332 research outputs found
Urban Renewal in Newcastle : Profile of Watkinson Glass Associates
No full textWritten by freelance author Melissa Barclay the article in Stained Glass Quarterly of America,charts the career of Cate Watkinson and her company Watkinson Glass Associates through words and illustrations of the work she has created in the last 20 years
Macrocycle size matters: “small” functionalized rotaxanes in excellent yield using the CuAAC active template approach
No full textBy shrinking the macrocycle in the CuAAC active template reaction not only is it demonstrated to be possible to use smaller macrocycles, but, surprisingly, that smaller macrocycles lead to higher yields of rotaxane product. The synthesis of “small” functionalized [2]rotaxanes showcases this as a method for the production of materials with potential applications in molecular electronics, drug delivery, sensing, and enantioselective catalysis
Chelating rotaxane ligands as fluorescent sensors for metal ion
No full textAlthough metal‐ion‐binding interlocked molecules have been under intense investigation for over three decades, their application as scaffolds for the development of sensors for metal ions remains underexplored. In this work, we demonstrate the potential of simple rotaxanes as metal‐ion‐responsive ligand scaffolds through the development of a proof‐of‐concept selective sensor for Zn2+
Modular ‘click’ sensors for zinc and their application in vivo
No full textAlthough the central role that zinc plays in many biological processes and important disease states is now well-established, there remains a pressing need to develop an absolute understanding of the underlying biology of zinc trafficking in terms of its dynamic and quantitative processing in specific organelles. Here we describe the modular synthesis of zinc sensors using a ‘click’ approach and demonstrate the applicability of our new sensors in vivo using a zebrafish model
Mathematics in the Mind\u27s Eye: Michael Schultheis Paints Poetic and Conceptual Geometries
No full textMichael Schultheis is an established artist and a formally-educated mathematician. In his practice the two disciplines are inextricably linked. His large-scale lyrical paintings at first glance seem to focus on the effects of light and atmospheres, representing cloudscapes or waterscapes in resonant color. Yet moving through these mists are decidedly mathematical references --- drawn geometric shapes and hand-written equations. These are employed by Schultheis to represent the physical world or to express feelings (or both). For example, he may examine the structure of a pine cone or reflect on human relationships or do both at the same time. The resulting works of art present a personal world understood conceptually through geometry and made tangible through paint
Open Access Books and the Lever Press
No full textSeveral high profile projects in North America and Europe are exploring the potential of flipped publishing models for long form digital scholarship in the humanities and qualitative sciences. Although the mechanisms proposed for achieving it vary, the “big idea” is that the costs of publishing monographs should be borne by the producer (author, institution, government agency) rather than the consumer. Such a system could offer economic advantages to publishers and libraries and theoretically better aligns funding responsibility with beneficiaries. However, the incentives for the authors themselves to engage with a flipped model are poorly defined, administrators are concerned about the financial implications, and librarians are struggling to identify thow they add value in this new ecosystem. This presentation suggests ways to better align the benefits of open access with the interests of those who care about scholarly book publishing and explores some implications for the design of new publishing programs and platforms. Initiatives underway at Michigan Publishing, the publishing division of the University of Michigan Library which includes a university press, are described (several are supported by the Andrew W. Mellon Foundation) and are put in the context of other national and international experiments in open access book publishing, including an important initiative from within the Liberal Arts College community, the Lever Press.-- Charles Watkinson is Director of University of Michigan Press and Associate University Librarian for Publishing
Terahertz spectroscopy: a powerful new tool for the chemical sciences?
No full textTerahertz spectroscopy is only now beginning to make its transition from initial development by physicists and engineers to broader use by chemists, materials scientists and biologists, thanks to the increasing availability of commercial terahertz spectrometers. With the unique insights that terahertz spectroscopy can provide into intermolecular bonding and crystalline matter, it could prove to be an invaluable addition to the chemist's analytical toolset. This tutorial review aims to give an introduction to terahertz spectroscopy, its techniques, equipment, current applications and potential for the chemical sciences to a broad readership
Generic protease detection technology for monitoring periodontal disease
No full textPeriodontal diseases are inflammatory conditions that affect the supporting tissues of teeth and can lead to destruction of the bone support and ultimately tooth loss if untreated. Progression of periodontitis is usually site specific but not uniform, and currently there are no accurate clinical methods for distinguishing sites where there is active disease progression from sites that are quiescent. Consequently, unnecessary and costly treatment of periodontal sites that are not progressing may occur. Three proteases have been identified as suitable markers for distinguishing sites with active disease progression and quiescent sites: human neutrophil elastase, cathepsin G and MMP8. Generic sensor materials for the detection of these three proteases have been developed based on thin dextran hydrogel films cross-linked with peptides. Degradation of the hydrogel films was monitored using impedance measurements. The target proteases were detected in the clinically relevant range within a time frame of 3 min. Good specificity for different proteases was achieved by choosing appropriate peptide cross-linkers.<br/
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