102,476 research outputs found
Double Wedding Ring quilt Maudie Merla Sharp Harbert
No full textImage of a Double Wedding Ring quilt created about 1931 by Maudie Merla Sharp Harbert. Also includes questionnaires describing the quilt completed by Emma G. Griffin as part of the Utah Quilt Guild\u27s documentation days held from 1988-1994. Estimated date of fabric in quilt probably 1930; Emma inherited it form her mother about 1975. Made by my mother with keep from bemuse busting Sharp (my grandmother)
The emerging role of Gβ subunits in human genetic diseases.
No full textEnvironmental stimuli are perceived and transduced inside the cell through the activation of signaling pathways. One common type of cell signaling transduction network is initiated by G-proteins. G-proteins are activated by G-protein-coupled receptors (GPCRs) and transmit signals from hormones, neurotransmitters, and other signaling factors, thus controlling a number of biological processes that include synaptic transmission, visual photoreception, hormone and growth factors release, regulation of cell contraction and migration, as well as cell growth and differentiation. G-proteins mainly act as heterotrimeric complexes, composed of alpha, beta, and gamma subunits. In the last few years, whole exome sequencing and biochemical studies have shown causality of disease-causing variants in genes encoding G-proteins and human genetic diseases. This review focuses on the G-protein β subunits and their emerging role in the etiology of genetically inherited rare diseases in humans
Nailfold capillaroscopy pattern recognition using texture analysis
No full textNailfold capillaroscopy (NC) is a non-invasive imaging technique employed to assess the condition of blood capillaries in the nailfold. It is particularly useful for early detection of scleroderma spectrum disorders and evaluation of Raynaud's phenomenon. While diagnosis based on NC is typically performed by manual inspection, computerised nailfold capillaroscopy can help to reduce the inherent ambiguity present in human judgement while greatly reducing the time for diagnosis. Diagnosis of NC images involves the recognition of early, active and late patterns, also known as NC patterns or scleroderma (SD) patterns, in the images. In this paper, we propose a holistic method to classify NC images in these well known patterns. In particular, we employ texture analysis to describe the underlying patterns, coupled with a classifier to first identify patterns in fingers, and then, through a voting strategy, reach a decision for a patient. Experimental results on a set of NC images with known ground truth demonstrate the efficacy of our approach
E3 Ubiquitin Ligase TRIM Proteins, Cell Cycle and Mitosis
No full textThe cell cycle is a series of events by which cellular components are accurately segregated into daughter cells, principally controlled by the oscillating activities of cyclin-dependent kinases (CDKs) and their co-activators. In eukaryotes, DNA replication is confined to a discrete synthesis phase while chromosome segregation occurs during mitosis. During mitosis, the chromosomes are pulled into each of the two daughter cells by the coordination of spindle microtubules, kinetochores, centromeres, and chromatin. These four functional units tie chromosomes to the microtubules, send signals to the cells when the attachment is completed and the division can proceed, and withstand the force generated by pulling the chromosomes to either daughter cell. Protein ubiquitination is a post-translational modification that plays a central role in cellular homeostasis. E3 ubiquitin ligases mediate the transfer of ubiquitin to substrate proteins determining their fate. One of the largest subfamilies of E3 ubiquitin ligases is the family of the tripartite motif (TRIM) proteins, whose dysregulation is associated with a variety of cellular processes and directly involved in human diseases and cancer. In this review we summarize the current knowledge and emerging concepts about TRIMs and their contribution to the correct regulation of cell cycle, describing how TRIMs control the cell cycle transition phases and their involvement in the different functional units of the mitotic process, along with implications in cancer progression
Ubiquitination, biotech startups, and the future of trim family proteins: A trim-endous opportunity
No full textUbiquitination is a post-translational modification that has pivotal roles in protein degradation and diversified cellular processes, and for more than two decades it has been a subject of interest in the biotech or biopharmaceutical industry. Tripartite motif (TRIM) family proteins are known to have proven E3 ubiquitin ligase activities and are involved in a multitude of cellular and physiological events and pathophysiological conditions ranging from cancers to rare genetic disorders. Although in recent years many kinds of E3 ubiquitin ligases have emerged as the preferred choices of big pharma and biotech startups in the context of protein degradation and disease biology, from a surface overview it appears that TRIM E3 ubiquitin ligases are not very well recognized yet in the realm of drug discovery. This article will review some of the blockbuster scientific discoveries and technological innovations from the world of ubiquitination and E3 ubiquitin ligases that have impacted the biopharma community, from biotech colossuses to startups, and will attempt to evaluate the future of TRIM family proteins in the province of E3 ubiquitin ligase-based drug discovery
Rise of TRIM8: A Molecule of Duality
No full textTRIM8, an E3 ubiquitin ligase and a member of TRIM family proteins, has been identified to function as both a tumor suppressor and an oncogenic molecule. Further, TRIM8 is emerging as an important player in bipolar spindle formation and mitotic progression, and its sphere of influence is growing across multiple human pathologies and cancers
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