1,138 research outputs found
Supplemental material for Outcomes of renal dysfunction in patients with acute liver failure
No full textSupplemental Material for Outcomes of renal dysfunction in patients with acute liver failure by Johannes Hadem, Jan T. Kielstein, Michael P. Manns, Philipp Kümpers and Alexander Lukasz in United European Gastroenterology Journal</p
Fecal calprotectin is significantly linked to azathioprine metabolite concentrations in Crohn’s disease
No full text
The Lancet-EASL Commission on liver diseases in Europe: overcoming unmet needs, stigma, and inequities
No full textSupplementary table -Supplemental material for Long-term changes in liver elasticity in hepatitis C virus-infected patients with sustained virologic response after treatment with direct-acting antivirals
No full textSupplemental material, Supplementary table for Long-term changes in liver elasticity in hepatitis C virus-infected patients with sustained virologic response after treatment with direct-acting antivirals by Veronika Pietsch, Katja Deterding, Dina Attia, Kristina Imeen Ringe, Benjamin Heidrich, Markus Cornberg, Michael Gebel, Michael Peter Manns, Heiner Wedemeyer and Andrej Potthoff in United European Gastroenterology Journal</p
Undervejs til katastrofen:Plötzlichkeits-oplevelser i Thomas Manns <em>Der Zauberberg</em>
No full textEn analyse af Thomas Manns roman Der Zauberberg med udgangspunkt i den tyske litterat Karl Heinz Bohrers begreb om "Plötzlichkeit".</p
Undervejs til katastrofen:Plötzlichkeits-oplevelser i Thomas Manns <em>Der Zauberberg</em>
No full textEn analyse af Thomas Manns roman Der Zauberberg med udgangspunkt i den tyske litterat Karl Heinz Bohrers begreb om "Plötzlichkeit".</p
T cells
No full textNecrotic cells are known to activate the innate immune system and trigger inflammation by releasing damage associated molecular patterns (DAMPs). However, how necrotic cells influence the induction of antigen-specific CD8(+) T cell-mediated adaptive immune responses under sterile conditions, in the absence of pathogen associated molecular patterns (PAMPs), remains poorly understood. Here, we examined antigen-specific CD8(+) T-cell responses to primary sterile necrotic tumor cells both in vitro and in vivo. We found that primary necrotic cells alone fail to generate CD8(+) T cell-dependent immune responses toward cell-associated antigens. We show that necrotic cells trigger CD8(+) T-cell immunity only in the presence of PAMPs or analogs, such as p(dI-dC) and/or unmethylated CpG DNA. The electroporation of tumor cells with these PAMPs prior to necrosis induction triggered antigen-specific CD8(+) T-cell responses through a TLR9/MyD88-dependent pathway. In addition, we found that necrotic cells contain factors that can block the cross-priming of CD8(+) T cells even under non-sterile conditions and can serve as a possible mechanism of immunosuppression. These results suggest that antigen-specific CD8(+) T-cell responses to primary necrotic tumor cells can be induced in the presence of PAMPs and thus have a substantial impact on the development of antitumor vaccination strategies
UEG913732 Supplemental Material - Supplemental material for Frequency, characteristics and impact of multiple consecutive nosocomial infections in patients with decompensated liver cirrhosis and ascites
No full textSupplemental material, UEG913732 Supplemental Material for Frequency, characteristics and impact of multiple consecutive nosocomial infections in patients with decompensated liver cirrhosis and ascites by Marie Schutalbers, Tammo L Tergast, Nicolas Simon, Abdul-Rahman Kabbani, Markus Kimmann, Christoph Höner zu Siederdissen, Svetlana Gerbel, Michael P Manns, Markus Cornberg and Benjamin Maasoumy in United European Gastroenterology Journal</p
- …
