251 research outputs found
Me and My House: James Baldwin, Prophet of Freedom
No full textIn this public lecture, David Leeming, a scholar of comparative literature and author of James Baldwin: A Biography, utilizes his experiences as a biographer and personal friend of James Baldwin to address the question, Who was, and who is, James Baldwin
Aztec antichrist: performing the apocalypse in early colonial Mexico
No full textIncludes bibliographical references and index.In Aztec Antichrist, Ben Leeming presents a transcription, translation, and study of two Nahuatl Antichrist plays that are likely the earliest surviving presentations of the Antichrist legend in the Americas, and possibly the earliest surviving play scripts in the whole of the New World in any language.--Provided by publisher
Reseña de: Ben Leeming. 2022. Aztec Antichrist. Performing the Apocalypse in Early Colonial Mexico. Louisville: University Press of Colorado. xxxi + 281 pp.
No full textThis review analyzes Ben Leeming’s Aztec Antichrist, which focuses on two 16th-century religious plays in Nahuatl composed by Fabián de Aquino. Through philological, historical, and theatrical analysis of these neixcuitilli, Leeming argues that the character of the Antichrist—portrayed by a Christianized Indigenous author—represents a veiled critique of colonial evangelization and an attempt to reassert Indigenous authority amid cultural upheaval. The book stands out for its integration of Nahua tradition and Franciscan eschatology, as well as its emphasis on performative writing infused with improvisation and symbolism. It is an innovative study that foregrounds Indigenous agency in the shaping of Christian discourseEsta reseña examina el libro Aztec Antichrist de Ben Leeming, centrado en dos autos religiosos en náhuatl compuestos por Fabián de Aquino en el siglo XVI. A través del análisis filológico, histórico y teatral de estos neixcuitilli, Leeming propone que el personaje del Anticristo, interpretado por un autor indígena cristianizado, representa una crítica velada a la evangelización colonial y un intento de rearticular el poder indígena en un contexto de crisis. La obra destaca por incorporar elementos de la tradición nahua y la escatología franciscana, así como por presentar una escritura performativa cargada de improvisación y simbolismo. Se trata de un estudio innovador que revela la agencia indígena en la producción de conocimiento cristianoUniversidad Nacional Autónoma de México. Instituto de Investigaciones Histórica
The comparative distinctiveness of equity
No full textComparative law is difficult and controversial. One reason for the difficulty is the complexity of legal systems and the need for more than a merely superficial knowledge of the foreign legal system in order to profit from recourse to it. One way in which it is controversial is that it has been suggested that the use of comparative law conceals the reasons for decisions reached on other grounds. This paper maintains that equity is distinctive, and that one of the ways in which equity is different from other bodies of law is that there is greater scope for the development of equitable principle by reference to foreign jurisdictions. That difference is a product of equity’s distinctive history, underlying themes and approach to law-making. Those matters are illustrated by a series of recent examples drawn from appellate courts throughout the Commonwealth.Peer reviewe
The Comparative Distinctiveness of Equity
No full textComparative law is difficult and controversial. One reason for the difficulty is the
complexity of legal systems and the need for more than a merely superficial knowledge
of the foreign legal system in order to profit from recourse to it. One way in which it
is controversial is that it has been suggested that the use of comparative law conceals
the reasons for decisions reached on other grounds. This paper maintains that equity is
distinctive, and that one of the ways in which equity is different from other bodies of
law is that there is greater scope for the development of equitable principle by reference
to foreign jurisdictions. That difference is a product of equity’s distinctive history,
underlying themes and approach to law-making. Those matters are illustrated by a series
of recent examples drawn from appellate courts throughout the Commonwealth.Peer reviewe
sj-pdf-2-jrs-10.1177_01410768231182389 - Supplemental material for COVID-19 risk mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region
No full textSupplemental material, sj-pdf-2-jrs-10.1177_01410768231182389 for COVID-19 risk mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region by Girvan Burnside, Christopher P Cheyne, Gary Leeming, Michael Humann, Alistair Darby, Mark A Green, Alexander Crozier, Simon Maskell, Kay O’Halloran, Elena Musi, Elinor Carmi, Naila Khan, Debra Fisher, Rhiannon Corcoran, Jake Dunning, W John Edmunds, Kukatharmini Tharmaratnam, David M Hughes, Liora Malki-Epshtein, Malcolm Cook, Ben M Roberts, Eileen Gallagher, Kate Howell, Meera Chand, Robin Kemp, Matthew Boulter, Tom Fowler, Malcolm G Semple, Emer Coffey, Matt Ashton, The COVID-19 Genomics UK (COG-UK) Consortium, Marta García-Fiñana and Iain E Buchan in Journal of the Royal Society of Medicine</p
Stable isotope labelling and computational data mining approaches in drug metabolism studies
No full text© 2017 Dr. Michael Gerard LeemingMany small organic molecules will be chemically modified in some way after entering the body through metabolism. Thus, metabolism plays a significant role in determining the biological properties of a compound including half-life and toxicity profile. Identifying the metabolites of a compound is an important part of drug discovery projects. This thesis describes the development and application of methodologies to detect such metabolites. A guiding principle of this work is the detection of metabolites from a complex sample without prior knowledge of their structure or formation pathways. This ‘non-targeted’ analysis approach allows unknown or unexpected metabolites to be detected, providing a complete picture of the metabolic fate of a xenobiotic.
The basis of the non-targeted approach is described in Chapter 2. Here, paracetamol (APAP) and an equal quantity of 13C6-APAP are simultaneously administered to rats. Analysis of blood plasma extracts by liquid chromatography mass spectrometry (LC-MS) resulted in mass spectra that contained pairs of ions that eluted simultaneously with equal intensity and are unique to metabolites. To automate data analysis, software called HiTIME was written enabling the non-targeted but selective detection of metabolites that appear as twin-ions from highly complex samples.
In some cases, xenobiotics form electrophilic metabolites that can covalently react with cellular proteins. This is thought to trigger allergic and toxic side-effects. The specific nature of the protein adduct may be a determinant of the biological response. Chapter 3 describes a reactivity survey of the electrophilic APAP metabolite, N-acetyl-p-benzoquinoneimine (NAPQI), towards a panel of amino acids and peptides. In addition to the well-known reactivity toward cysteine, previously undocumented covalent adducts between chemically synthesized NAPQI and tyrosine, tryptophan and methionine were also observed, isolated and characterised.
Chapter 4 introduces a non-targeted method to identify the protein targets of reactive metabolites which uses twin-ion and HiTIME analysis to detect tryptic peptides that have been covalently modified by drug metabolites. Software called Xenophile was developed that can identify the site of modification, the mass and the chemical formula of a reactive metabolite directly from shotgun LC-MS data. In Chapter 5, Xenophile was applied to identify the protein targets of APAP and 13C6-APAP metabolites following incubation with liver tissue extracts and global trypsin digest. The Xenophile software correctly identified the reactive metabolite as C8H7NO2 (i.e. NAPQI) and the adduction site as Cysteine residues. Further investigation identified 7 unique proteins that were modified by APAP including those that have been previously identified as adduction targets of NAPQI and other xenobiotic reactive metabolites.
HiTIME and Xenophile are then used to assess the small molecule metabolism and protein adduction profile of the environmental contaminants benzene, bromobenzene and toluene in liver extracts. Numerous twin-ions were detected that correspond to glutathione adducts of epoxide and quinone metabolites. No modified proteins were detected following analysis of global protein digests for any sample. To rule out false negatives, targeted approaches were taken to identify protein adducts. As these did not result in the recovery of any missed peptides, we conclude that protein adducts were not formed in these experiments. This finding is rationalized based on the extent of formation of small molecule GSH adducts
sj-pdf-6-jrs-10.1177_01410768231182389 - Supplemental material for COVID-19 risk mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region
No full textSupplemental material, sj-pdf-6-jrs-10.1177_01410768231182389 for COVID-19 risk mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region by Girvan Burnside, Christopher P Cheyne, Gary Leeming, Michael Humann, Alistair Darby, Mark A Green, Alexander Crozier, Simon Maskell, Kay O’Halloran, Elena Musi, Elinor Carmi, Naila Khan, Debra Fisher, Rhiannon Corcoran, Jake Dunning, W John Edmunds, Kukatharmini Tharmaratnam, David M Hughes, Liora Malki-Epshtein, Malcolm Cook, Ben M Roberts, Eileen Gallagher, Kate Howell, Meera Chand, Robin Kemp, Matthew Boulter, Tom Fowler, Malcolm G Semple, Emer Coffey, Matt Ashton, The COVID-19 Genomics UK (COG-UK) ConsortiumMarta García-Fiñana and Iain E Buchan in Journal of the Royal Society of Medicine</p
sj-pdf-4-jrs-10.1177_01410768231182389 - Supplemental material for COVID-19 risk mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region
No full textSupplemental material, sj-pdf-4-jrs-10.1177_01410768231182389 for COVID-19 risk mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region by Girvan Burnside, Christopher P Cheyne, Gary Leeming, Michael Humann, Alistair Darby, Mark A Green, Alexander Crozier, Simon Maskell, Kay O’Halloran, Elena Musi, Elinor Carmi, Naila Khan, Debra Fisher, Rhiannon Corcoran, Jake Dunning, W John Edmunds, Kukatharmini Tharmaratnam, David M Hughes, Liora Malki-Epshtein, Malcolm Cook, Ben M Roberts, Eileen Gallagher, Kate Howell, Meera Chand, Robin Kemp, Matthew Boulter, Tom Fowler, Malcolm G Semple, Emer Coffey, Matt Ashton, The COVID-19 Genomics UK (COG-UK) Consortium, Marta García-Fiñana and Iain E Buchan in Journal of the Royal Society of Medicine</p
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