154 research outputs found
Corruption Prevention Measures Recommended by Kautilya
No full textCorruption Prevention Measures Recommended by Kautilya
Author / Authors : Dr. Priti Pohekar
Page no. 107- 113
Discipline : Political Science/Polity/ Democratic studies
Script/language : Roman/English
Category : Research paper
Keywords:Corruption, remedies of corruption, Kautilya Arthashastra
EFFECT OF SHORT-TERM YOGA PRACTICES ON PSYCHOLOGICAL GENERAL WELL BEING IN MEDICAL STUDENTS
No full textFREEZE DRIED INJECTABLE DRUG PRODUCT DEVELOPMENT: SELECTION OF NON FUNCTIONAL ADDITIVES
No full textArticle Retracted from Publication due to copyright violenc
Comprehensive Assessment of Degradation Behavior of Aspirin and Atorvastatin Singly and in Combination by Using a Validated RP-HPLC Method
No full textA fixed-dose combination of atorvastatin and aspirin is widely used for the treatment of myocardial infarction. The present work describes a compre-hensive study of the stress degradation behavior of atorvastatin and aspirin alone as well as in combination of 1:1 and 1:7.5 ratios, respectively, as per ICH guidelines. The degradation products of aspirin as well as atorvastatin were successfully separated by a developed simple, selective, and precise stability-indicating reversed-phase HPLC method. Chromatographic separation was achieved on the Phenomenex Luna analytical column, 150 mm x 4.6 mm, 5μm. The mobile phase consisted of 0.1% glacial acetic acid in water and acetonitrile in the ratio of 50:50 v/v at a flow rate of 1.0 ml/min. UV detection was performed at 246 nm. The extent of degradation was significantly influenced when both of the drugs were present in combination. Stress degradation behavior of atorvastatin was highly influenced by aspirin under acid hydrolysis, thermal degradation, and oxidative stress conditions. Similarly, the stress degradation behavior of aspirin was affected by atorvastatin especially under neutral hydrolysis, thermal degradation, and oxidative stress conditions. Additionally, the combination ratio of aspirin and atorvastatin also influenced the percentage degradation of each other. A mixture of aspirin and atorvastatin was also analyzed after a one-month stability study at 40 °C and 75% RH. All the results indicate chemical incompatibility of both aspirin and atorvastatin if present in combination
Impact of Microwave Assisted Heating on Hydrolytic Forced Degradation Study of Pharmaceuticals
No full textMicrowave-assisted heating: innovative use in hydrolytic forced degradation of selected drugs
No full text
Simultaneous RP-HPTLC method for determination of levodopa, carbidopa, and entacapone in combined tablet dosage form
No full textBamboo a Supplement to Human Health: A Comprehensive Review on its Ethnopharmacology, Phytochemistry, and Pharmacological Activity
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