146 research outputs found
Anna Lappe, Small Planet Institute
No full textIf you are like me…50-something or even more chronologically gifted, you remember Frances Moore-Lappe’s book Diet for a Small Planet. Nothing short of revolutionary — for so many people it was life changing, many people converting to vegetarianism virtually overnight. When I heard that Frances’ daughter Anna was coming to town to be the keynote speaker at the Food Summit, sponsored by the Food Policy Council, I knew this was my opportunity to have a conversation with her. Anna is the author of many books and travels throughout the world speaking about food security and sovereignty. Through the great work of May Patino at the California Center for Rural Policy, located at Humboldt State University, it happened!
But you know how it is — so many questions and only 10 minutes for an interview — so of course I asked what it was like at the dinner table growing up with Frances Moore-Lappe
Comparative interactomics analysis of protein family interaction networks using PSIMAP (protein structural interactome map
No full textMotivation: Many genomes have been completely sequenced. However, detecting and analyzing their protein–protein interactions by experimental methods such as co-immunoprecipitation, tandem affinity purification and Y2H is not as fast as genome sequencing. Therefore, a computational prediction method based on the known protein structural interactions will be useful to analyze large-scale protein–protein interaction rules within and among complete genomes. Results: We confirmed that all the predicted protein family interactomes (the full set of protein family interactions within a proteome) of 146 species are scale-free networks, and they share a small core network comprising 36 protein families related to indispensable cellular functions. We found two fundamental differences among prokaryotic and eukaryotic interactomes: (1) eukarya had significantly more hub families than archaea and bacteria and (2) certain special hub families determined the topology of the eukaryotic interactomes. Our comparative analysis suggests that a very small number of expansive protein families led to the evolution of interactomes and seemed to have played a key role in species diversification
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Biochar Banquet & Demonstrations
No full textIn the Student Union Ballroom of the Campus Center at UMass Amherst, the Pioneer Valley Biochar Initiative will host a Biochar Banquet & Demonstration – tickets available here. Various food stations will feature locally grown produce grown in biochar conditioned soil, as well as a variety of meats, beverages and desserts enhanced by biochar. Come learn about this fascinating material and how it is benefiting agriculture and our climate. Monday October 14th beginning at 5pm with live biochar making demonstrations, poster presentations, book signings and more. Another very exciting feature of this Biochar Banquet is the Keynote Presentation by Frances Moore Lappe. Affectionately known as "Frankie", Moore Lappe is the renown author of Diet for a Small Planet, EcoMind and co-author of Hope's Edge with her daughter Anna Lappe. We will be regaled with tales of gastronomic excursions, forays into food and more! • • • Enjoy a variety of food stations featuring local items items grown in biochar conditioned soil. Sample meats and beverages that have been prepared with or enhanced by biochar and observe a variety of farm to plate many demonstrations and examples. Anyone interested in soil and healthy local food will be enriched by the Biochar Banquet. And anyone who wants to grow nutritious food, sink carbon in the soil, or utilize the filtration and remineralization properties of biochar will benefit from this tasty, yet educational event. I am a local farmer interested in participating or learning more. Who do I contact for details? Karen Ribeiro can be reached at [email protected]
Generating protein interaction maps from incomplete data: application to fold assignment
No full textAbstract
Motivation: We present a framework to generate comprehensive overviews of protein-protein interactions. In the post-genomic view of cellular function, each biological entity is seen in the context of a complex network of interactions. Accordingly, we model functional space by representing protein-protein-interaction data as undirected graphs. We suggest a general approach to generate interaction maps of cellular networks in the presence of huge amounts of fragmented and incomplete data, and to derive representations of large networks which hide clutter while keeping the essential architecture of the interaction space. This is achieved by contracting the graphs according to domain-specific hierarchical classifications. The key concept here is the notion of induced interaction, which allows the integration, comparison and analysis of interaction data from different sources and different organisms at a given level of abstraction.
Results: We apply this approach to compute the overlap between the DIP compendium of interaction data and a dataset of yeast two-hybrid experiments. The architecture of this network is scale-free, as frequently seen in biological networks, and this property persists through many levels of abstraction. Connections in the network can be projected downwards from higher levels of abstraction down to the level of individual proteins. As an example, we describe an algorithm for fold assignment by network context. This method currently predicts protein folds at 30% accuracy without any requirement of detectable sequence similarity of the query protein to a protein of known structure. We used this algorithm to compile a list of structural assignments for previously unassigned genes from yeast. Finally we discuss ways forward to use interaction networks for the prediction of novel protein-protein interactions.
Availability: http://www.ebi.ac.uk/~lappe/FoldPred/
Contact: [email protected]
*To whom correspondence should be addressed.</jats:p
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