19,402 research outputs found

    Tasigna (nilotinib) in chronic myeloid leukemia treatment-free remission after nearly 2 years: An interview with Adam Mead

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    Dr Mead earned his medical degree from the University of Oxford and trained in hematology at St Bartholomew's Hospital and University College London. In 2007, he earned his PhD at UCL, which focused on the analysis of FLT3 mutations in acute myeloid leukemia. He is now Associate Professor of Hematology and MRC Senior Clinical Fellow at the WIMM, University of Oxford. His research group focuses on myeloid diseases and normal blood stem-cell biology. Dr Mead is the lead clinician for myeloproliferative neoplasms (MPN) and chronic myeloid leukemia in the Thames Valley Strategic Clinical Network and is the chief investigator for several chronic myeloid leukemia and MPN clinical trials. Additionally, Dr Mead has helped shape the diagnostic and treatment guidelines for MPNs in the UK and serves as the chair of the MPN clinical study subgroup of the National Cancer Research Institute

    ADAM SMITH'S OPTIMISTIC TELEOLOGICAL VIEW OF HISTORY

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    Adam Smith's four-stage theory provides the framework for his writings on history. The fourth stage is the commercial epoch; the culmination of history in this stage is a key component in the conventional interpretation of Adam Smith as a prophet of commercialism. In two historical case studies Smith shows the capacity of commercial society to regenerate itself. This potent capacity suggests that commercial society is inevitable. At a certain point in time it also overcomes the major obstacles to its permanence. Smith's philosophy of history anticipates the end of history views of Kant and Hegel.Political Economy,

    How Might Adam Smith Pay Professors Today?

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    Adam Smith’s proposal for paying professors was intended to induce increased faculty knowledge. If students have imperfect information about what they learn, and universities can only imperfectly measure the input of faculty time in student learning, publications may be used to measure faculty knowledge. If professors’ ability to publish is positively related to their ability to produce student learning, which universities can imperfectly measure, publications may be necessary to attract more able professors. Since research signals faculty knowledge, schools that do not value publications per se could require higher publication standards and pay higher wages than schools that value only publications.

    ADAM SMITH'S VIEW OF HISTORY: CONSISTENT OR PARADOXICAL?

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    The conventional interpretation of Adam Smith is that he is a prophet of commercialism. The liberal capitalist reading of Smith is consistent with the view that history culminates in commercial society. The first part of the article develops this optimistic interpretation of Smith's view of history. Smith implies that commercial society is the end of history because 1) it supplies the ends of nature that he identifies; 2) it is inevitable; and 3) it is permanent. The second part of the article shows that Smith has some dark moments in his writings where he seems to reject completely such teleological notions. In this more civic humanist mood he confesses that commercial society does not supply the ends of nature, nor is it inevitable, nor is it permanent. Both views exist in Smith and the commentator is forced to choose between passages in Smith's work in order to support a particular interpretation of the former's view of history.Political Economy,

    Children\u27s Book Festival: Adam Rubin

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    Adam Rubin is the author of Those Darn Squirrel

    Adam Smith and Roman Servitudes

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    This essay is a preprint of an article that appeared at: Tijdschrift voor Rechstsgeschiedenis, 72 (2004), 327–57.This essay discusses Adam Smith historical jurisprudence and his use of Roman law materials in his Lectures on Jurisprudence. It argues that Smith found it difficult to maintain his theory of legal development in the face of a highly developed body of Roman law literature

    THE THEOLOGICAL FOUNDATION OF ADAM SMITH'S WORK

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    The paper will discuss the theological foundation to Smith's writings. Teleology, final causes and divine design were initially seen as central to understanding Smith's writings. Over time, this view fell out of fashion. In the period after World War II, with the rise of positivism, commentators tended to overlook or downplay this interpretation. In the last decade, or so, teleology has started to be restored to its former position as an essential element in understanding Smith. After spelling out Smith's teleology and his view of final causes, divine design and the ends of nature, we try to explain the Panglossian nature of the 'new theistic view' of Smith. While our view differs somewhat, we agree with the essence of the 'new view' claim: a theological view exists in Smith which underpins his moral and economic theories.Political Economy,

    Interview. Matthew Joseph with Adam Gussow, musician and author

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    Interview in which Adam Gussow discusses hill country blues musi

    Euphonium Concerto de Vladimir Cosma: um estudo comparativo entre a interpretação de Steven Mead e a de Adam Frey

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    Esta dissertação foca-se na análise técnico-interpretativa do "Euphonium Concerto" de Vladimir Cosma, com principal foco no seu enquadramento histórico e no estudo comparativo entre a interpretação de Steven Mead e a Adam Frey. Este concerto, escrito em 1997, é uma obra icónica no repertório para eufónio e orquestra sinfónica. A investigação começa com uma contextualização histórica dos concertos para eufónio e orquestra da década de 90, seguido da da vida e obra de Vladimir Cosma. Neste enquadramento teórico também são abordados o concurso Guebwiller, que encomendou esta obra, a análise descritiva da obra e a sua relação com as bandas sonoras de filmes do próprio Cosma. No final, são expostos diferentes exemplos de análise técnico-interpretativa. Este estudo envolve a transcrição e a análise técnico-interpretativa de excertos selecionados das performances de Steven Mead e Adam Frey, a partir da audição de gravações. Os parâmetros analisados incluem tempo (pulsação), precisão rítmica, timbre, articulação, dinâmicas, fraseado e respiração. Deste modo, é apresentado um estudo comparativo destas interpretações, destacando as escolhas interpretativas de cada intérprete. Com esta dissertação pretendo compreender o contexto do "Euphonium Concerto" na obra de V. Cosma, aprofundar a minha capacidade de transcrever excertos de gravação para partitura e conhecer as escolhas interpretativas de Steven Mead e Adam Frey, com o objetivo de auxiliar outros intérpretes na execução desta obra. A pesquisa culmina com a performance do concerto no meu recital final de mestrado, aplicando o conhecimento e conclusões obtidas durante o estudo.This dissertation focuses on the technical-interpretative analysis of Vladimir Cosma's “Euphonium Concerto”, with the main focus on its historical background and the comparative study between the interpretation as recorded on the CD’s of Steven Mead and Adam Frey. This concerto, written in 1997, is an iconic work in the repertoire for euphonium and symphony orchestra. The research begins with a historical contextualization of the concerti for euphonium and orchestra of the 1990s, followed by the life and work of Vladimir Cosma. This theoretical framework also covers the Guebwiller competition, which commissioned this work, the descriptive analysis of the work and its relationship with Cosma's own film soundtracks. Finally, different examples of technical-interpretative analysis are presented. This study involves the transcription and technical-interpretative analysis of selected excerpts from the recordings of Steven Mead and Adam Frey, based on active and repeated listening. The parameters analyzed include tempo (pulse), rhythmic precision, timbre, articulation, dynamics, phrasing and breathing. In this way, a comparative study of these interpretations is presented, highlighting the interpretative choices of each performer. With this dissertation, I intend to understand the context of the “Euphonium Concerto” in the work of V. Cosma, deepen my ability to transcribe excerpts from recordings into sheet music and learn about the interpretative choices of Steven Mead and Adam Frey, with the aim of helping other interpreters in the performance of this work. The research culminates with the performance of the concerto in my final master's recital, applying the knowledge and conclusions obtained during the study

    Książę Adam Jerzy Czartoryski i jego stronnicy w świetle historiografii ukraińskiej

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    In 1937, the Warsaw historian Marceli Handelsman published a work entitled Ukraińska polityka ks. Adama Czartoryskiego przed wojną krymską [Ukrainian politics of Prince Adam Czartoryski before the Crimean War]. So far, this book has been used by historians as the primary source of information on the Ukrainian issue in the views of the Hotel Lambert’s leader. The author of this text has decided to collect Ukrainian works referring to the topic inaugurated by Handelsman. Unfortunately, no larger study has been prepared on the Ukrainian side. However, a number of articles and encyclopaedic notes showing Prince Adam and his Eastern policy (especially during his stay at the court of Tsar Alexander I Romanov) has been published. Ukrainian authors paid much more attention to Czartoryski’s associates, who tried to put his ideas into practice. Ukrainian researchers wrote mainly about Michał Czaykowski (Sadyk Pasha) organizing the Cossack troops in the Ottoman Empire, about Hipolit Terlecki striving for the union of the Orthodox and Roman Catholic Churches, and finally about the ethnographer and writer Franciszek Duchiński clearly separating Ukraine from Russia in his writings
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