158 research outputs found
Supplemental Material - Experiences and expectations of parents when young people with congenital heart disease transfer from pediatric to adult care: A qualitative systematic review
No full textSupplemental Material for Experiences and expectations of parents when young people with congenital heart disease transfer from pediatric to adult care: A qualitative systematic review by Birgitte Lykkeberg, Marianne Wetendorff Noergaard, and Merete Bjerrum in Journal of Child Health Care</p
Physical activity for children and adolescents with attention deficit hyperactivity disorder: a protocol of a systematic review and meta-analysis
Get PDFINTRODUCTION: Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder among children and adolescents. The disorder negatively influences their academic performance and social relations, and their quality of life (QoL) is lower than that of peers without ADHD. The majority of children and adolescents with ADHD are treated with medication that potentially has an insufficient effect or frequently occurring adverse events. Physical activity is thought to alter the physiology of ADHD by affecting the same catecholaminergic system in the brain which is targeted by medication.METHODS AND ANALYSIS: This protocol is written in accordance with the 'Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols' guideline. Randomised clinical trials with participating children and adolescents between the ages of 3 and 18 years with a primary diagnosis of ADHD or hyperkinetic disorder will be included in the systematic review. The main objective of the review is to examine the effect of physical activity on QoL, executive functions, symptoms and functional impairment in this population. Previous systematic reviews on the effect of physical activity in children and adolescents with ADHD have several methodological and conceptual limitations. These reviews, for example, included both randomised and non-randomised clinical trials or had restrictions regarding the frequency and intensity of the physical activity interventions they included. The present review will include the newest studies in the field and follow the main principles outlined in the 'Cochrane Handbook for Systematic Reviews of Interventions'. Furthermore, it will be the first review in the field to include QoL as an outcome and to apply trial sequential analysis as part of the meta-analysis.ETHICS AND DISSEMINATION: As the systematic review is a secondary analysis of data from primary trials, approval from an ethics committee is not required. The results of the review will be published in a peer-reviewed scientific journal and presented at relevant conferences.TRIAL REGISTRATION NUMBER: This protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) on 16 August 2024 (CRD42024576670).</p
Experiences and expectations of parents when young people with congenital heart disease transfer from pediatric to adult care:A systematic review protocol
No full textObjective: The objective of this systematic review is to identify and synthesize the best available evidence on parents’ expectations and experiences when young people with congenital heart disease transfer from pediatric to adult care. Introduction: Transition programs are internationally acknowledged as a means to prevent lapses of care, loss of follow-up and provide young people with knowledge needed to be independent and take charge of their own health. Optimal transition from pediatric to adult care involves collaborating with parents, who also face several challenges during this transfer, including uncertainty and anxiety. Inclusion criteria: This review will consider qualitative studies that include parents’ views, expectations and experiences of the transition process and their role when young people aged 10 to 24 years with congenital heart disease are transferred from pediatric to adult care. Parents will include mothers, fathers and other primary caregivers (e.g. step-parents). This review will consider studies conducted in high-income countries and focus on qualitative data. Methods: A three-step search strategy will be utilized. An initial limited search of PubMed, CINAHL and PsycINFO (EBSCO) will be undertaken. Studies in English, German, Swedish, Norwegian and Danish will be considered for this review. Databases will be searched from their inception to the present date. Titles and abstracts will be screened by two independent reviewers for assessment against the inclusion criteria. Selected studies will be critically appraised by three independent reviewers for methodological quality. Findings will be pooled using meta-aggregation, and a ConQual Summary of Findings will be presented.</p
Secondary settlement of dikes in peat areas based on CPTu
No full textThis study aims for a software tool that predict secondary settlements in soft layers on which secondary dikes are founded based on cone penetration test data. In the literature study five equations have been found that relate cone resistance and friction ratio to volumetric weight and over consolidation ratio. With the volumetric weight and over consolidation ratio the NEN-Bjerrum settlement parameters can be determined and with that the strain for a layer. After this study the focus lies on developing a software tool and the resulting output. In the end it seems, qualitatively, that the results are not useful in engineering practise because the resulting settlements are unexpectedly large.Civil Engineerin
Perceptions of patients, significant others and health professionals of the role of significant others in programs for chronic non-malignant pain patients: a systematic review protocol
No full textImplementing nutritional guidelines - the effect of systematic training for nurse nutrition practitioners
No full textThe wider use of fixed-dose combinations emphasizes the need for a global approach to regulatory guideline development
No full textA fixed-dose combination (FDC) is a drug product in which two or more separate drug components (active pharmaceuticalingredients) are combined in a single-dosage form. Interest in developing FDCs is increasing in a range of diseases. This projectinvestigated the regulatory environment for FDCs in the EU and US. A review of the FDC guidelines set forth by the EMA, FDA,and ICH, followed by interviews of key informants in industry, identified 5 main industry concerns related to development ofFDCs. These concerns were presented to key informants from both the EU and US regulatory authorities. It was clear from theresults that the current regulatory environment for FDCs lacks consistency. This may create a barrier to innovation movingfrom the laboratory to the clinic, as companies cannot clearly see the development path requirements. This project also highlightedcertain challenges that currently face the regulatory world: how to improve the role of regulatory science and provideclear quantification in assessment decisions; the role of guidelines and their impact on innovation; and, most important, thequestion of globalization and how to move toward a more harmonized regulatory system
Qualitative content analysis–framing the analytical process of inductive content analysis to develop a sound study design
No full textQualitative content analysis (QCA) is often used in social and health sciences. However, as there are different approaches to using QCA, it can be challenging to understand and use the method. Recent articles have described what QCA is, and how it differs from other qualitative methods, such as thematic analysis and grounded theory. This article contributes to the methodological literature by framing the analytical process of QCA within the hermeneutic paradigm, specifically, it is based on the theoretical premises of philosophical hermeneutics. Thus, the aim is to describe how to conduct an inductive QCA clarifying how the analysis is based on preunderstanding and how meaning is grounded in the context. Further, to show how results can be developed and serve as reliable explanations to the problem under study. Hence, this presentation of the method seeks to bring clarity to the methodological and philosophical premises and the use of terminology.</p
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