2,668 research outputs found
Effects of adding Naloxone on in vitro survival of bovine embryos
No full textIACONO E, MERLO B, DELL'AQUILA M.E., MARI G (2007). Effects of adding Naloxone on in vitro survival of bovine embryos. REPRODUCTION IN DOMESTIC ANIMALS, ISSN: 0936-6768
Proc. 11th Annual Meeting of the European Society of Domestic Animal Reproduction (ESDAR) Mariensee- Hannover - Celle Germany 20-22 September 2007. Poster N° 8
Coming home to mother
No full textGift of Dr. Mary Jane Esplen.Piano vocal [instrumentation]We love to think of years ago [first line]We are coming home to Mother [first line of chorus]A flat [key]Piano [tempo]House, families, birds, photograph of M.E. Mollins [illustration]Popular song [form/genre]Publisher's advertisement on inside front [note]Mediatoon by G.A. Boyton [note
M.E. Church exterior
No full textA monochrome postcard of the M.E. Church in Georgetown, Delaware. The church was made out of brick and had a tall tower on its corner. Writing on the right indicates that the author was having a good time. Mrs. P. H. Adkins of Milton, Delaware, received this postcard. A postmark on the back indicates that this postcard was mailed from Georgetown, Delaware. The postage stamp is a one-cent U.S. #300, Benjamin Franklin. The back of the postcard is labeled 75.00 and 0240
M.E. Church exterior
No full textA monochrome postcard of the M.E. Church in Georgetown, Delaware. The church was made out of brick and had a tall tower on its corner. Writing on the right indicates that the author was having a good time. Mrs. P. H. Adkins of Milton, Delaware, received this postcard. A postmark on the back indicates that this postcard was mailed from Georgetown, Delaware. The postage stamp is a one-cent U.S. #300, Benjamin Franklin. The back of the postcard is labeled 75.00 and 0240
On using Directional Information for Parameter Space Decomposition in Ellipse Detection
No full textIn this paper we use the parametric polar representation to extend the application of edge directional information from circle to ellipse extraction. As a result we obtain a mapping which decomposes the parameter space required for ellipse extraction into two independent sub-spaces and one final histogram accumulator. The mapping includes the tangent of the angle of the first and second directional derivatives. These tangents are computed by considering edge direction at two border points. We show that the use of gradient information for parameter space decomposition avoids the intensive point labelling imposed by geometric constraints used by other approaches
NPMC+ AS A MODEL SYSTEM TO INVESTIGATE THE ROLE OF QUIESCENCE IN LEUKEMIA DEVELOPMENT
No full textThe evolution of Acute Myeloid Leukemia (AML) is a complex process characterized by the stepwise accumulation of mutations, primarily occurring in Hematopoietic Stem Cells (HSCs). Such mutations give rise to the so-called Leukemia Initiating Cell (LIC), characterized by enhanced self-renewal and impaired differentiation. The molecular mechanisms underlying this transition are still poorly understood but they are likely to be critical to understanding the leukemic stem cell (LSC) biology.
Recent functional and genetic studies on AML revealed NPMc+ as a critical driver oncogene, highly conserved at relapse, and characterizing the AML phenotype. Likely, NPMc+ has a pivotal role in the LIC evolution and LSC behavior.
Taking advantage of the extended pre-leukemic phase of our inducible NPMc+ mouse model, we elucidated the impact of NPMc+ expression on normal HSCs to define the early mechanisms of NPMc+ induced leukemogenesis. We have found that NPMc+ expression leads to the expansion of the HSC compartment by enforcing a stem-cell transcriptional program that promotes quiescence and increases self-renewal. Moreover, considering the strong co-occurrence of NPMc+ with FLT3-ITD in patients, we investigated the mechanisms of this cooperation in pre-leukemia. Strikingly, the expression of NPMc+ in the FLT3-ITD background i) prevents the HSCs exhaustion imposed by FLT3-ITD, ii) restores their repopulating capacity, iii) restores the same transcriptional program observed in the NPMc+ HSCs, including quiescence genes upregulation. These data strongly suggest that NPMc+ and FLT3-ITD mutations cooperate in inducing AML, thanks to the NPMc+ ability to limit LT-HSCs exhaustion and reconstitute a fully competent LT-HSC population in which the oncogenic activities of FLT3-ITD lead to a rapid selection of the LICs.
We thus hypothesized that enforced quiescence might be critical to maintain the transformed clone during both the pre-leukemic and the leukemic phase. In support, we xi
identified the TGFβ pathway, one of the most critical pathways that regulate HSCs quiescence, as being upregulated by NPMc+, either alone or in combination with FLT3- ITD. Moreover, we report that pharmacological inhibition of this pathway impacts on NPMc+/FLT3-ITD AML growth in vivo. Finally, we provide preliminary results suggesting that TGFb inhibition might modify the fitness and/or the number of LSCs
La fecondazione assistita dopo dieci anni di legge 40 : il punto di vista del costituzionalista
No full textThe Author of this paper adds the point of view of the constitutionalist to the debate on the Italian statute n.40/1994 on assisted reproduction illustrated by Flamigni and Mori in their work. The paper ends with a reflection on the recent decision n. 162/2014 issued by the Constitutional Court, which has declared the illegitimacy of the prohibition of heterologous reproduction
L'approvazione della legge Cirinnà : fra riconoscimento dei diritti e scontro ideologico
No full textThe New Italian Law on Civil Unions: Between Rights Recognition and Ideological Clash Abstract: The author examines the coming into force of the first Italian law on civil unions, which, for the first time, grants protection for both homosexual and different sex couples
La Corte costituzionale chiude la porta agli scienziati in nome della dignità dell’embrione
No full textThis essay aims to analize decision no. 84 of 2016 of the Italian Constitu-tional Court, on the matter of scientific research on embryos.
In particular the essay dwells with the problematic acknowledgement of the embryo dignity. The Author considers this aspect in the context of the relation between sci-entific evolution and legislative discretionality, taking into account the other deci-sions of the Court on the matter of medically assisted procreation
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