177,033 research outputs found

    Optimal design for goodness-of-fit of the Michaelis-Menten enzyme kinetic function

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    We construct efficient designs for the Michaelis-Menten enzyme kinetic model capable of checking model assumption. An extended model, called EMAX model is also considered for this purpose. This model is widely used in pharmacokinetics and reduces to the Michaelis- Menten model for a specific choice of the parameter setting. Our strategy is to find efficient designs for estimating the parameters in the EMAX model and at the same time test the validity of the Michaelis-Menten model against the EMAX model by maximizing a minimum of the D- or D1-efficiencies taken over a range of values for the nonlinear parameters. In addition, we show that the designs obtained from maximizing the D-efficiencies are (i) efficient for estimating parameters in the EMAX model or the Michaelis-Menten model, (ii) efficient for testing the Michaelis-Menten model against the EMAX model and (iii) robust with respect to misspecification of the unknown parameters. --Chebyshev polynomials,EMAX model,goodness of fit test,locally D-optimal design,robust optimal design

    [Memoirs of Gustav Michaelis].

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    Memoir manuscript in five parts. Also included is a family tree of the Michael Hirsch Michaelis family, originally from Guelzow in Pomerania.I. Wohl dem, der seiner Vaeter gern gedenktII. Lehrling bei Dahlheim & Co.III. MillionaerIV. WeltbebenV. 110 Chapman Crescent"In Memory of my Uncle, Mr. Gustav Michaelis"Gustav Michaelis was born October 28, 1873 in Berlin, Germany, the son of Hartwig Michaelis and his wife Anna, née Altmann; the brother of Professor Dr. med. Max Michaelis, Berlin, and of three sisters. Gustav Micaelis was the owner of a factory for the manufacturing of Oriental style rugs, Michaelis & Behrend, Nowawes, near Potsdam. He died on November 16, 1953 in London, England.Synopsis in fileDr. Anne Liese Michaelis Schwab (Mrs. C. Edgar Schwab) donated this manuscript in memory of her uncle, Mr. Gustav Michaelis.Neuenhagen bei Berlin

    Den frohen Geburts-Tag Des Hochgebohrnen Grafen und Herrn, Herrn Ernst Christoph, des Heil. Röm. Reichs Grafen von Manteuffel, Des Königl. Polnischen weissen Adler-Ordens Ritter, [et]c. [et]c. ... besinget am 22. Jul. 1740. im Namen der Wahrheitliebenden. / [Jacob Friedrich] Lamprecht [mutmaßl. Verf.]

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    Geburtstagsglückwunsch auf Ernst Christoph, Reichsgraf von Manteuffel, 22. Juli 1740Autopsie nach Ex. der ULB Sachsen-AnhaltVorlageform des Erscheinungsvermerks: Berlin, Gedruckt bei Joh. Gottfried Michaelis, Königl. privil. Buchdrucker

    Michaelis-Menten kinetics of HCHTs.

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    α-chitin, amorphous chitin or CNWs were hydrolyzed with HCHT50 or HCHT39 at 37°C for 1 min. The solid lines represent the best fit according to the Michaelis-Menten equation. Error bars show standard deviations and are from three independent experiments.</p

    Michaelis-Menten curves for cleavage reactions of Neu5Ac.

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    (A) AsNAL (B) AsNAL N168A (C) AsNAL N168T and (D) EcNAL. Initial velocities at different substrate concentrations were fitted to the Michaelis-Menten equation.</p

    Personal Papers (MS 80-0002)

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    Letter from D. W. Kempner to C. J. Michaelis Jr. claiming Model Laundry's work as unsatisfactory. Kempner is taking his cleaning business elsewhere
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