11,918 research outputs found
Luciferase values from individual experiments described in "Rhinovirus 2A is the predominant protease responsible for instigating the early block to gene expression encountered in infected cells"
No full textAn excel spreadsheet with details of individual luciferase values obtained in experiments undertaken for the manuscript "Rhinovirus 2A is the predominant protease responsible for instigating the early block to gene expression encountered in infected cells". Data contained within in individual excel tabs are matched to the figures as they are presented in the manuscript.</span
Interview with Nicholas Christopher, author of Somewhere in the Night: Film Noir and the American City
No full textInterview with Nicholas Christopher, author of Somewhere in the Night: Film Noir and the American Cit
Return International Migration and Geographical Inequality: The Case of Egypt
No full textThis paper explores entrepreneurship amongst return migrants, how their business locations and characteristics differ from other businesses, and the implications for rural–urban inequality. First, we examine, amongst returnees, the determinants of investment in a project/enterprise. Secondly, we study the impact of return migration on the characteristics and nature of non-farm small enterprises using a sample of return migrants and non-migrant owners of enterprises. Our data indicate that although the share of return migrants originating in urban areas is almost equal to those from rural areas, and that migrants tend to return to their origin region, urban areas benefit more than rural areas from international savings. The empirical evidence suggests that overseas savings, and the duration of stay overseas, have positive separate effects on the probability of investing in a project/enterprise amongst returnees. Furthermore, returnees of urban origin are more likely than rural ones to invest in a non-farm enterprise. The findings also indicate that there is a regional bias in the location of firms and jobs created by returnees compared with non-migrants, in favour of the capital city. Thus, overall, the results support a positive impact of return migration on enterprise investment in urban areas driven by the preference of returnees to invest in urban areas. <br/
The predominant species of nonstructural protein 4B in hepatitis C virus-replicating cells is not palmitoylated
No full textHepatitis C virus (HCV) represents a significant global health burden. Viral replication is thought to occur in close association with remodelled host cell membranes with non-structural protein 4B (NS4B) being a key player in this process. NS4B is a poorly characterized integral membrane protein, which has been reported to be palmitoylated at its carboxy-terminal end. In order to extend this observation and to establish a functional role for NS4B palmitolylation, we sought to determine the status of this post-translational modification when the protein was expressed as part of a functional viral replicase. We performed direct metabolic labelling and polyethylene glycol-maleimide palmitoylation reporter assays on NS4B expressed in cells containing subgenomic replicons and infectious viral RNA. In a vaccinia virus-based expression system NS4B palmitoylation was detected in a genotype-dependent manner. However, in spite of the high sensitivity of the methods used, no NS4B palmitoylation was found in physiologically more relevant systems. Thus, NS4B palmitoylation is most likely dispensable for HCV RNA replicatio
Matt Christopher Papers - Accession 1309
No full textThe collection includes letters written by the children’s book author, Matt Christopher, to his son, Marty Christopher. Many of the letters also contain newspaper articles of interest to Matt Christopher, which deal with local sports teams, his writing career, his participation in an exhibition baseball game against the New York Giants in 1938, and other of general interest. Most of the letters are personal in nature, however, a majority of the letters delve into Matt Christopher’s writing career, personal interests, the author’s health, as well as his family life.https://digitalcommons.winthrop.edu/manuscriptcollection_findingaids/2649/thumbnail.jp
ICAM-1 can play a major role in mediating P. falciparum adhesion to endothelium under flow
No full textWe have investigated the importance of adhesion molecule co-operation in mediating Plasmodium falciparum adhesion to endothelial cells under flow conditions. Using three laboratory parasite lines and a patient isolate which differ in their ICAM-1 and CD36-binding avidity, we found that blockade of ICAM-1 and CD36 separately reduced IRBC adhesion by up to 95 and 50%, respectively. These results confirm previous data showing that ICAM-1 and CD36 synergize to mediate adhesion, but differ in demonstrating that without ICAM-1, binding under flow conditions is severely impaired. Thus, in this system, ICAM-1 is critical for P. falciparum adhesion to activated endothelium and once bound, synergy with CD36 mediates the majority (?98%) of adhesion. <br/
Matt Christopher Papers - Accession 1221
No full textMatt Christopher (1917-1997) was a prolific author of children’s books having written over 100 books as well as over 300 short stories, articles, poems, and screenplays. Most of his writings dealt with sports themes, but he also wrote fantasy and mystery themed stories as well. The Matt Christopher Papers consist of both published and unpublished manuscripts, articles, and short stories. Also included are personal and business correspondence, biographical information, scrapbooks, photographs, and memorabilia.https://digitalcommons.winthrop.edu/manuscriptcollection_findingaids/1976/thumbnail.jp
Dr. Christopher von Rueden – Faculty Author Interview
No full textDr. Christopher von Rueden, an anthropologist and Assistant Professor in the Jepson School of Leadership Studies, discusses a recent article entitled, “Men’s status and reproductive success in 33 non-industrial societies: Effects of subsistence, marriage system, and reproductive strategy,” which he co-authored with Dr. Adrian Jaeggi, an anthropologist at Emory University. Their findings were recently published in the journal, Proceedings of the National Academy of Sciences
QUB HRC Response to the UK Government Consultation on Human Rights Act Reform
No full textThis document has been submitted on behalf of the Human Rights Centre of the School of Law at Queen’s University Belfast in response to the UK Ministry of Justice's consultation on whether and (if so) how to reform the Human Rights Act 1998. It was drafted jointly by Prof Brice Dickson, Dr Conor McCormick, Prof Louise Mallinder and Prof Christopher McCrudden. The response was submitted to the UK Government on 8 March 2022 and published for public consumption immediately thereafter
QUB HRC Response to the UK Government Consultation on Human Rights Act Reform
No full textThis document has been submitted on behalf of the Human Rights Centre of the School of Law at Queen’s University Belfast in response to the UK Ministry of Justice's consultation on whether and (if so) how to reform the Human Rights Act 1998. It was drafted jointly by Prof Brice Dickson, Dr Conor McCormick, Prof Louise Mallinder and Prof Christopher McCrudden. The response was submitted to the UK Government on 8 March 2022 and published for public consumption immediately thereafter
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