108 research outputs found
Response to article “Effect of the Dynamic Orthotic Garment on Postural Control, and Endurance in Children with Spastic Diplegic Cerebral Palsy: A Randomized Controlled Trial” [Letter]
No full textPayal Mehta, Sandeep Pattnaik, Sunanda Bhowmik Maharishi Markandeshwar Institute of Physiotherapy and Rehabilitation, Maharishi Markandeshwar (Deemed to be University), Mullana, Haryana, 133207, IndiaCorrespondence: Sunanda Bhowmik, Email [email protected]
The Neuropeptide VGF is Reduced in Human Bipolar Postmortem Brain and Contributes to Some of the Behavioral and Molecular Effects of Lithium
No full textRecent studies demonstrate that the neuropeptide VGF (non-acronymic) is regulated in the hippocampus by antidepressant therapies and animal models of depression and that acute VGF treatment has antidepressant-like activity in animal paradigms. However, the role of VGF in human psychiatric disorders is unknown. We now demonstrate using in situ hybridization that VGF is downregulated in bipolar disorder in the CA region of the hippocampus and Brodmann’s Area 9 (BA9) of the prefrontal cortex. The mechanism of VGF in relation to LiCl was explored. Both LiCl intraperitoneally (IP) and VGF intracerebroventricularly (ICV) reduced latency to drink in novelty-induced hypophagia and LiCl was not effective in VGF+/- mice suggesting that VGF may contribute to the effects of LiCl in this behavioral procedure that responds to chronic antidepressant treatment. VGF by intrahippocampal injection also had novel activity in an amphetamineinduced hyperlocomotion assay thus mimicking the actions of LiCl injected IP in a system that phenocopies manic-like behavior. Moreover, VGF+/- mice exhibited increased locomotion following amphetamine and did not respond to LiCl, suggesting that VGF is required for the effects of LiCl in curbing the response to amphetamine. Finally, VGF by ICV in vivo activated the same signaling pathways as LiCl and is necessary for the induction of MAPK and AKT by LiCl thus lending insight into the molecular mechanisms underlying the actions of VGF. The dysregulation of VGF in bipolar disorder as well as the behavioral effects of the neuropeptide similar to LiCl suggests that VGF may underlie the pathophysiology of bipolar disorder.Peer reviewe
The microphysical properties of Saharan dust obtainable from downwelling infrared radiances
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
Accelerating the execution of green hydrogen value chains with the use of programme management
No full textClimate change, driven primarily by carbon dioxide emissions, necessitates urgent action to decarbonize the energy sector. This urgency is highlighted by initiatives such as the European Green Deal aiming for a carbon-neutral European Union by 2050. The transition to green hydrogen contributes to reducing CO2 emissions, particularly in the Netherlands, where initiatives have been outlined but face challenges in execution. This research explores the application of programme management theory to accelerate the execution of green hydrogen value chains. Through literature study and semi-structured interviews, challenges in execution, such as cost, uncertainties, regulation, and lack of integration, are identified. Potential solutions include clarity on costs and regulations, long-term collaboration, improved communication and most importantly connection in the green hydrogen value chain. The application of program management, characterized by grouping projects, aligning objectives, and coordinating resources, emerges as a viable strategy. All the actors in the entire chain need to collaborate and work as one instead of working in isolation. A model is developed to guide the setup of programme management for a green hydrogen value chain, emphasizing clear goals, roles, and communication. This research contributes to filling gaps in the literature and offers practical insights for industry stakeholders to expedite the transition to green hydrogen. Recommendations include collaboration among sectors, regulatory clarity, and utilization of the developed model. Future research could focus on contract formation, broader application of the model, and addressing regulatory challenges at a policy level.Civil Engineering | Construction Management and Engineerin
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