87 research outputs found
Creation of humour in plays Antonin Prochazka "Pilsen Moliere"
No full textIn my bachelor thesis I focus on the comedy that Antonin Prochazka created in his plays. The starting point is the analysis of four plays that will become the medium for a broader investigation. Particular attention is paid to creating comedy and the comic schematic design which the author uses
The risk of second primary lung carcinoma in breast cancer patients
No full textThe overall aim of this thesis was to investigate the risk of second primary malignancies - with a special focus on lung cancer - in a cohort of approximately 152,000 Swedish women diagnosed with breast cancer between 1958 and 2000. With recent advances in early diagnosis and treatment, breast cancer is becoming an increasingly survivable disease. Women with breast cancer normally receive post surgical adjuvant therapy, either as radio-, chemo-, or hormonal therapy, or as a combination of any of those modalities. Adjuvant radiotherapy reduces the risk of local recurrence, and its use is increasing as more women today choose partial mastectomies as their surgical choice. However one of the growing concerns is the chronic or late-occurring complications to the normal tissue from treatment of primary malignancies, among them therapy-related second primary cancer.We found a statistically significant increased risk of second primary lung cancers more than 5 years after breast cancer diagnosis. The highest risk of a second primary lung cancer was observed among women The completeness and quality of the information on tobacco use is most important when studying the risk of lung cancer. We contacted next-of-kin and living patients by mailed questionnaire to validate the quality of smoking information of the studied patients given in patient records. The total response rates were 89% and 93% for next-of-kin and living patients respectively. When information about overall smoking history from patient records and next-ofkin was compared, an almost perfect agreement was found (kappa=0.83), and similar result was found for living patients (kappa=0.86). Our results demonstrated that next-of-kin data are reliable and that the time between patient death and contact with next-of-kin did riot affect the response rate nor the agreement.Patient records and radiotherapy charts were abstracted for detailed information about treatment for 182 cases. Information about smoking history was identified in patient records or retrieved from nextof-kin. Our results demonstrated that in women treated with radiotherapy the risk of lung cancer increased after a follow-up time of more (ban 15 years. This risk was mostly confined to squamous cell carcinomas. In addition, the increased risk was restricted to women who smoked at the time of radiotherapy. Notably, non smoking women who received radiotherapy were not found to have an increased risk of lung cancer. The estimated excess relative risk for women with follow-up time >10 years after radiotherapy for breast cancer was 0.11 per gray.Women previously diagnosed with breast cancer have a 20% increased risk of a second primary malignancy except breast cancer. The overall risk for second primary malignancy did not vary by follow-up period, but large differences were noted between individual cancer sites, probably reflecting different etiologies. Women with a breast cancer diagnosis before the age of 50 years and women with a family history of breast cancer had elevated risks of developing a number of second primary cancers indicating a genetic predisposition to develop multiple tumours and/or susceptibility to the carcinogenic effect of breast cancer therapy.In conclusion, we have been able to establish an association between radiotherapy, smoking and risk of second primary lung cancer. We have shown that next-of-kin can provide reliable information on lifetime smoking status and should be considered as a valuable resource in studies where information on tobacco use is missing. We confirmed that women diagnosed with breast cancer have increased risks of most second primary malignancies. Finally, we showed that family history of breast cancer as well as young age at the time of breast cancer diagnosis increases these risks.List of scientific papersI. Prochazka M, Granath F, Ekbom A, Shields PG, Hall P (2002). Lung cancer risks in women with previous breast cancer. Eur J Cancer. 38(11): 1520-5. https://doi.org/10.1016/S0959-8049(02)00089-8 II. Prochazka M, Czene K, Granath F, Shields PG, Hall P (2006). Validation of smoking history in cancer patients. [Submitted]III. Prochazka M, Hall P, Gagliardi G, Granath F, Nilsson BN, Shields PG, Tennis M, Czene K (2005). Ionizing radiation and tobacco use increases the risk of a subsequent lung carcinoma in women with breast cancer: case-only design. J Clin Oncol. 23(30): 7467-74. https://doi.org/10.1200/JCO.2005.01.7335 IV. Prochazka M, Hall P, Granath F, Brown LM, Czene K (2006). Family history of breast cancer and young age at diagnosis of breast cancer increase risk of second primary malignancies in women: a population-based cohort study. [Submitted]</p
Meaningful Occupations Impacted by Burn Injuries
No full textAbstract
Date Presented 3/31/2017
Burn injuries can significantly impact an individual’s ability to return to meaningful occupations and identity in society; every burn has a story. Occupational therapists can contribute to recovery through the use of therapeutic use of self and a holistic approach.
Primary Author and Speaker: Hayley Mata
Contributing Authors: Ruth Humphry, Shelley Sehorn, Heather S. Dodd, Sydney J. Thornton, Mark Prochazka, Bruce A. Cairns</jats:p
Political Marketing in Central Europe
No full textDiploma thesis Political Marketing in Central Europe analyzes the historical background, culture specifics, economical, geographical and socio-demographical factors which are influencing voters' decisions in individual countries, mentions the communication of political parties and analyzes the results of parliamentary elections in the Czech Republic, Slovak Republic, Hungary, and presidential elections in Austria and Poland, which took place in 2010. Based on the findings the author tries to predict the probable further development of political parties in the political scenes in the country and identifies key factors of voters' decisions in each country
Framework for Developing Innovation Systems in Small Island Developing States: Roadmap for turning Curaçao into the OTEC Centre of Excellence
No full textThe objective of this thesis was to design a generically applicable framework for guiding the development of technological innovation systems in small island developing states (SIDS). Existing theories formed the bases of the framework but important changes were derived from a cross-case study of five island based innovation systems and an in-depth case study of Ocean Thermal Energy Conversion (OTEC) technology on the island of Curaçao. Two key factors were found to make the development of innovation systems in SIDS different. Firstly, only specific technologies should be targeted – high-margin or service sectors, and the ones that utilize strategic locations or specific natural resources of the islands. Secondly, due to the characteristics of SIDS the innovation systems’ integration into the landscape and regimes of the islands is essential – the links between the innovation systems and regimes and landscapes are much stronger in SIDS than in developed states. Therefore strong network of local partners should be established in order to guarantee sufficient support from the islands’ regimes. Also, due to the potential impacts on the islands’ landscapes, projects that are parts of the TIS should be of ‘moderate’ sizes so that they do not make the SIDS overly dependent on the success or failure of the technology. Furthermore, the innovation systems should be developed gradually in order not to disrupt the fragile economies of the islands. By following this set of rules, close relationships between the sectors and the islands’ regimes and landscapes can be established. This results into a win-win situation where the TIS can develop as it benefits from the island’s support (permits, policies, tax exemptions etc.) and the island itself reaps socio-economic benefits. Without this win-win situation, the TIS will struggle to develop.Management of TechnologyTechnology Dynamics and Sustainable DevelopmentTechnology, Policy and Managemen
Studies on benzylchlorocarbene
No full textPT: J; CR: DOYLE MP, 1987, CHEM DIAZIRINES, CH8 GOULD IR, 1985, TETRAHEDRON, V41, P1587 GRAHAM WH, 1965, J AM CHEM SOC, V87, P4396 HAMMETT LP, 1970, PHYSICAL ORGANIC CHE, P119 JACKSON JE, UNPUB JACKSON JE, 1988, J AM CHEM SOC, V110, P5595 JONES WM, 1980, REARRANGEMENTS GROUN, V1, P95 LINDEN A, 1988, J ORG CHEM, V53, P1085 LIU MTH, 1985, J CHEM SOC CHEM COMM, P982 LIU MTH, 1987, J ORG CHEM, V52, P4223 NICKON A, 1982, J AM CHEM SOC, V104, P2022 PROCHAZKA M, 1980, COLLECT CZECH CHEM C, V45, P1388 SOUNDARARAJAN N, 1988, J AM CHEM SOC, V110, P7143 TOMIOKA H, 1986, CHEM LETT, P695 TURRO NJ, 1982, J AM CHEM SOC, V104, P1754; NR: 15; TC: 5; J9: J ORG CHEM; PG: 3; GA: R9767Source type: Electronic(1
Treatment of theme and characterisation in the works of Yusuf Idris.
No full textYusuf Idris is a short story writer, novelist and playwright. On the whole, he uses each genre for different purposes. In his short stories he is the subjective writer concerned with a minute analysis of mental states and moods. In his novels he is the socially aware and politically committed writer, while In his plays he tackles social problems on an abstract level. While he has succeeded to a great extent as a short story writer and a playwright Yusuf Idris has failed as a novelist. His novels appear to be a string of short stories held together tenuously by a main theme or else they are overblown short stories. Yusuf Idris then is to be seen primarily as a short story writer and a playwright. In the short stories the author treats his characters as lonely Individuals who suffer by being isolated from other human beings, and the solution to their problem lies in a return to the fold of the corporate entity. Here Yusuf Idris contradicts herself, as it is precisely this corporate entity, supposedly ensuring the happiness of the individual which is the source of his unhappiness. The characters ere depicted as living either in the city or the country. For Yusuf Idris it is the latter that promises harmonious human relationships while the former is the source of unhappiness. By idealising the country the author distorts the quality of urban living when contrasting town life and city life. The characters are constantly faced with defeat, mainly through poverty. Sex occupies a central position in his writing and it is treated In terms of its influence on behaviour. Physical and mental suffering are treated in detail and the author's training as a medical man is readily apparent. The author's major contribution, however, lies in his analysis of the obsession, which underlies many of his short stories, and influences his technique of characterisation. His plays are diametrically opposed to the rest of his work. In them the psychological element is lacking and issues ore discussed on an abstract level. It is as if the short stories and the ploys had been written by two different men
Bones, Glands, Ears and More: The Multiple Roles of FGF10 in Craniofacial Development
No full textMembers of the fibroblast growth factor (FGF) family have myriad functions during development of both non-vertebrate and vertebrate organisms. One of these family members, FGF10, is largely expressed in mesenchymal tissues and is essential for postnatal life because of its critical role in development of the craniofacial complex, as well as in lung branching. Here, we review the function of FGF10 in morphogenesis of craniofacial organs. Genetic mouse models have demonstrated that the dysregulation or absence of FGF10 function affects the process of palate closure, and FGF10 is also required for development of salivary and lacrimal glands, the inner ear, eye lids, tongue taste papillae, teeth, and skull bones. Importantly, mutations within the FGF10 locus have been described in connection with craniofacial malformations in humans. A detailed understanding of craniofacial defects caused by dysregulation of FGF10 and the precise mechanisms that underlie them offers new opportunities for development of medical treatments for patients with birth defects and for regenerative approaches for cancer patients with damaged gland tissues
Negotiating ludic normativity in Facebook meme pages
No full textTitle: Negotiating ludic normativity in Facebook meme pages Author: Ondřej ProcházkaAffiliation: Department of Culture Studies, Tilburg School of Humanities and Digital SciencesThis thesis explores the capacity of Internet memes to inflect social realities in the communities organized around them on social media, particularly Facebook. Memes are not mere playful ‘jokes’ or ‘parodies’ spreading virally on the Internet in countless variations, they are also powerful tools for political investment aimed to sway public attention and opinions. Memes have been increasingly documented as a vital component in the unprecedented spread and ‘normalization’ of hateful sentiments and ideologies characterized by ‘fake news’ and ‘post-truth’ politics appealing to emotions rather than ‘facts’ in the digital mainstream. Based on author’s more than five-year observation of communities around Countryball memes, this work argues that much of the socio-cultural and communicative dynamics involving memes can be understood in terms of ludic play. The object of the study – Countryballs memes – are simple meme-comics featuring ball-shaped creatures in colors denoting nation-states while satirically reinventing international ‘drama’ through the prism of socio-cultural and linguistic stereotypes. Having become a household name among memes, Countryballs offer communicative resources to playfully engage not only with wider socio-political issues, but also to with the linguistic, semiotic and ideological boundaries of our communicative norms shaped by the affordances of social media. The present work demonstrates how play can be used as a useful concept for understanding not only how matters of public attention are packed, framed and transmitted in the digital culture via (Countryball) memes, but more importantly how such matters are in fact interpreted by those who engage with them. More specifically, it shows how play enables alternative modes of expression and meaning making with different normative patterns and preferences which stand outside ‘standard’, ‘rational’ or ‘civil’ expectations. And it is precisely ludic play that fosters different types of communication and sociality which are often done ‘just for fun’, however serious or offensive their effects may be. To identify these effects and their implications in the contemporary digital age, the thesis employs a discourse-analytical methodology informed by current advances in digital ethnography and sociolinguistics. It focuses on negotiations among participants in memetic communities about what counts as ‘appropriate’, ‘acceptable’ or ‘correct’ in their socio-communicative behavior. Together in four case studies, the present work provides a comprehensive account of how participants articulate, police, break and re-construct ludic normativity in connection with recent socio-political issues and digital culture at large. This includes the role of memes in the newly emerging forms of communication, in the rise of populism and nationalism, algorithmic manipulation and exploitation, curating digital content and more. The concept of play is continually revisited throughout the discussion against the developments in the scholarship on Internet memes and their ludic genealogy. In doing so, the thesis also revisits some of the traditional concepts such as the notion of ‘community’ and ‘communicative competence’ to arrive at more precise accounts of the concrete processes of globalization and digitalization in our societies and their effects. <br/
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