448 research outputs found

    Dissertatio Historica De Sibyllarum Oraculis / Quam Auxiliante Divina Gratia & Amplissimae Facultatis Philosophicae In Academia Regiomontana Consensu, Publice defendet Praeses M. Michael Hoynovius Milca-Prussus, & Respondens Nicolaus Poppe Stada Bremensis. In Auditorio Philosophico Anno MDCLXXXV. die [ ] Octobris horis consuetis

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    DISSERTATIO HISTORICA DE SIBYLLARUM ORACULIS / QUAM AUXILIANTE DIVINA GRATIA & AMPLISSIMAE FACULTATIS PHILOSOPHICAE IN ACADEMIA REGIOMONTANA CONSENSU, PUBLICE DEFENDET PRAESES M. MICHAEL HOYNOVIUS MILCA-PRUSSUS, & RESPONDENS NICOLAUS POPPE STADA BREMENSIS. IN AUDITORIO PHILOSOPHICO ANNO MDCLXXXV. DIE [ ] OCTOBRIS HORIS CONSUETIS Dissertatio Historica De Sibyllarum Oraculis / Quam Auxiliante Divina Gratia & Amplissimae Facultatis Philosophicae In Academia Regiomontana Consensu, Publice defendet Praeses M. Michael Hoynovius Milca-Prussus, & Respondens Nicolaus Poppe Stada Bremensis. In Auditorio Philosophico Anno MDCLXXXV. die [ ] Octobris horis consuetis (1) Titelseite (1) Widmung (2) Dissertatio Historica De Sibyllarum Oraculis (3) Beiträge (33

    Poppe, Michael

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    Angaria neglecta Poppe & Goto 1993

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    neglecta, Angaria Poppe & Goto, 1993 Angaria neglecta Poppe & Goto, 1993: 22 (pl. 6). Gastropoda, Angariidae Paratype: MZSP 95951. Locality: Japan, Wakayama prefecture, Nada-Cho, 510 fms. Preservation: Dry. Remarks: Former Jens Hemmen Collection. The specimen listed above was initially designated as paratype # 12 in the original description. The senior author (Poppe, pers. comm.) confirmed the type status.Published as part of Cavallari, Daniel C., Dornellas, Ana Paula S. & Simone, Luiz Ricardo L., 2016, Second annotated list of type specimens of molluscs deposited in the Museu de Zoologia da Universidade de São Paulo, Brazil, pp. 1-59 in European Journal of Taxonomy 213 on page 38, DOI: 10.5852/ejt.2016.213, http://zenodo.org/record/384012

    Metformin differentially activates ER stress signaling pathways without inducing apoptosis

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    SUMMARY Endoplasmic reticulum stress signaling (ERSS) plays an important role in the pathogenesis of diabetes and heart disease. The latter is a common comorbidity of diabetes and worsens patient outcome. Results from clinical studies suggest beneficial effects of metformin – a widely used oral drug for the treatment of type 2 diabetes – on the heart of diabetic patients with heart failure. We therefore analyzed the effect of metformin on ERSS in primary rat cardiomyocytes. We found that metformin activates the PERK-ATF4 but not the ATF6 or IRE1-XBP1 branch in ERSS and leads to a strong upregulation of CHOP mRNA and protein. Surprisingly, long-term induction of CHOP by metformin is not accompanied by apoptosis even though CHOP is regarded to be a mediator of ER-stress-induced apoptosis. In conclusion, metformin induces distinct ER stress pathways in cardiomyocytes and our results indicate that CHOP is not necessarily a mediator of apoptosis. Metformin might exert its cardioprotective effect through selective activation of ERSS pathways in the cardiomyocyte

    1. B [Heinrich Beugger] 2. P [Felix Poppe]

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    Untereinander zwei Knaben im Profil nach linksM. Wchsmut. SculpDie Radierungen stehen vermutlich in Zusammenhang mit Lavater's PhysiognomikGemäss interner Notiz ist oben Heinrich Beugger und unten Felix Poppe aus Otelfingen porträtiertVermutlich aus der Sammlung Leonhard Ziegler zum Egli (1782-1854) Exemplar der Zentralbibliothek Zürich, Graphische Sammlung und Fotoarchi

    sj-docx-1-ine-10.1177_15910199231221491 - Supplemental material for Predicting outcome in acute stroke with large vessel occlusion—application and validation of MR PREDICTS in the ESCAPE-NA1 population

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    Supplemental material, sj-docx-1-ine-10.1177_15910199231221491 for Predicting outcome in acute stroke with large vessel occlusion—application and validation of MR PREDICTS in the ESCAPE-NA1 population by Martha Marko, Mayank Goyal, Johanna M Ospel, Nishita Singh, Esmee Venema, Raul G Nogueira, Andrew M Demchuk, Ryan A McTaggart, Alexandre Y Poppe, Bijoy K Menon, Charlotte Zerna, Maxim Mulder, Diederik WJ Dippel, Hester F Lingsma, Bob Roozenbeek, Michael Tymianski and Michael D Hill in Interventional Neuroradiology</p

    Different expression of the catalytic alpha subunits of the AMP activated protein kinase - an immunohistochemical study in human tissue

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    AMPK is an ubiquitously distributed multienzyme complex. It is an important energy sensor and regulator of cellular metabolic activity. In this study we analyzed for the first time the cellular distribution of the catalytically active subunits AMPK alpha 1 and alpha 2 in different human tissues by immunohistochemistry. We found different expression patterns for both isoforms. AMPK alpha 2 expression clearly dominates in skeletal myocytes and cardiomyocytes, whereas AMPK alpha 1 dominates in a number of secreting cells, like mammary glands, islets of langerhans and cells of the colon crypts.Deutsche Diabetes Gesellschaft (DDG
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