51 research outputs found
Trends in Social Work student research at the Atlanta university school of Social Work between 1958-1967, 1968
No full textWriting and the rights of reality: usurpation and potentiality in Derrida, Plato, Nietzsche, and Beckett
No full textThe thesis critically evaluates Jacques Derrida's conferral of the rights of reality on writing, focussing on his theory of an arche-text in light of the speculative nature of this theory. The theory is initially considered in the context of Derrida's elucidation of the usurpatory status of writing within the Platonic and Nietzschean texts. This consideration reveals an admission of writing's usurpatory status by both writers while at the same time demonstrating their awareness of the intrinsically speculative nature of this view, the significance of writing lying in its ability to exteriorise the radically indeterminate status of consciousness m relation to reality rather than its ability to displace consciousness or reality The analyses, therefore, not only bring the Derridean hypothesis of a repressive or phonocentric metaphysical episteme into question but also exhibit the historical and philosophical role of potentiality in relation to writing, writing's ultimate significance lying in its capacity to exteriorise our existence as a mode of potentiality. Accordingly, in the second half of the thesis the Derridean theory of writing is countered with a specifically Aristotelian theory of the text as it is exhibited in the prose of Samuel Beckett, an author whose significance lies in his close alignment with Derridean theory within contemporary criticism. It is demonstrated that this identification has obviated an awareness of the significance of potentiality within the Beckettian text, his work consequently being appraised in the previously neglected context of Aristotelian metaphysics
Le Grand Henderson Correspondence
No full textEntries include letters, a newspaper clipping of Le Grand\u27s obituary, and a letter written on Abingdon-Cokesbury Press stationery
The workshop as the work: white anti-racism organising in 1960s, 70s, and 80s US social movements
No full textThis thesis explores the rise of anti-racism workshops developed by white activists in various United States social movements from the late 1960s through the mid-1980s. The shifting ideology of the black freedom movement in the late 1960s, from integration to Black Power, transformed white activists‘ place within racial justice struggles. While recent scholarship has begun to turn its attention towards whites‘ ongoing racial justice activities, one of the most radical and widespread of these efforts is consistently overlooked: anti-racism workshops. Increasingly prevalent from the late 1960s through to the diversity-trainings explosion of the 1990s, this thesis demonstrates that these workshops had their roots in the black freedom, women‘s liberation and gay liberation movements. White activists from these movements led these workshops in order to examine white racial domination and privilege within both leftist social movements and larger US society.
Analysing case studies from the black freedom, women‘s liberation and gay liberation/rights movements, this thesis explores the foundational assumptions of anti-racism workshops. It seeks to explain how and why these efforts sought to frame race and racism as issues of knowledge and consciousness and why such efforts constituted radical praxis. It is argued that early anti-racism workshops were pedagogical projects that sought to confront the racial ignorance that structured the lives of whites in the US, including progressives and their liberation movements. This thesis draws attention to the efficacy and power of these workshops in terms of their epistemological effects, in the transformations they brought about in whites‘ understanding, or awareness, of racial realities
Poetry as a performing art in the English-speaking Caribbean.
No full textThis thesis seeks to demonstrate that there is a direct relationship
between the emergence of poetry as a performing art in the English speaking Caribbean and phases of nationalist agitation from the uprisings
against unemployment, low pay and colonial neglect during 1937-8 to the
present. Though the poetry has many variations in scope, ranging from
light-hearted entertainment, its principal momentum has been one of
protest, nationalism and revolutionary sentiment. The thesis seeks to
relate tone, style and content both to specific periods and cultural
contexts, and to the degree of engagement of the individual artist in the
political struggle against oppression.
Frequently theatrical, the poetry has commanded a stage and a
popular audience. Though urban in style, it is rooted in older, rural
traditions. Creole, the vernacular of the masses, is a vital common
denominator. The poetry is aurally stimulating, and often highly
rhythmic. The popular music of the day has played an integral part, and
formative role in terms of composition.
The fundamental historical dynamic of the English-speaking Caribbean
has been one of violent imperialist imposition on the one hand, and
resistance by the black masses on the other. Creole language, with its
strong residuum of African grammatical constructs, concepts and
vocabulary, has been a central vehicle of resistance. It is a low-status
language in relation to the officially-endorsed Standard English. The
thesis argues that artists' assertion of Creole, and total identification
with it through their own voice, is a significant act of defiance and
patriotism.
Periods of heightened agitation in the recent past have each led to
the emergence of a distinctive form of performance poetry. Chapter two
examines the role of Louise Bennett as a mouthpiece of black pride and
nationalist sentiment largely in the period preceding independence. Her
principal aim is the affirmation of the black Jamaican's fundamental
humanity. She uses laughter both as a curative emotional release and as
an expression of mental freedom. She lays the foundations of a comic
tradition which does not fundamentally challenge the contradictions of
the post-independence period.
Chapter three relates the emergence of the Dub Poets of Jamaica to
the development of Rastafarianism into a mass post-independence
nationalist revival, and to the contribution of intellectuals, most
symbolically Walter Rodney, to the process of decolonization. Reggae
music, the principal creative response to the dynamics of the period both
in terms of lyrics and rhythmic tension, infuses the work of Michael
Smith, Cku Onuora, Mutabaruka and Erian Meeks examined in this study.
Chapter four illustrates the development of performed poetry in the
context of periods of insurrection and revolution in the East Caribbean.
It examines the Black Rower movement as a stimulus to cultural
nationalism and revolutionary sentiment, and its transcendence to
internationalism and socialism in the context of the Grenada Revolution.
Abdul Malik straddles and exemplifies the creative dynamic which exists
between urban, industrial Trinidad and its tiny, rural and poor
neighbour, Grenada
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Rural life in English poetry of the mid-eighteenth century
No full textThis thesis examines several mid-eighteenth century poems, assessing their portrayal of rural life, its literary and historical significance, and the aesthetic and ideological issues it presents. An introductory essay on developments in rural poetry sets the scene for two extended essays. The first essay is a comparative reading of the subject of rural labour in three poems: James Thomson’s The Seasons (1726-44), Stephen Duck’s The Thresher’s Labour (1730, 1736) and Mary Collier’s The Woman’s Labour (1739). The viewpoints of a professional poet (Thomson), a farm labourer (Duck), and a working woman (Collier) are compared in relation to kinds of work all three address as well as to individual labouring subjects. The responses of the three poets to such related issues as folk traditions, forms of charity and other ‘compensations’, are also compared. Some surprising similarities as well as instructive differences are located; and an interesting picture of idealistic and realistic, male-oriented and female-oriented attitudes to labour and labour-related themes emerges
Enfermedad de Chagas, evasión de la respuesta inmune y perspectivas terapéuticas - revisión de literatura-
No full textLa enfermedad de Chagas es una enfermedad causada por el protozoario flagelado
Trypanosoma cruzi (T. cruzi), este circula en sangre y puede alterar la función de
órganos como el corazón, colon y esófago aumentando el tamaño de los mismos.
Es transmitida principalmente vía vectorial por las heces de diversos triatóminos
entre ellos el Rhodnius prolixus. Al ser catalogada una enfermedad desatendida
representa un problema de salud pública en América Latina.
T. cruzi, durante su ciclo evolutivo atraviesa por diferentes estadios: Tripomastigote,
amastigote y epimastigote. Cada estadio expresa un patrón de proteínas
específicas, las cuales proveerán al parásito de características propias en cuanto a
biología, morfología y función que se asocian con la virulencia y la infección de este,
por consecuente la dificultad para emplear tratamientos efectivos. Además de que
el parásito cuenta con diversos mecanismos de evasión que son obstáculo en la
recuperación de la enfermedad. La revisión bibliográfica permitió indagar acerca de
los diversos mecanismos de evasión inmune y relacionarlos con posibles
perspectivas terapéuticas funcionales en contraparte con el tratamiento
convencional, añadido se expone un algoritmo diagnostico que permita la valoración
oportuna de la enfermedad de acuerdo a la vía de transmisión. En ese sentido, se
realizó una búsqueda de revistas científicas, libros y otras fuentes sobre los temas
objeto de estudio. Se encontró como el mecanismo de evasión más reportado el del
complemento por la inhibición de la porción C3, de otro modo las perspectivas
terapéuticas las más prometedoras se enfocan en la inhibición del metabolismo del
parásito.RESUMEN 15
INTRODUCCIÓN 16
OBJETIVOS 18
1. ANTECEDENTES 19
2. MARCO TEÓRICO 23
2.1 ENFERMEDAD DE CHAGAS 23
2.1.1 Agente etiológico 23
2.1.2 Vector 27
2.1.3 Ciclo de vida 29
2.1.4 Vías de transmisión 32
2.1.5 Manifestaciones clínicas 32
2.1.5.1 Fase aguda 32
2.1.5.2 Fase indeterminada y Fase crónica 33
2.2 EPIDEMIOLOGÍA 33
2.3 DIAGNÓSTICO 37
2.3.1 Métodos directos 37
2.3.2 Métodos indirectos. 38
2.3.3 Métodos Serológicos 40
2.4 DETERMINANTES ANTIGÉNICOS 45
2.4.1 Mucinas 45
2.4.2 GP72 45
2.4.3 Superfamilia GP85/ TSA 45
2.4.4 Gp90 47
2.4.5 Gp35/50 47
2.4.6 Gp30 47
2.4.7 HSP70 47
2.4.8 Cruzipaina o Gp57/51 48
2.4.9 Oligopeptidasa B 49
2.5 INVASIÓN CELULAR DE Trypanosoma cruzi. 49
2.6 RESPUESTA INMUNE FRENTE A INFECCIÓN POR Trypanosoma cruzi51
2.6.1 Innata 51
2.6.2 Adaptativa 54
2.6.2.1 Celular 54
2.6.3 Humoral 55
2.7 EVASIÓN DE LA RESPUESTA INMUNE POR Trypanosoma cruzi 56
2.7.1 Invasión celular y sobrevida al stress oxidativo 56
2.7.2 Escape del fagolisosoma 60
2.7.3 Inactivación del complemento 61
2.7.3.1 Proteínas involucradas en la evasión del complemento. 62
2.7.4 Inmunomodulación a partir de la activación de patrones de
reconocimiento molecular 65
2.7.5 Activación policlonal de células B de forma inespecífica 67
2.7.6 Inmunodominancia 67
2.8 TRATAMIENTOS 68
2.8.1 Convencionales 68
2.8.1.1 Benzonidazol 68
2.8.1.2 Nifurtimox 70
2.8.2 Perspectiva de medicamentos 71
2.8.2.1 Itraconazol 71
2.8.2.2 Amiodarona 71
2.8.2.3 Alopurinol 72
2.8.2.4 Fexinidazol 72
2.8.3 Esquema terapéutico 73
2.8.4 Intervención en el metabolismo del parásito 74
2.8.4.1 Bloqueo de la proteína Cruzipaina 74
2.8.4.2 Inducción de estrés 75
2.8.4.3 Inhibición de metabolismo de pirofosfatos 75
2.8.5 Resincronización cardiaca 75
2.8.6 Vacunas contra Trypanosoma cruzi 76
3. DISEÑO METODOLÓGICO 79
3.1 TIPO DE INVESTIGACIÓN 79
3.2 UNIVERSO 79
3.3 POBLACIÓN 79
3.4 MUESTRA 80
3.5 CRITERIOS 80
3.5.1 Criterios de inclusión 80
3.5.2 Criterios de exclusión 80
3.6 PROCEDIMIENTOS 80
3.6.1 Obtención de la información 81
3.6.2 Análisis de la información 81
4. RESULTADOS 82
4.1 TIPO DE DOCUMENTOS 82
4.2 AÑO DE PUBLICACIÓN 83
4.3 PAÍS DE PUBLICACIÓN 83
4.4 IDIOMA DE PUBLICACIÓN 84
4.5 TEMA DE LOS DOCUMENTOS 85
4.6 MECANISMOS DE EVASIÓN INMUNE 86
4.7 TRATAMIENTOS UTILIZADOS 86
4.7.1 Tratamientos convencionales 86
4.7.2 Perspectivas terapéuticas 87
4.7.3 Tipos de Vacunas 88
4.8 TRATAMIENTO Y PERSPECTIVAS FRENTE A LA EVASION DEL
SISTEMA INMUNE 88
4.9 ALGORITMOS DIAGNÓSTICOS BASADOS EN LA LITERATURA 89
4.9.1 Transmisión vectorial 90
4.9.2 Transmisión pos-transfusional 91
4.9.3 Transmisión congénita 92
4.9.4 Transmisión en paciente inmunosuprimido 93
4.9.5 Transmisión Oral 95
4.9.6 Transmisión por accidente en el laboratorio 96
4.10 ALGORITMO TERAPÉUTICO BASADO EN LA LITERATURA 98
4.10.1 Fase Aguda 98
4.10.2 Fase indeterminada y crónica 99
5. DISCUSIÓN 101
6. CONCLUSIONES 110
7. REFERENCIAS BIBLIOGRÁFICAS 111PregradoBacteriólogo(a) y Laboratorista Clínic
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