18,769 research outputs found
Mechanisms of sphingolipid functions during heat stress in "Saccharomyces cerevisiae"
No full textSphingolipids are important membrane constituents in all eukaryotic cells. Ongoing sphingolipid synthesis is required for a variety of cellular processes including response to heat shock. During heat stress, de novo sphingolipid synthesis is upregulated and mutants defective in the biosynthesis of sphingolipids show a significantly greater loss of viability. To dissect the mechanisms of sphingolipid functions during heat stress we made use of the Saccharomyces cerevisiae lcb1-100 mutant. This mutant is conditionally impaired in serine palmitoyltransferase activity, the first committed step in sphingolipid biosynthesis. lcb1-100 cells are highly sensitive to heat shock and die at elevated temperatures. In this study we could show that the increased sensitivity to heat stress in lcb1-100 cells correlated with a lack of induction of the major heat shock proteins at high temperature. This defect could be restored by the overexpression of ubiquitin, a situation that increased turnover of proteins and prevented accumulation of protein aggregates in lcb1-100 cells. These data showed that the essential function of heat shock protein induction is the removal of misfolded or aggregated proteins. Furthermore it suggested that heat stressed cells do not die because of the loss of protein activity due to their denaturation, but because of the inherent toxicity of the denatured and/or aggregated proteins. In addition we tried to explain the lack of induction of heat shock proteins in lcb1-100 cells. We could show that transcription and nuclear export of heat shock protein mRNA was not affected in these cells. Under heat stress conditions, lcb1-100 cells exhibit a strong decrease in protein synthesis and polysome analyses demonstrated a defect in translation initiation. Furthermore we demonstrate that efficient translation under these conditions relies upon the synthesis of sphingoid base. Deletion of the eIF4E binding protein Eap1p partially restores translation initiation and the synthesis of heat shock proteins in lcb-100 cells. Thus, sphingoid bases signal to the cap-dependent translation initiation apparatus to enhance heat shock protein synthesis. In addition, ubiquitin overexpression in the lcb1-100 mutant allowed recovery of translation, but not at the initial phase where heat shock proteins are made. Therefore the recovery process seems to be dependent upon the function of the heat shock proteins that are made during the initial phase of heat stress. Altogether we have uncovered a new function for sphingoid bases and provide an explanation for the sphingoid base synthesis requirement for survival during heat stress
An Amazing Turn of Events
No full textHow the master regulator of cell growth, TOR, came to be identified and understood, from the perspective of its discoverer, Michael N. Hall
B.J. Thomas plus Sop with Camel, Little Feat and The Raspberries, Michael Murphy with J. Boy Adams poster
No full textColor poster of B.J. Thomas plus Sop with Camel, Little Feat and The Raspberries, Michael Murphy with J. Boy Adams performance at Liberty Hall. At the top of the page the text reads: "LIBERTY HALL 1610 CHENEVERT - 225-6250 PROUDLY PRESENTS IN CONCERT January 31–February 1 and 2 1974 B. J. THOMAS PLUS SOP WITH CAMEL February 3 and 4 1974 LITTLE FEAT AND The RASPBERRIES February 5 Only MICHAEL MURPHY ALONG WITH J. BOY ADAMS Welcome N E C Conventioners Be High Thanx ALL TICKETS $3.50 AT DOOR ONLY. Fred Marshall Press 5303 Lyons Ave. Houston".The Houston music venue, Liberty Hall, was open between 1971 and 1978
Empirical antibiotics for suspected early neonatal sepsis
No full text‘Empirical treatment of neonatal sepsis: are the current guidelines adequate?’1 makes recommendations for empirical antibiotic treatment of neonates based on voluntary surveillance data relating to blood culture isolates. The adverse effects of antibiotic treatment do not appear to have been considered and the recommendations do not differentiate between early and late sepsis. <br/
New Residence Hall Warren Hall
No full textOn July 16, 1992 Dr. William B. DeLauder, president of Delaware State University along with the honorable Michael N. Castle, Governor of the State of Delaware, Dr. Cora N. Selby, DSC Board Member, Dr. William G. Dix, President DSC. Board, Mr. Pat Meconi, Architect attended a groundbreaking ceremony for Warren-Franklin Hall. Warren Hall is a residence hall on Delaware State University campus
New Residence Hall Warren Hall
No full textOn July 16, 1992 Dr. William B. DeLauder, president of Delaware State University along with the honorable Michael N. Castle, Governor of the State of Delaware, Dr. Cora N. Selby, DSC Board Member, Dr. William G. Dix, President DSC. Board, Mr. Pat Meconi, Architect attended a groundbreaking ceremony for Warren-Franklin Hall. Warren Hall is a residence hall on Delaware State University campus
Hall polynomials for the representation-finite hereditary algebras
No full textRingel CM. Hall polynomials for the representation-finite hereditary algebras. Advances in mathematics. 1990;84(2):137-178
Theory of spin Hall magnetoresistance
No full textWe present a theory of the spin Hall magnetoresistance (SMR) in multilayers made from an insulating ferromagnet F, such as yttrium iron garnet (YIG), and a normal metal N with spin-orbit interactions, such as platinum (Pt). The SMR is induced by the simultaneous action of spin Hall and inverse spin Hall effects and therefore a nonequilibrium proximity phenomenon. We compute the SMR in F|N and F|N|F layered systems, treating N by spin-diffusion theory with quantum mechanical boundary conditions at the interfaces in terms of the spin-mixing conductance. Our results explain the experimentally observed spin Hall magnetoresistance in N|F bilayers. For F|N|F spin valves we predict an enhanced SMR amplitude when magnetizations are collinear. The SMR and the spin-transfer torques in these trilayers can be controlled by the magnetic configuration.QN/Quantum NanoscienceApplied Science
Biosecurity: a significant issue for wine tourism?
No full textPeople may be significant vectors for vine diseases and pests. Yet despite the potential biosecurity risks of visitation few New Zealand wineries have biosecurity strategies in place. The paper therefore aims to examine biosecurity threats to wineries in terms of first, visitor understanding of terms used in customs declaration and their relation to their perception of vineyards; and second, the behaviours of winery visitors. In order to undertake an exploratory assessment of biosecurity risks associated with wine tourism a short convenience survey was undertaken of winery visitors in the Canterbury, Marlborough and Central Otago wine regions of the South Island of New Zealand in January-March 2002. The survey had 324 respondents of which 69 were international visitors. The demographic profile of respondents was similar to previous profiles of New Zealand wine tourists. The results indicated that relatively few respondents recognised a vineyard as a farm therefore raising concerns about the extent to which present customs forms may identify winery or vineyard visits. Of equal concern was the extent to which the same clothing items are used from one winery visit to another, and on different trips. The paper concludes by noting the urgent need to develop more appropriate biosecurity strategies for wineries and vineyards in the light of the development of wine tourism.UnpublishedPeer ReviewedAgriculture Western Australia (2000a). Grape Phylloxera: Exotic threat to Western Australia, Factsheet no.0002-2000, Perth: Department of Agriculture.
Agriculture Western Australia (2000b). Viticulture Industry Protection Plan, Perth: Department of Agriculture.
Australian Viticulture (2003). Review uncovers need for better quarantine. Australian Viticulture May-June: 55-56
Biosecurity Strategy Development Team (2001a). A Biosecurity Strategy for New Zealand, Strategy Vision Framework Background Paper for Stakeholder Working Groups, Wellington: Biosecurity Strategy Development Team.
Biosecurity Strategy Development Team (2001b). Issues Paper: Developing a Biosecurity Strategy for New Zealand: A Public Consultation Paper, Wellington: Biosecurity Strategy Development Team.
Biosecurity Strategy Development Team (2002) Developing a Biosecurity Strategy for New Zealand Submissions on the ‘Issues Paper’: A Summary Report, Wellington: Biosecurity Strategy Development Team
Central Otago Winegrowers Association (COWA) (2002). Winegrowers Respond to Phylloxera, COWA Press Release, 4 February
Commonwealth of Australia (1999). Incoming Passenger Card, Canberra: Commonwealth of Australia.
Department of the Treasury (ND) United States Customs Declaration, Customs Form 6059B (101695), Washington DC: Department of Treasury.
Hall, C.M. and Johnsom, G. (1998). Wine tourism: an imbalanced partnership, in: Dowling, R. and Carlsen, J. (eds) Wine Tourism Perfect Partners, Proceedings of the first Australian Wine Tourism Conference, Margaret River, Western Australia, May 1998 (pp. 51-72), Canberra: Bureau of Tourism Research.
Hall, C.M., Sharples, E., Cambourne, B. and Macionis, N. (eds) (2000). Wine Tourism Around the World: Development, Management and Markets, Oxford: Butterworth-Heinemann.
Hall, C.M., Sharples, E., Mitchell, R., Cambourne, B. and Macionis, N. (eds) (2003). Food Tourism Around the World: Development, Management and Markets, Oxford: Butterworth-Heinemann.
Hall, C.M., Sharples, E., and Smith, A. (2003). The experience of consumption or the consumption of experiences? Challenges and issues in food tourism, in: Hall, C.M., Sharples, E., Mitchell, R., Cambourne, B. and Macionis, N. (eds.) Food Tourism Around the World: Development, Management and Markets (pp.314-331), Oxford: Butterworth-Heinemann.
Land Access Ministerial Reference Group (2003) Walking Access in the New Zealand Outdoors: A report by the Land Access Ministerial Reference Group. Wellington: MAF Policy, Ministry of Agriculture and Forestry.
Mitchell, R. and Hall, C.M. (2001). The winery consumer: A New Zealand perspective, Tourism Recreation Research, 26(2), 63-75.
New Zealand Customs Service (2001). New Zealand Passenger Arrival Card – and Notes, Wellington: New Zealand Customs Service.
New Zealand Winegrowers (2003). http://www.nzwine.com/statistics/
Ordish, G. (1987). The Great Wine Blight, 2nd ed., London: Sedgwick and Jackson.
Pearson, R.C. and Goheen, A.C. (eds) (1998). Compendium of Grape Diseases, Saint Paul: The American Phytopathological Society.
Smith, A. and Hall, C.M. (2001). A Stakeholder Generated SWOT Analysis of the New Zealand Food and Wine Tourism Industry, paper presented at the New Zealand Wine and Food Tourism Conference, Hawkes Bay, November.
Wilkins, M. and Hall, C.M. (2001). An industry stakeholder SWOT analysis of wine tourism in the Okanagan Valley, British Columbia, International Journal of Wine Marketing, 13(3), 77-81.
Wine Institute Of California (2002). Pierce's Disease Update, San Francisco: Wine Institute of California
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