1,532 research outputs found
Cozy
No full textMetcalfe considers Collyer’s work as commenting on gender and its relation to domesticity. On the artist’s use of decorative art and crafts to render things nonfunctional, Metcalfe recalls P. Dykhuis’ description of them as “dysfunctional.” There is a fine line between humour and unease in the work, the author notes, as it evokes serious issues like domestic violence. List of works. Biographical notes. 8 bibl. ref
The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells
No full textActivated mast cells are a major source of the eicosanoids PGD(2) and leukotriene C(4) (LTC(4)), which contribute to allergic responses. These eicosanoids are produced following the ERK1/2-dependent activation of cytosolic phospholipase A(2), thus liberating arachidonic acid, which is subsequently metabolized by the actions of 5-lipoxygenase and cyclooxygenase to form LTC(4) and PGD(2), respectively. These pathways also generate reactive oxygen species (ROS), which have been proposed to contribute to FcepsilonRI-mediated signaling in mast cells. In this study, we demonstrate that, in addition to ERK1/2-dependent pathways, ERK1/2-independent pathways also regulate FcepsilonRI-mediated eicosanoid and ROS production in mast cells. A role for the Tec kinase Btk in the ERK1/2-independent regulatory pathway was revealed by the significantly attenuated FcepsilonRI-dependent PGD(2), LTC(4), and ROS production in bone marrow-derived mast cells of Btk(-/-) mice. The FcepsilonRI-dependent activation of Btk and eicosanoid and ROS generation in bone marrow-derived mast cells and human mast cells were similarly blocked by the PI3K inhibitors, Wortmannin and LY294002, indicating that Btk-regulated eicosanoid and ROS production occurs downstream of PI3K. In contrast to ERK1/2, the PI3K/Btk pathway does not regulate cytosolic phospholipase A(2) phosphorylation but rather appears to regulate the generation of ROS, LTC(4), and PGD(2) by contributing to the necessary Ca(2+) signal for the production of these molecules. These data demonstrate that strategies to decrease mast cell production of ROS and eicosanoids would have to target both ERK1/2- and PI3K/Btk-dependent pathways
Interview with Michael Pasley (FA 805)
No full textInterview conducted by Amy Jo Wilk with Michael Pasley about homesteading in Metcalfe County, Kentucky in the 1970s. Part of Folklife Archives Project 805 titled Voices from the Homestead. This audio file may take several minutes to download
Multiple egg allergens elicit th2 cytokine responses that are associated with the incidence of egg allergy`
No full textJessica Metcalfe, Nina D, Vaz, Maria Makrides, Michael S.Gold, Patrick Quinn, Richard Loh, Susan L. Prescott, Debra J.Palme
Interaction between baseline participant factors and treatment effects following peanut oral immunotherapy
No full textAbstract not availableMelanie Lloyd, Paxton Loke, Sarah Ashley, Adriana C. Lozinsky, Francesca Orsini, Michael O, Sullivan, Michael Gold, Patrick Quinn, Jessica Metcalfe, and Mimi L.K. Tan
Cavity-enhanced Raman and Helmholtz resonator photoacoustic spectroscopy to monitor the mixed sugar metabolism of E. coli
No full textWe introduce and compare two powerful new techniques for headspace gas analysis above bacterial batch cultures by spectroscopy, Raman spectroscopy enhanced in an optical cavity (CERS) and photoacoustic detection in a differential Helmholtz resonator (DHR). Both techniques are able to monitor O2 and CO2 and its isotopomers with excellent sensitivity and time resolution to characterise bacterial growth and metabolism. We discuss and show some of the shortcomings of more conventional optical density (OD) measurements if used on their own without more sophisticated complementary measurements. The spectroscopic measurements can clearly and unambiguously distinguish the main phases of bacterial growth in the two media studied, LB and M9. We demonstrate how 13C isotopic labelling of sugars combined with spectroscopic detection allows the study of bacterial mixed sugar metabolism, to establish whether sugars are sequentially or simultaneously metabolised. For E. coli, we have characterised the shift from glucose to lactose metabolism without a classic diauxic lag phase. DHR and CERS are shown to be cost-effective and highly selective analytical tools in the biosciences and in biotechnology, complementing and superseding existing, conventional techniques. They also provide new capabilities for mechanistic investigations and show a great deal of promise for use in stable isotope bioassays.</p
Labrador Development Corporation
No full textMike Martin and Sam Metcalfe discuss the Royal Commission recommendation to establish a development corporation for Labrador, and to stimulate strong local economics at the community level. Interview in English and Inuttut
Book review : The people of the great river by Michael Tremmel and the River Tonga people
No full textReview of: Michael Tremmel and the River Tonga people. The people of the great river. Gweru, Zimbabwe: Mambo Press, 199
Almost Global Existence for Systems of Nonlinear Wave Equations in Three Spatial Dimensions
No full textThis work establishes an almost global existence result for systems of semilinear wave equations in three spatial dimensions of the form □u = Q(u, u′) with sufficiently small initial data. We make the additional assumptions that Q vanishes to second order at the origin and (∂u_J ∂u_K Q)(0, 0) = 0 to avoid terms of the form u^2 in the nonlinearity. The result is an extension of the almost global existence result established by Lindblad for scalar equations in three dimensions. To prove this existence statement, we rely on two key components. The first is a new local energy estimate that results from combining an r^p weighted multiplier, inspired by the work of Dafermos and Rodnianski, with a ghost weight e^{−σ(t−r)}, which was initially used by Alinhac. The second is a Klainerman-Sobelev type estimate from the work of Metcalfe, Tataru, and Tohaneanu, which is used to obtain sufficient decay of solutions to close an iteration argument.Doctor of Philosoph
Local Smoothing of the Schrödinger Equation on a Multi-Warped Product with Degenerate Trapping
No full textGeodesic trapping is an obstruction to dispersive estimates for solutions to the Schrödinger equation. In [CW13], Christianson and Wunsch prove a local smoothing estimate on a surface of revolution with degenerate trapping. In this thesis, we look to extend this result to the case of a multi-warped product with two infinite directions. A multi-warped product manifold with one infinite direction was used in [CN22], where a local smoothing result was proven for inflection-transmission type trapping studied initially by Christianson and Metcalfe in [CM14]. We construct a multi-warped product with two infinite ends where each warped piece has degenerate trapping at different points in the radial direction. In the inflection-transmission type trapping case, the trapping in each warped direction did not interact leaving the trapping at just two points in the radial direction. However, in this thesis, the trapping is complicated. The projection of all trapped trajectories onto the radial direction after separating variables will be a countable dense subset of points in the interval [-ε,ε]. The main result of this thesis is to show that while the trapping is more complicated, we gain the same local smoothing estimates from [CW13] in each angular direction.Doctor of Philosoph
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