617 research outputs found
Chemical Composition, Antioxidant, Anticholinesterase and Anti-Tyrosinase Activities of Essential Oils of Two Sideritis Species from Turkey
No full textTel-Cayan, Gulsen/0000-0002-1916-7391; DURU, Mehmet Emin/0000-0001-7252-4880; Deveci, Ebru/0000-0002-2597-9898WOS: 000468959200032PubMed ID: 31531072Sideritis species have been known as medicinal plants since ancient times, and used as tea in Mediterranean countries such as Turkey, Greece, and Spain. They are also used for the treatment of several ailments such as a cough, common cold, and gastrointestinal disorders. The aim of the present study was to perform the chemical composition, antioxidant, anticholinesterase, and anti-tyrosinase activities of the essential oils of Sideritis albiflora and S. leptoclada. beta-caryophyllene (21.2%) and Germacrene D (17.9%) were identified as the major compounds in S. albiflora and S. leptoclada essential oils, respectively. The essential oil of S. albiflora showed the highest lipid peroxidation inhibitory (IC50 : 73.8 +/- 0.8 mu g/mL), DPPH free radical scavenging (28.3 +/- 0.1%), ABTS cation radical scavenging (IC50 : 50.6 +/- 1.0 mu g/mL), reducing power (A(0.05) : 181.7 +/- 0.6 mu g/mL), acetylcholinesterase (22.1 +/- 0.4%), butyrylcholinesterase (IC50 : 157.2 +/- 0.9 mu g/mL) and tyrosinase (15.2 +/- 0.4%) inhibitory activities. Moreover, S. albiflora essential oil had rich total phenolic and flavonoid contents indicating 41.5 +/- 0.8 mu g PEs/mg and 21.4 +/- 1.0 mu g QEs/mg respectively. This study suggests that consumption of Sideritis species as tea may protect one against melanogenesis, amnesia, and oxidative stress without any observable side effect
Structural characterization and determination of biological activities for different polysaccharides extracted from tree mushroom species
No full textTel-Cayan, Gulsen/0000-0002-1916-7391; Deveci, Ebru/0000-0002-2597-9898; DURU, Mehmet Emin/0000-0001-7252-4880WOS: 000486235900021PubMed ID: 31489667Chemical composition and structural characterization of polysaccharides of Fomes fomentarius (FF), Fuscoporia torulosa, Ganoderma adspersum, Ganoderma applanatum (GAP), Ganoderma lucidum, Phellinus igniarius, Pleurotus ostreatus (PO), and Porodaedalea pini (PP) tree mushrooms with antioxidant and anticholinesterase activities were determined in this research. Total carbohydrate contents of the polysaccharides were ranged between 65.06 +/- 6.76 and 88.27 +/- 5.15 mu g/mg and total protein contents were ranged between 3.18 +/- 0.72 and 6.56 +/- 1.25 mu g/mg. Galactose, glucose, and mannose were identified as major monosaccharides in all polysaccharides using gas chromatography-mass spectrometry. FT-IR analysis showed the characteristic peaks of the polysaccharides and high performance liquid chromatography-diode array detection was used to determine the molecular weight of the polysaccharides. In beta-carotene-linoleic acid assay FF (IC50: 2.55 +/- 0.40 mu g/ml) displayed the highest antioxidant activity, whereas GAP indicated the highest antioxidant activity in cupric reducing antioxidant capacity (A(0.50):59.90 +/- 0.53 mu g/ml), ABTS(center dot+) (IC50: 16.62 +/- 0.31 mu g/ml), and DPPH center dot (IC50: 45.58 +/- 0.21 mu g/ml) assays. In cholinesterase inhibitory activity test, PO (56.31 +/- 0.0.74%) showed significant inhibitory activity against butyrylcholinesterase enzyme. Practical applications Polysaccharides from mushrooms are the major class of bioactive compounds with various biological activities. Several studies were performed on the biological activity of the polysaccharide extracts from different mushrooms. However, to our knowledge, this is the first report on the chemical composition, structural characterization, antioxidant, and anticholinesterase activities of extracted polysaccharides from studied mushrooms in detail. This investigation shows that polysaccharide extracts obtained from tree mushrooms show a significant bioactivity and these polysaccharides might be used as bioactive natural sources in the pharmaceutical, food, and cosmetic industries
[Podcast] Rooney Rule with Dr. Jeremi Duru
No full textTheNFLGirl chats with sports law professor and author Dr. N. Jeremi Duru regarding the Brian Flores lawsuit, the Rooney Rule and the future of minority coaches in the NFL
Episide 25: Jeremi Duru & Jesse Washington
No full textIn Forward, Thinking | Episode 25, David and Ricky are joined by legal expert and professor N. Jeremi Duru and Senior Writer at ESPN\u27s The Undefeated and co-author of I Came As A Shadow Jesse Washington.Jeremi discusses his career, his work with the..
Intravenous tranexamic acid as an adjunct haemostat to ornipressin during open myomectomy. A randomized double blind placebo controlled trial
No full textMyomectomy is a surgical technique used for removal of uterine fibroids and historically hysterectomy has represented the mainstay of treatment. The options of conservative surgical approaches mainly aim at retention of fertility but have to be balanced against potential risks such as haemorrhage; blood loss at myomectomy still remains troublesome with use of various pharmacologic agents yielding inconclusive results. This trial aimed to explore the benefit of combining ornipressin and tranexamic acid during open myomectomy.Peer reviewe
Multiple item economic lot sizing problem with inventory dependent demand
No full textWe consider a multiple item Economic Lot Sizing problem where the demands for items depend on their stock quantities. The objective is to find a production plan such that the resulting stock levels (and hence demands) maximize total profit over a finite planning horizon. The single item version of this problem has been studied in the literature, and a polynomial time algorithm has been proposed when there are no bounds on production. It has also been proven that the single item version is NP-hard even when there are constant (i.e., time-invariant) finite capacities on production. We extend this single item model by considering multiple items and production capacities. We propose a Lagrangian relaxation method to find an initial solution to the problem. This solution is a hybrid solution obtained by combining two distinct solutions generated in the process of solving the Lagrangian dual problem. Starting with this initial solution, we then implement a Tabu Search algorithm to find better solutions. The performance of the proposed solution method is compared with the performance of a standard commercial software that works on a mixed integer programming formulation of the problem. We show that our solution approach finds better solutions within a predetermined time limit in general.TÜBİTAKPublisher versio
Identification and quantification of phenolic acid compounds of twenty-six mushrooms by HPLC-DAD
No full textDeveci, Ebru/0000-0002-2597-9898; Tel-Cayan, Gulsen/0000-0002-1916-7391; DURU, Mehmet Emin/0000-0001-7252-4880WOS: 000516177700006Phenolic acids are found in different foods in the human diet, for example mushrooms. Determination of phenolic acids is important because of their relationship to their role in disease prevention due to their bioactive properties. In this study, the phenolic acid profile of 26 mushroom species was analyzed by using high-performance liquid chromatography method coupled with photodiode array detector (HPLC-DAD) and 16 phenolic acid compounds were identified. The chromatographic separation was performed using Intertsil ODS-3 reverse phase C-18 column (5 mu m, 250 mm x 4.6 mm i.d), gradient solvent system with 1.5 mL/min flow rate and detected at 280 nm. The coefficient of determination (R-2) was in the range of 0.9965-0.9999. Limit of detection and quantification ranged from 0.001-0.970 to 0.001-2.940 mu g/L, respectively. The phenolic compounds were characterized according to their retention times and UV data were compared with commercial standards. S. granulatus (71.79 mu g/g) and L. nuda (68.38 mu g/g) revealed the highest concentration of total phenolic compounds among the studied mushrooms. Gallic acid was found as the major phenolic compound in R. aurora (2.96 +/- 0.56 mu g/g) while 6,7-dihydroxy coumarin was identified as major phenolic compounds in A. tabescens (2.07 +/- 0.25 mu g/g) and L. leucothites (9.02 +/- 0.87 mu g/g). Fumaric acid was found as the most abundant compounds in 16 out of 26 mushrooms. Catechin hydrate was identified as major phenolic compounds in the rest of mushrooms. This method provided a beneficial standardization procedure of phenolic acid compounds in mushroom samples
Antibiofilm, antiquorum sensing and antioxidant activity of secondary metabolites from seeds of Annona senegalensis, Persoon
No full textCeylan, Ozgur/0000-0002-1865-1093; Ozturk, Mehmet/0000-0001-8932-4535; CHI, GODLOVES FRU/0000-0002-1484-3995; Alfred Ngenge, Tamfu/0000-0001-6683-3337; DURU, Mehmet Emin/0000-0001-7252-4880WOS: 000537563900030PubMed ID: 322987490000-0001-89320000-0001-7252-4880The increasing resistance of bacteria to antibiotics has motivated the interest in potent natural compounds capable of disrupting bacterial cell-to-cell communication. Column chromatography of seed extract of Annona senegalensis afforded N-cerotoyltryptamine (1), asimicin (2) and ent-19-carbomethoxykauran-17-oic acid (3). The compounds were tested for their antimicrobial, antibiofilm, and anti-quorum sensing activities. The minimum inhibitory concentrations (MIC) values ranged from 50 mu g/mL to 100 mu g/mL for C. albicans ATCC 10239 and S. aureus ATCC 25923 E. coli ATCC 25922, C. violaceum CV026 and C. violaceum CV12472. All the compounds inhibited biofilm formations of all microorganisms tested in various percentages at MIC and MIC/2. Compound 2 also exhibited the highest antibiofilm activity against C. albicans (yeast) and E. coli with percentage inhibitions ranging from 6.3 +/- 4.1 (MIC/4) to 37.9 +/- 4.5 (MIC) for C. albicans and from 18.8 +/- 1.1 (MIC/4) to 43.2 +/- 0.5 (MIC) for E. coll. Compound 1, however, showed highest biofilm inhibition on S. aureus as the percentage inhibition varied from 26.7 +/- 3.6 (MIC/4) to 43.8 +/- 2.1 (MIC). Compound 2 showed highest percentage violacein inhibition on C. violaceum CV12472 ranging from 10.2 +/- 0.5 (MIC/8), 65.76 +/- 1.3 (MIC/2) and 100 (MIC). Compound 1 and 3 had percentage violacein formation inhibitions on C. violaceum CV12472 ranging from 9.66 +/- 1.1 (MIC/4) to 100 (MIC), and from 17.4 +/- 2.4 (MIC/4) to 100 (MIC), respectively. Swimming and swarming motility of P. aeruginosa PA01 strain was evaluated at three concentrations of 50, 75 and 100 mu g/mL. The compounds inhibited the P. aeruginosa swimming and swarming motility at the three tested concentrations (50, 75 and 100 mu g/ml) in a dose-dependent manner. The extents of inhibition of motility migration was relatively higher in the swimming model than in the swarming model for all compounds. Compound 1 exhibited the highest percentage inhibition of motility of 41.50 +/- 3.5 and 39.73 +/- 1.5 in swimming model and swarming model respectively at 100 mu g/ml. Compound 3 showed the lowest percentage inhibition of 30.36 +/- 2.0 and 23.50 +/- 2.5 in swimming and swarming respectively at 100 mu g/ml. At the lowest tested concentration of 50 mu g/ml, it was compound 2 showing the highest inhibition of motility of 17.49 +/- 0.5 and 14.29 +/- 1.0 in swimming and swarming respectively. Compound 1 showed highest quorum sensing (QS) activity with QS inhibition zone of 20.0 +/- 1.5 mm at MIC and 11.0 +/- 1.0 mm at MIC/8 while compound 2 had the highest antimicrobial (AM) zone diameter amongst the compounds at MIC. Compound 3 was the QS inhibitory sample and did not show any QS inhibition at MIC/8 while showing its highest QS inhibition zone of 13.0 +/- 1.6 mm at MIC. For antioxidant assays, no sample showed better activity than the standards. Compound 2 had highest activity with IC50, values of 87.79 +/- 2.70 and 42.77 +/- 1.53 mu g/mL in DPPH and beta-carotene-linoleic acid assay respectively and was more active (IC50 of 97.69 +/- 1.40 mu g/mL) than standard quercetin (IC50, 250.09 +/- 0.87 mu g/mL) in metal chelation assay.Turkish Scholarship (Turkiye Burslari) [19CM000746]; Higher Education Commission of Pakistan (HEC)Higher Education Commission of Pakistan [5738]This work was supported by the Turkish Scholarship (Turkiye Burslari 19CM000746) and the Higher Education Commission of Pakistan (HEC project: 5738)
Elimination by Gamification the 5th Grade Students’_x000D_ Misconceptions about the Matter and Phase Change
No full textWhile the purpose of this study is to reveal misconceptions about the Phase Change of Matter in thefifth grade Matter and Its Nature unit at the same time to overcome these misconceptions with gamified education.In accordance with these purposes, the "The Form of Misconceptions about Matter and Phase Change" consistingof four open-ended questions that was developed and implemented. This form was applied as a pre-and post-testto 20 students who are fifth grade students in the 2019-2020 academic year. While the instruction was carried outwithin the current teaching plan, the gamification components were added to the course and the intruction wasperformed. At the end of the study, it was determined that the students had difficulty in distinguishing the conceptsof evaporation and boiling, and they used the concept of smoke instead of vapor. After the course, which wascarried out using gamification components, it was determined that the students did not confuse the phase changesand could differentiate between the concepts of steam and smoke
Analysis of 2016 LYS and YGS Physics Questions According to Bloom Taxonomy and Outcomes in the Curriculum
No full textIn this study document analysis method which is one of the qualitative research methods is used in order to examine the physics questions in terms of the Bloom taxonomy and outcomes in the curriculum in LYS and YGS examinations conducted in 2016. The data of the research is composed of the YGS science test conducted on March 13th, 2016 and the LYS-2 physics test conducted on June 25th, 2016. The analysis of the questions was carried out in two stages. In the first stage, the physics questions asked in YGS and LYS were examined according to the outcomes in the secondary school physics and primary science and technology lessons curriculum (changes in the curriculum with the decision of the board dated 26/08/2011 and numbered 130) which is accepted by the board of education. In the second stage, physics questions were analyzed according to the revised Bloom taxonomy. The data obtained as a result of the analysis are presented as tables and are depicted with frequency values. When the physics questions in the YGS science test are examined, it is seen that five questions are asked about the outcomes in the 9th grade Physics curriculum. Six of the remaining eight questions were derived from primary education (6, 7, 8th grades) and the remaining two questions were derived from 10th and 11th grade physics program outcomes. Despite all candidates in YGS are responsible for common issues, asking questions from 10th and 11th grades show that these questions can only be solved by students taking elective physics courses
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