2,197 research outputs found
Demanding Reflexivity: Lazy Ozzie and Other Stories.
No full textOne of the orthodoxies of supervising research within the framework of a radical approach to adult education is that you 'demand' a reflexive approach. That is, you ask that the
researcher adopt a paradigm of research that does not pretend scientific validity, one that recognises that the researcher's own assumptions, experiences and subjectivity constitute the major source of colour in the canvas he or she is painting. Reflexivity in research involves developing 'critical literacy' by not only exploring the external world but also turning the research gaze both on the medium of research and on the researcher him/herself (Davies et al., 2006, p. 88). Researchers therefore, as well as being concerned with doing research, are also concerned with their own story as researchers and with the
story of the research
Author response
No full textPerforin-2 (MPEG1) is an effector of the innate immune system that limits the proliferation and spread of medically relevant Gram-negative, -positive, and acid fast bacteria. We show here that a cullin-RING E3 ubiquitin ligase (CRL) complex containing cullin-1 and βTrCP monoubiquitylates Perforin-2 in response to pathogen associated molecular patterns such as LPS. Ubiquitylation triggers a rapid redistribution of Perforin-2 and is essential for its bactericidal activity. Enteric pathogens such as
Yersinia pseudotuberculosis
and enteropathogenic
Escherichia coli
disarm host cells by injecting cell cycle inhibiting factors (Cifs) into mammalian cells to deamidate the ubiquitin-like protein NEDD8. Because CRL activity is dependent upon NEDD8, Cif blocks ubiquitin dependent trafficking of Perforin-2 and thus, its bactericidal activity. Collectively, these studies further underscore the biological significance of Perforin-2 and elucidate critical molecular events that culminate in Perforin-2-dependent killing of both intracellular and extracellular, cell-adherent bacteria.
DOI:
http://dx.doi.org/10.7554/eLife.06505.001
A wide range of bacteria and other microbes can infect animals and cause disease. Throughout evolution, these microbes and their hosts have been fighting never ending arms races in which the microbes deploy ever more elaborate weapons, while the hosts adapt to defend themselves. An animal's first line of defense is provided by its ‘innate’ immune system. This system is activated by the general features of microbial cells; for example, the molecules that make up the walls surrounding most bacteria. Microbes must defeat the innate immune system in order to cause disease, and ultimately to spread from one host to the next.
One component of innate immunity is a protein called Perforin-2 that is present in most, if not all, animal cells. This protein forms pores on bacterial cells, causing them to split open and die. However, it was not clear how Perforin-2 is switched on and what, if anything, bacteria do to counteract it. To address these questions, McCormack et al. infected human and mice cells with bacteria that cause serious diseases of the digestive tract.
The experiments show that when animal cells detect bacteria, or merely a fragment of their cell wall, a specific group of proteins, called the CRL complex, attaches a molecule called ubiquitin to Perforin-2. Ubiquitin works much like the shipping label of a package, enabling the efficient targeting of Perforin-2 to the invading bacteria. McCormack et al. also show that some bacteria use a protein called a cell cycle inhibiting factor (or Cif for short) to inhibit the CRL complex. This blocks the ubiquitin labeling of Perforin-2, which renders it a useless weapon that can no longer be directed towards bacteria.
Mice that are infected with a bacterium called
Yersinia pseudotuberculosis
become seriously unwell and often die. However, McCormack et al. found that mice infected with mutant
Y. pseudotuberculosis
that lacked Cif remained healthy. Also, mice that lacked Perforin-2 are highly susceptible to infectious diseases. McCormack et al.'s findings reveal how Perforin-2 is activated during the innate immune response and how some bacteria can defeat this pivotal defense. In the current age of antibiotic resistant bacteria, these studies may spur the development of new drugs that restore or increase the activity of Perforin-2.
DOI:
http://dx.doi.org/10.7554/eLife.06505.00
(PDF) Ryan Tanner's Smart Solar Box Review
No full text<p><strong>Product Name:</strong> Smart Solar Box: Smart Power 4 All</p>
<p><strong>Creator Name:</strong> Ryan Tanner</p>
<p><strong>Bonus:</strong> Yes</p>
<p><strong><a href="http://bit.ly/smartpowerforall">Official Website: Click Here</a></strong></p>
<p><a href="http://bit.ly/smartpowerforall"><em><strong>Smart Solar Box</strong></em></a> is an online system designed to teach you how to create an endless source of self-sustaining energy right here, right now. There’s no need for you to spend a fortune on materials or break your back trying to lift a massive generator. No, you don’t have to go back to school to get an engineering degree nor do you need to have any special skills because everything is provided to you in this step-by-step guide. And I know what you’re thinking – solar panels are expensive. They certainly can be, but they aren’t when you have a book that reveals the solar industry secrets to creating your own solar power station, and one that fits in a toolbox. So, if you’re tired of getting robbed by your electricity bills, finding yourself in the pitch dark when the power suddenly goes out or just want to have your own energy source, you’ve come to the right place. It’s time to learn how to build a Smart Solar Box.</p>
<p><strong>About the Smart Solar Box Program</strong></p>
<p>If you’re ready to cut your energy bills significantly, it’s time to create your own endless source of self-sustained energy. <a href="http://bit.ly/smartpowerforall"><strong>Smart Solar Box</strong></a> is an online program that provides you with the exact steps to doing just that. This system is more of an instruction manual-tutorial than it is a program, as it doesn’t have all the nonsense that many other “programs” provide. Instead, it gets right down to business – building your own solar power plant in a toolbox.</p>
<p><strong>When you start the program, you receive:</strong></p>
<ul>
<li>The Main eBook</li>
<li>3 Video Tutorials on Building the Box</li>
<li>10 Easy Steps to Build Your Solar Panels</li>
<li>Build Your Own Wind Generator</li>
</ul>
<p><strong>The Table of Contents for “Smart Solar Box” Guide.</strong></p>
<p>The main eBook is where you’ll find the step-by-step instructions needed to create the Smart Solar Box. It covers everything from the tools and electrical components you need, where to get each of them, and of course, what to do when you have all the materials needed. But don’t let this deter you because you don’t need to be a handyman (or woman), nor do you even have to know what a wrench is. The program breaks it down so meticulously that even the most unskilled (ahem, myself) people can make their own energy. Oh, but you aren’t just learning how to make an energy box that sparks a little bit of juice. This toolbox solar system that you learn how to build is strong enough to power up an entire cabin, garage, refrigerator – you name it. You can use it for pretty much everything, and it’s so lightweight and portable, making it easy to do just that.</p>
<p>Now, you also receive 3 video tutorials which are pretty much the main eBook broken down into videos. So, if you’re more of a visual person, you’ll definitely like this addition. Just click play and follow along.</p>
<p>You also receive 10 Easy Steps to Build Your Solar Panels and Build Your Own Wind Generator which have nothing to do with your Smart Solar Box. However, once you start creating your own energy source (and saving a ton of money from doing so), you’ll want to dive even deeper into it. With these bonuses, you can do just that.</p>
<p>The best part? You don’t have to wait for shipping to get started. The guide is entirely online. So, you just download the content onto your desktop, tablet, smartphone or laptop and start following through the steps. I recommend having it on whatever device is going to be in the space where you intend on building your box, whether it’s your office with a desktop or in the man cave or backyard where you’ll need a tablet or smartphone.</p>
<p><strong>About the Author of Smart Solar Box</strong></p>
<p>What may surprise you is that this solar box wasn’t created by some big tech engineer. Instead, the creator, Ryan Tanner, is just like you and I. After seeing his father creating and using his own energy source while living in a cabin in Wisconsin, he sought out to do the same in his home. And well, here we are!</p>
<p><strong>Brief Summary of the Smart Solar Box Guide</strong></p>
<p>To help you have a better idea of the steps needed to build your own solar power plant in a toolbox, here is a sneak peek at the sections that you’ll be working through with the Smart Solar Box program:</p>
<p><strong>Chapter 1: Introduction</strong></p>
<ul>
<li>Basic Principle Regarding Solar Energy</li>
<li>General Technical Regards</li>
</ul>
<p><strong>Chapter 2: Tools and Components</strong></p>
<ul>
<li>Tools</li>
<li>Components (electronic parts needed)</li>
</ul>
<p><strong>Chapter 3: Building The Box</strong></p>
<ul>
<li>Assembling Solar Panels</li>
<li>Preparing the Box</li>
<li>Wiring Process</li>
<li>Recap – Short Review of the Process</li>
</ul>
<p><strong>Chapter 4: Testing the Device</strong></p>
<p><strong>Chapter 5: List of Places Where You Can By the Components</strong></p>
<p>Again, you do have three video tutorials that cover all of this as well. So, whether you prefer to read instructions or thrive on visual instructions, there’s an option for you.</p>
<p>Add on the 10 Easy Steps to Build Your Solar Panels and Build Your Own Wind Generator bonus tutorials you receive, and you’re pretty much ready for anything that comes your way.</p>
<p>You also receive extra-extra bonus programs at no extra charge to you. Some apply to this energy-saving endeavor you’re embarking on and others, not so much. But they’re free. So, might as well download them while you’re at it. They are:</p>
<ul>
<li>Personal Home Security</li>
<li>Martial Arts for Seniors</li>
<li>Backyard Bio Gardening</li>
<li>Going Green 101</li>
<li>Saving Energy in Your Home</li>
</ul>
<p><strong>The Verdict</strong></p>
<p>Put it all together, and you get a solar power plant that is affordable, portable and small enough that it fits in a toolbox, plus 7 bonus programs at absolutely no extra charge to you, and a 60 Day Money Back Guarantee to figure out whether or not you’re serious about saving money. Certainly, once you see how easy it is to do just that, you’d be crazy to opt to pay for city-electricity when you can have your own brewing in the sun. Oh, which leaves me to one more thing. <a href="http://bit.ly/smartpowerforall"><strong>The Smart Solar Box</strong></a> is designed so well that even the cloudiest of days provide enough power for you to use this box as your primary source of energy, as a generator, or as a backup in case of an emergency.</p>
<p>So, do you continue to pay utterly ridiculous prices for unreliable electricity or do you take matters into your own hands and make your own? The choice is yours!</p
Demonstration of a healthy young adult walking under the conditions tested in Experiment 2.
No full textAuthor name: Ryan T. Roemmich, PhD. Videographer: Jan Stenum, PhD. Participant: Ryan T. Roemmich, PhD. Length: 1:51. Size: 77,700 MB. (MP4)</p
Corrigendum: Expression analysis of candidate genes regulating successional tooth formation in the human embryo
No full textA corrigendum on
Expression analysis of candidate genes regulating successional tooth formation in the human embryo
by Olley, R., Xavier, G. M., Seppala, M., Volponi, A. A., Geoghegan, F., Sharpe, P. T., et al. (2014). Front. Physiol. 5:445. doi: 10.3389/fphys.2014.00445
The author Ryan Olley should appear as Olley RC on the published article “Expression analysis of candidate genes regulating successional tooth formation in the human embryo.”
The original article was updated
The Nones: Where They Came From, Who They Are, and Where They Are Going
No full textIn The Nones: Where They Came From, Who They Are, and Where They Are Going, Ryan P. Burge details a comprehensive picture of an increasingly significant group--Americans who say they have no religious affiliation.
Author Biohttps://thekeep.eiu.edu/authors_at_eiu_books/1004/thumbnail.jp
Quasi-cyclic Generalized LDPC codes with low error floors
No full textIn this paper, a novel methodology for designing structured generalized LDPC (G-LDPC) codes is presented. The proposed design results in quasi-cyclic G-LDPC codes for which efficient encoding is feasible through shift-register-based circuits. The structure imposed on the bipartite graphs, together with the choice of simple component codes, leads to a class of codes suitable for fast iterative decoding. A pragmatic approach to the construction of G-LDPC codes is proposed. The approach is based on the substitution of check nodes in the protograph of a low-density parity-check code with stronger nodes based, for instance, on Hamming codes. Such a design approach, which we call LDPC code doping, leads to low-rate quasi-cyclic G-LDPC codes with excellent performance in both the error floor and waterfall regions on the additive white Gaussian noise channel
Patterns of Prejudice Paper Submission-Ryan Buesnel.pdf
No full textAbstract: ‘National Socialist Black Metal’ (NSBM) emerged in the early 1990s as a subsidiary genre of the broader Black Metal movement. NSBM is distinguished by its thematic content, which promotes Aryan superiority and an anti-Capitalist stance. This paper explores the history of the early NSBM movement through an analysis of the bands Graveland (Poland) and Absurd (Germany), who have both played vital roles in the establishment of the NSBM genre. The author highlights the resilience of National Socialist ideology within music subcultures and concludes with observations about the diversification far-right extremism within Heavy Metal. </p
Learning from the learners' experience: e-Learning@greenwich post-conference reflections
No full textThis publication comprises papers from presenters who, having made a conference presentation, were invited to author an academic paper about their work
Internal consistency of distance measures for each author.
No full textInternal consistency of distance measures for each author.</p
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