1,721,220 research outputs found
How the Seven Countries Study contributed to the definition and development of the Mediterranean diet concept: a 50-year journey
No full textAbstract The Seven Countries Study of Cardiovascular Diseases was started at the end of the
1950s and it continues to be run after >50 years. It enrolled, at entry, 16 population cohorts in
eight nations of seven countries for a total of 12,763 middle-aged men. It was the prototype of
epidemiological studies seeking cultural contrasts and the first to compare cardiovascular disease
(CVD) rates related to diet differences. The study has shown that populations suffer widely
different incidence and mortality rates from coronary heart disease (CHD) as well as from other
CVDs and overall mortality. Higher rates were found in North America and northern Europe, and
lower rates in southern Europe e Mediterranean countries e and Japan. These differences in
CHD rates were strongly associated with different levels of saturated fat consumption and
average serum cholesterol levels, with lowest rates in Greece and Japan where the total fat intake
was very different. The cohorts were also different in dietary patterns defined by the ratio of calories
derived from plant foods and fish on the one hand and calories derived from animal foods
and sugar on the other. These findings pointed to the so-called Mediterranean diet, which is
characterized by large values of that plant/animal ratio, a pattern associated with lower incidence
and mortality from CHD and also with the lowest death rates and the greatest survival
rates. More recent studies have refined these concepts and documented on a larger scale the virtues
of these eating habits
Natural history of coronary heart disease and heart disease of uncertain etiology: findings from a 50-year population study
No full textObjectives: To describe the natural history of common heart disease incidence on a population study.
Material and methods: A sample of 1712 men aged 40–59 was enrolled in 1960 and followed-up for 50 years. Coronary
heart disease (CHD) was categorized if manifested as sudden death, fatal and non-fatal myocardial infarction
and other acute coronary syndromes, and as Heart Disease of Uncertain Etiology (HDUE) if manifested as
heart failure, chronic arrhythmia, blocks, diagnoses of chronic CHD or hypertensive heart disease. Their characteristics
and prognosis in terms of age at event, mortality and expectancy of life up to 50 years were analyzed.
Results: Incidence of first CHD and HDUE event or diagnosis was of 26.9 and 20.6%, respectively. First eventswere
equally manifested as fatal or non-fatal occurrences among CHD, while non-fatal occurrences were almost always
observed among HDUE. Cases of HDUE presented at a more advanced age and also average age at death
was significantly more advanced than in CHD, respectively around 79 and 76 years. Expectancy of life was significantly
longer for HDUE (30.7 years) than for CHD (27.6 years). Strokes weremore frequently ascertained among
HDUE (14%) while 14% of death causes were due to cancer in both CHD and HDUE. Cancers were much higher
(40%) among those never diagnosed CHD or HDUE who also had more stroke-due deaths (17%).
Conclusion: This is the first investigation to report heart disease incidence and its natural history in a quasiextinction
cohort data from Italy in a pre-cardiac surgery era
Coronary heart disease differences in eastern versus western euroe, a demanding situation
No full textCoronary heart disease differences in Eastern versus Western Europ
The U-shaped risk of estimated glomerular filtration rate for all-cause mortality and the role of serum uric acid
No full textRisk factors measured in middle-aged men predicting coronary events in geriatric age
No full textOBJECTIVES: To explore the duration of the predictive power of major coronary risk factors measured on a single occasion in middle aged men for the occurrence of coronary heart disease (CHD) incidence and mortality during 50years of follow-up. MATERIAL AND METHODS: In the Italian Rural Areas of the Seven Countries Study1677 CHD-free men aged 40-59 were enrolled in 1960 and age, cigarette smoking, systolic blood pressure and serum cholesterol were measured. During 50years of follow-up 1641 men died, 451 had a major fatal or non-fatal CHD event (incidence) and 263 died from CHD. Five partitioned Cox proportional hazards models were computed, one for each independent and subsequent 10-year period. Five 10-year partitioned hazard scores, derived from multivariable coefficients, were cumulated for each risk factor and plotted against time. RESULTS: The resulting curves showed increasing time trends for CHD incidence and mortality as a function of cigarette smoking, systolic blood pressure and serum cholesterol for the first 30-40years followed by a decline in the association that was more evident for serum cholesterol. The curves fit straight lines with large correlation coefficient ranging 0.82 to 0.99. The loss of predictive power after 30-40years was confirmed in a model covering 50years of follow-up and including the interaction term of risk factors/time. CONCLUSION: A single measurement of major coronary risk factors is associated with CHD incidence and mortality for at least 30-40years of follow-up, entering the gerontologic age
Epidemiologia delle malattie cardiovascolari: insegnamenti dalle aree Italiane del Seven Countries Study.
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Comparison of the Framingham risk function-based coronary risk chart with risk function from an Italian population
No full textTwenty-five-year cardiovascular disease incidence among middle-aged men. Disease burden, time shape, predictors, risk probabilities.
No full textLa ventata di pessimismo sui risultati della prevenzione della cardiopatia ischemica è giustificata? Su molti ponti sventola bandiera bianca.
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