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Randomized clinical trials of PFO closure for migraine headaches (MIST, PRIMA, PREMIUM)
Full text linkA number of observational studies describe patients with chronic and debilitating migraine headaches who experienced improvement or resolution of their migraine attacks following percutaneous patent foramen ovale (PFO) closure. These observations led to 3 randomized controlled trials to further investigate the efficacy and safety of PFO device closure plus standard of care medical therapy versus medical therapy alone (with or without a sham procedure), for the treatment of migraine headaches. The randomized trials failed to meet their primary endpoints that were defined to replicate the results of prior observational studies. Yet, all showed partial benefits in their subanalyses. The goal of this chapter is to discuss the clinical trials of PFO closure for migraine headache, with emphasis on the lessons learned, limitations, and meta-analyses of these studies. This chapter will serve to provide clinicians with insight to help guide their migraine patients who are found to have a PFO on echocardiographic testing
Bern – eine Stadt bricht auf. Schauplätze und Geschichten der Berner Stadtentwicklung zwischen 1798 und 1998
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Caratteristiche modali delle voci nelle composizioni polifoniche
No full textIl capitolo tradotto esamina gli Exordia di composizioni polifoniche tratte dal repertorio in relazione ai modi di riferiment
Left atrial appendage occlusion for stroke prevention in atrial fibrillation: multicenter experience with the Amplatzer cardiac plug
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