1,721,070 research outputs found
Concept of associated photodynamic therapy with porphyrin – cis-platin drug system and applications on HeLa cells.
No full textQuantification of Arsenic in Soil Samples Collected in an Industrial Area of Brindisi (Apulia, Italy): Speciation Analysis and Availability
Full text linkArsenic (As) is a well-known toxic metalloid, but environmental risks due to excessive As content in soils or sediments depend on the chemical forms present and their relative mobility. Long-term exposure to arsenic may cause several diseases. In order to assess the possible risks in the heavily impacted Consorzio per lo Sviluppo Industriale e di Servizi Reali alle Imprese (Consortium for Industrial Development and Effective Services for Business, S.I.S.R.I.) industrial area of Brindisi (Apulia, southern Italy), 38 soil samples were collected in the area, from 18 sampling points previously determined as outliers. Total As determination, speciation analysis, and a cession test with acetic acid were performed. Speciation analysis was performed by HPLC coupled to hydride generation-atomic absorption spectroscopy (HG-AAS). Total As determination obtained by mineralization showed a concentration range between 51.8 and 169.6 mg kg-1, which is higher than the limit of 50 mg kg-1 established by D.M. (Ministerial Decree) 471/99 for industrial areas. The highest concentrations of extracted As were obtained in the top-soil layers. As(III) and As(V) were detected in all the samples, while the concentrations of the organic species monomethyl arsonic acid (MMAA) and dimethyl arsenic acid (DMAA) were always under the detection limit. The samples releasing the highest As quantities in the acetic acid cession test were in every circumstance collected from the superficial soil levels. The different amounts of As determined in the sampling sites could depend on the distance from the specific sources of pollution, even if it is very difficult to identify them in a very complex industrial zone such as the S.I.S.R.I. area of Brindisi. In this study, As occurs mainly as relatively immobile or slowly exchangeable forms: for this reason, it is more abundant in the top-soil and is little affected by the action of rainwater, which transports only reduced quantities of As into the deeper layers
Water soluble five-coordinate platinum(II) ethylene complexes: characterization and biological activity.
No full textCYTOTOXIC ACTIVITY OF TWO NOVEL OXALIPLATIN ANALOGUES: [(R,R) AND (S,S)-DACHPTCL(ETA-2-C2H4)]CL COMPLEXES.
No full textNew cationic complexes of the type [PtCl(η2-C2H4)(N-N)]+ as high water soluble potential oxaliplatin antitumor pro-drugs.
No full textNew organometallic Platinum containing biomimetic Vitamin E analogues.
No full textBioorganometallic chemistry is an emerging area of organometallic chemistry. The presence of a metal in a biomimetic molecule may be useful for the possibility to deliver, a particular metal, to a specific target, for therapeutic and/or imaging purposes. In this work, we report the synthesis of new Pt(II) containing organometallic species, having the same structural core of Vitamin E, a remarkable family of biologically active chromane derivatives. Such compounds are characterized by substitution of the carbon atom in 2 position within the chromane pseudo-pyran heterocycle with a square planar Pt(II) centre, which carries also a chelate dinitrogen ligand. Cytotoxicity and Pt uptake measurements, performed on health or cancer cells, show interesting structure-activity relationships for the new metalla-chromanes
Heavy metals in five Sabellidae species (Annelida, Polychaeta): ecological implications
No full textThe present work analyzed three hard-bottom and
two soft-bottom species of sabellid polychaetes to determine
the content of several heavy metals in their branchial crown
and body. The highest concentrations of heavy metals were
recorded in the hard-bottom species Branchiomma bairdi, a
recent Mediterranean introduction. Differences in the metal
concentrations were most notable in the high trace metal levels
of the branchial crown for all the studied species. Statistical
analysis showed that the Mediterranean hard-bottom species
were similar each other in their heavy metal content in the
body as well as in the branchial crown and appeared separated
from all the other species. Arsenic and vanadium
hyperaccumulation in the branchial crowns of the considered
sabellid species probably acts as a deterrent for predation. The
observed differences among the examined species were
discussed not only at the light of habitat colonization but also
in terms of the phylogeny
Ligands derived from sugars: synthesis and characterization of hydrophilic Pt(II) complexes
No full textIn vitro Cytotoxic Activity of Homologous New Dinuclear Pt(II) Complexes. Comparison between Bifunctional Effects: Bis-intercalating or Synchronic Intercalating and Covalent
No full textSynthesis, characterization, and cytotoxic activity of new platinum(ii) complexes with Acylpyrazolones
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