1,721,422 research outputs found
La storia dello stent per sé. Minerva Cardioangiologica. 57 (Suppl. I al N.6):3-5, 2009.
No full textA brief summary of the stents is here proposed with particular attention to the technological development in the stent area. Materials properties, design requirement and market aspects have been the driving forces in the stent development. Since the introduction of stent in 1988 by Palmaz a large number of people has taken advantage from percutaneous stent intervention. Clinical application has increased and the stenting experience has led to new concepts of devices throughout the years: from bare metal stents to drug eluting stents. Other platform such as bioabsorbable stents have been studied with promising results. In parallel, technologies have increased and developed to fulfil the new stent requirements
Plaque Mechanics
Full text linkPlaque mechanics, the deformation and corresponding stress distribution, play an important role in various aspects of atherosclerotic disease. This special issue is composed of reviews and original research articles of the state-of-the-art, focusing on different topics that relate to plaque mechanics. These articles, which represent a snapshot of the cutting edge research currently conducted in these area, were contributed by leading groups in the field
Is modeling stents still an important issue?
Full text linkNumerical models of cardiovascular devices have always appeared in literature studies few years after their use in clinical practice. As example, FDA approval of Palmaz-Schatz stent was in 1994, while the first numerical studies on a similar stent model appeared after 1999. The same temporal delay can be observed for degradable stents, transcatheter valves or more recently for devices like the stent retrievers. This observation does not necessarily mean that numerical modeling had not been used in the design of the stents or cardiovascular devices. Companies might have used numerical tools but not published the results. Was the publication activity committed mainly to the academic world? Or was the numerical modeling an exclusive academic activity until a few years ago? Modeling has intrinsic errors, while prototyping looks immune, as it is the natural design process for a company. The real world has always attracted more attention than the virtual world. Models are useful and the gap between the industrial production and numerical tools in the designing of devices is being reduced recently. Nowadays advances in medical images and augmentation of computer power allow to think of building real-time simulations as well as patient-specific models to be used to predict the device behavior; this is a plus that numerical modeling has over the traditional design process of cardiovascular devices. Furthermore, as in the past, the identification of new unknown problems/failures will always make the usage of numerical modeling a useful tool to explain the reasons of failure. The future in modeling stents is envisioned in their use for in silico trials and in the link between biology, engineering, and science. (C) 2019 The Authors. Published by Elsevie
Modeling Stented Coronary Arteries: Where We are, Where to Go
No full textIn the last two decades, numerical models have become well-recognized and widely adopted tools to investigate stenting procedures. Due to limited computational resources and modeling capabilities, early numerical studies only involved simplified cases and idealized stented arteries. Nowadays, increased computational power allows for numerical models to meet clinical needs and include more complex cases such as the implantation of multiple stents in bifurcations or curved vessels. Interesting progresses have been made in the numerical modeling of stenting procedures both from a structural and a fluid dynamics points of view. Moreover, in the drug eluting stents era, new insights on drug elution capabilities are becoming essential in the stent development. Lastly, image-based methods able to reconstruct realistic geometries from medical images have been proposed in the recent literature aiming to better describe the peculiar anatomical features of coronary vessels and increase the accuracy of the numerical models. In this light, this review provides a comprehensive analysis of the current state-of-the-art in this research area, discussing the main methodological advances and remarkable results drawn from a number of significant studies
Editorial: Special Issue on Verification, Validation, and Uncertainty Quantification of Cardiovascular Models: Towards Effective VVUQ for Translating Cardiovascular Modelling to Clinical Utility
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Ottimizzazione emodinamica di un trattamento chirurgico di patologie cardiache congenite
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