196,631 research outputs found
Dalle sette all'Unità d'Italia: il garibaldino Nicola Mignogna (1808-1870)
No full textRuolo fondamentale nell'Unificazione d'Italia avuto da taluni patrioti poco noti, tra i quali un posto preminente deve essere attribuito al tarantino Nicola Mignogna, sia per le sue lotte all'interno del Comitato politico napoletano, alla vigilia dell'Unificazione, sia come collaboratore di Garibaldi, dal quale fu nominato prodittatore della Basilicata
Structure-function relationships of temporins, small anti-microbial peptides from amphibian skin
No full textTemporins, antimicrobial peptides of 10±13 residues, were isolated from secretions of Rana temporaria
[Simmaco, M., Mignogna, G., Canofeni, S., Miele, R., Mangoni, M.L. & Barra, D. (1996) Eur. J. Biochem. 242,
788±792]. These molecules are specific to this amphibian species, which is also able to secrete on its skin other
antimicrobial peptides similar to those found in different Rana species. The effect of temporins A, B and D (13
residues, net charge +2), and H (10 residues, net charge +1 and +2, respectively) against both artificial
membranes of differing lipid composition and bacteria has been investigated in order to gain insight into their
mechanisms of action. The results indicate that: the lytic activity of temporins is not greatly affected by the
membrane composition; temporins A and B allow the leakage of large-size molecules from the bacterial cells;
temporin H renders both the outer and inner membrane of bacteria permeable to hydrophobic substances of low
molecular mass; and temporin D, although devoid of antibacterial activity, has a cytotoxic effect on erythrocytes.
The results allow important conclusions to be drawn about the minimal structural requirements for lytic
efficiency and specificity of temporins
ANTIMICROBIAL PEPTIDES FROM SKIN SECRETIONS OF RANA ESCULENTA. MOLECULAR CLONING OF cDNAs ENCODING ESCULENTIN AND BREVININS AND ISOLATION OF NEW ACTIVE PEPTIDES
No full textThree cytolytic peptides, termed brevinin-1E, brevinin-2E, and esculentin, were isolated from skin secretions of the European frog Rana esculenta (Simmaco, M., Mignogna, G., Barra, D., and Bossa, F. (1993) FEBS Lett. 324, 159-161). Nucleotide sequence analysis of cDNAs coding for the corresponding precursors revealed that in all of them a single copy of the sequence of the mature peptide is present preceded by a dibasic cleavage site and followed by a stop codon. The signal peptides of these precursors show a clear homology to the corresponding region of the precursor of dermorphin, a neuropeptide occurring in the skin of amphibians of the subfamily Phyllomedusinae. Ten new peptides, ranging in size from 24 to 46 residues, all possessing an intramolecular disulfide bridge located at the carboxyl-terminal end, were isolated from skin secretions of R. esculenta. These peptides can be grouped into four subfamilies on the basis of their distinctive structural and/or functional properties. All of these new peptides have antimicrobial and/or hemolytic activities typical for the respective subfamily. In addition, we demonstrate that esculentin-1 also inhibits the growth of Pseudomonas aeruginosa, Candida albicans, and Saccharomyces cerevisiae
La malattia herpetica del cavo orale: interazioni ospite-virus in relazione all'approccio terapeutico.
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Il controllo degli effetti collaterali nella terapia steroidea ad alto dosaggio del pemfigo orale.
No full textMetodiche riabilitative incruente nelle "microstomie": indicazioni e tecniche operative.
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Comparison of two glucocorticoid preparations (deflazacort and prednisone) in the treatment of oral pemphigus.
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