1,052 research outputs found
Characterizing Family Forest Owners who are Eligible to Participate in Preferential Forest Property Tax Programs (PFPTPs) across the U.S.
No full text1 electronic resource (PDF; 84 pages)Kilgore, Michael A.; Blinn, Charles R.; Meier, Justin T.; Frey, Greg; Snyder, Stephanie. (2018). Characterizing Family Forest Owners who are Eligible to Participate in Preferential Forest Property Tax Programs (PFPTPs) across the U.S.. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/202223
Justin and the Revelation of John The Reception of the Apocalypse by the Apologists in their Relevance to their Dating
No full textWitulski T. Justin and the Revelation of John The Reception of the Apocalypse by the Apologists in their Relevance to their Dating. EPHEMERIDES THEOLOGICAE LOVANIENSES. 2016;92(2):179-202.A thorough analysis shows that the statements of Justin Martyr in Dial. 81,4 and 82,1 give no reason to assume that the Book of Revelation was written before AD 120. In fact, there are two issues that strongly suggest a date of the Apocalypse of John in the time of the emperor Hadrian: 1. The author of Revelation is introduced by Justin as a contemporary of both Bar Kokhba and the 'text-internal' Justin appearing in the dialogus cum Tryphone. 2. The attribution of Revelation to John the Apostle in Dial. 81,4 can be ascribed to Justin himself or to a secondary addition
Occupational Therapy’s Role in the Criminal Justice System: A Scoping Review
No full textAbstract
Date Presented 4/1/2017
This scoping review maps the range of literature and emerging evidence articulating the role of occupational therapy (OT) in criminal justice systems. Practice guidelines for OT in these settings do not currently exist. This synthesis provides useful data for occupational therapists interested in growing the profession in these settings.
Primary Author and Speaker: Jaime Muñoz
Additional Authors and Speakers: Justin T. McTish, Joelle M. Ruggeri, Gesina Phillips
Contributing Authors: Abigail Catalano</jats:p
Erratum: Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination
No full textIMMUNOLOGY AND INFLAMMATION: Correction for "Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination," by Sophie V. Pageon, Thibault Tabarin, Yui Yamamoto, Yuanqing Ma, John S. Bridgeman, André Cohnen, Carola Benzing, Yijun Gao, Michael D. Crowther, Katie Tungatt, Garry Dolton, Andrew K. Sewell, David A. Price, Oreste Acuto, Robert G. Parton, J. Justin Gooding, Jérémie Rossy, Jamie Rossjohn, and Katharina Gaus, which appeared in issue 37, September 13, 2016, of Proc Natl Acad Sci USA (113:E5454-5463; first published August 29, 2016; 10.1073/pnas.1607436113). The authors note that Philip R. Nicovich should be added to the author list between Yuanqing Ma and John S. Bridgeman. Philip R. Nicovich should be credited with contributing new reagents/analytic tools. The corrected author line, affiliation line, and author contributions appear below. The online version has been corrected
Black Laughter/Black Protest . . . Cultural Politics of African American Comedy, 1934-1968
No full textBlack Laughter / Black Protest explores the relationship between comedy and the modern civil rights movement. In the early years of the civil rights movement, black leaders, intellectuals and journalists claimed that African American comedy undermined black claims to respectability and prevented policy makers and the white public from taking black concerns seriously. In an effort to eliminate these images from the mass media, the NAACP, with assistance from other organizations and members of the black press, organized a number of campaigns against Hollywood studios, Broadway producers and most notably, the Amos ‘n ’ Andy television show. Though often overlooked by civil rights scholars, these actions were a central component of civil rights activism during the 1940s and 1950s and an important precursor to Brown v. Board of Education. In detailing these efforts, this project provides new evidence of the cultural dimensions of the civi
Programmed Death-1 Culls Peripheral Accumulation of High-Affinity Autoreactive CD4 T Cells to Protect against Autoimmunity
No full textSummarySelf-reactive CD4 T cells are incompletely deleted during thymic development, and their peripheral seeding highlights the need for additional safeguards to avert autoimmunity. Here, we show an essential role for the coinhibitory molecule programmed death-1 (PD-1) in silencing the activation of high-affinity autoreactive CD4 T cells. Each wave of self-reactive CD4 T cells that escapes thymic deletion autonomously upregulates PD-1 to maintain self-tolerance. By tracking the progeny derived from individual autoreactive CD4 T cell clones, we demonstrate that self-reactive cells with the greatest autoimmune threat and highest self-antigen affinity express the most PD-1. Reciprocally, PD-1 deprivation unleashes high-affinity self-reactive CD4 T cells in target tissues to exacerbate neuronal inflammation and autoimmune diabetes. Reliance on PD-1 to actively maintain self-tolerance may explain why exploiting this pathway by cancerous cells and invasive microbes efficiently subverts protective immunity, and why autoimmune side effects can develop after PD-1-neutralizing checkpoint therapies
Investigation of T cell-mediated immune surveillance against tumor-specific antigens in genetically engineered mouse models of cancer
No full textThesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2011.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis. Vita.Includes bibliographical references.The association of tumor cells and lymphocytes has led to the hypothesis that our immune system actively inhibits the formation and progression of cancer, a phenomenon called tumor immune surveillance. T cells specific to mutant proteins have been identified in cancer patients and the recent success of cancer immunotherapies provides evidence that the immune system can fight this disease. Yet the frequent occurrence of malignant disease despite T cell recognition presents a significant medical problem. Only after we determine how tumors bypass the immune system can immunotherapeutic approaches be improved. To understand how tumors subvert immune responses, tumor transplantation or transgenic mice expressing tumor-associated antigens have been used to model cancer. To assess the role of anti-tumor T cells in models that more accurately reflect the human disease, I developed new systems to introduce exogenous antigens, to mimic neoantigens, into genetically engineered mouse models of lung cancer and sarcomas. Utilizing the mouse model of lung cancer, I show that endogenous T cells respond to and infiltrate lung tumors, delaying malignant progression. Despite continued antigen expression, T cell infiltration does not persist and tumors ultimately escape immune attack. Transplantation of cell lines derived from lung tumors that express these antigens or prophylactic vaccination against autochthonous tumors, however, results in rapid tumor eradication or selection of tumors that lose antigen expression. These results support clinical data that suggest a role for the immune system in cancer suppression rather than prevention. Tumor immune surveillance and immunoediting have largely been defined using carcinogen-driven models of sarcomagenesis. Using a genetically engineered model of sarcomagenesis, I show that immunoediting requires potent T cell antigens and that lymphocytes drive the evolution of less immunogenic tumors by selecting for antigen loss. Finally, immunotherapies have historically been ineffective in treating cancer patients. I show that vaccination against specific antigens expressed in mouse lung cancers leads to sustained anti-tumor T cell responses that eradicate recently initiated tumors. Vaccination also stimulates anti-tumor T cell responses in an antigen-independent fashion by enhancing the expansion and activity of T cells that recognize antigens only expressed in tumors.by Michel Justin Porter Du Page.Ph.D
China's economic reforms : pointers for other economies in transition?
No full textChina's two main economic problems before reform were low incentives to workers and the misallocation of resources among sectors. These problems were theresult of a development strategy oriented toward heavy industry. By improving material incentives, China's reforms created a flow of new resources and allowed them to be allocated to sectors suppressed under pre-reform strategies. The onset of reform in China was not allowed to disrupt production from existing resources. Instead, the newly created resources were permitted to accrue and to flow into the more productive, often light industrial sectors, thus stimulating continuous growth of the national economy during reform. Low incentives and the suppression of nonpriority sectors are common features of the legacy of economies in transition from central planning that based their development on the rapid growth of heavy industry. China's approach may be of interest to them. Among lessons China learned are that: (a) Autonomy must be granted to micromanagement units and preserved to improve the incentive structure and create a new flow of resources. (b) While maintaining essential minimum levels of production in the pre-reform priority sectors, autonomous enterprises must be permitted and encouraged to allocate new incremental resource flows to the previously suppressed sectors. (c) In parallel, the distorted policy environment and planned-allocation system must be progressively reformed to bring them into line with the new system of incentives and modus operandi of autonomous enterprises.Banks&Banking Reform,Municipal Financial Management,Water and Industry,Economic Theory&Research,Environmental Economics&Policies
Kaplan-Meier curves in tuberculosis patients in Victoria, Australia from 2012 to 2019.
No full textKaplan-Meier curves in tuberculosis patients in Victoria, Australia from 2012 to 2019.</p
Technoeconomic analysis of perovskite photovoltaic manufacturing for powering telecommunications Towers
No full textThesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2018.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (pages 71-73).In recent years, metal halide perovskite solar cells have gained traction as a potential competitor to the mature silicon-based solar cells in terms of both cost and performance. Being a young technology, however, means little is known about its true market value. In order to understand this, it is important to both get an accurate estimate of manufacturing cost and explore potential applications. In this thesis, we develop a Monte Carlo cost analysis method and apply it towards a realistic perovskite module manufacturing sequence today. We determine a nominal cost estimate of 0.68/W. Compared to silicon, which hovers around $0.40/W, this is rather competitive, since most of the installed system cost comes from non-module components such as installation labor and racking. With the lightweight and flexible form factor of perovskite solar modules, new applications become possible. One such application is the installation of perovskite photovoltaics (PV) vertically on telecommunications towers. Since such towers cannot support the weight of conventional silicon PV, this is a potential market for perovskite PV that silicon cannot satisfy. Using HOMER microgrid simulation software, we determine that it is financially feasible to install vertical PV in countries with high diesel prices and low grid reliability, such as India.by Justin Xiao.M. Eng
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