148,920 research outputs found
Mecanismo genético da herança de resistência à Stemphylium solani e insensibilidade a sua fitotoxina em algodoeiro.
No full textA mancha preta do algodoeiro causada por Stemphylium solani ocorre em várias regiões produtora de algodão do Brasil, causando severos prejuízos em rendimento especialmente no Estado do Paraná (Mehta, 1998; Lima et al, 1997). O patógeno ataca apenas as folhas e as infecções de maçã e do colmo até agora não foram observadas. Recentemente, Mehta & Brogin (2000), reportaram que S. solani do algodoeiro produziu fitotoxina, ..
Replication Data for: Chemokine Binding to PSGL-1 is Controlled by O-Glycosylation and Tyrosine Sulfation
No full textThis dataset is for the paper titled "Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation" by Goth, C. K. and Mehta, A. Y. et al
Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells
No full textCopyright @ 2011 Mehta et al.; licensee BioMed Central Ltd. This article has been made available through the Brunel Open Access Publishing Fund.
This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.BACKGROUND: Hutchinson-Gilford progeria syndrome (HGPS) is a premature ageing syndrome that affects children leading to premature death, usually from heart infarction or strokes, making this syndrome similar to normative ageing. HGPS is commonly caused by a mutation in the A-type lamin gene, LMNA (G608G). This leads to the expression of an aberrant truncated lamin A protein, progerin. Progerin cannot be processed as wild-type pre-lamin A and remains farnesylated, leading to its aberrant behavior during interphase and mitosis. Farnesyltransferase inhibitors prevent the accumulation of farnesylated progerin, producing a less toxic protein. RESULTS: We have found that in proliferating fibroblasts derived from HGPS patients the nuclear location of interphase chromosomes differs from control proliferating cells and mimics that of control quiescent fibroblasts, with smaller chromosomes toward the nuclear interior and larger chromosomes toward the nuclear periphery. For this study we have treated HGPS fibroblasts with farnesyltransferase inhibitors and analyzed the nuclear location of individual chromosome territories. We have found that after exposure to farnesyltransferase inhibitors mis-localized chromosome territories were restored to a nuclear position akin to chromosomes in proliferating control cells. Furthermore, not only has this treatment afforded chromosomes to be repositioned but has also restored the machinery that controls their rapid movement upon serum removal. This machinery contains nuclear myosin 1β, whose distribution is also restored after farnesyltransferase inhibitor treatment of HGPS cells. CONCLUSIONS: This study not only progresses the understanding of genome behavior in HGPS cells but demonstrates that interphase chromosome movement requires processed lamin A.This work was funded by an ORSAS award and the Brunel Progeria Research Fund
El debate sobre la población en la crisis ecosocial
No full textThe article presents the interventions of Eileen Crist and Lyla Mehta in the online forum on population “The Population Debate Revisited”
organised by the Great Transition Initiative in 2022. The authors represent two paradigmatic positions in the population debates: Crist
defends the need for global population reduction while Mehta advocates focusing on issues of power, distribution and how the concept
of scarcity is socially generated.El artículo recoge las intervenciones de Eileen Crist y de Lyla Mehta en el foro online sobre población «The Population Debate Revisited»
organizado por Great Transition Initiative en 2022. Las autoras representan dos posiciones paradigmáticas de los debates sobre población: Crist defiende la necesidad de reducción de la población mundial mientras que Mehta aboga por poner el foco en cuestiones de
poder, de distribución y cómo se genera socialmente el concepto de escase
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Institutional Variability in Anesthesia Time for Mehta Casting in Early-Onset Scoliosis (EOS).
No full textPURPOSE: Mehta casting is a potentially curative intervention for early-onset scoliosis (EOS) that typically requires multiple anesthetics. The Food and Drug Administration (FDA) reported that >3 hours of anesthesia under the age of 3 years old may alter brain development; however, no standard exists for the duration of anesthesia during casting. The purpose of this study is to quantify the variability in anesthesia during Mehta casting. We hypothesize that significant institutional variability exists and may be attributed to modifiable factors. METHODS: An EOS registry was used to identify patients who underwent at least one Mehta casting procedure. Anesthesia exposure was quantified, and site variability was assessed by patient characteristics, cast placement, procedure type, and equipment used. RESULTS: Our cohort consisted of 208 patients from 5 institutions (age 2.6±1.4 y). There were 1097 Mehta casting procedures, with 5.4±3.6 castings per patient. Of these patients, 106 (51%) were female, with an average age of 2.11±1.29 years old at the time casting was initiated. Patient etiologies included 154 idiopathic (74.0%), 22 syndromic (10.6%), 18 congenital (8.7%), 11 neuromuscular (5.3%), and 3 unknown (1.4%). Anesthesia time was 69±31 minutes and varied significantly between sites (59±14 to 117±46 min; P <0.001). Cumulative anesthesia time for patients under 3 years was 320±197 minutes with 120/161 (74.5%) patients exceeding 3 hours. Anesthesia time was lower after the FDA warning in 2016 compared with pre-2016 (71±30 vs. 66±32, P =0.008). CONCLUSIONS: Patients undergoing Mehta casting are at significant risk of exceeding 3 hours of anesthesia, which the FDA has stated may be harmful for children <3 years. Significant site variability indicates that standardization protocols should be developed to encourage best practices and minimize anesthetic times. LEVEL OF EVIDENCE: Prognostic Level II
Online revenue maximization for server pricing
No full textEfficient and truthful mechanisms to price resources on servers/machines have been the subject of much work in recent years due to the importance of the cloud market. This paper considers revenue maximization in the online stochastic setting with non-preemptive jobs and a unit capacity server. One agent/job arrives at every time step, with parameters drawn from the underlying distribution. We design a posted-price mechanism which can be efficiently computed and is revenue-optimal in expectation and in retrospect, up to additive error. The prices are posted prior to learning the agent’s type, and the computed pricing scheme is deterministic, depending only on the length of the allotted time interval and on the earliest time the server is available. We also prove that the proposed pricing strategy is robust to imprecise knowledge of the job distribution and that a distribution learned from polynomially many samples is sufficient to obtain a near-optimal truthful pricing strategy
Kerr nonlinear switching in silicon fibre-based microcylindrical resonators
No full textWe investigate the Kerr nonlinearity in a a-Si:H microcylindrical resonator fabricated from the silicon fibre platform. The large resonant wavelength shift observed for pulsed excitation is used to demonstrate ultrafast all-optical switching
A continuous network design model in stochastic user equilibrium based on sensitivity analysis
No full textThe continuous network design problem (CNDP) is known to be difficult to solve due to the intrinsic properties of non-convexity and nonlinearity. Such kinds of CNDP can be formulated as a bi-level programme, in which the upper level represents the designer's decisions and the lower level the travellers' responses. Formulations of this kind can be classified as either Stackelberg approaches or Nash ones according to the relationship between the upper level and the lower level parts. This paper formulates the CNDP for road expansion based on Stackelberg game where leader and follower exist, and allows for variety of travellers' behaviour in choosing their routes. In order to solve the problem by the Stackelberg approach, we need a relation between link flows and design parameters. For this purpose, we use a logit route choice model, which provides this in an explicit closed-form function. This model is applied to two example road networks to test and briefly compare the results between the Stackelberg and Nash approaches to explore the differences between them
Spatially-localized time dependent solutions including turbulence and their interactions in 2D Kolmogorov flow
No full textIn 2D Kolmogorov flow in small aspect ratio domains, spatially-localized solutions such as kink, traveling or time-dependent kink-antikink pars coexist. However, the conservation of the flow rate in the y direction strongly restrict combination of localized solutions and their positioning. We find that by adding a homogeneous flow U y their positioning is controlled and each of localized solutions including a spatially-localized chaos is isolated. Numerical results suggest that these isolated solutions can be elements constructing a whole flow
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