324,591 research outputs found
Paesaggi Intermedi - Concorso Internazionale ad inviti Nuovo Quartiere Cornaredo
No full textProgetto presentato al Concorso internazionale con prequalificazione sulla base della presentazione di un team multidisciplinare, curricula dei componenti e proposta di metodo. Il concorso si è svolto in un'unica fase. Il team multidisciplinare è composto da N. Privileggio (architettura - capogruppo), F. Infussi (urbanistica), C. Merlini (urbanistica), M. Secchi (urbanistica), M. Giuliani (ingegneria civile), I. Curulli (paesaggio), M. Mastromarino (viabilità), P. Fareri (politiche attuative) S. Sbardella (infrastrutture
A Digital Touch : The “Body Issue” in Computational Creativity
No full textIn this article, Mattia Merlini and Stefano Maria Nicoletti ask themselves if machines ever take our place in the creation of art, and particularly music. Despite the outstanding results of some well-known Ais, the authors argue that machines present some intrinsic limits in creative contexts. In particular, their attention focuses on what they call the »body issue«, i.e. the role of the body in the experience and creation of music, grounded in contemporary findings in neuroscience, especially on embodied cognition, and also on the theories of Maurice Merleau-Ponty and Roland Barthes
Hemilamprops merlini Muhlenhardt-Siegel 2005
No full textHemilamprops merlini Mühlenhardt-Siegel, 2005 Hemilamprops merlini Mühlenhardt-Siegel, 2005: 114–117, figs 1–2. Type material. Holotype: ZMH K 40,416, non ovigerous female. Paratypes: ZMH K 40,417, 15 females, 10 subadult males, 9 juveniles. Angola Basin, 22°20.0’– 22°20.2’S, 3°18.3’– 3°18.4’E. Not seen. Diagnosis. Carapace without lateral ridges, without setae, dorsal crest entire. Pleonites without dorsal crest. Telson 0.6 length of uropod peduncles, with 4–5 pairs lateral setae, 5 terminal setae. Uropod exopod article 1 0.9 length of article 2. Adult male unknown. Depth. 1798–5144 m. Distribution. Angola Basin, 22°20’S, 3°18.3’E, and Bellingshausen Sea. Remarks. Hemilamprops merlini is most similar to the Australian species H. diversus, but can be distinguished by the equal length terminal setae on the telson. In H. diversus the terminal setae on the telson are unequal in length.Published as part of Gerken, Sarah, 2018, The Lampropidae (Crustacea: Cumacea) of the World, pp. 1-192 in Zootaxa 4428 (1) on page 78, DOI: 10.11646/zootaxa.4428.1.1, http://zenodo.org/record/376977
Demolition as a Territorial Reform Project
No full textThe widespread conditions of obsolescence and risk emerging in many parts of our country pose new questions to the territorial project and entail a review of its operational tools. In this sense, even demolition can acquire a new meaning, soliciting a technical and cultural reflection that has repercussions on the future of the contemporary territory
Development of a rapid method for qualitative detection of microbiological contamination based on enzymatically-induced ATP luminescence
No full textNamen je bil razvoj hitre metode za kvalitativno določanje mikrobiološke kontaminacije na osnovi encimsko sprožene luminiscence ATP. Nova metoda za določevanje mikrobiološke kontaminacije v sterilnih farmacevtskih izdelkih je zasnovana na uporabi instrumenta Celsis Accel, ki s pomočjo bioluminiscence dosega visoko stopnjo občutljivosti. To omogoča pridobitev rezultatov o sterilnosti izdelka v krajšem času kot standardna metoda testa sterilnosti. S pripravo redčitvenih vrst testnih mikroorganizmov smo ugotovili visoko občutljivost, tako na bakterijske kot tudi glivne celice. Z instrumentom lahko pri bakterijah zaznamo koncentracije 480±45 CFU/ml. Pri glivah pa lahko zaznamo koncentracije 35±18 CFU/ml. Sama metoda ne omogoča zaznavanja bakterijskih spor in bakterijskih endotoksinov, kar pa je prav tako pomembno za varen farmacevtski izdelek. Na rezultate analize imajo velik vpliv tekoča gojišča ki se redno uporabljajo za standardno metodo testa sterilnosti. Svetlobni signal tekočega gojišča lahko zamaskira svetlobni signal celice, s čimer lahko dobimo lažno negativni rezultat. Obravnavana metoda omogoča pridobitev rezultatov v 6-ih dneh, kar je za 8 dni hitrejše od standardnega testiranja sterilnosti. S tem je doseženo tudi hitrejše sproščanje sterilnih farmacevtski izdelkov na trg in posledično tudi hitrejša dobavo le teh do pacientov.The purpose was development of a qualitative rapid method for determining microbiological contamination in sterile pharmaceutical products. The method for determining microbiological contamination in sterile pharmaceutical products is based on the use of the instrument Celsis Accel, which achieves a high level of sensitivity through bioluminescence ATP. This enables obtaining results regarding product sterility in a shorter time compared to the standard sterility test method. By preparing dilution
series of test microorganisms, we have found high sensitivity to both bacterial and fungal cells. The instrument can detect bacterial concentrations at 480±45 CFU/ml and fungal concentrations at 35±18 CFU/ml. However, the method itself does not allow for the detection of bacterial spores nor bacterial endotoxins, which are important for a safe pharmaceutical product. The results of the analysis are influenced by the liquid growth medium used daily for the standard sterility test method. The light signal from the liquid medium can mask the light signal from the cells, resulting in a false negative result. The method in question, enables us to achive results in 6 days, which is 8 days faster than the standard method of sterility testing. This allows for a faster release of sterile pharmaceutical products to the market and thus faster delivery to patients
A new synthesis of the cytotoxic alkaloid Luotonine A
No full textA convenient synthesis of the cytotoxic alkaloid Luotonine A has been achieved using cheap and readily accessible reagents. The key intermediate in the synthesis is the tricyclic compound 2,3-dihydro[1H]-pyrrolo[3,4-b]quinolin-3-one (5)
Enantioselective total synthesis and absolute configuration of the alleged structure of crassinervic acid
No full textAn enantioselective synthesis of the structure reported for the natural antifungal compound, (-)-crassinervic acid (1), has been achieved starting from geraniol and p-hydroxybenzoic acid. The key chirality-inducing step is a Sharpless asymmetric epoxidation of an allylic alcohol, on the basis of which the S configuration can be assigned to the (-) natural enantiomer. The discrepancies between the spectroscopic data for synthetic and natural crassinervic acid cast some doubts on the structure assigned to the natural compound. A possible revised structure is discussed
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