122,066 research outputs found
Capitolo 1.3 - La biodiversità: le specie vegetali
No full textSi tratta di una rassegna del patrimonio naturale vegetale (specie e comunità) di uno dei tratti di costa emiliano-romagnola di maggior pregio naturalistico, area protetta della Rete Ecologica Natura 2000
L'informazione e la comunicazione pubblica: dalla legge n. 150 alle prospettive di differenziazione regionale
No full textLa 'moralizzazione' delle università (commento a decr. legge 10 novembre 2008, n. 180 conv. con modif., dalla legge 9 gennaio 2009, n. 1)
No full textIl d. lgs. n. 39 del 2013. Inconferibilità e incompatibilità degli incarichi nella prospettiva dell’imparzialità dei funzionari pubblici.
No full textLa trasparenza come strumento di lotta alla corruzione tra legge n. 190 del 2012 e d. lgs. n. 33 del 2013.
No full textTailored therapy in patients treated with fluoropyrimidines: focus on the role of dihydropyrimidine dehydrogenase
No full textFluoropyrimidines are widely used in the treatment of solid tumors, mainly gastrointestinal, head and neck and breast cancer. Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme for catabolism of 5-FU and it is encoded by DPYD gene. To date, many known polymorphisms cause DPD deficiency and subsequent increase of 5-FU toxicity. In addition, reduced inactivation of 5-FU could lead to increased 5-FU intracellular concentration and augmented efficacy of this drugs. Therefore DPD expression, particularly intratumoral, has been investigated as predictive and prognostic marker in 5-FU treated patients. There also seems to be a tendency to support the correlation between DPD expression and response/survival in patients treated with fluoropyrimidine even if definitive conclusions cannot be drawn considering that some studies are conflicting. Therefore, the debate on intratumoral DPD expression as a potential predictor and prognostic marker in patients treated with fluoropyrimidines is still open. Four DPD-polymorphisms are the most relevant for their frequency in population and clinical relevance. Many studies demonstrate that treating a carrier of one of these polymorphisms with a full dose of fluoropyrimidine can expose patient to a severe, even life-threatening, toxicity. Severe toxicity is reduced if this kind of patients received a dose-adjustment after being genotyped. CPIC (Clinical Pharmacogenetics Implementation Consortium) is an International Consortium creating guidelines for facilitating use of pharmacogenetic tests for patient care and helps clinicians ensuring a safer drug delivery to the patient. Using predictive DPD deficiency tests in patients receiving 5FU-based chemotherapy, in particular for colorectal cancer, has proven to be a cost-effective strategy
SATELLITE AND UNMANNED AERIAL VEHICLE DATA FOR THE CLASSIFICATION OF SAND DUNE VEGETATION
No full textWithin coastal systems, sand dunes are the only natural barriers able to counteract erosive processes. Since their equilibrium is often threatened by human activities and high vulnerability of the coastal environment, dunes require increasing attention and specific monitoring. Located between the mainland and the sea, dunes are unique residue habitats for some plant and animal species. In particular, their vegetation is important because it has a consolidation function and promotes the vertical dune accretion. A georeferenced vegetation classification can be useful to define the advancements or erosion stage of the dune, usually based only on the geometric reconstruction.
The proposed study aims to compare the classifications performed with some combinations of two of the last generation sensors and traditional image processing techniques. High spectral resolution satellite image (WorldView-2) and a multispectral orthophoto, obtained from data acquired by an unmanned aerial vehicle, were used. Objects and pixel algorithms were applied and the results were compared by a statistical test. Using the same bands, the findings show that both data are suitable for monitoring the evolutionary dune status. Specifically, the WorldView-2 pixel-based classification and UAV object-based classification provide the same accurate results
Comparison of pixel- and object-based classification methods of unmanned aerial vehicle data applied to coastal dune vegetation communities: Casal borsetti case study
No full textCoastal dunes provide the hinterland with natural protection from marine dynamics. The specialized plant species that constitute dune vegetation communities are descriptive of the dune evolution status, which in turn reveals the ongoing coastal dynamics. The aims of this paper were to demonstrate the applicability of a low-cost unmanned aerial system for the classification of dune vegetation, in order to determine the level of detail achievable for the identification of vegetation communities and define the best-performing classification method for the dune environment according to pixel-based and object-based approaches. These goals were pursued by studying the north-Adriatic coastal dunes of Casal Borsetti (Ravenna, Italy). Four classification algorithms were applied to three-band orthoimages (red, green, and near-infrared). All classification maps were validated through ground truthing, and comparisons were performed for the three statistical methods, based on the k coeffcient and on correctly and incorrectly classified pixel proportions of two maps. All classifications recognized the five vegetation classes considered, and high spatial resolution maps were produced (0.15 m). For both pixel-based and object-based methods, the support vector machine algorithm demonstrated a better accuracy for class recognition. The comparison revealed that an object approach is the better technique, although the required level of detail determines the final decision
Internationalisation in the household appliances sector in Fabriano (Italy). A case study
No full textThis paper analyses the household appliances district of Jesi-Fabriano. It shows how the internationalisation strategies of many enterprises are gradually modifying the organizational structure of the local production system. The diverse goals that have led the internationalisation processes and the strategies chosen by enterprises to effectively approach far away markets are at the core of the paper that includes a broad review of the fragmentation actions of the local enterprises. Special attention is paid to the effects of the internationalisation process on the relationships among actors along the whole filire and on the models of internal enterprise management. After an analysis of the history of the district and its current transformations, the main conclusions focus on possible scenarios regarding external and endogenous factors, on the main opportunities that enterprises should seize in order to successfully complete the ongoing internationalisation process and on the important role of local and national institutions in supporting the evolution of the model of local economic development.Internationalisation, Iinternational Fragmentation, Industrial Districts, Household Appliance Industry
MODELING X-RAY DATA OF BLACK HOLE BINARIES
No full textWe test the truncated disc models using multiwavelength (optical/UV/X-ray) data from the 2005 hard state outburst of the black hole SWIFT J1753.5-0127. This system is both fairly bright and has fairly low interstellar absorption, so gives one of the best datasets to study the weak, cool disc emission in this state. We fit these data using models of an X-ray illuminated disc to constrain the inner
disc radius throughout the outburst. Close to the peak, the observed soft X-ray component is consistent with being produced by the inner disc, with its intrinsic emission enhanced in temperature and luminosity by reprocessing of hard X-ray illumination in an overlap region between the disc and corona. This disc emission provides the seed photons for Compton scattering to produce the hard X-ray
spectrum, and these hard X-rays also illuminate the outer disc, producing the optical emission by reprocessing.
However, towards the end of the outburst, all these conclusions may change. The optical points clearly lie on an extrapolation of the hard X-ray flux, which may indicate that the seed photons for Compton scattering are now self-generated in the flow by Cyclo-Synchrotron radiation rather than being from the disc. The weak soft X-ray emission implies a small disc radius, unchanged from the outburst peak, in conflict with the expectations of the truncated disc model. However, this also requires that the energy to power the corona is advected vertically and radially in a dissipationless fashion from the disc. Thus it seems more likely that the soft X-ray component is not direct emission from the disc itself. We show that a similarly dim low/hard state spectrum from XTE J1118+480 puts similar constraints on the soft X-ray emission region, but here the very low interstellar absorption (an order of magnitude smaller than in SWIFT J1753.5-0127) allows detection of a much larger, cooler, UV component which is well fit by a truncated disc. Thus whatever the origin of the additional weak soft X-ray emission (irradiation of the inner face as opposed to the top surface of the inner edge of the disc, residual inner disc left from evaporation, ionised reflection, jet etc), its existence as a clearly separate component from the truncated disc in XTE J1118+480 shows that it does not trace the inner disc radius, so cannot be used to constrain the truncated disc models
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