11 research outputs found
Sub Rosa Volume I: Bloom in Secret
No full textSome people read scholarly articles, others prefer graphic novels, and most prefer a good novel. Every novel comes uniquely designed by an author, giving readers characters, drama, and a carefully crafted plot that draws them in. For my senior honors project, I decided to create a novel filled with mystery, love, and an assortment of carefully selected flowers.Choosing to incorporate flowers into the core concept of my novel stemmed from having grown up surrounded by them; my grandma has a really green thumb. I use the secret language of flowers throughout my novel to communicate hidden messages to those who look for them, as well as my protagonist Iris. To do this, I have researched different floral arrangements, learning the inner-workings of the murder mystery genre, and allowing myself to work through the creative process. Straying away from my business administration major, writing a fictional novel has allowed me to grow creatively
Original picturebooks and Houghton Mifflin anthologies: a comparative analysis.
No full textThis study examines the Houghton Mifflin reading anthologies to
determine whether the story selections are “authentic” as the publisher claims.
Since picturebooks are a unique literary art form whereby the illustrations, text,
and peritext are interconnected and contribute to the aesthetic experience of the
reader, any alteration modifies the author’s intentions and impacts the reading
experience. A comparative analysis of the original picturebooks with the
corresponding story selections in the anthologies concludes that the anthologized
versions are not authentic as the publisher contends. The significant extent of
these alterations distorts the author-reader relationship and diminishes the
aesthetic reading experience. The effect of these abridged anthologies is farreaching since the majority of school districts in the state of California have
adopted the Houghton Mifflin reading program
Review of The Price of Poverty: Money, Work and Culture in the Mexican American Barrio
No full textEven though these two communities shared similar experiences with poverty, they differed in their responses and expectations. To explain why Chávez residents view job opportunities as a glass half empty and Guadalupe residents view them as half full the author relies on theories of transnational immigration and social networks. US-born Mexican Americans of Chávez who faced limited options turned to "hustling," combining lowwage work with crime and public assistance to make ends meet. Guadalupe's Mexican immigrants worked multiple jobs or "overworked" to send remittances "back home" and save enough money to retire in their homeland. As [Daniel Dohan] suggests, "Social network connections to Mexico gave the dollar a value in Guadalupe that it did not have in Chávez, where dollars were earned and spent exclusively in the United States." (91) The negative aspects of transnational networks were the enormous demands and expectations imposed on families that took an emotional and physical toll. Remittances could also impede economic mobility over time, especially if families decided to remain in the United States.Alamillo, José M. Review of The Price of Poverty: Money, Work and Culture in the Mexican American Barrio by Daniel Dohan for Labour/ Le Travail, Vol. 57 (Spring 2006): 220-222
La psicomotricitat. El plaer de la representació infantil
No full text[cat] La Psicomotricitat és una eina educativa molt utilitzada en edats primerenques i de cada vegada agafa més importància dins el món d’Educació Infantil. Amb ella és concep a l’infant com un individu capaç d’anar construint del seu desenvolupament cognitiu, motriu i afectiu a través del domini progressiu del seu cos, de la seva persona i del que l’envolta.
Amb aquest treball es pretén donar a conèixer una manera de dur a terme la psicomotricitat en les aules d’infantil seguint el model de l’autor Bernard Aucouturier, així com fer una proposta de programació trimestral enfocada a activitats relacionades amb la representació. Així mateix, aquest document s’elabora també amb la finalitat de deixar una programació viable de psicomotricitat al centre educatiu.[eng] Psychomotricity is an educational idea widely used in primary schools and of increasing importance in the field of Early Childhood Education. With it, the child is conceived as an individual capable of building his cognitive, motor and affective development through the mastery of the progress of his cos, his person and his surroundings.
The purpose of this work is to present a way to carry out psychomotor skills in infant classrooms following the model of the author Bernard Aucouturier, as well as to make a proposal for a trimestral program focused on activities related to representation. In addition, this document is also elaborated with the purpose of making a viable programming of psychomotor skills in the educational center
Author Correction: BIM and mTOR expression levels predict outcome to erlotinib in EGFR-mutant non-small-cell lung cancer.
No full text20.500.12530/8788
AMARO, Joaquín (Gral.)
No full textAnonymus letter (possibly from “El Chato Lopez) sent to Generals Juan Andrew Almazán, Aarón Sáenz, Plutarco Elías Calles and Lázaro Cardenas. The author points Gen. Joaquín Amaro as the intellectual murderer of Generals Francisco Serrano and Arnulfo R. Gómez. He also says that Gen. Amaro is the murderer of Gen. Alvaro Obregón. The authors writes that Gen. Amaro is planning a coup to become president of Mexico. He mentions the attack against Daniel Flores and says it is more convenient for Gen. Amaro and Gen. Agustín More to go out of the country. Gen. Plutarco Elías Calles sends a letter of recommendation for his brother-in-law Andrés Chacón to Gen. Amaro. Letters of recommendation for Major José Abril González and Lieutenant Margarito Flores Rodríguez. Letter from Bartolome García Correa to Gen. Plutarco Elías Calles asking him to intervene so that the son of Felipe Carrilo Puerto, Hernán Carillo is accepted at the Military School. Two promissory notes issued by Enrique Lira. Letter from Gen. Amaro to Gen. Plutarco Elías Calles with a copy of an invitation from Ricardo M. Kleberg to Gen. Plutarco Elías Calles, Gen. Miguel Acosta, Engr. Luis L. León and Francisco S. Elías to visit the King Ranch and the livestock exhibition in Corpus Christi, Texas. Letter from Gen. Plutarco Elías Calles to Gen. Amaro asking him to accept Arturo Lerma at the Military School. Telegram from Gen. Amaro to Gen. Plutarco Elías Calles congratulating him for the inauguration of a building at the Superior School of War in San Jerónimo. Letter from Gen. Amaro to Gen. Plutarco Elías Calles sending copies of the lectures given by the faculty at the Superior School of War in 1932. Letter from Gen. Amaro to Gen. Plutarco Elías Calles informing him of the visit of Lieutenant Col. Alamillo, Principal of the Superior School of War, who will explain the plan to teach history in Naco, Sonora in 1914. Letter from Fructuoso Ochoa to Gen. Plutarco Elías Calles asking him for help so that Gen. Amaro pays him the 1,295 pesos that he owes him since 1931. Work by Gen. Amaro entitled “Our Social Problems and the National Army”. “The Socialist Teachings”. He points out the goals of the Socialist Mexican School within the political and social development. He writes about the ideology of the Mexican revolution and the purpose of the socialist education. / Carta anónima (posiblemente de "el Chato López"), dirigida a los Grales. Juan Andrew Almazán, Aarón Sáenz, PEC y Lázaro Cárdenas, a la que viene anexa una tarjeta personal de Arturo M. Elías, Director General de Correos. Presenta una carta de alerta denunciando al Gral. Joaquín Amaro a quien señala como uno de los asesinos intelectuales de los Grales. Francisco Serrano y Arnulfo R. Gómez y socios, respecto a lo cual promete pruebas. Igualmente, dice que el Gral. Amaro fue el asesino del Gral. Alvaro Obregón y menciona, como posible testigo, a un Tte. Corl. de Artillería Morelos. Señala algunas deslealtades del Gral. Amaro durante las administraciones de Obregón y Calles y manifiesta que el Gral. Amaro prepara un golpe de estado para apoderarse del poder e imponerse como Presidente. Menciona el atentado de Daniel Flores de quien responsabiliza al Gral. Saturnino Cedillo, al Gral. PEC y al Lic. Portes Gil. Indica la conveniencia de que salgan del país los amaristas y el propio Gral. Amaro a Japón, igual que el Gral. Agustín Mora. Rechaza toda ayuda pero pide una contestación indirecta. Carta del Gral. PEC al Gral. Amaro recomendándole a su cuñado Andrés Chacón. Oficio del Gral. Amado Aguirre, Jefe del Departamento de Caballería de la Secretaría de Guerra y Marina, al Gral. Jefe de la Guarnición de la plaza de la Ciudad de México, comunicándole la disposición superior por la cual el Mayor de Caballería, José Abril González, causa alta en el 51o. Regimiento, después de haber estado comisionado con el Gral. PEC. Carta del Gral. PEC al Gral. Amaro, Secretario de Guerra y Marina, recomendándole al Mayor de Caballería José Abril González. Carta del Gral. PEC al Gral. Amaro recomendándole al Tte. Margarito Flores Rodríguez para que ingrese al Colegio Militar. Carta del Prof. Bartolomé García Correa al Gral. PEC solicitándole su valiosa intervención para que sea aceptado en el Colegio Militar el joven Hernán Carrillo, hijo del malogrado Felipe Carrillo Puerto. Dos recibos (copias fotostáticas) provisionales, extendidos por Enrique Lira al Gral. Amaro, Jefe de las Fuerzas del Ejército Constitucionalista, 5a. División del Cuerpo de Ejército del Noroeste, a título de préstamo de pronto reintegro. Los recibos van acompañados de una nota del ayudante J. M. García quien le informa a Soledad González, secretaria particular del Gral. PEC, que el Gral. Pablo Quiroga, Subsecretario de Guerra, comunica que los documentos ya fueron pagados. Carta del Gral. Amaro, Director del Colegio Militar, al Gral. PEC en la cual adjunta copia de la carta que recibió del Ricardo M. Kleberg, miembro del Congreso de los Estados Unidos, quien formula una invitación al Gral. Amaro, al Gral. PEC, al Gral. Miguel Acosta, Secretario de Comunicaciones, al Ing. Luis L. León y a Francisco S. Elías, para visitar el King Ranch y la exposición ganadera de Kingsville cerca de Corpus Christi. Carta del Gral. PEC al Gral. Amaro pidiéndole ordene sea admitido en el Colegio Militar el joven Arturo Lerma. Telegrama del Gral. Amaro al Gral. PEC felicitando, a nombre de la Dirección General de Educación Militar, al Jefe Máximo de la Revolución, por la inauguración del edificio de la Escuela Superior de Guerra en San Jerónimo. Carta del Gral. Amaro, Director Gral. de Educación Militar al Gral. PEC remitiéndole una colección empastada de las conferencias sustentadas por el profesorado de la Escuela Superior de Guerra, durante el año de 1932. Considera que dichos trabajos son el primer fruto de la investigación científica que, para la transformación educativa y orgánica del Ejército Nacional, se llevaron a efecto en dicho plantel de estudios militares superiores. Carta del Gral. Amaro al Gral. PEC informándole de la visita que le hará el Tte. Corl. Alamillo, Director de la Escuela Superior de Guerra, quien le expondrá el plan de trabajo que desarrollará la escuela para estudiar la historia del sitio de Naco en 1914. Carta de Fructuoso Ochoa e hijos, de Puebla, al Gral. PEC pidiéndole su ayuda para que el Gral. Amaro le pague mil doscientos noventa y cinco pesos que les debe desde 1931, según copias de facturas que acompaña. Escrito del Gral. Amaro, titulado"Nuestros problemas sociales y el Ejército Nacional". "La enseñanza socialista". Señala los objetivos de la escuela socialista mexicana dentro de la evolución política y social de la revolución y la absoluta identificación del ejército con la obra revolucionaria. Habla de la ideología revolucionaria mexicana y de la labor de la educación social
Prevalence and clinical association of gene mutations through multiplex mutation testing in patients with NSCLC: Results from the ETOP Lungscape Project
No full textBackground: Reported prevalence of driver gene mutations in non-small-cell lung cancer (NSCLC) is highly variable and clinical correlations are emerging. Using NSCLC biomaterial and clinical data from the European Thoracic Oncology Platform Lungscape iBiobank, we explore the epidemiology of mutations and association to clinicopathologic features and patient outcome (relapse-free survival, time-to-relapse, overall survival). Methods: Clinically annotated, resected stage I-III NSCLC FFPE tissue was assessed for gene mutation using a microfluidicsbased multiplex PCR platform. Mutant-allele detection sensitivity is>1% for most of the 150 (13 genes) mutations covered in the multiplex test. Results: Multiplex testing has been carried out in 2063 (76.2%) of the 2709 Lungscape cases (median follow-up 4.8 years). FFPE samples mostly date from 2005 to 2008, yet recently extracted DNA quality and quantity was generally good. Average DNA yield/case was 2.63 mg; 38 cases (1.4%) failed QC and were excluded from study; 95.1% of included cases allowed the complete panel of mutations to be tested. Most common were KRAS, MET, EGFR and PIK3CA mutations with overall prevalence of 23.0%, 6.8%, 5.4% and 4.9%, respectively. KRAS and EGFR mutations were significantly more frequent in adenocarcinomas: PIK3CA in squamous cell carcinomas. MET mutation prevalence did not differ between histology groups. EGFR mutations were found predominantly in never smokers; KRAS in current/former smokers. For all the above mutations, there was no difference in outcome between mutated and non-mutated cases. Conclusion: Archival FFPE NSCLC material is adequate for multiplex mutation analysis. In this large, predominantly European, clinically annotated stage I-III NSCLC cohort, none of the mutations characterized showed prognostic significance. © The Author 2017
La reforma constitucional de 2020: ¿una nueva etapa de la construcción estatal en Rusia?
No full textThe given article offers an analysis of the amendments made to the Constitution of Russia in 2020. The author conducted an analysis of the reasons of the past reform, its course and features. The author comes to the conclusion that the shortcomings of the 1993 Constitution, adopted in the context of a political crisis, doomed it to change. In the new socio-political conditions of the 2010-20’s, the Russian authorities decided for the first time to establish communication with the society, which forced them to propose a procedure for a popular vote on amendments and support the value of “unconditional sovereignty” as a goal of constitutional changes. Having received approval to change the Constitution, the political regime of Vladimir Putin, being a compromise between the transnational and national elites, announced a new stage of state-building. Will the opportunity become a reality? The answer to this question depends on the future socio-economic course of the Russian authorities.El artículo representa en sí un análisis de las enmiendas a la Constitución de Rusia en 2020. Se analizan las causas de la pasada reforma, su procedimiento y particularidades. La autora llega a la conclusión de que debido a que la Constitución de 1993 fue adoptada en condiciones de una crisis política con imperfecciones estaba, desde entonces, condenada a sufrir cambios. En las nuevas condiciones sociopolíticas de los años 2010-2020, las autoridades rusas, por primera vez, decidieron establecer un diálogo con la sociedad. Este procedimiento obligó a las autoridades a proponer una votación nacional de las enmiendas y a apoyar los valores de la “soberanía incondicional” como objetivo de los cambios constitucionales. Al recibir la aprobación para reformar la Constitución, el régimen político de Vladímir Putin, vínculo de compromiso entre las élites transnacional y nacional, declaró una nueva etapa de la construcción estatal. ¿Se convertirá en realidad esta posibilidad? La respuesta a esta pregunta depende del futuro de la línea socioeconómica de las autoridades rusas
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The human myeloproliferative disorders: molecular pathogenesis and clonal heterogeneity
No full textThe classical myeloproliferative disorders (MPD), comprising essential thrombocythaemia (ET), polycythaemia vera (PV) and idiopathic myelofibrosis (IMF), are clonal premalignant haematopoietic neoplasms associated with activating mutations in signalling pathway molecules and a variable tendency to develop acute myeloid leukaemia (AML). This thesis examined genotype-phenotype associations of JAK2 and MPL mutations, the presence of clonal diversity in the MPD and the genetic events associated with progressive disease.
Mutations in MPL were identified in 4% of ET and 7% of IMF but not in PV. Three different acquired MPL mutations were identified, one of which had been reported as an inherited allele. Although MPL mutations did not delineate a distinct clinical or histopathological subtype of ET, molecular testing provides an important new tool in the diagnostic armamentarium. Clones homozygous for the JAK2 V617F mutation were identified in female but not male patients with ET, suggesting that gender differences may be important in the determination of disease phenotype. In patients with two acquired genetic alterations, a signalling pathway mutation and a cytogenetic abnormality were usually present within the same clone. By contrast, coexistence of two signalling pathway mutations indicated the presence of biclonal disease that in two patients had arisen independently and not from a shared founder clone.
RAS mutations were identified as potential cooperating events in patients with JAK2 or MPL mutant IMF. In patients developing AML following a JAK2 V617F-positive MPD, those with V617F-positive leukaemia had progressed via an accelerated phase of disease and harboured acquired alterations of RUNX1 or EVI1. V617F-negative leukaemias tended to follow directly from ET or PV, and loss of the JAK2 mutation by reversion to wild-type due to mitotic recombination, gene deletion or gene conversion was excluded. The thesis concludes with a discussion of how clonal heterogeneity can be integrated into current models of MPD disease pathogenesis
Rigorismo e integridad : un ensayo sobre la concepción del yo dividido en la filosofía práctica kantiana
No full textLa filosofía moral kantiana se ha asociado usualmente al rigorismo moral. Según esta posición, los deberes morales deben ser cumplidos incondicionalmente. Por ejemplo, afirma Kant, debemos cumplir el deber moral de la veracidad incluso ante un asesino que nos pregunte por el paradero de alguien que se refugia en nuestra casa. El objetivo de esta investigación es realizar una crítica al rigorismo moral kantiano. Para ello he dividido el texto en tres partes. En la primera parte presento las posición de Kant sobre la mentira (capítulo 1) y tras analizar el procedimiento del imperativo categórico explico en qué sentido este autor está comprometido con el rigorismo moral (capítulo 2). En la segunda parte, muestro que el rigorismo moral está fundamentado en el modelo de la agencia del yo dividido. Según este modelo, la agencia es un ejercicio de control por parte de un yo racional que debe controlar o someter a la parte pasiva no racional (capítulo 3). Siguiendo el trabajo de Bernard Williams, muestro que este modelo agencial conduce al problema de la integridad personal, pues en ocasiones la moralidad nos exige actuar en contra de nuestro carácter y de aquello que configura nuestra integridad (capítulo 4). En la tercera parte, examino la respuesta de Christine Korsgaard al problema de la integridad. Esta autora rechaza la concepción del yo dividido, y en cambio propone el modelo constitucional. Según este modelo, ser agente solo es posible cuando este está constituido como un todo integrado, y solo es posible estar integrado si existe un compromiso con la moralidad. De esta manera, ella puede articular una respuesta al problema de la integridad sin abandonar lo que denomino “la tesis de la prioridad normativa de la moralidad” (capítulo 5). En contra de esta posición, y siguiendo a Josep Corbí, articulo una crítica al modelo constitucional mostrando que este todavía está comprometido con la concepción del yo dividido (capítulo 6.1). Corbí también realiza una crítica a la tesis de la prioridad normativa de la moralidad (6.2 y 6.3). Al final concluyo que la filosofía moral kantiana, ya sea en su versión clásica o en la versión contemporánea de Korsgaard, no puede responder al problema de la integridad personal, en la medida en que desestima injustificadamente el valor normativo de fenómenos prácticos no morales.Kantian moral philosophy has usually been associated with moral rigorism. According to this position, moral duties must be fulfilled unconditionally. Kant claims that we must fulfill the moral duty of truthfulness even in the face of a murderer who asks us about the whereabouts of someone who takes refuge in our house. The aim of this investigation is to make a criticism of Kantian moral rigorism. To this purpose, I have divided the text in three parts. In the first part, I present Kant's position on lying (chapter 1), and after analyzing the procedure of categorical imperative I explain in which sense this author is committed to moral rigorism (chapter 2). In the second part, I show that moral rigorism is based on the conception of the divided self. According to this model, agency is an exercise of control by a rational self that must control the non-rational passive part (chapter 3). Following to Bernard Williams, I show that this model leads to the problem of personal integrity, since sometimes morality requires us to act against our character and against that which configures our integrity (chapter 4). In the third part, I examine Christine Korsgaard's response to the problem of integrity . She rejects the model of the divided self and proposes instead the constitutional model. According to this model, being an agent is only possible when it is constituted as an integrated whole, and it is only possible to be integrated if there is a commitment to morality. In this way, she can articulate a response to the problem of integrity without abandoning what I call “the thesis of the normative priority of morality” (chapter 5). Contrary to this position, and following Josep Corbí, I show that the constitutional model is still committed to the conception of the divided self (chapter 6.1). In addition, I also make a critique of the thesis of the normative priority of morality (6.2 and 6.3). I conclude that Kantian moral philosophy , whether in its classical version or in Korsgaard's contemporary version, cannot respond to the problem of personal integrity because it unjustifiably disregards the normative value of practical non-moral phenomena.COLCIENCIASDilemas morales y agencia. Una lectura a partir de KantLínea de investigación: Ética.Doctorad
