8,436 research outputs found
Ab initio phase diagrams of binary alloys in the low solute concentration limit
No full textPhase diagrams are crucial to the design of new materials, to understand their phase stability and metastability under different thermodynamic conditions, such as composition, temperature, and pressure. Here, we use an ab initio approach to study the phase diagram of a binary alloy within the low concentration limit of a solute. Using the ab initio molecular dynamics calculations based on density functional theory, we estimate the solute partitioning ratios in solid–liquid phase equilibria. The chemical potential difference between the solvent and solute atoms in both solid and liquid phases is calculated using thermodynamic integration. As an illustration of the techniques, we have applied this method to reproduce the phase diagram of the Al–Mg alloy at zero pressure. We also compute the ab initio solid–liquid coexistence curve of pure Al by applying the phase-coexistence method with the free energy correction technique. The calculated results are in close agreement with the experiment, demonstrating the reliability of the models
Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells
No full textCopyright @ 2011 Mehta et al.; licensee BioMed Central Ltd. This article has been made available through the Brunel Open Access Publishing Fund.
This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.BACKGROUND: Hutchinson-Gilford progeria syndrome (HGPS) is a premature ageing syndrome that affects children leading to premature death, usually from heart infarction or strokes, making this syndrome similar to normative ageing. HGPS is commonly caused by a mutation in the A-type lamin gene, LMNA (G608G). This leads to the expression of an aberrant truncated lamin A protein, progerin. Progerin cannot be processed as wild-type pre-lamin A and remains farnesylated, leading to its aberrant behavior during interphase and mitosis. Farnesyltransferase inhibitors prevent the accumulation of farnesylated progerin, producing a less toxic protein. RESULTS: We have found that in proliferating fibroblasts derived from HGPS patients the nuclear location of interphase chromosomes differs from control proliferating cells and mimics that of control quiescent fibroblasts, with smaller chromosomes toward the nuclear interior and larger chromosomes toward the nuclear periphery. For this study we have treated HGPS fibroblasts with farnesyltransferase inhibitors and analyzed the nuclear location of individual chromosome territories. We have found that after exposure to farnesyltransferase inhibitors mis-localized chromosome territories were restored to a nuclear position akin to chromosomes in proliferating control cells. Furthermore, not only has this treatment afforded chromosomes to be repositioned but has also restored the machinery that controls their rapid movement upon serum removal. This machinery contains nuclear myosin 1β, whose distribution is also restored after farnesyltransferase inhibitor treatment of HGPS cells. CONCLUSIONS: This study not only progresses the understanding of genome behavior in HGPS cells but demonstrates that interphase chromosome movement requires processed lamin A.This work was funded by an ORSAS award and the Brunel Progeria Research Fund
The vanishing author in computer-generated works: a critical analysis of recent Australian case law
No full textAbstract
The use of software is ubiquitous in the creation of many copyright works, yet the requirement in copyright law that every work have a human author who engages in independent intellectual effort means that its use may prevent copyright subsistence. Several recent Australian cases have refocused attention on authorship as an essential criterion of copyright subsistence, and these cases suggest that much computer-produced output may be authorless and thus lack copyright protection. This article, the first in a two-part series, analyses how each case deals with the question of authorship of computer-produced works and why the use of software diminishes copyright protection for a significant number of computer-generated works. The article critiques the application of conventional notions of human authorship developed in the pre-computer age to modern productions and suggests alternative approaches to authorship that satisfy both the major objectives of copyright policy and the need to adapt to the computer age. The article argues that, without a broader judicial approach to authorship of computer-generated works, Parliament must remedy the lacuna in protection for these ‘authorless’ works. Possible solutions for reform are suggested. In a forthcoming article, the author comprehensively examines those reform proposals
Drumheller, AB
No full textNotes - A history of the Ursaline order in Drumheller, AB from 1935 to 1985 (2 pages)Drumhelle
Souvenir of Edmonton, AB
No full textBooklet - Souvenir of Edmonton - The Capital City of Alberta. Collection of photographs in a green cover tied with string, Edmonton, AB (48 pages
Ab initio thermodynamics and phase diagram of solid magnesium: A comparison of the LDA and GGA
No full textThe finite temperature density functional theory and quasiharmonic lattice dynamics have been used to compute numerous thermodynamic properties of hexagonal close packed magnesium using both the local density approximation (LDA) and the generalized gradient approximation (GGA) for the exchange-correlation potential. Generally, it is found that there exist only minor differences between the LDA and GGA computed properties, with both giving good agreement with experiment. The hcp-bcc phase boundary has also been computed and is found to be in agreement with experimental observation. Again, only slight differences are found between the LDA and GGA. (c) 2006 American Institute of Physics
Ab initio pair potentials at metal-ceramic interfaces
No full textA systematic approach is proposed to obtain the interfacial interatomic potentials. By inverting ab initio adhesive energy curves for the metal-MgO ceramic interfaces, We derive interfacial potentials between Ag and O2-, Ag and Mg2+, Al and O2-, Al and Mg2+. The interfacial potentials, obtained from this method, demonstrate general features of bondings between metal atoms and ceramic ions
Perceptions of pre- and post-event impacts of PEI 2014 year-long celebrations
No full textThis study examines Canadian perceptions of pre- and post-event impacts of the PEI 2014 Celebrations using the 2013 and 2015 surveys of PEI residents and other Canadians conducted by the Centre for Tourism Research. Overall, results indicate that Canadians’ awareness of, knowledge about, and attitudes toward the 1864 Charlottetown Conference and the PEI 2014 Celebrations increased and positively changed over time. The research also suggests that event organizers and/or destination tourism managers need to put greater emphasis on the “socio-cultural aspects” of the event such as community participation and cultural identity, and make an effort to increase tourism volume and value in order to obtain strong support from residents and be successful
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