135 research outputs found

    Il pensiero di Massimo D’Antona sul diritto al lavoro = Massimo D’Antona's thought on the right to work. WP C.S.D.L.E. “Massimo D’Antona”.IT – 216/2014 5

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    The author reconstructs the in the Italian Constitution thought of Massimo D'Antona on the right to work both and in the EU legal order, starting with the report that he gave at the University of Naples Federico II, on 8 May 1999: the last of his life, since he was murdered by the Red Brigades twelve days later, on 20 May 1999. The right to work, in D’Antona’s opinion, is very marked by historicity: at the beginning it is not "taken seriously", much less in a Europe dominated by the prevalence of the market. Then some glimmer opens. The author - in stressing the differences between the time of the speech of D'Antona and the dramatic current period - points out that in Europe, as regards the effectiveness of the right to work, lights still prevail over the shadows

    Evaluation of patients’ perception of safety in an italian hospital using the pmos-30 questionnaire

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    Background: In our study, an Italian version of the PMOS-30 questionnaire was used to evaluate its feasibility and to improve health care quality in an Italian hospital. Methods: A cross-sectional study was conducted with 435 inpatients at a hospital in the Campania Region of Southern Italy using the PMOS-30 questionnaire and two other questions to assess patient feedback about the overall perception of safety. Results: The item “I was always treated with dignity and respect” showed the greatest percentage of agreement (agree/strongly agree = 89.2%; mean = 4.24). The least agreement was associated with the four “Staff Roles and Responsibilities” items (agree/strongly agree ranged from 31.5 to 40.0%; weighted mean = 2.84). All other 25 items had over 55.0% agree-ment, with 19 items over 70%. Moreover, 94.5% of the patients considered the safety of the ward sufficient/good/very good, and 92.8% did not notice situations that could cause harm to patients. Conclusion: Patient perception of safety was found to be satisfactory. The results were presented to the hospital decision makers for suggesting appropriate interventions. Our experience showed that the use of the PMOS-30 questionnaire may improve safety and health care quality in hospital settings through patient feedback

    Who Wrote the Erotic Novel Josefine Mutzenbacher? Speculations, Theories, and Stylometric Analyses

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    The paper proposes a series of stylometric analyses aimed at attributing the erotic novel Josefine Mutzenbacher (1906) to one of its possible authors: Felix Salten, Arthur Schnitzler, Hermann Bahr, Peter Altenberg, Hugo von Hofmannsthal, Ernst Klein, and Willi Handl. After reviewing the discussion among literary scholars, two analyses have been performed: one that combines 480 different methods to compare the seven candidate authors; one that verifies the attribution using the “impostors” method. Results show how the most probable author is Felix Salten, more commonly known for his children’s book Bambi

    De-escalation strategies in patients with acute coronary syndrome: a step towards precision medicine

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    Introduction. Dual antiplatelet therapy (DAPT) with aspirin and a P2Y(12) inhibitor is a cornerstone in the treatment of patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). Current international guidelines recommend the use of 12 months of DAPT with newer P2Y(12) inhibitors (i.e. ticagrelor or prasugrel) as first-line therapy in this setting. However, intense and prolonged DAPT regimens are associated with an increased risk of bleeding, with relevant prognostic implications. Recently, a strategy of de-escalation of P2Y(12) inhibitors has been proposed as an alternative to conventional DAPT to mitigate the risk of bleeding while preserving ischemic protection after ACS.Areas coveredIn this review, we summarize the available evidence on guided and unguided strategies for P2Y(12) inhibitor de-escalation in patients with ACS undergoing PCI.Expert OpinionAmong patients with ACS, guided and unguided de-escalation strategies are safe and effective for secondary cardiovascular prevention. Although the implementation of genetic and platelet function tests is of interest for treatment personalization, the routine use of guided de-escalation strategies seems impractical. In this context, unguided de-escalation approaches appear more attractive, convenient, and suitable for contemporary practice

    The physical principles of the ERANOS neutronic deterministic code and its application to the LFR and VENUS-F critical cores

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    This work was carried out in the framework of the EU FP7 project FREYA “Fast Reactor Experiments for hYbrid Applications”. It reports the lecture held by the author during the FREYA WP5 session for training and education on February 22-26th, 2016, at the SCK•CEN Academy for nuclear science and technology in Mol (B). The main goal was to illustrate the potentiality of the ERANOS neutronic deterministic code to PhD students coming from the EU universities. At the same time, this document could be used also in ENEA for students and researchers that may be interested and/or have to be introduced to the utilisation of the code. ERANOS (together with Monte Carlo codes) was widely utilised in the FREYA project: in the design phase of the experiments to be realised in the VENUS-F zero-power reactor (at the Belgian Nuclear Research Centre, SCK•CEN), as well as in the post-processing analyses of the experimental results. Starting from the basic physical principles of the deterministic neutronic analyses, the lecture describes the application of ERANOS to the Lead Fast Reactor (LFR) concept and to a couple of VENUS-F Critical Cores (named CC5 and CC6), assembled and experimentally characterised during FREYA. In particular, the CC6 layout was specifically designed to reproduce locally the typical spectrum of the LFR. The main calculation procedures were briefly shown: the cell / lattice calculations providing multi-group cross-sections of the different reactor zones for full core calculations, which can be carried out with finite differences and variational nodal methods. The experimental measurements on the CC5 and CC6 cores demonstrated the accuracy of the ERANOS results, obtained with JEFF3.1 and ENDF/B6.8 nuclear data libraries. The lecture is focused on the core criticality and spectral index calculations, by pointing out at which extent the CC6 core can reproduce accurately the LFR spectrum

    Circulating culprit or therapeutic bullseye: lipoprotein(a) in cardiovascular risk assessment and novel therapeutic prospects

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    Lipoprotein(a) [Lp(a)] has emerged as a significant player in the realm of cardiovascular disease (CVD), exerting a pivotal role in atherosclerotic cardiovascular disease (ASCVD), aortic valve stenosis (AVS), and overall cardiovascular (CV) and all-cause mortality. Since its discovery in 1963 by Kåre Berg, our understanding of Lp(a) has undergone significant evolution. This comprehensive review delves into the genetics, structure, assembly, and inter-population differences of Lp(a), shedding light on its intricate involvement in CVD. Genetically, Lp(a) is primarily influenced by variations in the LPA gene. The LPA gene encodes apo(a) and the variation in the kringle domains is the main determinant of plasma Lp(a) levels. Other genetic variants, such as SNPs in the LPA gene region, the pentanucleotide repeat polymorphism, and specific SNPs in the coding sequences of kringle domains, have also been associated with varying Lp(a) concentrations. Additionally, genes outside the LPA locus, including APOE, APOH, and CEPT gene regions, contribute to Lp(a) variability across different populations. Inter-population differences in Lp(a) levels are evident, with ethnicity and sex playing significant roles. Racial disparities in median Lp(a) concentration have been observed, with black individuals often displaying higher levels compared to their white counterparts. The review underscores Lp(a) as an independent, heritable CV risk factor in both primary and secondary settings. High Lp(a) levels are closely linked to the recurrence of myocardial infarction, AVS, and CV events. The necessity of measuring Lp(a) concentration at least once in life to assess an individual's absolute global CV risk is emphasized. Despite substantial progress, many questions remain unanswered about Lp(a), including its physiological role in the cardiovascular system and its involvement in inflammatory and thrombotic processes. Ongoing research holds promise for the development of therapeutic interventions, such as pharmacological agents and apheresis, to mitigate the cardiovascular risks associated with elevated Lp(a) levels. This review highlights the multifaceted nature of Lp(a) in the context of cardiovascular health, emphasizing the importance of continued research efforts to unravel its complexities and develop innovative strategies for managing its associated risks

    Recensioni

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    Massimo Piattelli Palmarini, Le scienze cognitive classiche: un panorama di Daniela Mario Arthur L. Costa, Bena Kallick, Habits of Mind: A developmental series, Association Supervision for Curriculum Development di Daniele Morselli Sarah-Jayne Blakemore, Uta Frith, The Learning Brain: Lessons for Education di Giuseppe Longo Xenia Chryssochoou, Cultural diversity. Its social psychology di Francesca Lazzari Carl Bereiter, Education and mind in the knowledge age di Francesco Caviglia Isabel Beck, Margareth McKeown, Improving Comprehension with Questioning the Author: A Fresh and Expanded View of a Powerful Approach di Irith Davidzo

    The spread of double-entry bookkeeping method in the 16th Century: "Quaderno doppio col suo giornale novamente composto et dilegentissimamente ordinato secondo il costume di Venetia" of Dominico Manzoni (1540)

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    In the history of accounting, the book of Dominico Manzoni, “Quaderno doppio col suo giornale novamente composto et dilegentissimamente ordinato secondo il costume di Venetia” (1540) has not had the recognition which probably would have deserved. The fame of the Paciolian “Summa”, which Manzoni constantly refers to in the theoretical part of his work, has obscured the role and importance of this book. However, there are many interesting profiles of analysis. Manzoni can be considered the first “accountant” or “quaderniere”. He used the double entry bookkeeping method serving the great merchants of the time. Then he decided to describe and to spread the accounting techniques according to the “Venice method”, for the benefit of all who were interested in. But the central element of Manzoni’s work is, certainly, the exemplification that the Author presents. It has a sort of “educational” intention, based on Manzoni’s work experience at the company of the merchant Alvise Vallaresso in Venice. The aim was, firstly, to empirically apply what is described in the theoretical section, but also to make understandable some technical steps. These are related, for example, to the closure and the reopening of accounts, not supported by precise theoretical explanations. Through an analysis of Manzoni’s work, aim of this study is to understand how – and how deeply – the Author could have contributed to the advancement of accounting tecniques. These considerations are made also in light of the particular diffusion of the book in the years after its first edition of 1540, as evidenced by the numerous reprints and translations

    A influência de la Dialectique des “exercices spirituels” de Saint Ignace de Loyola no pensamento de Jorge Mario Bergoglio

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    When in October 2016 I started working on my book Jorge Mario Bergoglio. An intellectual biography I did not have the slightest idea of the importance played by the figure and work of Gaston Fessard in the formation of Bergoglio’s thought. There was nothing to suggest that Gaston Fessard could be a relevant author for the intellectual formation of the future Pope. I was struck by the polar and dialectical model of thought that animated him, the possibility of harmonizing opposites, of inviting concepts to a common table that apparently could not be approached, because it places them in a higher plane in which they find their synthesis. This paradigm, of the Church and of the Society of Jesus as complexio oppositorum, finds its verification, according to Bergoglio, in the way in which the Jesuits have achieved the inculturation of the faith in the indigenous peoples of Latin America. Bergoglio rereads Ignatius in the light of a dialectical model. As he will say in one of the interviews he gave me on the occasion of the writing of my book: “In Ignatian spirituality there is always this bipolar tension”. It is certainly an original, uncommon reading of Ignatius’s thought. It is the ideal factor that allows us to explain why Bergoglio, when in 1986 he went to Frankfurt to write his doctoral thesis, chose the Guardinian essay dedicated to the polar opposition. When I concluded my volume on the intellectual biography of the future Pontiff in February 2017, one element, however, remained obscure. Where, from which author had Bergoglio drawn his polar model? Where did your antinomic reading of Ignatian spirituality come from? Not by Guardini discovered philosophically in 1986. Francis indicated the starting point of his intellectual formation. The reading of Fessard’s La dialectique des Exercices spirituels de saint Ignace de Loyola, published in 1956, is the work that “had a great influence” on him. It is the work that clarifies Bergoglio’s antinomian thought, his subsequent ideal encounter with Guardini’s philosophy.Quando, em outubro de 2016, comecei a trabalhar em meu livro “Jorge Mario Bergoglio: Uma biografia intelectual”,  eu não tinha a menor ideia da importância que desempenhava a figura e obra de Gaston Fessard na formação do seu pensamento. Não havia nada que sugerisse que Gaston Fessard pudesse ser um autor relevante para a formação intelectual do futuro Papa. Fiquei impressionado com o modelo polar e dialético de pensamento que o animava, a possibilidade de harmonizar opostos, invocar conceitos para uma pauta comum que aparentemente não poderia ser abordada, pois os coloca em um plano superior na qual encontram sua síntese. Este paradigma, da Igreja e da Companhia de Jesus como opositor complexo, encontra sua verificação, segundo Bergoglio, na forma como os jesuítas conseguiram a inculturação da fé nos povos indígenas da América Latina. Bergoglio relê Ignatius à luz de um modelo dialético. Como ele dirá em uma das entrevistas que me deu por ocasião da redação do meu livro: "Na espiritualidade inaciana há sempre esta tensão bipolar". É certamente uma leitura original e pouco comum do pensamento de Inácio. Trata-se de um fator ideal que nos permite explicar por que Bergoglio, quando em 1986 foi a Frankfurt para escrever sua tese de doutorado, escolheu o ensaio guardiniano dedicado à oposição polar. Quando concluí minha obra sobre a biografia intelectual do futuro Pontífice, em fevereiro de 2017, um elemento, no entanto, permaneceu obscuro. De qual autor Bergoglio esboçou seu modelo polar? De onde veio sua leitura antinômica da espiritualidade inaciana? Não foi descoberto por Guardini filosoficamente em 1986. Francisco indicou o ponto de partida de sua formação intelectual. A leitura de La dialectique des Exercices spirituels de saint Ignace de Loyola, de Fessard, publicada em 1956, é a obra que "teve uma grande influência" sobre ele. É a obra que esclarece o pensamento antinomiano de Bergoglio, seu posterior encontro ideal com a filosofia de Guardini

    L’omicidio volontario a Terni dal 2010 al 2018: casistica autoptica e comparazione con precedente studio.

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    l presente studio si è posto come obiettivo quello di esaminare il fenomeno dell’omicidio volontario nella città di Terni nel periodo che va dal 2010 al 2018, integrando poi i dati ottenuti con quelli di un analogo studio condotto in precedenza dall’Istituto di Medicina Legale di Terni relativo al periodo 1984-2009. I dati analizzati sono stati estrapolati a partire da sopralluoghi giudiziari, ispezioni cadaveriche esterne, autopsie giudiziarie, sentenze del GIP, della Corte d’Appello, della Suprema Corte di Cassazio- ne. Ai fini dello studio sono stati individuati un totale di 11 casi di omicidio volontario perpetrati in questo periodo di 9 anni, con una media di 1,07 omicidi/anno/100.000 abitanti, maggiore rispetto alla media nazionale, che si attesta a 0,79 omicidi/anno/ 100.000 abitanti. L’integrazione con lo studio precedente ha mostrato inoltre un trend in crescita nel numero di omicidi volontari a Terni, che è passato da 0,5 omicidi/anno/ 100.000 abitanti del quinquennio 1994-1998 a 1,4 omicidi/anno/100.000 del quinquennio 2014-2018. Le vittime sono risultate soprattutto di sesso maschile (55%); nei casi di omicidi perpetrati contro donne l’omicidio ha avuto luogo prevalentemente in un’abitazione privata, mentre nel caso degli uomini, in una pubblica via. Gli autori del delitto sono risultati uomini nella totalità dei casi, sottolineando però che in 2 casi l’autore risulta ad oggi sconosciuto. Si è registrato inoltre, già a partire dai primi anni 2000, un aumento sia di vittime che di assassini di nazionalità straniera, che, in quest’ultimo caso, sono risultati in numero superiore rispetto a quelli di nazionalità italiana; dato assolutamente coerente con l’incremento dei flussi migratori che hanno riguardato anche la città di Terni. Le armi principalmente utilizzate sono state armi da punta e da taglio, seguite da armi da fuoco e mezzi contundenti, mentre il ricorso all’asfissia meccanica è stato infrequente. Il teatro dell’omicidio è rappresentato soprat- tutto da abitazioni ad uso privato, e il movente è stato prevalentemente di natura passionale; tali riscontri, se consideriamo anche che nella maggior parte dei casi la vittima conosceva il proprio assassino, sono fortemente suggestivi della dimensione “domestica” del reato di omicidio volontario, e permette di affermare come Terni sia una città a basso di tasso di criminalità violenta.The purpose of this study is to examine the phenomenon of voluntary homicides in the city of Terni in the period beetwen 2010 and 2018, the results was also integrated with a previous study, carried out by the section of Legal Medicine of Terni for the period 1984-2009. The analyzed data have been extrapolated from judicial ispections, autopsies and sentences issued by the Terni Criminal Court. A total of 11 cases were identified in this 9 years period, with an average of 1,07 homicides/year/100.000 inhabitants, higher then the National average rate of 0,79 homicides/year/100.000 inhabitants. The integration with the previous study have showed a growing trend for the number of homicides in Terni, from 0,5 homicides/year/100.000 inhabitants of the period 1994-1998 to 1,4 homicides/year/100.000 inhabitants of the period 2014-2018. Victims was mainly males (55%); women victims was killed above all in private houses, while men, in public places. The authors of the crime was males in all cases, however, in 2 cases, the author is, today, unknown. There was also an increase of foreigner victims and murderers; this data is in line with the increase of migration flows also in the ciy of Terni. Sharp weapons was the most used, followed by firearms and blunt weapons, while asphyxia was rare. The place of the crime was mainly a private house, and the motive was especially passionate; these results, considering also that in more than half of the cases the victim knew his murder, suggest the domestic dimension of the crime, and it’s possible to say that Terni is a city with a low violent crime rate
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