86,609 research outputs found
Bleeding is not the main clinical issue in many patients with inherited thrombocytopaenias
No full textBleeding diathesis has been considered for a long time the main clinical issue impacting the lives of patients affected by inherited thrombocytopaenias. However, the number of known inherited thrombocytopaenias greatly increased in recent years, and careful evaluation of hundreds of patients affected by these 'new' disorders revealed that most of them are at risk of developing additional life-threatening disorders during childhood or adult life. These additional disorders are usually more serious and dangerous than low platelet count. For instance, it is known that mutations in RUNX1, ANKRD26 and ETV6 cause congenital thrombocytopaenia, but we now know that they also predispose to haematological malignancies. Similarly, MYH9 mutations result in congenital thrombocytopaenia and increase the risk of developing kidney failure, cataracts and hearing loss at a later stage, while MPL mutations cause a congenital thrombocytopaenia that almost always evolves into deadly bone marrow failure. Thus, identification of patients with these disorders is essential for evaluation of their prognosis, enabling effective genetic counselling, personalizing follow-up and giving appropriate treatments in case of development of additional diseases. Careful clinical evaluation and peripheral blood film examination are extremely useful tools in guiding the diagnostic process and identifying the candidate genes to be sequenced
Massive mediastinal enlargement due to extramedullary haematopoiesis in a patient with MYH9-related thrombocytopenia
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Transizione e impatto di un modello di scuola sperimentale all’interno del contesto istituzionale
No full textPrototyping an employee experience model. A participatory action research project to support organizations in redefining the working routines starting from Employee Experience Design.
No full textIn the post-pandemic context, organizations are facing critical and systemic changes, particularly in people’s way of working and related processes. In the last decades, Design and Business Innovation literature presented the different ways Design supports organizations' innovation and transformation processes. This paper starts analyzing experimental approaches - namely design intervention - that Design may implement to support organizations in redefining working modes. The focal point of this contribution consists in the redefinition of working routines through the prototype of employee experience models. Furthermore, the existing literature presents a gap in the experimentation and implementation of prototyping activities in the employee experience design. Indeed, the application of service prototyping to employees' experience represents a stimulating challenge among design practitioners and researchers. In a moment of massive uncertainty in knowledge workers’ routines, how can Design be applied to Employee Experience to support organizations in redefining working scenarios? More specifically, how may we be able to co-design employee experience through a service prototyping approach? The theoretical purpose is to reflect on whether implementing service prototyping to employee experience may represent a fertile design research topic. The study presents a qualitative analysis with a Participatory Action Research method, partnering with an Italian bank's HR department and involved employees. Specifically, the paper is built on an experimental project that applies Employee Experience Design and Service Design Prototyping methods to redefine working habits in evolving contexts. Findings show the importance of employee experience prototyping in activating behavioral changes by triggering awareness-raising mechanisms in individuals. Additionally, the lengthy process of changing working practices and routines within organizations can be approached effectively by co-designing employee experience models and iteratively testing and evaluating them. The paper aims to show the potential benefits of exploration for design research in applying prototyping to employee experience design
Brain vascular changes in adults with congenital heart disease : a systematic review
No full textLess information is available on brain integrity in adults with congenital heart disease than on brain changes in newborns and children with heart defects. Nevertheless, the number of adults with congenital heart disease is increasing rapidly and it has been shown that adults with congenital heart disease develop dementia almost twice as frequently as adults in the general population. In the context of a rapidly growing congenital heart disease population, neuroradiological-oriented investigations of biomarkers distinctive for vascular damage, brain aging, and possible cognitive impairment is a crucial challenge. We provide an overview of the existing literature on neuroimaging studies in adults with congenital heart disease and discuss methodology issues to further investigate this subject. Overall, we aim to raise awareness of the importance of brain health studies in adults with congenital heart disease given the likely increasing impact on social and healthcare systems
Narrative in design and business: a literature review and research agenda for the future
No full textThis paper presents a systematic cross-disciplinary literature review of narrative and storytelling in design and business studies. Although narrative has attracted attention in both design studies, which emphasises narrative’s role in the design process, and business studies, including innovation processes, there is still no research bridging the interdisciplinary gap. First, this review underlines established and emerging research topics on narrative in each field respectively. Within design studies, extant research was synthesised into three main areas: narrative as competency, narrative as process, and narrative as artifact.. In business studies, the discussions of narratives in the four areas: narrative in organizational practices, narrative in strategic management, narrative in innovation process, and narrative in entrepreneurship were reviewed and organized in an integrated manner. Second, the authors highlight avenues for further research at the intersection of the two disciplines by creating a common linguistic framework. The authors argue that design narratives have the potential to contribute to different management issues, such as organisational and managerial sensemaking, strategic change/strategy-as-practice, innovation processes, and entrepreneurial identity and legitimacy building. It is revealed that core traits of narrative (i.e. abduction, empathy cultivation, and temporal work) are common research agendas between design and business studies
Design Thinking Methods to Activate Co-creation Process Among Policymakers, Creative Industries and SMEs
No full textThis paper is based on the exploration ofhow design approaches to innovation can be learnt and adopted by policymakers in order to enable SMEs to co-create with Creative Industries. More specifically it aims to research how design experts from the academic institution can effectively train policymaker and R&D department of companies in embracing design thinking methods as a way to support innovation. In order to comprehend this process, CILab (a departmental laboratory of research from the department of design of Politecnico di Milano) conducted a series of analysis based on an empirical research project that involved a panel of European policymakers, SMEs and Creative Industries, developing a set of tools implemented with different methods and activities. This process of investigation through workshops and user observation were implemented during the Co-Create European project. In this paper, design thinking is considered as an approach to innovation characterised by the implementation of methods and tools coming from the design discipline (Kolko in Design thinking comes of age, 2015, [11]). The reason why policymakers and SMEs in Europe could benefit from the implementation of design thinking approach refers to the growing recognition of the effectiveness of Design thinking approach in promoting innovation. Co-creation is intended as the practice of developing meaningful solutions (products, services, systems and business models) through a more participative process with engaged company stakeholders, involved in collective creativity environments (Galvagno and Dalli in Managing Service Quality 24:643–683, 2014, [7]). In addition to the explanation on the validity of this approaches to innovation, this paper illustrates how to approach design process and co-creation involving a variety of stakeholders: activities are triggered by the academic world that train policymakers from public administration in order to make industries, from the creative and manufacturing sectors, to benefit from the process of activating new path of innovation
Co-creation of new solutions through gamification: A collaborative innovation practice
No full textThis paper aims to explore the main implications of gamification approaches to collaborative innovation and particularly to co-creation, i.e. the interaction and interchange of ideas between users, customers, suppliers and other actors in the development of new solutions. Despite the few approaches attempting to make co-creation more ludic and accessible, researchers have yet to analyse the link between gamification and co-creation in an extensive manner. In order to better understand this unexplored relationship, empirical case research studies have been conducted with multi-actors participating in a real-life co-creation project through the deployment of a gamified method and tool (ideaChef®), as well as a combination of different instruments, involving speed meetings, workshops, debriefings and interviews. Besides advancing the body of knowledge on collaborative innovation practices and conceptualizing the relationship between gamification and co-creation, this paper provides important implications for managers on how multiple actors can be engaged and coordinated in such practices through gamification. The paper's main contribution lies in the suggestion that engagement goes hand in hand with coordination, and that a combination of both will be the best strategy for co-creating new solutions through gamification
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