1,124 research outputs found
Spinal cord injury and regeneration
No full textIncludes bibliographical references and indexWorld-renowned experts share the latest updates in translational research as well as surgical and nonsurgical strategies for treating spinal cord injury Spinal cord injury (SCI) is a devastating, clinically challenging injury, leading to varying degrees of neurological function impairment and paralysis. Underlying biological mechanisms either inhibit or promote new growth in the spinal cord. Researchers have been making important discoveries about how neurons and their axons grow in the central nervous system and why they fail to regenerate after SCI. Although progress has been steady, there r.Pathobiology of spinal cord injury / Hiroaki Nakashima, Narihito Nagoshi, and Michael G. Fehlings -- Assessment of functional status and outcomes of individuals with traumatic spinal cord injury / Christian Schuld and Norbert Weidner -- Serum and CSF biomarkers to predict functional recovery after spinal cord injury / Seth S. Tigchelaar and Brian K. Kwon -- Magnetic resonance imaging of the injured spinal cord : the present and the future / Allan R. Martin, Julien Cohen-Adad, and Michael G. Fehlings -- Acute nonoperative management of traumatic spinal cord injury : state of the art / Joshua S. Catapano, Gregory W.J. Hawryluk, and Michael G. Fehlings -- Role and timing of surgery for traumatic spinal cord injury : what do we know and what should we do? / Christopher D. Witiw and Michael G. Fehlings -- Methylprednisolone as a valid option for acute spinal cord injury : a reassessment of the literature / Michael G. Fehlings and Newton Cho -- Neuroprotection of the injured spinal cord : what does the future hold? / Michael G. Fehlings and Christopher S. Ahuja -- Hydrogel biomaterials in spinal cord repair and regeneration / Manuel Ingo Gunther, Thomas Schackel, Norbert Weidner, and Armin Blesch -- Neural stem cell transplantation for spinal cord repair / Ina Simeonova, Beatrice Sandner, and Norbert Weidner -- Strategies to overcome the inhibitory environment of the spinal cord / Elizabeth J. Bradbury and Emily R. Burnside -- Functional electrical stimulation and neuromodulation approaches to enhance recovery after spinal cord injury / Cesar Marquez-Chin, Emilie Sagripanti, and Milos R. Popovic -- Advanced rehabilitation strategies for individuals with traumatic spinal cord injury / William Z. Rymer, Sheila Burt, and Arun Jayaraman -- Brain-computer interfaces to enhance function after spinal cord injury / Rudiger Rupp1 online resource
Supplemental Material, Riluzole_Appendix - The Impact of Riluzole on Neurobehavioral Outcomes in Preclinical Models of Traumatic and Nontraumatic Spinal Cord Injury: Results From a Systematic Review of the Literature
No full textSupplemental Material, Riluzole_Appendix for The Impact of Riluzole on Neurobehavioral Outcomes in Preclinical Models of Traumatic and Nontraumatic Spinal Cord Injury: Results From a Systematic Review of the Literature by Lindsay A. Tetreault, Mary P. Zhu, Jefferson R. Wilson, Spyridon K. Karadimas and Michael G. Fehlings in Global Spine Journal</p
Supplemental Material - The 2023 AO Spine-Praxis Guidelines in Acute Spinal Cord Injury: What Have We Learned? What Are the Critical Knowledge Gaps and Barriers to Implementation?
No full textSupplemental Material for The 2023 AO Spine-Praxis Guidelines in Acute Spinal Cord Injury: What Have We Learned? What Are the Critical Knowledge Gaps and Barriers to Implementation? by Michael G. Fehlings, Ali Moghaddamjou, Nathan Evaniew, Lindsay A. Tetreault, Mohammed Ali Alvi, Andrea C. Skelly, and Brian K. Kwon in Global Spine Journal</p
Supplemental Material - Accuracy of Intraoperative Neuromonitoring in the Diagnosis of Intraoperative Neurological Decline in the Setting of Spinal Surgery—A Systematic Review and Meta-Analysis
No full textSupplemental Material for Accuracy of Intraoperative Neuromonitoring in the Diagnosis of Intraoperative Neurological Decline in the Setting of Spinal Surgery—A Systematic Review and Meta-Analysis by Mohammed Ali Alvi, Brian K. Kwon, Nader Hejrati, Lindsay A. Tetreault, Nathan Evaniew, Andrea C. Skelly, and Michael G. Fehlings in Global Spine Journal</p
Supplemental Material - The 2023 AO Spine-Praxis Guidelines in Acute Spinal Cord Injury: What Have We Learned? What Are the Critical Knowledge Gaps and Barriers to Implementation?
No full textSupplemental Material for The 2023 AO Spine-Praxis Guidelines in Acute Spinal Cord Injury: What Have We Learned? What Are the Critical Knowledge Gaps and Barriers to Implementation? by Michael G. Fehlings, Ali Moghaddamjou, Nathan Evaniew, Lindsay A. Tetreault, Mohammed Ali Alvi, Andrea C. Skelly, and Brian K. Kwon in Global Spine Journal</p
Supplemental Material - The 2023 AO Spine-Praxis Guidelines in Acute Spinal Cord Injury: What Have We Learned? What Are the Critical Knowledge Gaps and Barriers to Implementation?
No full textSupplemental Material for The 2023 AO Spine-Praxis Guidelines in Acute Spinal Cord Injury: What Have We Learned? What Are the Critical Knowledge Gaps and Barriers to Implementation? by Michael G. Fehlings, Ali Moghaddamjou, Nathan Evaniew, Lindsay A. Tetreault, Mohammed Ali Alvi, Andrea C. Skelly, and Brian K. Kwon in Global Spine Journal</p
Supplemental Material - The 2023 AO Spine-Praxis Guidelines in Acute Spinal Cord Injury: What Have We Learned? What Are the Critical Knowledge Gaps and Barriers to Implementation?
No full textSupplemental Material for The 2023 AO Spine-Praxis Guidelines in Acute Spinal Cord Injury: What Have We Learned? What Are the Critical Knowledge Gaps and Barriers to Implementation? by Michael G. Fehlings, Ali Moghaddamjou, Nathan Evaniew, Lindsay A. Tetreault, Mohammed Ali Alvi, Andrea C. Skelly, and Brian K. Kwon in Global Spine Journal</p
Supplemental Material - The 2023 AO Spine-Praxis Guidelines in Acute Spinal Cord Injury: What Have We Learned? What Are the Critical Knowledge Gaps and Barriers to Implementation?
No full textSupplemental Material for The 2023 AO Spine-Praxis Guidelines in Acute Spinal Cord Injury: What Have We Learned? What Are the Critical Knowledge Gaps and Barriers to Implementation? by Michael G. Fehlings, Ali Moghaddamjou, Nathan Evaniew, Lindsay A. Tetreault, Mohammed Ali Alvi, Andrea C. Skelly, and Brian K. Kwon in Global Spine Journal</p
Immunoglobulin G: A Potential Immuno-modulatory Therapy for Traumatic Spinal Cord Injury
No full textSpinal cord injury (SCI) is a devastating condition that causes its victims to experience functional deficits. Inflammation plays a complex role in the progression of SCI. While some inflammatory cells attenuate further damage to the spinal cord tissue, other inflammatory mediators exacerbate the damage. Attenuating the detrimental aspects of inflammation after SCI is an attractive neuroprotective strategy that could potentially lead to significant functional improvement. In this regard, intravenous immunoglobulin G (IgG), which has many proposed immuno-modulatory mechanisms, is a potential treatment candidate. In this study, we investigated the neuroprotective properties of IgG by examining its effects after SCI at the molecular, cellular, and neurobehavioral levels. We observed that IgG treatment after SCI is associated with significant reduction in pro-inflammatory mediators and significant improvement in neurobehavioral recovery compared to the control. The results of the study suggest that IgG could potentially be used as an immuno-modulatory therapy for SCI.MAS
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