177,297 research outputs found
The use of a double suture and conjunctival cuts in the lateral tarsal strip: A new approach to involutional ectropion
No full textPurpose: To describe the use of a double suture and conjunctival cuts in the lateral tarsal strip (LTS) and to evaluate postsurgical outcome in patients with severe involutional ectropion. Methods: A prospective randomized study was conducted on 16 eyelids of 8 patients with symptomatic severe involutional ectropion. The 8 patients were between 62 and 79 years. They were distributed into 2 groups consisting of 4 patients each. The control group was treated with a conventional lateral tarsal strip (C-LTS), the second group underwent a modified lateral tarsal strip (M-LTS). The mean follow-up was 18 months. Success was defined as relief in lid laxity. The recurrence rate was also evaluated. Results: Patients treated with M-LTS showed lower horizontal laxity (3.5 0.2) than patients treated with C-LTS (5.7 0.2). During the 18-month follow-up, a statistically significant difference was found between the 2 groups with P value <0.05. Conclusions: The use of a double suture and conjunctival cuts in the lateral tarsal strip proposed by Meduri showed a reduction of postsurgical ectropion's grade and postsurgical recurrences. This technique could be used for the treatment of patients with a severe ectropion
Apprendimento e riabilitazione
No full textL’apprendimento è un processo neuro-psicologico attraverso cui la nostra sfera sensoriale mette in comunicazione la corteccia cerebrale con il mondo esterno. Vi intervengono fenomenologie complesse che si svolgono dai recettori periferici alla corteccia specializzata, alla corteccia associativa e alla regioni dell’ippocampo. Molte di queste connessioni hanno un controllo genetico rigido altre hanno una impronta genetica più fluida che viene perfezionata dalla esperienza sensoriale ed è caratterizzata da una peculiare plasticità, chiave della adattabilità ambientale ed evolutività dell’encefalo umano.
Le procedure riabilitative implicano l’attivazione dei meccanismi coinvolti nell’apprendimento. Puntualizzare i metodi riabilitativi delinea la possibilità di miglioramenti degli specifici deficit sensoriali presenti
Effect of cytochrome c peroxidase on the corneal epithelial healing process after excimer laser photo-ablation in transgenic mice.
No full textAIM: To evaluate the role of commercially prepared cytochrome c peroxidase eye drops in corneal epithelial healing of transgenic B6(A)-Rpe65rd12/J mice after excimer laser photo-ablation.
MATERIALS AND METHODS: In our prospective animal series, 72 eyes of 36 mice had uneventful bilateral excimer laser photo-ablation. In each mouse, one eye received standard topical postoperative therapy with tobramycin, diclofenac, and dexamethasone eye drops plus cytochrome c peroxidase eye drops (two drops three times a day for 1 week or until corneal re-epithelialization was complete, corresponding to 15,000 IU/day). The fellow eye served as the control and received standard postoperative therapy plus placebo. The mice were monitored daily, commencing on the day after surgery, for 7 days to evaluate the corneal re-epithelialization rate using a video slit lamp camera with cobalt blue light. The mean diameter of the corneal wounds was measured. Videotaped images were recorded and analyzed by computer planimetry.
RESULTS: All eyes treated with cytochrome c peroxidase eye drops healed completely before day 5 after surgery, with a mean re-epithelialization time of 92 +/- (SD) 10 h; the mean re-epithelialization time was 121 +/- 8 h in the eyes receiving placebo (p < 0.05). There were no statistically significant differences between the two groups in corneal haze presentation during the follow-up period (p = 0.70), perhaps because the observation period was too short (7 days). However, the corneal clarity, on slit lamp biomicroscopy, in the study group was higher than that in the control group. No side effects or toxic effects were observed
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Diagnostic imaging and therapy in a case of myasthenia gravis associated with thymic hyperplasia
No full textThe diagnostic approach to a patient with myasthenia gravis to verify the presence of thymic hyperplasia/thymoma is presented. The study of the mediastinal region was necessary. Mediastinal MRI showed the presence of a mass. The differential diagnosis between a mediastinal and an extramediastinal lesion is possible with MRI for its high contrast resolution, good spatial resolution and multiplanarity that allow the detection, localization, evaluation of the extent and/or infiltration of adjacent tissues/organs based on the analysis of adipose cleavages and typing in the different pulse sequences of pathologic tissue with contrast enhancement. Definitive diagnosis of thymic hyperplasia was established. Therefore surgery should be essentially associated with the severity of the clinical presentation rather than with thymic hyperplasia
Glucocorticoid (GC) treatment in severe community acquired pneumonia (CAP): comparison of hydrocortisone (HC) vs. methylprednisolone (MP).
No full textIntraoperative OCT Pachymetry in Patients Undergoing Dextran-Free Riboflavin UVA Accelerated Corneal Collagen Crosslinking
No full textPurpose: To assess intraoperative corneal pachymetry in patients undergoing accelerated corneal collagen crosslinking with a dextran-free riboflavin solution. Methods: Prospective, non-comparative, multicenter interventional study. Thirty patients with progressive keratoconus were enrolled in the study from the Siena Crosslinking CenterTM in Siena, Italy and the Eye Center in Catanzaro, Italy. The mean age was 26.9 ± 6.5 years. Patients underwent pulsed light accelerated crosslinking (PL-ACXL) by KXL I UV-A source (Avedro Inc., Waltham, MS, USA) with 8 min (1 s on/1 s off) of UV-A exposure, 30 mW/cm2and an energy dose of 7.2 J/cm2. Corneal stroma was soaked with a dextran-free 0.1% riboflavin solution plus hydroxyl-propyl methylcellulose (HPMC) (VibeX Rapid, Avedro). Intraoperative corneal thickness was preoperatively (PRE-OP) evaluated by corneal optical coherence tomography (iVUE Optovue Inc., Fremont, CA, USA) after epithelium removal (EPI-R), after 10 min of riboflavin soaking (RS) and after UV-A irradiation (IR). Statistical analysis was conducted using a Wilcoxon test and SPSS v16.0. A p-value of <0.05 was considered to be statistically significant. Results: Average PRE-OP central corneal thickness (CCT) and thinnest corneal thickness (TCT) were 437.3 ± 36.9 and 418.9 ± 28.8 μm, respectively. Average EPI-R CCT and TCT values were 388.5 ± 36.8 and 381.5 ± 36.61 μm, respectively. Average CCT and TCT values after 10 min RS were 385.2 ± 37.8 and 380.6 ± 36.7 μm, respectively. The final average CCT and TCT values after IR were 379.4 ± 37.2 and 378.1 ± 36.4 μm, respectively. Conclusions: The study demonstrated a non-statistically significant intraoperative corneal thickness reduction in patients undergoing PL-ACXL corneal collagen crosslinking by using dextran free HPMC 0.1% riboflavin solution.Purpose: To assess intraoperative corneal pachymetry in patients undergoing accelerated corneal collagen crosslinking with a dextran-free riboflavin solution. Methods: Prospective, non-comparative, multicenter interventional study. Thirty patients with progressive keratoconus were enrolled in the study from the Siena Crosslinking CenterTM in Siena, Italy and the Eye Center in Catanzaro, Italy. The mean age was 26.9 ± 6.5 years. Patients underwent pulsed light accelerated crosslinking (PL-ACXL) by KXL I UV-A source (Avedro Inc., Waltham, MS, USA) with 8 min (1 s on/1 s off) of UV-A exposure, 30 mW/cm2 and an energy dose of 7.2 J/cm2. Corneal stroma was soaked with a dextran-free 0.1% riboflavin solution plus hydroxyl-propyl methylcellulose (HPMC) (VibeX Rapid, Avedro). Intraoperative corneal thickness was preoperatively (PRE-OP) evaluated by corneal optical coherence tomography (iVUE Optovue Inc., Fremont, CA, USA) after epithelium removal (EPI-R), after 10 min of riboflavin soaking (RS) and after UV-A irradiation (IR). Statistical analysis was conducted using a Wilcoxon test and SPSS v16.0. A p-value of <0.05 was considered to be statistically significant. Results: Average PRE-OP central corneal thickness (CCT) and thinnest corneal thickness (TCT) were 437.3 ± 36.9 and 418.9 ± 28.8 μm, respectively. Average EPI-R CCT and TCT values were 388.5 ± 36.8 and 381.5 ± 36.61 μm, respectively. Average CCT and TCT values after 10 min RS were 385.2 ± 37.8 and 380.6 ± 36.7 μm, respectively. The final average CCT and TCT values after IR were 379.4 ± 37.2 and 378.1 ± 36.4 μm, respectively. Conclusions: The study demonstrated a non-statistically significant intraoperative corneal thickness reduction in patients undergoing PL-ACXL corneal collagen crosslinking by using dextran free HPMC 0.1% riboflavin solution
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