression was that governments had a major role to play in managing the economy. The use of subsidies to affect economic outcomes was one manifestation of this expanded role. In a recession, sector specific subsidies will likely be requested by firms. Subsidies can distort trade, leading to the potential for beggar thy neighbour subsidy wars. Subsidies will be difficult to discipline in a global recession.beggar thy neighbour, deficits, paradox of thrift, recession, subsidies, International Relations/Trade,
A Future Vision For The Engineering Design Environment: A Future Sociotechnical Scenario
No full textThis paper presents a future vision for the working practices of designers within a manufacturing organisation. By its very nature the engineering design environment is highly distributed in nature and is characterised by a large number of information sources, which together with the designers forms a complex sociotechnical system. In discussions with designers it is apparent that changes are required to this environment to reflect the changes in the design process and organisations. We have developed a scenario that incorporates many of the features requested by designers and managers to improve the design environment. The scenario sets out a route map for the development of technical and social tools that aid the designer
Race for the Kerr field
No full textRoy P. Kerr has discovered his celebrated metric 45 years ago, yet the problem to find a generalization of the Schwarzschild metric for a rotating mass was faced much earlier. Lense and Thirring, Bach, Andress, Akeley, Lewis, van Stockum and others have tried to solve it or to find an approximative solution at least. In particular Achilles Papapetrou, from 1952 to 1961 in Berlin, was interested in an exact solution. He directed the author in the late autumn of 1959 to work on the problem. Why did these pre-Kerr attempts fail? Comments based on personal reminiscences and old notes
Microwave and RF photonic applications of integrated Kerr micro-combs
No full textWe report applications of integrated Kerr micro-combs to RF photonic systems and demonstrate a wide range of advanced functions including a microwave photonic intensity differentiator, filters and true time delays. The on-chip Kerr optical comb is CMOS-compatible and serves as a high-performance multi-wavelength source for transversal filter functions, thus greatly reducing the cost, size, and complexity of the system. © 2018 The Author(s).</p
Change over a 16 month period in the psychological well-being of mothers of girls and women with Rett syndrome
No full textPurpose: There is an emerging research literature on the experiences of family members of girls and women with Rett syndrome (RTT), but a lack of longitudinal data. Methods. Fifty mothers whose daughters had RTT were surveyed 16—17 months after an earlier cross-sectional study. Measures completed at both time points focused on maternal positive and negative psychological well-being and their daughters’ behavioural and emotional problems and RTT behavioural phenotype severity. Results: Maternal stress, anxiety and depression demonstrated at least moderate levels of stability. Maternal positive perceptions were also moderately stable over 16—17 months. Longitudinal analyses suggested that their daughters’ behavioural and emotional problems rather than RTT behavioural phenotype severity predicted later maternal well-being. Conclusion: Mothers with RTT daughters experience chronic stress (persisting over time) but also ongoing positive perceptions. Practitioners should recognise positive perceptions, and also consider targeted behavioural parent training to reduce behaviour problems in individuals with RTT
Political Precaution, Pandemics and Protectionism
No full textDespite strong scientific evidence and representations made by international scientific organizations, a considerable number of countries have imposed import bans on pork in response to the H1N1 pandemic. The imposition of these barriers is contrary to WTO rules. The motivation for the imposition of these barriers does not appear to have arisen from producers’ requests or consumer lobbying – political precaution provides the motivation. There appears to be little control over political precaution in the rules of international trade. Hence, the balance between the strong rules of trade desired by firms wishing to engage in international commerce and the need, at times, for politicians to respond to requests for protection may be changing in favour of more protection. Keywords: H1N1, import bans, pork, precaution, protection, swineH1N1, import bans, pork, precaution, protection, swine, Food Consumption/Nutrition/Food Safety, Health Economics and Policy, International Relations/Trade, Livestock Production/Industries, Political Economy, Public Economics, Risk and Uncertainty,
Polynomial rings over Goldie-Kerr commutative rings
No full textAll rings in this paper are commutative, and
acc
⊥
\operatorname {acc} \bot
(resp.,
acc
⊕
\operatorname {acc} \, \oplus
) denotes the acc on annihilators (resp., on direct sums of ideals). Any subring of an
acc
⊥
\operatorname {acc} \bot
ring, e.g., of a Noetherian ring, is an
acc
⊥
\operatorname {acc} \bot
ring. Together,
acc
⊥
\operatorname {acc} \bot
and
acc
⊕
\operatorname {acc} \, \oplus
constitute the requirement for a ring to be a Goldie ring. Moreover, a ring
R
R
is Goldie iff its classical quotient ring
Q
Q
is Goldie. A ring
R
R
is a Kerr ring (the appellation is for J. Kerr, who in 1990 constructed the first Goldie rings not Kerr) iff the polynomial ring
R
[
x
]
R[x]
has
acc
⊥
\operatorname {acc} \bot
(in which case
R
R
must have
acc
⊥
\operatorname {acc} \bot
). By the Hilbert Basis theorem, if
S
S
is a Noetherian ring, then so is
S
[
x
]
S[x]
; hence, any subring
R
R
of a Noetherian ring is Kerr. In this note, using results of Levitzki, Herstein, Small, and the author, we show that any Goldie ring
R
R
such that
Q
=
Q
c
(
R
)
Q = {Q_c}(R)
has nil Jacobson radical (equivalently, the nil radical of
R
R
is an intersection of associated prime ideals) is Kerr in a very strong sense:
Q
Q
is Artinian and, hence, Noetherian (Theorems 1.1 and 2.2). As a corollary we prove that any Goldie ring
A
A
that is algebraic over a field
k
k
is Artinian, and, hence, any order
R
R
in
A
A
is a Kerr ring (Theorem 2.5 and Corollary 2.6). The same is true of any algebra
A
A
over a field
k
k
of cardinality exceeding the dimension of
A
A
(Corollary 2.7). Other Kerr rings are: reduced
acc
⊥
\operatorname {acc} \bot
rings and valuation rings with
acc
⊥
\operatorname {acc} \bot
(see 3.3 and 3.4).</p
- …
