70 research outputs found
Locoregional Therapies for Colorectal Cancer Liver Metastases: Options Beyond Resection
No full textColorectal cancer was the third most common malignancy worldwide in 2018, and most patients present with or develop distant metastases. Colorectal liver metastases are most commonly observed because of the vascular drainage of the colon and superior rectum. Current guidelines recommend surgical resection as first-line treatment; however, 80% to 90% of patients with colorectal liver metastases are ineligible for primary resection. For patients with unresectable disease, a multidisciplinary treatment approach is favored, incorporating systemic therapy and a toolbox of local ablative therapies. These treatments either aim at cytoreduction to enable a conversion to surgical resectability or control of disease progression and spread. Each of these treatments carries unique outcomes and risk profiles, thereby contributing to an individualized treatment strategy for patients with colorectal liver metastases. This review summarizes evidence on hepatic artery infusion, stereotactic body radiation therapy, thermal ablation, transarterial chemoembolization with drug-eluding beads, and transarterial radioembolization for treatment of colorectal liver metastases. Results of large-scale prospective and retrospective studies and international guidelines are discussed to provide detailed background on the current and prospective use of local ablative techniques in management of colorectal liver metastases
Huntsville Times sleeve HT0009127
No full textEast Limestone coach Phil Cavnar, with one or two players / East Limestone High School stadium / Eric Pitts / Eddie Robiso
Assessing neutrophil viability after atypical antipsychotic exposure using cell line PLB-985
No full textNeutrophils comprise 60-70% of an individual's white blood cells and are an essential part of our innate immune systems. Neutrophils act as first-responders to sites of injury or potential infection, where they help to initiate inflammatory responses and/or aid in destruction of an infectious agent. (Witko-Sarsat, 2000)
Atypical antipsychotics, a class of drug commonly used to treat disorders like schizophrenia and insomnia, are known to cause neutropenia and agranulocytosis (a depletion of circulating neutrophils) as a rare, but severe, side effect. (Hong & Wong, 2001) However, the mechanism(s) by which these drugs induce neutropenia is still in question.
In this study, we used the neutrophil model cell line, PLB-985, to assess the effects of four atypical antipsychotics (clozapine, olanzapine, aripiprazole and quetiapine) on cell viability using a plate-based, colorimetric bioassay.
After collecting this initial data, we hypothesize that the reduction in cell viability seen after 48-hour exposure to 20μM and 50μM concentrations of aripiprazole is due to its unique mechanism of action as a partial dopamine agonist. Therefore, we seek to determine if we can both rescue the reduction of cell viability by introducing dopamine antagonists, as well as replicate the phenotype by exposing cells to dopamine hydroc
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Disaster on the horizon ::high stakes, high risks, and the story behind the Deepwater well blowout /
No full textProvides detail about the oil well accident that occurred in April of 2010, which the author describes as the worst oil well accident in United States history, and examines the oil industry, its resistance to regulations, and government concessions that cause the issues to remain
Effects of hierarchical mentoring on freshman retention in a biology first-year experience course
No full textHigher education must improve student retention and graduation rates to meet increased demand for STEM degrees in the workforce projected for the next ten years. The high rate of attrition among STEM students entering college compels institutions to implement strategies that improve student retention because more states now employ performance-based funding models with increased pressures to improve student outcomes, such as first- and second-year retention rates. We piloted a two-year hierarchical mentoring model as part of a first-year experience course developed for biology students (BioSkills) to increase retention rates among first-time-in-college (FTIC) students. We describe the mentoring structure we adopted and how the design of BioSkills supports and educates future biology professionals. Our findings show that FTIC students who participated in this program earned significantly higher first-year GPAs and were retained at higher rates than students who did not participate, which documents the impact of BioSkills as a successful first-year intervention. However, we were
surprised that the benefit of BioSkills was not replicated among under-represented minority (URM) students. We briefly speculate on explanations for this finding. Lastly, we offer best practice suggestions for future implementation.Journal ArticlePublishe
. 76 Año 26 (2019) mayo-agosto. Dimensión Antropológica
No full text- Introducción. Mover enfoques, otras perspectivas de lectura de los antiguos textos novohispanos por Clementina Battcock. - Los tlatoque en la Decimatercia relación de Fernando de Alva Ixtlilxóchitl por Yukitaka Inoue Okubo. - El relato cosmogónico del Códice Vaticano A. Una reflexión en torno a la tecnología sacrificial y la dinámica cronológica por Ana Díaz Álvarez. - Los textos cristianos en lengua náhuatl del periodo novohispano: fuentes para la historia cultural por Berenice Alcántara Rojas. - Fuentes de las instancias locales del gobierno novohispano: los cabildos y la jurisdicción de Actopan, siglo XVIII por Annia González Torres. - De neófitos a cristianos. Los indios a través de una fuente eclesiástica: 1527-1728 por Berenise Bravo Rubio. - Biografía y archivos: fray Baltasar de Covarrubias, obispo novohispano del siglo XVII por Patricia Escandón. - Los indios del Museo Nacional de Antropología: una mirada paralela por Haydeé López Hernández. - Beatriz Caiuby Labate y Clancy Cavnar (eds.) Peyote. History, Tradition, Politics, and Conservation por Carlo Bonfiglioli. - José Eduardo Zárate Hernández. La celebración de la infancia. El culto al Niño Jesús en el área purhépecha por Claudia Tomic Hernández Rivera
1686 Laparoscopic-Assisted Endoscopic Submucosal Dissection of Early Gastric Adenocarcinoma
No full textBeatriz Caiuby Labate y Clancy Cavnar (eds.), Peyote. History, Tradition, Politics, and Conservation, James A. Bauml y Stacy B. Schaefer (pról.), Santa Barbara, Praeger, 2016, 280 pp. . Dimensión Antropológica Vol. 76 Año 26 (2019) mayo-agosto
No full textComo lo subrayan Bauml y Schaefer en el prólogo de la obra, “he aquí un libro que reúne nuevas aportaciones sobre una figura bastante conocida en el medio antropológico: la Lophophora williamsii”, planta mejor conocida como peyote. Este cacto genera interés desde hace tiempo por su uso en contextos rituales o por sus características botánicas
An Organotypic Microcosm for the Pancreatic Tumor Microenvironment
No full textPancreatic duct adenocarcinoma (PDAC) is projected to become the second leading cause of cancer-related deaths in the next few years. Unfortunately, the development of novel therapies for PDAC has been challenged by a uniquely complex tumor microenvironment. The development of in vitro cancer organoids in recent years has demonstrated potential to increase therapies for patients with PDAC. Organoids have been established from PDAC murine and human tissues and they are representative of the primary tumor. Further, organoids have been shown beneficial in studies of molecular mechanisms and drug sensitivity testing. This review will cover the use of organoids to study PDAC development, invasiveness, and therapeutic resistance in the context of the tumor microenvironment, which is characterized by a dense desmoplastic reaction, hindered immune activity, and pro-tumor metabolic signaling. We describe investigations utilizing organoids to characterize the tumor microenvironment and also describe their limitations. Overall, organoids have great potential to serve as a versatile model of drug response and may be used to increase available therapies and improve survival for patients with PDAC
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