340 research outputs found
Multiple myeloma exosomes establish a favourable bone marrow microenvironment with enhanced angiogenesis and immunosuppression
No full textMultiple myeloma (MM) pathogenesis and progression largely rely on the cells and extracellular factors in the bone marrow (BM) microenvironment. Compelling studies have identified tumour exosomes as key regulators in the maintenance and education of the BM microenvironment by targeting stromal cells, immune cells, and vascular cells. However, the role of MM exosomes in the modification of the BM microenvironment and MM progression remains unclear. Here, we explored the functions of MM exosomes in angiogenesis and immunosuppression in vitro and in vivo. Murine MM exosomes carrying multiple angiogenesis-related proteins enhanced angiogenesis and directly promoted endothelial cell growth. Several pathways such as signal transducer and activator of transcription 3 (STAT3), c-Jun N-terminal kinase, and p53 were modulated by the exosomes in endothelial and BM stromal cells. These exosomes promoted the growth of myeloid-derived suppressor cells (MDSCs) in naive mice through activation of the STAT3 pathway and changed their subsets to similar phenotypes to those seen in MM-bearing mice. Moreover, MM exosomes up-regulated inducible nitric oxide synthase and enhanced the immunosuppressive capacity of BM MDSCs in vivo. Our data show that MM exosomes modulate the BM microenvironment through enhancement of angiogenesis and immunosuppression, which will further facilitate MM progression
Correction to: Should Doctors Offer Biomarker Testing to Those Afraid to Develop Alzheimer’s Dementia?: Applying the Method of Reflective Equilibrium for a Clinical Dilemma (Journal of Bioethical Inquiry, (2022), 19, 2, (287-297), 10.1007/s11673-022-10167-x)
No full textIn this article the author name Eline M. Bunnik was incorrectly written as Eline M. Bunnick. The original article has been corrected
On ableism and anthropocentrism: A canine perspective on the workplace inclusion of disabled people
No full textDespite growing attention for how disabled people become Othered in organizational settings and similar scholarly interest in the treatment of non-humans at work, no analysis so far has focused on the potential double marginalization that takes place when disabled people go to work with their service animal. In filling this void, this study draws attention to the embodied entanglement of 'humanimal' in a number of organizations where animals are unexpected. The study argues that the spatial, discursive and affective treatment of service dogs operates as a proxy for the in/exclusion of employees with mobility and visual impairments. This way, processes of ableism become masked as subtle and indirect performances towards non-human Others. Contributions are made towards several literatures by introducing the idea of a 'proxy' to help understand the different modes of peripheral inclusion of disabled employees via their legally accepted service animals, by bringing in the role of affect in workplace disablement, and finally by taking animal labour more seriously.The author received no financial support for the research, authorship and/or publication of this article.
The illustrations used in this article are the intellectual property of Benoît Raucent (UCLouvain). I thank Benoît and I thank the participants in this study for their valuable contributions
Turning disability into a business: Disabled entrepreneurs' anomalous bodily capital
No full textIn a time and place where being impaired is equated to being of lesser economic value, some disabled people take matters into their own hands by creating their own job and converting their bodily difference into bodily capital. This paper uses a Bourdieuan lens to discover what sets apart disabled entrepreneurs who build their business around disability and those who do not. Building on the experiences of 40 entrepreneurs, we outline the existence of certain bodily and mental schemata that lead to a body habituated to run a business centred around one's impairment and experience of living as a disabled person in an ableist world. We specify such 'anomalous' bodily capital and discuss the constraints to its conversion related to the social environment and impairment effects. This study speaks back to the literature on disability in organizational contexts by extending the 'value in disability' debate whilst remaining cognizant of the danger of 'supercrip' stereotyping and disability ghettoization. In addition, the complex structure/agency interplay inherent to the practice of leveraging anomalous bodily capital offers a contribution to entrepreneurship research that tends to adhere to a simplistic view of the body.The author(s) received no financial support for the research, authorship, and/or publication of this article
Editorial: The impact of exposure to environmental chemicals, pharmaceuticals and particles via human breast milk: a focus on health effects and underlying mechanisms
No full textThe author(s) declare that financial support was received for the research and/or publication of this article. Charlotte Cosemans was financially supported by the Research Foundation Flanders (FWO; 1249025N)
Application of the ECOV method for assessing the load-bearing capacity of existing structures
No full textThis publication contains the proceedings of the 2nd International Conference on Circularity in the Built Environment (CiBEn2025), held in Tampere, Finland, in September 16–18, 2025. The book includes both abstracts and papers of the contributions presented in the conference, as the authors were given the freedom to choose which type they submitted. All the contributions, except the keynotes, have been peer-reviewed in a double-blind setting by two independent reviewers. In this book, the contributions are listed under each theme in the alphabetical order of the title, so no order of importance is implied. The proceedings have been put together from ‘camera-ready’ files delivered by the authors. Due to this, some discrepancies may appear in the graphical appearance and/or how the content is structured. How to cite this publication as a whole: Huuhka, S. (Ed.). 2025. Circularity in the Built Environment: Proceedings of the 2025 conference held in Tampere, Finland, September 16–18 2025. Tampere: Tampere University. https://doi.org/10.5281/zenodo.17092525 How to cite a contribution in this publication: Author, A. (2025). Title of the contribution. In: Huuhka, S. (Ed.). Circularity in the Built Environment: Proceedings of the 2025 conference held in Tampere, Finland, September 16–18 2025. Tampere: Tampere University. https://doi.org/10.5281/zenodo.17092525Reusing precast concrete for a circular economy. European Commission. award Number:958200. 10.13039/50110000078
Proof of concept of social impact assessment of sustainable commuting measures for employee profiles
No full textCivil Engineering | Transport and Plannin
"Making the unimaginable imaginable?" The power of artmaking in understanding animal vulnerabilities and "humanimal" relationality in Organization Studies
No full textThe vulnerabilities of nonhuman animals in human-animal relationships have received scant attention in Organization Studies (OS). What could OS scholars learn about animal vulnerability and "humanimal" relationality by turning to the context of artmaking, where sensate animals, human artists, spaces, materialities, artworks, affects and critical audiences come together? Building on feminist vulnerability literature and insight from posthumanist affirmative ethics, we here analyze Finnish artists Terike Haapoja and Laura Gustafsson's artmaking, works, and their exhibition Siat - Pigs in particular, where the agency and vulnerability of animals can be conceived in non-anthropocentric, immersive and affective ways. We contribute to OS research by demonstrating the affective power of posthumanist artmaking that comes with the radical repositioning of the human in relation to others, as well as political motivation to elicit empathy for the plight of animals in the factory-farming complex. Specifically, we show how these insights can illuminate what is currently not centered or discussed enough in OS, help us to better acknowledge co-constituted humanimal vulnerabilities, and extend discussions on empathy in OS to include (hyper-vulnerable) animals in the factory-farming complex. We contend that by extending vulnerability ascriptions to animals, caring with the unseen and silenced agents in society, acknowledging our shared vulnerability and by taking further action, we can gradually change the exploitive ways in which humans have treated other animals in our organized society, and more emphatically work for the well-being of the many unseen "others."The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research is funded by the Research Council of Finland for project PAWWS - People and Animal Wellbeing at Work and in Society (funding decision #355434)
Immune therapy in multiple myeloma : can iNKT cells be targeted?
No full textMultiple myeloma (MM) is a plasma cell cancer where, despite the major therapeutic advances, still the majority of patients relapse and develop a non-responsive disease. Consequently, there’s an urgent need for the development of new treatments. In the bone marrow microenvironment of MM patients most of the immune cells are numerically and functionally impaired, such as the invariant natural killer T (iNKT) cell. iNKT cells are unconventional lipid antigen reactive T cells bearing an important role in anti-tumor immunity. Mechanisms behind their deficiency still remain enigmatic and controlling iNKT cell activity has been challenging so far, affecting their implications in immunotherapy. Therefore, we aimed to unravel and overcome possible mechanisms causing iNKT cell deficiency in MM.
We were the first to reveal the leptin – leptin receptor (LR) axis as an important iNKT cell-mediating pathway in MM and anti-tumor immunity. Progressive increase of leptin serum and LR expression levels were observed on iNKT cells during MM progression, both in human disease and the 5T33MM model. Functional analyses proved leptin to profoundly inhibit the iNKT cell functionality in vitro and in vivo. iNKT anergy, a major drawback in iNKT-based therapies, was strongly alleviated by blocking LR signaling and an almost complete tumor protection in the 5T33MM model was observed when iNKT cells were stimulated in presence of a LR antagonist. Finally, by means of intravital microscopy, we provided for the first time a detailed time course of iNKT cell dynamics in response to α-GalCer. In the second part of the PhD project, the implication of checkpoint molecule PD-1, in mediating iNKT cell deficiency and deficiencies in mucosal-associated invariant T (MAIT) cells, another invariant T cell subset, was evaluated. Not only iNKT cells but also MAIT cells proved to be numerically and functionally impaired in MM, a novel observation that hasn’t been reported before. Moreover, we discovered MAIT cell deficiency to be correlated with reduced iNKT cell numbers in MM patients. MAIT cells showed poor activation by α-GalCer-stimulated iNKT cells, illustrating a dysfunctional interaction between MAIT and iNKT cells. Remarkably, elevated PD-1 levels were found on both iNKT and MAIT cells. Treatment with a combination of PD-1 blockade and iNKT stimulation was able to significantly rescue the functionality of iNKT and MAIT cells and conferred superior tumor protection in the 5T33MM model.
To conclude, the work presented here uncovers new promising ways to enhance the anti-tumor function of iNKT cells by restoring them from their state of anergy in MM. The results are groundbreaking in the fight against cancer, as they reveal a new form of cancer immunotherapy, potentially shining a light on future therapeutic avenues for aggressive cancers with currently limited treatment options as well
PENGARUH LASHING PADA MUATAN PETI KEMAS TERHADAP KESELAMATAN PELAYARAN DI MV. ELINE ENTERPRISE
No full textMuhammad Abdul Mufid, 2018, NIT: 50134817.N, “The Influence of Lashing
Container Load on Safety of Voyages in MV. Eline Enterprise”, Essay of
Nautical Departement, Diploma IV Program, Politeknik Ilmu Pelayaran
Semarang, Pembimbing I : Ir. Boedojo Wiwoho, S.J., M.T. and
Pembimbing II : Okvita Wahyuni, S.ST., M.M
Types of container vessels can be broadly divided into two types, namely
full container and semi container vessels. In principle, all ships have a purpose to
maintain the safety of cargo and crew during the voyage. Especially in the case of
lashing the load during the voyage should be really taken care of. The existence of
problems in the process of lashing that is not appropriate procedures can endanger
the safety of shipping, because it is necessary to implement lashing properly and
solemnly to overcome the constraints in the lashing process. The procedure in
keeping the charge tight does not shift especially the deck charge and the system
is in the form of bonding to the load so as not to shift from its place.
The author uses descriptive qualitative research methods, namely by
retelling the events that occurred on the ship and conduct interviews directly to the
crew of MV. Eline Enterprise. The author describes all data obtained at the time
of carrying out the pre-sourced from the First Deck by way of interview.
Based on these interviews the process of lashing that is not appropriate
procedure occurs due to lack of accuracy and knowledge of the crew of the ship
against lashing procedures and limitations of lashing tools due to damage. Such
matter may endanger the safety of the vessel during the voyage, so it is necessary
to hold the implementation of the metting before carrying out the lashing and the
maintenance of lashing tools on a regular basis to maintain the quality of lashing
tools to be used properly. By conducting lashing according to the procedure that
includes preparation, execution, checking and supported by adequate lashing tools
and crew that understands in terms of lashing, it will be accomplished lashing
process smoothly and lashingnya strong, so as to create a safe and safe voyage to
the destination port.
Keywords: Lashing, container, safety of voyages
- …
