831 research outputs found
Can Blockchains and Linked Data Advance Taxation
No full textPermissioned distributed ledgers (permissioned blockchains) supporting smart contracts that automatically adjust accounts and coordinate records among multiple parties, present a valid platform opportunity for establishing a fully digital tax regime. We propose a permissioned blockchain-based system aimed at eliminating some of the losses that tax authorities globally are currently struggling with. These multi-billion flaws manifest themselves as the tax gap, or the inability to collect the full amount that is owed by a given entity to a particular authority. Illegitimate or inefficient tax operations could be prevented with a global suite of smart contracts deployed on top of a consortium distributed ledger with on-chain governance. We also introduce the vision for a VAT Invoice 2.0 modelled as a Linked Data document. A tax reference generated by a smart contract would allow anyone with the right permissions to immediately investigate the entire commercial chain for any taxable item on an ontology-based tax document
Educating health professionals about drug and device promotion: authors' reply
No full textCopyright: © 2007 Mansfield et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Peter R. Mansfield, Jerome R. Hoffman and Joel Lexchi
Relationships Between Hoffman Reflex Parameters, Trait Stress, and Athletic Performance
No full textThis study evaluated the relationships between trait stress, Hoffman reflex, and performance among 36 healthy amateur male athletes. We first obtained a trait stress questionnaire from participants and then assigned them to high- and low-stress groups. We next recorded Hoffman reflex data from the soleus and lateral gastrocnemius muscles and then examined their athletic performance on testing protocols separated by a 72-hour washout period. Performance testing utilized vertical jump height, 20 -m sprint time, and standing stork tests. There were significant correlations between (a) the standing stork test, vertical jump height, and trait stress and (b) Hmax/Mmax ratios, threshold intensity (Hth), the intensity of the Hmax, and the intensity of the Hlast. Hth, the intensity of Hmax, and the intensity of Hlast were significantly higher among the low-stress compared with the high-stress participant groups (p <.05), despite participants� similar training history. We suggest that self-perceived psychological stress affects performance through neural adaptation. © The Author(s) 2018
Hierarchical Population Genetic Structure in a Direct Developing Antarctic Marine Invertebrate
No full textHoffman J, Clarke A, Clark MS, Peck LS. Hierarchical Population Genetic Structure in a Direct Developing Antarctic Marine Invertebrate. PLoS ONE. 2013;8(5): e63954.Understanding the relationship between life-history variation and population structure in marine invertebrates is not straightforward. This is particularly true of polar species due to the difficulty of obtaining samples and a paucity of genomic resources from which to develop nuclear genetic markers. Such knowledge, however, is essential for understanding how different taxa may respond to climate change in the most rapidly warming regions of the planet. We therefore used over two hundred polymorphic Amplified Fragment Length Polymorphisms (AFLPs) to explore population connectivity at three hierachical spatial scales in the direct developing Antarctic topshell Margarella antarctica. To previously published data from five populations spanning a 1500 km transect along the length of the Western Antarctic Peninsula, we added new AFLP data for four populations separated by up to 6 km within Ryder Bay, Adelaide Island. Overall, we found a nonlinear isolation-by-distance pattern, suggestive of weaker population structure within Ryder Bay than is present over larger spatial scales. Nevertheless, significantly positive Fst values were obtained in all but two of ten pairwise population comparisons within the bay following Bonferroni correction for multiple tests. This is in contrast to a previous study of the broadcast spawner Nacella concinna that found no significant genetic differences among several of the same sites. By implication, the topshell's direct-developing lifestyle may constrain its ability to disperse even over relatively small geographic scales
Uniqueness of Semigraphical Translators
No full textWe prove a conjecture by Hoffman, White, and the first author regarding the uniqueness of pitchfork and helicoid translators of the mean curvature flow in . We employ an arc-counting argument motivated by Morse-Radó theory for translators and a rotational maximum principle. Applications to the classification of semigraphical translators in and their limits are discussed, strengthening compactness results of the first author with Hoffman-White and with Gama-Moller.This paper has been superseded by the more recent preprint, available as arXiv:2411.1688
Genus 3 curves whose Jacobians have endomorphisms by Q(zeta(7) + (zeta)over-bar(7))
No full textIn this work we consider constructions of genus 3 curves X such that End(Jac(X)) circle times Q contains the totally real cubic number field Q(zeta(7) + (zeta) over bar (7)). We construct explicit two-dimensional families defined over Q(s, t) whose generic member is a nonhyperelliptic genus 3 curve with this property. The case when X is hyperelliptic was studied in Hoffman and Wang (2013). We calculate the zeta function of one of these curves. Conjecturally this zeta function is described by a modular form. (C) 2015 Elsevier Ltd. All rights reserved.NSA [115-60-5012]; NSF [OISE-1318015]; NSFC [11571241]; Southeast Missouri State UniversitySCI(E)[email protected]; [email protected]; [email protected]; [email protected]
Instructive Alchemies [Reviews of Philip Levine, Daniel Hoffman, George Keithley, J. Michael Yates, Annie Dillard]
No full textJOHN R. REED teaches English at Wayne State University and is the author of many poems, critical essays, and reviews, which have appeared in such journals as Prairie Schooner, Modern Poetry Studies, and Poetry. His books include Old School Ties and Perception and Design in Tennyson\u27s Idylls of the King
Spontaneous ATM gene reversion in A-T iPSC to produce an isogenic cell line
No full textA spontaneously reverted iPSC line was identified from an A-T subject with heterozygous ATM truncation mutations. The reverted iPSC line expressed ATM protein and was capable of radiation-induced phosphorylation of CHK2 and H2A.X. Genome-wide SNP analysis confirmed a match to source T-cells and also to a distinct, non-reverted iPSC line from the same subject. Rearranged T-cell receptor sequences predict that the iPSC culture originated as several independently reprogrammed cells that resolved into a single major clone, suggesting that gene correction likely occurred early in the reprogramming process. Gene expression analysis comparing ATM-/- iPSC lines to unrelated ATM+/- cells identifies a large number of differences but comparing only the isogenic pair of A-T iPSC lines reveals that the primary pathway affected by loss of ATM is a diminished expression of p53-related mRNAs. Gene reversion in culture, while likely a rare event, provided a novel, reverted cell line for studying ATM function.Peer reviewe
Using bacterial biomarkers to identify early indicators of cystic fibrosis pulmonary exacerbation onset
No full textAcute periods of pulmonary exacerbation are the single most important cause of morbidity in cystic fibrosis patients, and may be associated with a loss of lung function. Intervening prior to the onset of a substantially increased inflammatory response may limit the associated damage to the airways. While a number of biomarker assays based on inflammatory markers have been developed, providing useful and important measures of disease during these periods, such factors are typically only elevated once the process of exacerbation has been initiated. Identifying biomarkers that can predict the onset of pulmonary exacerbation at an early stage would provide an opportunity to intervene before the establishment of a substantial immune response, with major implications for the advancement of cystic fibrosis care. The precise triggers of pulmonary exacerbation remain to be determined; however, the majority of models relate to the activity of microbes present in the patient's lower airways of cystic fibrosis. Advances in diagnostic microbiology now allow for the examination of these complex systems at a level likely to identify factors on which biomarker assays can be based. In this article, we discuss key considerations in the design and testing of assays that could predict pulmonary exacerbations
Naomi Duff Smith papers
No full textNaomi Duff Smith (1902-1973) was a poet, author of short stories and radio scripts, and owner of a Baltimore, Maryland, public relations firm. Her collection consists of poems, short stories, correspondence, and awards documenting her literary output and business and civic achievements. Significant correspondents represented in the collection include Lizette Woodworth Reese, R. P. Harriss, Millard E. Tydings, Amy Winslow, Alan P. Hoblitzell, E. Paul Mason, Joseph R. Byrnes, Emory J. Niles, William D. MacMillan, and Hugo R. Hoffman
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