1,725,009 research outputs found
MicroRNA modulation of caenorhadbitis elegans dietary restriction and longevity
No full textAging is a universal biological phenomenon involving a complex decline in the ability of the organism to respond adequately to intrinsic and extrinsic stresses, leading to age-related diseases and pathologies. All organisms age, but the larger questions of how and why aging occurs are still being deciphered despite decades of research and experimentation . We present evidence identifying microRNAs, small non-coding RNAs that regulate gene expression by repressing target mRNAs through partially complementary binding, significantly impact Caenorhabditis elegans longevity. We have identified several mir mutants that impact not only lifespan but also specific aspects of aging like metabolic aging vs muscle aging. Excitingly we have also identified that the mir-80 mutant animal is under chronic dietary restriction – a conserved pathway that extends life- and healthspan in many diverse organisms. The mir-80(Δ) mutant exhibits multiple parameters of healthy aging, reduced fecundity and expression of molecular reporters associated with dietary restriction. Using a targeted RNAi approach we have identified several stress response transcription factors (daf-16, hsf-1 and skn-1), the metabolic energy sensor (AMPK) and the transcriptional co-factor cbp-1 as important requirements for mir-80(Δ) longevity and the DR-state. Finally we show that mir-80 longevity is also partially regulated by the conserved insulin/IGF-1 signaling pathway. In summary, we identify the first metazoan microRNA that regulates longevity through conserved dietary restriction and suggest a model whereby mir-80 may regulate a network of stress response and metabolic genes to impact C. elegans longevity. In conclusion, we identify novel miRNAs that modulate C. elegans longevity and the first microRNA that modulates longevity through dietary restriction.Ph. D.Includes bibliographical referencesby Mehul M Vor
ReferralWeb--a resource location system guided by personal relations
Get PDFThesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1997.Includes bibliographical references (p. 47-[48]).by Mehul A. ShahM.Eng
Lung Cancer: Then and Now
No full textLung Cancer: Then and Now, Mehul Patel, MD, Hematology/Oncology
Objectives: Current management of non-small cell lung cance
French Opera and the French Revolution, Etienne Nicolas Mehul
Get PDFAlthough Etienne Nicolas Méhul is relatively unknown today, he was greatly respected by his contemporaries, including Beethoven, Cherubini and Berlioz. He rose to popularity and notoriety during the most turbulent years of the French Revolution, when most intellectuals fled for their lives, and yet he managed to maintain his status as a favorite of the people. From an examination of some of his operas - Euphrosine (1790), Ariodant (1799), Adrien (1792, 1799), and Horatius Coclès (1794) - it is apparent that Mehul used thinly veiled allegories to express his views. His heroes in these operas were Romans, Scottish nobles, and Crusaders; his libretti referred to France\u27s history, but they represented political figures and scenes of his time. Mehul was also famous for his revolutionary anthems, which might have protected him from harsh critiques from the censor. While musicologists like M.E.C. Bartlet and David Charlton studied Mehul\u27s works mainly for his musical innovations, my research uses an historian\u27s lens to examine the libretti, scores, and the reviews of these operas. My findings reveal that Mehul was not only an excellent composer, but also a critic of the regime who sometimes knew how to overcome censorship through allegorical expression in libretti and musical themes
Mehul Raithatha's Quick Files
No full textThe Quick Files feature was discontinued and it’s files were migrated into this Project on March 11, 2022. The file URL’s will still resolve properly, and the Quick Files logs are available in the Project’s Recent Activity
Mehul Raithatha's Quick Files
No full textThe Quick Files feature was discontinued and it’s files were migrated into this Project on March 11, 2022. The file URL’s will still resolve properly, and the Quick Files logs are available in the Project’s Recent Activity
Mehul Raithatha's Quick Files
No full textThe Quick Files feature was discontinued and it’s files were migrated into this Project on March 11, 2022. The file URL’s will still resolve properly, and the Quick Files logs are available in the Project’s Recent Activity
No.2. From the Oratoria of "Joseph." "Remember now thy Creator . . ." Series Title The Holy Family. Admired Sacred Melodies By The Most Celebrated Composers. Second Series.
No full textthrough-composedpianoads on back cover for Robert Cocks & Co. stock13.296cover same as Box 33 Item 80-aCover is duplicated in 033.080a.Music is duplicated in 033.081b.Johns Hopkins University, Levy Sheet Music Collection, Box
033, Item 080bNo.2. Mehul. Arranged for the Piano Forte as Solos & Duets, with ad libitum Accts. for Flute, Violin & Violinc., by William Hutchins Callcott.Printed in Oil Colours By G. Baxter R. Patentee
No.2. From the Oratoria of "Joseph." "Remember now thy Creator . . ." Series Title The Holy Family. Admired Sacred Melodies By The Most Celebrated Composers. Second Series.
No full textthrough-composedpianoads on back cover for Robert Cocks & Co. stock13.296cover same as Box 33 Item 80-aCover is duplicated in 033.080a.Music is duplicated in 033.081b.Johns Hopkins University, Levy Sheet Music Collection, Box
033, Item 080bNo.2. Mehul. Arranged for the Piano Forte as Solos & Duets, with ad libitum Accts. for Flute, Violin & Violinc., by William Hutchins Callcott.Printed in Oil Colours By G. Baxter R. Patentee
No.2. From the Oratoria of "Joseph." "Remember now thy Creator . . ." Series Title The Holy Family. Admired Sacred Melodies By The Most Celebrated Composers. Second Series.
No full textthrough-composedpianoads on back cover for Robert Cocks & Co. stock13.296cover same as Box 33 Item 80-a; music same as Box 33 Item 80-bCover is duplicated in 033.080a.Music is duplicated in 033.080b.Johns Hopkins University, Levy Sheet Music Collection, Box
033, Item 081bNo.2. Mehul. Arranged for the Piano Forte as Solos & Duets, with ad libitum Accts. for Flute, Violin & Violinc., by William Hutchins Callcott.Printed in Oil Colours By G. Baxter R. Patentee
- …
