523 research outputs found
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A study of John Clare in his historical and political context
No full textAs the title indicates, the basis of the thesis is to set John Clare’s life and work within the context of the social and political history of his time. It is a study that is long overdue. The manner in which topical and political matters were mediated to him and were reflected in his work are analysed. His introduction to the literary and social worlds of Stamford and London is evaluated, and the advantages and disadvantages of patronage assessed. The active and complex political culture of Stamford has been taken into account as this may have affected his later political statements and a growing awareness of his audience. His antagonism to enclosure and the social changes that it engendered are considered. Three major questions that arise from this are addressed. The two local newspapers that Clare is known to have read are used throughout. His correspondence with friends, colleagues and casual correspondents has provided valuable insights as have his poetry and prose writings. Research in the Northamptonshire Record Office has revealed important new information in the form of one book of Enclosure Commissioners’ Minutes dated 1809-14, the first five years of the enclosure of Helpstone, Clare’s native village
The life and works of Osbert of Clare
No full textOsbert of Clare was an English monastic writer, whose works extended from
the mid-1120s to the mid-1150s. His Latin hagiography reflects a deep admiration for
Anglo-Saxon saints and spirituality, while his letters provide a personal perspective
on his turbulent career. As prior of Westminster Abbey, Osbert of Clare worked to
strengthen the rights and prestige of his monastery. His production of forged or
altered charters makes him one of England's most prolific medieval forgers. At times
his passion for reform put him at odds with his abbots, and he was sent into exile
under both Abbot Herbert (1121-c.1136) and Abbot Gervase (1138-c.1157). Also
Osbert, as one of the first proponents of the Immaculate Conception of Mary, wrote
about the feast, worked to legitimize its celebration, and provided us with the only
significant narration of its introduction to England.
This thesis is divided into two sections. The first section is principally
historical and the second is principally literary. In the first section, I provide an
overview of Osbert of Clare's career and examine in greater detail two of his most
significant undertaking: his promotion of Westminster Abbey and his attempted
canonization of Edward the Confessor. In the second section, I give a philological
study of Osbert Latin style and examine themes that nm throughout his writings, such
as virginity, exile and kingship. Osbert's promotion of the feast of the Immaculate
Conception is included in the second section of the thesis because of its ties to the
themes of virginity and femininity within his writings. There are also two appendices:
the first is a survey of the extant manuscripts of Osbert's writings, and the second is
an edition of Osbert's unpublished Life of St Ethelbert from Gotha,
Forschungsbibliothek MS Memb. i. 8l
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An Archaeological Evaluation at Clare Hall, Cambridge
Full text linkThe C A U was commissioned to undertake an evaluation in the grounds of Clare Hall prior to the construction of new residential and study apartments. The assessment area, centred on TL 4391 5827 is situated in the south-west corner of the existing accommodation and garden complex covering an area of approximately 420 square metres. The work was carried out for Nicholas Ray Associates (Chartered Architects) on behalf of Clare Hall. Fieldwork, under the direction of the author, began on December 4th 1995 and was completed in two days
The Practice of Evaluation
Full text linkAs of the current issue, this column takes on a slightly different character-and we do not mean the additional author. Clare Rose will co-author the next two columns and then assume full responsibility during the year I will be serving as editor of the Quarterly. This issue also marks the beginning of a series of brief discussions of the most prominent and influential models in educational and social science evaluation practice
An ethnography of tourism and traditional Irish music in Doolin, Ireland
Full text linkThis thesis is an ethnographic study of the complex interplay between tourism and traditional Irish music based on fourteen months of fieldwork in Doolin, County Clare, Ireland between June 2002 and August 2003. The historical development of traditional Irish music and the localised tourist industry have become conjoined during the last three decades, and as a result the music and the idea of Doolin as a 'place' have become institutionalised and consolidated. This has further led to the development of a complex socioeconomic structure surrounding the music, its performance, and its commercialisation and consumption. The local social structure has also become complicated and internationalised. Specifically, the locale has seen a significant growth in the 'incomer' population, called 'blow-ins'. Blow-ins in this case have in fact become the inheritors and propagators of the local music scene, but this causes surprisingly little cognitive dissonance or tension between locals and incomers. This is despite the fact that the music is the raison d'etre of the local tourism industry. I propose that those incomers who successfully inherit and propagate the local music become assets to the cultural capital of the village, not a drain on it. Moreover, I suggest that the 'authenticity' of the music is not an ascribed quality but interdependently related to social status, seasonality, one’s relationship with the music, context, and phenomenologically inter subjective relations. By means of holistic anthropological research, this thesis attempts to refine our understanding of complex social relations in touristed destinations, the appropriation of musical 'traditions', and sharpen current anthropological theories surrounding the issues of 'authenticity' and globalisation
Vaginal rings for delivery of HIV microbicides
No full textR Karl Malcolm, Susan M Fetherston, Clare F McCoy, Peter Boyd, Ian MajorSchool of Pharmacy, Queen's University Belfast, Belfast, UKAbstract: Following the successful development of long-acting steroid-releasing vaginal ring devices for the treatment of menopausal symptoms and contraception, there is now considerable interest in applying similar devices to the controlled release of microbicides against HIV. In this review article, the vaginal ring concept is first considered within the wider context of the early advances in controlled-release technology, before describing the various types of ring device available today. The remainder of the article highlights the key developments in HIV microbicide-releasing vaginal rings, with a particular focus on the dapivirine ring that is presently in late-stage clinical testing.Keywords: controlled release, sustained release, antiretroviral, dapivirine, SILCS diaphragm, silicone elastomer, thermoplasti
Cryptic Species? Patterns of Maternal and Paternal Gene Flow in Eight Neotropical Bats
No full textPMCID: PMC3144194This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
The role of subjective social status in living well for carers of people with dementia: findings from the IDEAL programme
No full text‘Improving the experience of Dementia and Enhancing Active Life: living well with dementia. The IDEAL study’ was funded jointly by the Economic and Social Research Council (ESRC) and the National Institute for Health Research (NIHR) through grant ES/L001853/2. Investigators: L. Clare, I.R. Jones, C. Victor, J.V. Hindle, R.W. Jones, M. Knapp, M. Kopelman, R. Litherland, A. Martyr, F. Matthews, R.G. Morris, S.M. Nelis, J. Pickett, C. Quinn, J. Rusted, J. Thom. ESRC is part of UK Research and Innovation (UKRI). ‘Improving the experience of Dementia and Enhancing Active Life: a longitudinal perspective on living well with dementia. The IDEAL-2 study’ is funded by Alzheimer’s Society, grant number 348, AS-PR2-16-001. Investigators: L. Clare, I.R. Jones, C. Victor, C. Ballard, A. Hillman, J.V. Hindle, J. Hughes, R.W. Jones, M. Knapp, R. Litherland, A. Martyr, F. Matthews, R.G. Morris, S.M. Nelis, C. Quinn, J. Rusted. The views expressed are those of the author(s) and not necessarily those of the ESRC, UKRI, NIHR, the Department of Health and Social Care, the National Health Service, or Alzheimer’s Society. The support of ESRC, NIHR and Alzheimer’s Society is gratefully acknowledged
Formulation development of an ethylene vinyl acetate ring for sustained release of the experimental entry inhibitor DS003
No full textFormulation development of an ethylene vinyl acetate ring for sustained release of the experimental entry inhibitor DS003AuthorsDiarmaid J. Murphy, Clare F. McCoy, Yahya H. Dallal Bashi, Brid Devlin, Jeremy Nuttall, Wendy Blanda, R. Karl Malcolm, Peter BoydKeywordsethylene vinyl acetate, vaginal ring, DS003BackgroundDS003 is an entry inhibitor being developed as a vaginal microbicide for HIV prevention. We report the development and in vitro testing of ethylene vinyl acetate (EVA) vaginal rings containing DS003 in support of pharmacokinetic/efficacy testing in macaques. Methods Matrix-type EVA rings containing 40%w/w DS003 were manufactured on a Babyplast injection molding machine. Initial drug content was measured by dissolving ring segments in dichloromethane (72hr, 37˚C) and determining the DS003 concentrations using UV spectroscopy at 350nm. In vitro release testing was performed into 100mL sodium acetate buffer (pH 4.2) containing 2% w/w Kolliphor® HS15, with daily sampling (except weekends) and complete media replacement. Drug release was quantified by reverse-phase HPLC. Residual DS003 content was measured following efficacy testing in macaques.ResultsTwo ring batches were prepared with initial content values of 629±18 and 617±10 mg DS003 per ring, respectively. In vitro release testing showed linear cumulative release vs. time profiles indicating solubility-limiting release kinetics. The daily release rate (95% confidence interval) was 39.3 (37.8, 40.9) µg/day for rings tested immediately after manufacture, and 21.5 (20.7, 22.3) µg/day for rings tested after one month on storage at 4˚C, a release rate decline of ~45%. The mean total amount of DS003 released over 28 days in vitro was 1.1 mg for rings tested immediately and 0.66 mg for rings tested after one month storage. Mean residual content of rings returned from the macaque study was 628±16 and 629±32 mg DS003 per ring. Based on these values, it was not possible to determine definitively that DS003 was released from the rings in the macaque study.ConclusionIn vitro release of DS003 was solubility constrained, reflecting the poor water solubility of DS003. A substantial reduction in release rate was observed following ring storage, likely due to time-dependent crystallisation of DS003 and/or the EVA polymer. Initial and residual DS003 content measurements of rings following testing in macaques suggested that no or only very small quantities of DS003 are released in vivo. <br/
Formulation development of an ethylene vinyl acetate ring for sustained release of the experimental entry inhibitor DS003
No full textFormulation development of an ethylene vinyl acetate ring for sustained release of the experimental entry inhibitor DS003AuthorsDiarmaid J. Murphy, Clare F. McCoy, Yahya H. Dallal Bashi, Brid Devlin, Jeremy Nuttall, Wendy Blanda, R. Karl Malcolm, Peter BoydKeywordsethylene vinyl acetate, vaginal ring, DS003BackgroundDS003 is an entry inhibitor being developed as a vaginal microbicide for HIV prevention. We report the development and in vitro testing of ethylene vinyl acetate (EVA) vaginal rings containing DS003 in support of pharmacokinetic/efficacy testing in macaques. Methods Matrix-type EVA rings containing 40%w/w DS003 were manufactured on a Babyplast injection molding machine. Initial drug content was measured by dissolving ring segments in dichloromethane (72hr, 37˚C) and determining the DS003 concentrations using UV spectroscopy at 350nm. In vitro release testing was performed into 100mL sodium acetate buffer (pH 4.2) containing 2% w/w Kolliphor® HS15, with daily sampling (except weekends) and complete media replacement. Drug release was quantified by reverse-phase HPLC. Residual DS003 content was measured following efficacy testing in macaques.ResultsTwo ring batches were prepared with initial content values of 629±18 and 617±10 mg DS003 per ring, respectively. In vitro release testing showed linear cumulative release vs. time profiles indicating solubility-limiting release kinetics. The daily release rate (95% confidence interval) was 39.3 (37.8, 40.9) µg/day for rings tested immediately after manufacture, and 21.5 (20.7, 22.3) µg/day for rings tested after one month on storage at 4˚C, a release rate decline of ~45%. The mean total amount of DS003 released over 28 days in vitro was 1.1 mg for rings tested immediately and 0.66 mg for rings tested after one month storage. Mean residual content of rings returned from the macaque study was 628±16 and 629±32 mg DS003 per ring. Based on these values, it was not possible to determine definitively that DS003 was released from the rings in the macaque study.ConclusionIn vitro release of DS003 was solubility constrained, reflecting the poor water solubility of DS003. A substantial reduction in release rate was observed following ring storage, likely due to time-dependent crystallisation of DS003 and/or the EVA polymer. Initial and residual DS003 content measurements of rings following testing in macaques suggested that no or only very small quantities of DS003 are released in vivo. <br/
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