40 research outputs found
A CLINICAL STUDY OF NEUROFIBROMATOSIS WITH A SPECIAL REFERENCE TO CUTANEOUS MANIFESTATIONS
No full textCLINICAL PROFILE OF PATIENTS WITH CHRONIC DERMATOPHYTOSIS- A DESCRIPTIVE STUDY FROM A TERTIARY CARE CENTRE IN KERALA
No full textPrescription pattern of topical corticosteroids in dermatology department in a tertiary care hospital
No full textBackground: Topical steroids are sometimes combined with other active ingredients including antibacterial agents, antifungal agents and calcipotriol. The study of prescription pattern measures the performance of health care providers in several key dimensions related to the appropriate use of drugs. The objectives of the study were to study the prescription pattern of topical corticosteroids in terms of indications, its potency, average number of topical corticosteroids per patient and in fixed dose combinations.
Methods: Data of patients prescribed with topical corticosteroids in dermatology department OPD were collected. Data included age, gender, clinical diagnosis, topical & systemic corticosteroids prescribed and their dosing schedule
Results: Out of 500 cases, 229 were males and 271 were females. Mean age of patients was 40.60±19.789 years. Most common dermatological condition for topical corticosteroid prescription was dermatitis (43.8%). 45. 9% of prescribed corticosteroids were moderate potent agents. Average number of topical corticosteroids per prescription was 1.04. Most commonly prescribed topical corticosteroids were betamethasone dipropionate. Most common dosage form was cream. Most common fixed dose combination was with gentamicin. Among 103 fixed dose combinations 42.7% were combined with moderately potent steroids. 72% drugs were prescribed in generic name. 4% of prescription had strength of steroids mentioned. 80% of prescription stated site of application and in 76% cases frequency of drug application was mentioned. Duration of treatment was mentioned in 86.4% of cases.
Conclusions: Study demonstrates variability of topical corticosteroid utilization in various dermatological conditions
CLINICAL STUDY OF DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS) – WITH SPECIAL FOCUS ON THE INCITING DRUG AND THE INDICATION FOR STARTING THE DRUG
No full textObjective: This study was undertaken to identify the most common drug causing drug reaction with eosinophilia and systemic symptoms (DRESS) inpatients admitted in our center and possible factors associated with it.
Methods: This was a cross-sectional observational study of patients with DRESS admitted from January 2018 to December 2020. Data were entered in MS Excel and analyzed using SPSS software.
Results: Eighty-four consecutive patients who were diagnosed as DRESS were included in the study. The most common inciting drug was phenytoin and the most common indication for starting phenytoin was traumatic brain injury (TBI) to prevent seizures. DRESS to phenytoin after neurotrauma (NT) was more in patients who sustained combined extradural (EDH) and subdural hematoma (SDH), and those were managed conservatively for NT. None of the patients recognized fever as an initial feature of DRESS and did not stop the drug. More than one-third of patients with erythema multiforme (EM) like rash developed drug induced liver injury(DILI). The majority of patients who had sub-arachnoid hemorrhage (SAH) developed DILI.
Conclusion: Phenytoin though time-tested and cost-effective for prevention of seizures after TBI, it very commonly leads to DRESS which adds to the morbidity and rarely mortality of patient. In this present era of increasing road traffic accidents, using newer non-aromatic anticonvulsants may be more beneficial than phenytoin. The patients should be made aware of the likely time DRESS can occur, the earliest symptom of DRESS, and the need to stop the drug at the earliest
RRAM-based Low-Power Neuromorphic Computing Engine for Space Applications
No full textWith recent breakthroughs in AI and deep learning, applying these techniques to on-board computers for space applications has grown in interest to engineers on space applications. The space field brings its own challenges, such as reliability and power restrictions. The proposed solution in this work concerns a neuromorphic accelerator for a spiking neural network (SNN) designed using memristive devices (RRAM), dubbed the Newtype Learning Computer. To this end, this work presents the following contributions: A design for a behavioral VHDL implementation of a target SNN boasting software-level accuracy, specifically built for edge AI in space. We also present a characterized ASIC design of one layer of this SNN, analyzed using RTL design tools. An analysis of this same layer designed using Memristive Crossbar Arrays is also provided, and we present a comparison of both. When simulating 4096 neurons, the RRAM-based design shows 174x smaller area, power dissipation reduction of 27x energy reduction by 4 orders of magnitude and over 80x faster by latency compared to the CMOS-based design. This thesis presents a confident first step towards the use of RRAM-based neuromorphic accelerators for spiking neural networks in space-based applications.https://github.com/HeatPhoenix/NLC4Space Github repository for the project's files.Computer EngineeringElectrical Engineering | Embedded System
Creating a link between CAMHS and children's centres in a deprived area: A case of setting up a Work Discussion Group
No full textThis thesis explores the process of setting up a Child Psychotherapy-led outreach
service in Children’s Centres (CC) in a deprived urban setting. Our team decided that
setting up Work Discussion Groups (WDGs) for CC staff would be the best starting
point towards engaging and sensitising frontline workers to early signs of mental
health problems. This research focuses primarily on exploring both CC staff and
Child Psychotherapists’ (CPs’) experience of participating in this initiative. Semistructured interviews were conducted and then analysed using Interpretative
Phenomenological Analysis (IPA), coupled with a psychoanalytic understanding, to
shed light into the lived experience of the participants in this project. The author
draws attention to CC being containers for significant child and parental anxieties.
The CC’s increasing safeguarding role is a concerning finding of this study as it is
particularly stressful for CC staff and has implications for their practice. The study -
in line with existing literature- highlights the importance of time and a consistent
‘therapeutic presence’ in CC. Understanding the culture of the institution and taking
into account the impact of deprivation and financial insecurity are essential aspects
to be considered when designing and implementing an intervention in a deprived
community. Powerful dynamics that give rise to unconscious attacks on the outreach
worker, splitting between good and bad services, paranoid anxieties and lack of trust
are likely to occur. CC staff struggle with managing safeguarding concerns while
they tend to focus more on parents’ difficulties and developmental issues and less on
children’s emotional wellbeing and attachment to their carers. The author suggests
that CC staff could benefit from working closely with CPs and from participating in
WDGs on a regular and voluntary basis, so that they can be better equipped to think
about children’s emotional states
Roe v. Workman\u27s Compensation Appeals Board: Something Fishy in California Workers\u27 Compensation Law
No full textIn California an injured employee receives workers compensation from his employer and can also bring an action for damages against a third party tortfeasor. The Labor Code provides the employer with subrogation rights in order to avoid double recovery by the employee. In Roe v. WCAB, the California Supreme Court held that concurrent employer negligence will bar his credit rights and that the WCAB has jurisdiction to determine the issue of employer negligence. This note traces pre-Roe appellate decisions and then analyzes and criticizes the Roe opinion. Finally, the author proposes an alternative solution utilizing certain comparative negligence principles announced in Li v. Yellow Cab Co
Roe v. Workman\u27s Compensation Appeals Board: Something Fishy in California Workers\u27 Compensation Law
No full textIn California an injured employee receives workers compensation from his employer and can also bring an action for damages against a third party tortfeasor. The Labor Code provides the employer with subrogation rights in order to avoid double recovery by the employee. In Roe v. WCAB, the California Supreme Court held that concurrent employer negligence will bar his credit rights and that the WCAB has jurisdiction to determine the issue of employer negligence. This note traces pre-Roe appellate decisions and then analyzes and criticizes the Roe opinion. Finally, the author proposes an alternative solution utilizing certain comparative negligence principles announced in Li v. Yellow Cab Co
Lehren der Weisheit und Tugend in auserlesenen Fabeln, Erzählungen und Liedern: Ein Buch für die Jugend
No full textSomeone must have found some very useful material in this book, since it went through ten editions! It is organized into three major sections. The first has five subsections: Activity and Industriousness; Moderation and Self-Control; Orderliness; Carefulness; and Wisdom and Innocence. The second major section has seven subsections: Love and Obedience; Brotherly Love; Charity; Justice; Honesty; Envy; and Gentleness. The third major section deals with the love and greatness of God. Some 212 texts are subsumed under these headings. I have sampled some texts. They seem surprisingly simple. A smart young mouse recognizes a trap but wants to smell the bacon. She just touches the bacon and is trapped (Kazner). Play with danger and you may get hurt (39)! A child enjoys the house of cards he built, but it falls down. What he builds next is better. Patience and courage can do great things (Gellert, 83). A good version of Hercules and the Carter comes, apparently, from Zacharia: Prayer helps, but not alone; work, and then prayer will be effective! (104). A young mouse debates -- and then makes the wrong choice -- as her mother warns and as the cat beckons (124-5). Hagedorn does a good verse presentation of The Stag and the Vine: I die because I wounded the one who gave me safety (144-45). Similarly, Gellert's The Blind and the Lame makes its point nicely (175). Lohn der Luege (193) is a good presentation of BW. This book is in surprisingly good condition for its age.This is a hardbound book (hard cover)Language note: GermanZehnte verbesserte und vermehrte AusgabeHerausgegeben von Friedrich Ludwig Wagne
The Renovationist Schism in the Don Region and the Activities of «Archbishop» Melchizedek (Nikolayev)
No full textThe article deals with the history of the renovationist schism in the Diocese of Don and Novocherkassk and with the role played in that process by “Archbishop” Melchizedek (also known as Nikolayev, Nikolev, or Nikolin). Based on a wide range of archive sources and materials of the 1920s periodicals, the author shows that the renovationist schism in the Don area was initiated by “Archbishop” Melchizedek supported by the State Political Directorate of Don Oblast. On 18 June 1922, supported by that governmental body, there was established an eparchial renovationist committee in Novocherkassk, which was the reason why Archbishop Mitrofan (Simashkevich) refused to be the head of the Diocese any longer. The renovationism localized in Novocherkassk started to spread all over the Diocese only after the arrest of the opposition Novocerkassk clergy. The parish priests who obeyed submissively to the authority of “Archbishop” Melchizedek were misinformed and so believed that he was the legitimate successor of Metropolitan Mitrofan who had “retired”. Regardless of the fast dissemination of renovationism, there were no radical reforms in the Don area as both the priests and the church people of the Diocese of Don and Novocherkassk were quite conservative. After Patriarch Tikhon had been released from prison on 26 June 1923, there started spontaneous anti-renovationist movement, both among the priests and the active laity who were not numerous though. The decisive organizational stage for the movement was the episcopal cheirotonia of Archpriest Zacharia Lobov. The coming of an active bishop to the church helm became the reason both for Metropolitan Mitrofan’s return to the church administration and eparchial parishes. And the big number of the Don parishes leaving the renovationist church administration were the reason for the arrests of Bishop Zacharia and his most active followers
