10 research outputs found

    CHANGES OF LUMBOPELVIC RWTHM DURING TRUNK EXTENSION IN ADOLESCENT SOCCER PLAYERS

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    Hip-spine coordination (or lumbopelvic rhythm) can be used to assess the lower-limb and spine functions. We measured low-back pain (LBP) in adolescent soccer players before and after a 6-month period and divided them into four groups: no LBP both before and after the period, LBP before but not after 0,LB P after but not before (NP), and LBP both before and after. We used 3D motion analysis during trunk extension to measure the lumba spine and hip ranges of motion QOMs). During the 6-month follow-up, lumbar spine ROM decreased in the NP group. This group extended their lumbar spine excessively compared with the hip before the period, which could cause LBP, but decreased the extension after the period. Lumbar extension relative to hip extension decreased in the PN group, which could decrease the excessive load on the lumbar spine and eliminate LBP

    新規腰部運動測定法を応用したLumbopelvic Rhythmの解析

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    学位の種別:課程博士University of Tokyo(東京大学

    Heterogeneous effects of cytotoxic chemotherapies for platinum-resistant ovarian cancer

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    Background: Single-agent chemotherapy with or without bevacizumab (Bev) is a standard therapy for platinum-resistant ovarian cancer (PR-OC). However, there is a lack of literature on chemotherapy agent selection in heterogenous PR-OC. Therefore, we aimed to clarify the heterogeneous treatment effects of each chemotherapy agent. Methods: Patients who underwent single-drug chemotherapy agents or Bev combination therapy for PR-OC between January 2009 and June 2022 were included in this study. We assessed the impact of each chemotherapy agent on the time to treatment failure (TTF) according to histological type, platinum-free interval (PFI), and Bev usage. Results: A total of 158 patients received 343 different chemotherapy regimens. In patients with clear cell carcinoma/mucinous carcinoma (CC/MC), gemcitabine (GEM) had the strongest effect with a median TTF of 5.3 months, whilst nedaplatin (NDP) had the lowest effect with a median TTF of 1.4 months. In contrast, in the non-CC/MC group, irinotecan (CPT-11) and NDP had a better TTF than GEM and pegylated liposomal doxorubicin (PLD). There were notable differences in the treatment efficacy of NDP according to PFI. Specifically, NDP prolonged the TTF in patients with a PFI ≥ 3 months. Compared with GEM alone, GEM + Bev tended to prolong the TTF more effectively; however, an additive effect was not observed with PLD + Bev. Conclusions: This study demonstrated that the effect of chemotherapy agents differed according to the tumor and background characteristics of the patient. Our findings will improve selection of effective therapies for patients with PR-OC by considering their background characteristics. © 2023, The Author(s).Open access articleThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

    Proapoptotic regimes for HTLV-I-transformed cells: targeting Tax and the NF-κB pathway

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