170,065 research outputs found
Impiego di un'associazione cofosfolattamina precostituita (fosfomicina + amoxicillina) nell'insufficienza renale
No full textThe rationale for a preformed combination of fosfomycin and amoxicillin is briefly discussed. These two antibacterial drugs block the peptidoglycal biosynthesis sequentially, thus exerting a true synergistic effect. On the other hand, there is no no synergism as far as toxicity is concerned. As the kinetics of the two molecules are different, further research on this topic is needed. This is especially true for renal failure patient
Human cytomegalovirus DNAemia and preemptive treatment of CMV infection in children after hematopoietic stem-cell transplantation: is any question settled?
No full textComments on a prospective trial on the use of CMV DNAemai for the early diagnosis of CMV infectio
Treatment of chronic hepatitis C in haemophilic patients with interferon and ribavirin: a meta-analysis.
No full textBackground: Hepatitis C virus (HCV) infection is a major cause of morbidity and mortality among haemophilic patients who were treated with clotting factor concentrates before the availability of virus-inactivated factors in the mid 1980s. In order to analyse the effect of the current combination anti-HCV treatment [i.e. ribavirin plus interferon (IFN)] in this subset of HCV-infected patients, we performed a systematic review with meta-analysis of the available literature. Methods: The outcome was sustained viral suppression. When trials included for the main predictors two arms (positive and negative), the effect size was described as a comparative index [odds ratio (OR)] and a standard meta-analytical procedure was applied. However, when trials did not report the outcome in separate study arms, the effect size was a non-comparative index (success rate) and comparisons between predictor-positive and -negative studies were performed by meta-regression. Results: Data involving 824 haemophilic HCV-infected patients treated with IFN plus ribavirin were collected from 18 articles (14 prospective cohort studies, 1 retrospective study and 3 randomized controlled trials). The higher rate of sustained viral response was observed in human immunodeficiency virus (HIV)-negative naive haemophiliacs treated with pegylated-IFN in combination with ribavirin (61%, ranging from 45% for genotype 1 to 79% for non-1 genotypes). Genotype 1 (OR, 0.15; 95% CI, 0.09-0.25) and co-infection with HIV (OR, 0.25; 95% CI, 0.08-0.81) were strong predictors of worse response to IFN therapy. Conclusions: Our meta-analysis shows that the pattern of response to combination anti-HCV therapy of chronically HCV-infected haemophiliacs is similar to that achieved in the general HCV-infected population. © The Author 2008. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved
Breast granulomatosis with polyangiitis mimicking breast cancer
No full textInflammatory lesions of the breast encompass primary reactive processes and local manifestation of systemic diseases. They are very rare and they are generally treated without resort to biopsy. Nevertheless they could be clinically challenge mimicking malignant process and needing surgery to reach a correct diagnosis. Here we describe a rare case of breast granulomatosis with polyangiitis, which presented with radiological and clinical alarming features that immediately raised the suspicious of malignancy leading to breast-conserving surgery
Lymphocyte transformation response to B-specific mitogens and its correlation with delayed hypersensitivity in HIV-infected patients
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