2,351 research outputs found
On unitary convex decompositions of vectors in a -algebra
No full textsummary:By exploiting his recent results, the author further investigates the extent to which variation in the coefficients of a unitary convex decomposition of a vector in a unital -algebra permits the vector decomposable as convex combination of fewer unitaries; certain -algebra results due to M. Rørdam have been extended to the general setting of -algebras
Tn5 synaptic complex formation : role of transposase residue W450
No full textAuthor Posting. © American Society for Microbiology, 2008. This article is posted here by permission of American Society for Microbiology for personal use, not for redistribution. The definitive version was published in Journal of Bacteriology 190 (2008): 1484-1487, doi:10.1128/JB.01488-07.A series of Tn5 transposases (Tnp's) with mutations at the conserved amino acid position W450, which was structurally predicted to be important for synapsis, have been generated and characterized. This study demonstrates that W450 is involved in hydrophobic (and possibly aromatic) contacts within the Tnp monomer that negatively regulate synaptic complex formation.This work was supported by the NIH (grant no. GM50693) and the University of Wisconsin—Madison (grant no. WIS04792) and through the Evelyn Mercer Professorship in Biochemistry and Molecular Biology
Erratum: Half-supersymmetric solutions in five-dimensional supergravity (Journal of High Energy Physics (2007) 12 (025))
No full text[No abstract available]Gutowski JB, 2007, J HIGH ENERGY PHYS11
Verbesserung der Wundheilung durch wassergefiltertes Infrarot A (wIRA) bei Patienten mit chronischen venösen Unterschenkel-Ulzera einschließlich infrarot-thermographischer Beurteilung
No full textBackground: Water-filtered infrared-A (wIRA) is a special form of heat radiation with a high tissue-penetration and with a low thermal burden to the surface of the skin. wIRA is able to improve essential and energetically meaningful factors of wound healing by thermal and non-thermal effects.
Aim of the study: prospective study (primarily planned randomised, controlled, blinded, de facto with one exception only one cohort possible) using wIRA in the treatment of patients with recalcitrant chronic venous stasis ulcers of the lower legs with thermographic follow-up.
Methods: 10 patients (5 males, 5 females, median age 62 years) with 11 recalcitrant chronic venous stasis ulcers of the lower legs were treated with water-filtered infrared-A and visible light irradiation (wIRA(+VIS), Hydrosun® radiator type 501, 10 mm water cuvette, water-filtered spectrum 550–1400 nm) or visible light irradiation (VIS; only possible in one patient). The uncovered wounds of the patients were irradiated two to five times per week for 30 minutes at a standard distance of 25 cm (approximately 140 mW/cm2 wIRA and approximately 45 mW/cm2 VIS). Treatment continued for a period of up to 2 months (typically until closure or nearly closure of the ulcer). The main variable of interest was “percent change of ulcer size over time” including complete wound closure. Additional variables of interest were thermographic image analysis, patient’s feeling of pain in the wound, amount of pain medication, assessment of the effect of the irradiation (by patient and by clinical investigator), assessment of feeling of the wound area (by patient), assessment of wound healing (by clinical investigator) and assessment of the cosmetic state (by patient and by clinical investigator). For these assessments visual analogue scales (VAS) were used.
Results: The study showed a complete or nearly complete healing of lower leg ulcers in 7 patients and a clear reduction of ulcer size in another 2 of 10 patients, a clear reduction of pain and pain medication consumption (e.g. from 15 to 0 pain tablets per day), and a normalization of the thermographic image (before the beginning of the therapy typically hyperthermic rim of the ulcer with relative hypothermic ulcer base, up to 4.5°C temperature difference). In one patient the therapy of an ulcer of one leg was performed with the fully active radiator (wIRA(+VIS)), while the therapy of an ulcer of the other leg was made with a control group radiator (only VIS without wIRA), showing a clear difference in favour of the wIRA treatment. All mentioned VAS ratings improved remarkably during the period of irradiation treatment, representing an increased quality of life. Failures of complete or nearly complete wound healing were seen only in patients with arterial insufficiency, in smokers or in patients who did not have venous compression garment therapy.
Discussion and conclusions: wIRA can alleviate pain considerably (with an impressive decrease of the consumption of analgesics) and accelerate wound healing or improve a stagnating wound healing process and diminish an elevated wound exudation and inflammation both in acute and in chronic wounds (in this study shown in chronic venous stasis ulcers of the lower legs) and in problem wounds including infected wounds. In chronic recalcitrant wounds complete healing is achieved, which was not reached before. Other studies have shown that even without a disturbance of wound healing an acute wound healing process can be improved (e.g. reduced pain) by wIRA.
wIRA is a contact-free, easily used and pleasantly felt procedure without consumption of material with a good penetration effect, which is similar to solar heat radiation on the surface of the earth in moderate climatic zones. Wound healing and infection defence (e.g. granulocyte function including antibacterial oxygen radical formation of the granulocytes) are critically dependent on a sufficient energy supply (and on sufficient oxygen). The good clinical effect of wIRA on wounds and also on problem wounds and wound infections can be explained by the improvement of both the energy supply and the oxygen supply (e.g. for the granulocyte function). wIRA causes as a thermal effect in the tissue an improvement in three decisive factors: tissue oxygen partial pressure, tissue temperature and tissue blood flow. Besides this non-thermal effects of infrared-A by direct stimulation of cells and cellular structures with reactions of the cells have also been described. It is concluded that wIRA can be used to improve wound healing, to reduce pain, exudation, and inflammation and to increase quality of life.Hintergrund: Wassergefiltertes Infrarot A (wIRA) ist eine spezielle Form der Wärmestrahlung mit hoher Gewebepenetration bei geringer thermischer Oberflächenbelastung. wIRA vermag über thermische und nicht-thermische Effekte wesentliche und energetisch bedeutsame Faktoren der Wundheilung zu verbessern.
Ziel der Studie: prospektive Studie (primär randomisiert, kontrolliert, verblindet geplant, de facto mit einer Ausnahme nur eine Kohorte möglich) mit wassergefiltertem Infrarot A (wIRA) in der Therapie von Patienten mit therapierefraktären chronischen venösen Unterschenkel-Ulzera mit thermographischer Verlaufskontrolle.
Methoden: 10 Patienten (5 Männer, 5 Frauen, Median des Alters 62 Jahre) mit 11 therapierefraktären chronischen venösen Unterschenkel-Ulzera wurden mit wassergefiltertem Infrarot A und sichtbarem Licht (wIRA(+VIS), Hydrosun®-Strahler Typ 501, 10 mm Wasserküvette, wassergefiltertes Spektrum 550–1400 nm) oder mit sichtbarem Licht (VIS; nur bei einem Patienten möglich) bestrahlt. Die unbedeckten Wunden der Patienten wurden zwei- bis fünfmal pro Woche über bis zu 2 Monate (typischerweise bis zum Wundschluss oder Fast-Wundschluss des Ulkus) für jeweils 30 Minuten mit einem Standardabstand von 25 cm bestrahlt (ungefähr 140 mW/cm2 wIRA und ungefähr 45 mW/cm2 VIS). Hauptzielvariable war die „prozentuale Änderung der Ulkusgröße über die Zeit“ einschließlich des kompletten Wundschlusses. Zusätzliche Zielvariablen waren thermographische Bildanalyse, Schmerzempfinden des Patienten in der Wunde, Schmerzmittelverbrauch, Einschätzung des Effekts der Bestrahlung (durch Patient und durch klinischen Untersucher), Einschätzung des Patienten des Gefühls im Wundbereich, Einschätzung der Wundheilung durch den klinischen Untersucher sowie Einschätzung des kosmetischen Zustandes (durch Patienten und durch klinischen Untersucher). Für diese Erhebungen wurden visuelle Analogskalen (VAS) verwendet.
Ergebnisse: Die Studie ergab eine vollständige oder fast vollständige Abheilung der Unterschenkel-Ulzera bei 7 Patienten sowie eine deutliche Ulkusverkleinerung bei 2 weiteren der 10 Patienten, eine bemerkenswerte Minderung der Schmerzen und des Schmerzmittelverbrauchs (von z.B. 15 auf 0 Schmerztabletten täglich) und eine Normalisierung des thermographischen Bildes (vor Therapiebeginn typischerweise hyperthermer Ulkusrandwall mit relativ hypothermem Ulkusgrund, bis zu 4,5°C Temperaturdifferenz). Bei einem Patienten wurde ein Ulkus an einem Bein mit dem Vollwirkstrahler (wIRA(+VIS)) therapiert, während ein Ulkus am anderen Bein mit einem Kontrollgruppenstrahler (nur VIS, ohne wIRA) behandelt wurde, was einen deutlichen Unterschied zugunsten der wIRA-Therapie zeigte. Alle aufgeführten VAS-Einschätzungen verbesserten sich während der Bestrahlungstherapie-Periode sehr stark, was einer verbesserten Lebensqualität entsprach. Ein kompletter oder fast kompletter Wundschluss wurde nur bei Patienten mit peripherer arterieller Verschlusskrankheit, Rauchern oder Patienten mit fehlender venöser Kompressionstherapie nicht erreicht.
Diskussion und Schlussfolgerungen: wIRA kann sowohl bei akuten Wunden als auch bei chronischen Wunden (in dieser Studie für chronische venöse Unterschenkelulzera gezeigt) und Problemwunden einschließlich infizierter Wunden Schmerzen deutlich mindern (mit eindrucksvoller Abnahme des Schmerzmittelverbrauchs) und die Wundheilung beschleunigen oder einen stagnierenden Wundheilungsprozess verbessern sowie eine erhöhte Wundsekretion und Entzündung mindern.
Bei chronischen therapierefraktären Wunden werden vollständige Abheilungen erreicht, die zuvor nicht erreicht wurden. Andere Studien haben sogar ohne Wundheilungsstörung eine Verbesserung (z.B. Schmerzreduktion) der akuten Wundheilung durch wIRA gezeigt.
wIRA ist ein kontaktfreies, verbrauchsmaterialfreies, leicht anzuwendendes, als angenehm empfundenes Verfahren mit guter Tiefenwirkung, das der Sonnenwärmestrahlung auf der Erdoberfläche in gemäßigten Klimazonen nachempfunden ist.
Wundheilung und Infektionsabwehr (z.B. Granulozytenfunktion einschließlich antibakterieller Sauerstoffradikalbildung der Granulozyten) hängen ganz entscheidend von einer ausreichenden Energieversorgung (und von ausreichend Sauerstoff) ab. Die gute klinische Wirkung von wIRA auf Wunden und auch auf Problemwunden und Wundinfektionen lässt sich über die Verbesserung sowohl der Energiebereitstellung als auch der Sauerstoffversorgung (z.B. für die Granulozytenfunktion) erklären. wIRA bewirkt als thermischen Effekt im Gewebe eine Verbesserung von drei entscheidenden Faktoren: Sauerstoffpartialdruck im Gewebe, Gewebetemperatur und Gewebedurchblutung. Daneben wurden auch nicht-thermische Effekte von Infrarot A durch direkte Reizsetzung auf Zellen und zelluläre Strukturen mit Reaktionen der Zellen beschrieben.
Es wird geschlossen, dass wIRA verwendet werden kann, um Wundheilung zu verbessern, Schmerzen, Sekretion und Entzündung zu reduzieren und die Lebensqualität zu steigern
Comparative sequence analysis of IS50/Tn5 transposase
No full textAuthor Posting. © American Society for Microbiology, 2004. This article is posted here by permission of American Society for Microbiology for personal use, not for redistribution. The definitive version was published in Journal of Bacteriology 186 (2004): 8240-8247, doi:10.1128/JB.186.24.8240-8247.2004.Comparative sequence analysis of IS50 transposase-related protein sequences in conjunction with known
structural, biochemical, and genetic data was used to determine domains and residues that play key roles in
IS50 transposase function. BLAST and ClustalW analyses have been used to find and analyze six complete
protein sequences that are related to the IS50 transposase. The protein sequence identity of these six homologs
ranged from 25 to 55% in comparison to the IS50 transposase. Homologous motifs were found associated with
each of the three catalytic residues. Residues that play roles in transposase-DNA binding, protein autoregulation,
and DNA hairpin formation were also found to be conserved in addition to other residues of unknown
function. On the other hand, some homologous sequences did not appear to be competent to encode the
inhibitor regulatory protein. The results were also used to compare the IS50 transposase with the more
distantly related transposase encoded by IS10.J.A. was supported by a grant from the National Science Foundation
(MCB0084089) administered by W.S.R. S.R.B. held a National Research
Council Research Associateship Award. W.S.R. is the Evelyn
Mercer Professor of Biochemistry and Molecular Biology. Additional
thanks are given to the NASA Astrobiology Institute (Cooperative
Agreement NNA04CC04A to Mitchell L. Sogin) and the W. M. Keck
Ecological and Evolutionary Genetics Facility within the Josephine
Bay Paul Center for Comparative Molecular Biology and Evolution at
the M.B.L. Molecular graphics images were produced by using the
UCSF Chimera package from the Computer Graphics Laboratory,
University of California, San Francisco (supported by NIH grant P41
RR-01081)
Surjective isometries between unitary sets of unital JB∗-algebras
No full textWe would like to thank Prof. Lajos Molnár for encouraging us to explore this problem.
We are also indebted to the anonymous reviewer for several useful comments.
First and fifth authors partially supported by the Spanish Ministry of Science, Innovation and Universities (MICINN) and European Regional Development Fund project
no. PGC2018-093332-B-I00, Programa Operativo FEDER 2014-2020 and Consejería de
Economía y Conocimiento de la Junta de Andalucía grant numbers A-FQM-242-UGR18
and FQM375. First author partially supported by EPSRC (UK) project “Jordan Algebras, Finsler Geometry and Dynamics” ref. no. EP/R044228/1. Second author partially
supported by JSPS KAKENHI Grant Number JP 21J21512. Fourth author partially
supported by JSPS KAKENHI (Japan) Grant Number JP 20K03650.
* Funding for open access charge: Universidad de Granada / CBUAThis paper is, in a first stage, devoted to establishing a topological–algebraic characterization of the principal component, U0(M), of the set of unitary elements, U(M), in a unital JB⁎-algebra M. We arrive to the conclusion that, as in the case of unital C⁎-algebras, U0(M)=M1−1∩U(M)={Ue⋯Ue(1):n∈N,hj∈Msa∀1≤j≤n}={u∈U(M): there exists w∈U0(M) with ‖u−w‖<2} is analytically arcwise connected. Actually, U0(M) is the smallest quadratic subset of U(M) containing the set eiM. Our second goal is to provide a complete description of the surjective isometries between the principal components of two unital JB⁎-algebras M and N. Contrary to the case of unital C⁎-algebras, we shall deduce the existence of connected components in U(M) which are not isometric as metric spaces. We shall also establish necessary and sufficient conditions to guarantee that a surjective isometry Δ:U(M)→U(N) admits an extension to a surjective linear isometry between M and N, a conclusion which is not always true. Among the consequences it is proved that M and N are Jordan ⁎-isomorphic if, and only if, their principal components are isometric as metric spaces if, and only if, there exists a surjective isometry Δ:U(M)→U(N) mapping the unit of M to an element in U0(N). These results provide an extension to the setting of unital JB⁎-algebras of the results obtained by O. Hatori for unital C⁎-algebras.CBUAConsejería de Economía y Conocimiento de la Junta de Andalucía
A-FQM-242-UGR18, FQM375Ministerio de Ciencia, Innovación y UniversidadesEngineering and Physical Sciences Research Council
EP/R044228/1Universidad de GranadaMinisterio de Ciencia e InnovaciónJapan Society for the Promotion of Science JP 20K03650, JP 21J21512European Regional Development Fund
PGC2018-093332-B-I0
Flexible time–space network formulation and hybrid metaheuristic for conflict-free and energy-efficient path planning of automated guided vehicles
No full textOperations of Automated Guided Vehicles (AGVs) are desired to be more energy-efficient while maintaining high transport productivity, motivated by the green production requirements. This paper investigates a new energy-efficient planning problem for determining conflict-free paths of the AGVs in its transport roadmap. In this problem, the vehicle path and transport time in the roadmap are jointly optimized, based on a flexible time–space network (FTSN). We provide the mathematical problem formulation of the energy-efficient path planning problem. The resulting optimization problem is proved to be a non-convex mixed-integer nonlinear programming which is computationally intractable. We further propose a hybrid metaheuristic that integrates the genetic algorithm and estimation of the distribution algorithm to improve its computational efficiency. Numerical results show the effectiveness of the developed algorithm based on the FTSN framework, compared to the existing metaheuristics, the conventional path planning method, and a commercial solver. The proposed method has a wide application in improving energy use of material handling, providing a guiding significance on promoting cleaner production of flexible manufacturing systems.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Transport Engineering and Logistic
Decoupling of genome size and sequence divergence in a symbiotic bacterium
No full textAuthor Posting. © American Society for Microbiology, 2000. This article is posted here by permission of American Society for Microbiology for personal use, not for redistribution. The definitive version was published in Journal of Bacteriology 182 (2000): 3867-3869, doi:10.1128/JB.182.13.3867-3869.2000.In contrast to genome size variation in most bacterial taxa, the small genome size of Buchnera sp. was shown to be highly conserved across genetically diverse isolates (630 to 643 kb). This exceptional size conservation may reflect the inability of this obligate mutualist to acquire foreign DNA and reduced selection for genetic novelty within a static intracellular environment.Financial support was provided by a National Institute of Health
postdoctoral training grant to J.J.W. (Center for Insect Science, University
of Arizona) and a National Science Foundation grant (DEB-
9815413) to N.A.M
Transient nonlinear heat transfer analysis using the finite element method in the context of the requirements of thermal analysis in a mine
No full textBibliography: leaves 106-108.The aim of this thesis is to develop a computer program, together with a users' guide, to analyse two-dimensional; nonlinear, transient heat conduction in non-isotropic solids using the finite element method. This program is an extension of an existing program that analyses thermomechanical stress in solids which may have prescribed temperature and flux boundary conditions. The program has been extended using the requirements for modelling heat transfer in mines as a guide. The theory of conduction, thermal radiation, convection and heat transfer due to evaporation and condensation is presented
A qualitative study of patients' views on quality of primary care consultations in Hong Kong and comparison with the UK CARE measure
No full text<b>Background</b> Patients' priorities and views on quality care are well-documented in Western countries but there is a dearth of research in this area in the East. The aim of the present study was to explore Chinese patients' views on quality of primary care consultations in Hong Kong and to compare these with the items in the CARE measure (a process measure of consultation quality widely used in the UK) in order to assess the potential utility of the CARE measure in a Chinese population.<p></p>
<b>Methods</b> Individual semi-structured interviews were conducted on 21 adult patients from 3 different primary care clinics (a public primary healthcare clinic, a University health centre, and a private family physician's clinic). Topics discussed included expectations, experiences, and views about quality of medical consultations. Interviews were typed verbatim, and a thematic approach was taken to identify key issues. These identified issues were then compared with the ten CARE measure items, using a CARE framework: Connecting (Care Measure items 1–3), Assessing (item 4), Responding (items 5,6), and Empowering (items 7–10).<p></p>
<b>Results</b> Patients judged doctors in terms of both the process of the consultation and the perceived outcomes. Themes identified that related to the interpersonal process of the consultation fitted well under the CARE framework; Connecting and communicating (18/21 patients), Assessing holistically (10/21 patients), Responding (18/21 patients) and Empowering (19/21 patients). Patients from the public clinic, who were generally of lower socio-economic status, were least likely to expect holistic care or empowerment. Two-thirds of patients also judged doctors on whether they performed an adequate physical examination, and three-quarters on the later outcomes of consultation (in terms of relief or cure and/or side-effects of prescribed drugs).<p></p>
<b>Conclusion</b> These findings suggest that Chinese patients in Hong Kong value engaged, empathic primary care doctors and judge the quality of consultations largely on these human skills and the attitudes and values that underpin them, as well as on the perceived outcomes of treatment. The match between themes relating to consultation process and the CARE Measure items suggests utility of this measure in this population, but further quantitative validation is required
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