561 research outputs found
2022 IEEE Long Island Systems, Applications and Technology Conference (LISAT 2022)
No full textUma Balaji (with Patrick Evans, Ryan Avery, Maxwell Malcy, and Maverick Ruiz) is a contributing author, Multipurpose Solar Charging Station.https://digitalcommons.fairfield.edu/engineering-books/1079/thumbnail.jp
The Sarmatian Review, Vol., 34, No. 3
No full textIn this issue: Sarmatian Review Data -- Bronislaw M.J. Kamiski, Reflections on the Ukrainian Maydan -- Sally Boss, Germany's Wild East: Constructing Poland as Colonial Space (review) -- Ewa Wampuszyc, Narrating Migration (review) -- Bozena Karwowska, Reprezentacje Europy w prozie polskiej (review) -- Maciej B. Stepie, The Lost German East (review) -- Farrah Madanay, The Forgotten Holocaust (review) -- MORE BOOKS -- Richard J. Hunter, Jr. and Leo V. Ryan, C.S.V., A Report from Poland on the Economy -- Translating Cyprian Kamil Norwid: Patrick Corness and Agata Brajerska-Mazur -- Chesterton Review anniversary -- Thank You Note -- About the Author
Lindsay Crawford's 'Impossible Demand'? The Southern Irish Dimension of the Independent Orange Project
No full textThe Magheramorne Manifesto of the Independent Orange Order has been hailed as a bold attempt from an unlikely quarter to positively address the sectarian divisions and regional polarisation of early 20th century Ireland. But the Order's leading light, Lindsay Crawford, has also been indicted for formulating an 'empty radicalism' which demanded changes in the field of education that it was impossible for the Catholic community to accept. This working paper reassesses Crawford's ideological project in the light of hitherto underused sources of evidence. It highlights convergence between Crawford's thinking and that of 'Irish Ireland' activists in movements such as the Gaelic League and Sinn Fein. It argues that heterodox educational views were prevalent to a significant extent among the Irish Irelanders to whom Crawford looked for a positive response to his national regeneration project. The case is also made that, in the absence of unanimous acceptance of their desirability among lay Catholics, the support of Protestants - and particularly that of Crawford's fellow Irish Anglicans - provided existing school management arrangements with a vital source of sustenance.
An extracellular vesicle therapeutic attenuates inflammation and damage in a Rhesus monkey model of cortical injury
No full text2026Cortical injury in the aged brain leads to acute cell death and inflammation, which trigger chronic secondary neurodegeneration resulting in long-term cognitive and motor deficits. There are no U.S. Food and Drug Administration (FDA)-approved therapeutics that address cortical injury pathologies. Recent studies in rodents and pigs have identified mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) as a promising therapeutic for cortical injury, reducing inflammation and enhancing neuroprotection. We have used MSC-EV treatment in a Rhesus monkey model of primary motor cortex injury which impairs fine motor function of the hand. When treated with MSC-EVs 24 hours and 2 weeks following injury, monkeys recovered pre-injury levels of function within the first 3-5 weeks post-injury, while untreated monkeys had an incomplete recovery. Analysis of brain tissue harvested 16 weeks post-injury found that MSC-EVs promoted homeostatic microglial phenotypes, neuronal plasticity, and myelin maintenance. These findings demonstrated the efficacy of MSC-EVs, but at which stage of recovery MSC-EVs acted remains unclear. Here, we assessed the progression of biomarkers of inflammation and damage across recovery and examined the brain at an earlier timepoint, 6-weeks post injury. The current study addresses the hypothesis that in the early stages of recovery, MSC-EVs attenuate the inflammatory response and reduce tissue damage. We first assessed how MSC-EVs affect the temporal progression of the inflammatory response, using a multiplex protein quantification platform (Olink) on plasma and cerebrospinal fluid (CSF) collected across recovery (pre-injury, 24 hours, 2-, 4-, and 6-weeks post-injury). MSC-EV treatment decreased inflammatory proteins in plasma 2 weeks following injury, with reductions in pro-inflammatory proteins persisting throughout recovery. Assessments of brain tissue revealed that at 6-weeks post-injury, MSC-EV treatment increased homeostatic microglial phenotypes, supporting an early shift towards an anti-inflammatory environment. Next, we assessed if MSC-EV treatment affected the progression, clearance and resolution of neurodegeneration across recovery. MSC-EV treatment was associated with increased levels of neurofilament-light (NF-L) chain, an axonal damage biomarker, in CSF after, coupled with increased neuronal structural integrity markers (MAP2) in brain tissue, suggesting an MSC-EV-mediated clearance of neuronal debris. MSC-EV treatment was also associated with a decrease in Galectin-3, presumably phagocytically active, microglia. Finally, to identify potential mechanisms of action, we performed lipidomic and metabolomic analyses of MSC-EV contents. We found sex-differences in MSC-EV cargo, female EVs were enriched in sugars, while male EVs were enriched in nitrogen-rich compounds. MSC-EVs cargo were related to cellular energy metabolism, supporting its potential role in metabolic efficiency in aging and after injury. Overall, these findings present a role of MSC-EVs in the early resolution of inflammation following cortical injury, creating a neuroprotective environment that supports recovery of motor function.2027-01-23T00:00:00
Do We Still Need The Eighteenth Century?
No full textThe 18th century was a time of great change, both philosophically and politically. Yet many people reject its ideals, calling out the hypocrisy of Thomas Jefferson and the oppression that comes from being committed to Truth rather than the downtrodden. On this episode of Why?, we take another look at this exciting period of time and ask whether the enlightenment and its philosophers still have a place in today’s intellectual and political debate.
Ryan Patrick Hanley is an Associate Professor of Political Science at Marquette University. His research in the history of political philosophy focuses on the Scottish Enlightenment. He is the author of Adam Smith and the Character of Virtue (Cambridge University Press, 2009), and co-editor, with Darrin M. McMahon, of The Enlightenment: Critical Concepts in History, 5 vols. (Routledge, 2010). In addition, Professor Hanley is the editor of the Penguin Classics edition of Adam Smith’s Theory of Moral Sentiments (Penguin, 2010), the editor of the forthcoming Adam Smith: A Princeton Guide (Princeton University Press), and current President of the International Adam Smith Society. His recent articles have appeared or are forthcoming in American Political Science Review, American Journal of Political Science, Political Theory, European Journal of Political Theory, Review of Politics, History of Political Thought and Journal of the History of Philosophy, among others. He is also the recipient of Fellowships from the Mellon Foundation, the National Endowment for the Humanities, and the Arête Initiative, and is currently at work on a study of love and wisdom in Enlightenment moral and political philosophy.https://commons.und.edu/why-radio-archive/1045/thumbnail.jp
Cycling on the Verge? Exploring the Place of Utility Cycling in Contemporary New Zealand Transport Policy
No full textEfforts to increase cycling as a mode of transport (utility cycling) occur at central, regional and local levels of government through a range of supportive strategies, research, and guidelines. Despite these efforts, utility cycling levels in New Zealand have remained persistently low. This thesis examines the apparent disparity between policy intent and policy result, using a discourse analytical approach. It examines how cycling is positioned in contemporary New Zealand transport policy documents, and explores whose priorities are shaping transport policy with what implications for utility cycling.
This study uses a critical discourse analysis (CDA) approach to analyse the land transport documents from across the institutions of government. The CDA approach, grounded in the work of van Dijk and Fairclough, draws on ideas from the interpretive tradition of discourse analysis, inspired by Foucault’s concepts of knowledge and power. This approach reveals the position of utility cycling by exposing the framing, dominant discourses, and discursive strategies that privilege certain transport objectives and activities over others.
The findings show transport is promoted almost exclusively by central government as an activity to facilitate economic growth and efficiency, despite its potential (and actual) impacts on health and well-being, social justice, and environmental sustainability. The discursive practices of the government privilege private motor vehicle use, helping to both legitimate and maintain that privilege at all levels of government, while positioning utility cycling as a marginalised mode of transport.
This thesis contributes to scholarship on utility cycling and land transport policy in New Zealand by identifying how the discursive strategies of government control the position of utility cycling in New Zealand. This study underscores the need for a central government-led, long-term strategic vision for a genuinely integrated, multi-modal transport system, in order for the benefits of utility cycling to be fully maximised
Artificial empathy : using vector space modeling and mixed scope alignment to infer emotional states of characters in stories
No full textThesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2016.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (pages 61-62).Emotions greatly influence human cognition. Therefore, if we are to develop artificially intelligent programs that work closely with humans, we must ensure that they are capable of empathy. In an effort to realize the goal of emotionally aware programs, I created a multi-corpus informed vector space model to determine the emotions evoked by individual terms. I then combined that information with the semantic parse trees produced by the Genesis Story Understanding System to ascertain the emotions evoked by a single sentence. Additionally, I used the story aligner within Genesis to determine the emotions evoked by stories described over multiple sentences. My program can infer characters' emotional states based on their descriptions, the situations they are involved in, and the actions they perform. For instance, it infers that Alice is joyful from the sentence "Alice wins an award" and that James is probably experiencing sadness from the sentence "James is lonely." Additionally, the program can identify that Austin is likely surprised if "Austin has to take a test" and "Austin doesn't know about the test."by Ryan Cherian Alexander.M. Eng
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No full textRepublican memorial, Bombay Street, Clonard, West Belfast, 2020. 'Gairdín Cuimhneacháin Mhairtirigh Chluain Árd Clonard Martyrs Memorial Garden; crests of four provinces of Ireland, Republican sypbol of phoenix rising; left section: plaque: 'This Plaque Is Dedicated To The People Of The Greater Clonard Who Have Resisted And Still Resist The Occupation Of Our Country By Britain. We Acknowledge With Pride The Sacrifices They Made Throughout Every Decade. Their Names Would Be Too Numerous To Mention, And Their Deeds Of Bravery And Resistance Are Un-Equalled In The History Of Our Struggle. We, The Republican Ex-Prisoners Of The Greater Clonard, Salute You, And Your Reward Will Only Be A United Ireland'; small plaque underneath: 'Renee Marie Margaret Madaline Rosthbotham', and smaller plaque underneath: 'Dedicated to the memory of Renee and Marie Rosbotham'; plaque: 'Greater Clonard Memorial Garden Committee This plaque is dedicated to the memory of members and friends who, over the years, assisted in the completion and upkeep of our memorial garden. Their dedication and comradeship is sorely missed Tommy Haddock Rita Canavan Bernie Tohill'; central section: Celtic Cross, Clonard Martyrs I gCuimhme na Mairbh Dílis' [In memory of the faithful departed]; plaque against rear wall: military figure, reverse arms; ‘I measc laochra na nGaedheal go rabh said’ [They were among the heroes of the Gaels] Clonard Martyrs C Coy 2nd Battalion Belfast Brigade Oglaigh na h-Eireann Roll Of Honour Vol. Sean Gaynor 26th Sept. 1920 " Dan Duffin 23rd April 1921 " Pat Duffin 23rd April 1921 " Seán McCartney 8th May 1921 " Gerard O'Callaghan 31st Aug. 1942 " Tom Williams 2nd Sept. 1942 " Seamus Burns 12th Feb. 1944 Fian. Gerard McAuley 15th Aug. 1969 Vol. Peter Blake 27th Oct. 1970 " Seamus Simpson 11th Aug. 1971 " Danny O'Neill 7th Jan. 1972 " Gerard Crossan 9th March 1972 " John Johnston 9th March 1972 " Tony Lewis 9th March 1972 " Tom McCann 9th March 1972 Fian. Seán O'Riordan 23rd March 1972 Vol. Joe McKenna 17th May 1973 " Martin McKenna 23rd Oct. 1979 Vol. Liam Hannaway 2nd Feb. 1981 " Brian Dempsey 25th June 1986 " Jim McKernan 14th Sept. 1986 " Finbarr McKenna 2nd May 1987 " Dan McCann 6th March 1988 " Seán Savage 6th March 1988 " Proinsias Mac Airt 8th Jan. 1992 We Also Remember All The Civilians From The Clonard Area Who Were Killed By Crown Forces And Loyalist Murder Gangs’; 'Go ndeana Dia trócaire ar a n-anamacha [May God have mercy on their souls] Civilians Murdered By Loyalists And British Forces During The Course of The Conflict Francis Finnegan ~ 21-7-20 (40) Br. Michael Morgan ~ 22-7-20 (28) Bernard Devlin ~22-7-20 (18) John J. Giles ~ 22-7-20 (19) Alexander McGoran ~ 22-7-20 (25) Thomas Robinson ~ 22-7-20 (33) John Downey ~ 22-7-20 (20) John McCartney ~ 25-7-20 (32) John McFadden ~ 26-7-20 (40) Kathleen Collins ~ 13-6-21 (18) Alexander Hamilton ~ 10-7-21 (21) Henry Mulholland ~ 10-7-21 (49) Seamus Ledlie ~ 11-7-21 (19) Anne Hobbs ~ 18-7-21 (5) William Tennyson ~ 13-2-22 (23) Frank McCoy ~ 14-2-22 (26) James Thompson ~ 7-2-22 (30) Mary Wilson ~ 15-3-22 (4) Patrick Devlin ~ 18-4-22 (28) John McMenemy ~ 7-6-22 (50) Patrick Doyle ~ 13-9-72 (19) John Scullion ~ 11-6-66 (28) Harry Thornton ~ 7-8-71 (28) Maura Meenan ~ 23-10-71 (31) James McCallum ~ 17-12-71 (31) Patrick Magee ~ 17-4-72 (20) Gerald Mccrea ~ 2-7-72 (27) Anthony Davidson ~ 22-7-72 (27) Rose McCartney ~ 22-7-72 (27) Patrick O'Neill ~ 22-7-72 (26) Hugh Connolly ~ 7-2-73 (38) Michael Coleman ~ 18-2-73 (30) Edward Coogan ~ 19-5-73 (39) Patrick Brady ~ 2-2-73 (28) Anthony Mitchell ~ 12-6-73 (38) Patrick Bracken ~ 6-7-73 (28) Eric Morgan ~ 21-10-74 (27) Michael Loghran ~ 21-10-74 (18) Michael Hanratty ~ 22-11-74 (44) Charles Irvine ~ 13-7-75 (16) Francis Mallon ~ 9-4-76 (51) Daniel Carson ~ 1-9-73 (29) Frank Moyna ~ 25-1-77 (68) Kevin Dyer ~ 17-6-78 (26) Francis Sullivan ~ 20-6-79 (34) Sean Cairns ~ 31-12-79 (19) Brendan McLaughlin ~ 29-2-80 (35) Carl McParland ~ 2-4-80 (21) Nora McCabe ~ 9-7-81 (33) Dominic O'Connor ~ 25-6-87 (29) Patrick Hamill ~9-9-87 (29) Gerard Slane ~ 23-9-88 (26) Jim Mccartney ~ 10-3-89 (39) Eamon Quinn ~ 11-3-90 (32) John Judge ~ 31-7-91 (34) Seamus Sullivan ~ 3-9-91 (24) Philomena Hanna ~ 28-4-92 (26) James Cameron ~ 26-10-93 (54) Arthur McDonnell ~ 1-2-94 (35) John Hemsworth ~ 1-2-98 (39) Michael Duggan ~ 12-11-75 (32) Michael Donnelly ~ 9-8-80 (21) Dominic Marron ~ 17-8-04 (39)'; mural against Peace Line (above): pictures of IRA volunteers (commemorated below) against burned out Bombay Street, with Phoenix 'C' (Clonard, 'Dedicated to the memory of local Republican Billy Davidson'; right section: plaque: 'In loving memory of the deceased Republican prisoners from the Greater Clonard area 1916 Peter Burns (Snr) Joseph Robinson Henry Dobbyn Seamus Dobbyn Sean Kelly Sean Neeson Bernard McMakin Harry Loughran Seamus Robinson 1920's Leo McGuinne James O'Doherty Patrick O'Doherty Edward Kane Joseph Allen Michael Ryan Seamus McKenna Patsy Dougan James Dougan Thomas Fox Pat Smyth Pat Magill Seomarle MacCanna Joseph Connolly Robert Boyle Patrick Boyle Thomas Watson John Malone Joseph McGuinne James Tanney Art O'Donnell Thomas McMorrow J.Kearney J.Savage Hugh Corvin David Matthews J.McNamara Charles McCartney Patrick Campbell Patrick Malone Edward Murphy Sean McArdle Patrick McArdle Henry McArdle James Ryan Philip Ryan Andy Jones James Cunningham Con O'Neill Leo O'Neill Alfred Downey James McCarthy John McCarthy William Hamilton Tommy Hunter John McNamee Joseph McAtamney John Kearney Patrick McCann John Cooper John O'Loan' plaque: '1930′s/40′s Brian Burns Peter Burns Anthony Lavey John Joe McKee William Mooney Bobby Dempsey P.J.Grace John Maguire John Monaghan Peter Fanning Michael Canavan Jack Gracey Pat McCotter Pearce Corry Jimmy Perry pat Simpson Dixie Cordner Ta Marley Billy Meenan Billy Downey Jim McFadden Gerry Watson Tommy O'Malley Hugh Ramsey Leo McGuigan Fra Gillen Tony Cranney Dinny Toner Eddie Collins Frank McKearney Seamus McKearney Joe McKearney Nora McAleer Rosaleen Twomey Jackie Blong P.J.Collins Joe McManus Sean Corry Jim Tennyson P. Morrison Seamus McCallum Tom Delaney Bary Donnelly Paddy Joe Doyle Barney Morgan Charles Carroll W.Watson Angelo Forte Michael McNamara Alex Mullan Alex Millar John McLoughlin Ben McKenna Patsy hughes Alfie Hannaway James Moylan Charlie McWilliams John Tierney Willie McAreavey Michael Ferris Sean Fox Gerry Boyle Dan O'Toole Michael Hall Herbie Smith Paddy Cairns Frank Malone Peter McCollough Johnny O'Rawe Harry O'Rawe Seamie O'Rawe Albie O'Rawe Frank Fitzsimmons Paddy Connolly Bily Rooney'; plaque: '1921-22 Henry McKee Charles McKee John McKee James Tanney Edward Murphy Rose Black Alfred Downey James McCarthy John McCarthy John Kirk Jospeh Magee Sean O'Neill Henry McGarry Joseph Walker Charlie McKee'; plaque: 'Joe Lunney John McGlone Edward McCatney Gerard Higgins John McDonnell Patsy Lavery Mickey Hughes Jimmy Byrne Sean Hughes Eddie Keenan 1956-1962 Sean McParland Liam McParland Bridie O'Neill Bob McMillen Tom Heenan 1970's Dermy Reynolds Dessie Reynolds Gerry Cunningham Sandy Molloy Jimmy Roe Dan Turley Alex Robinson John Bracken Alex Comerford Mary McCartney Larry Peland Brian Kelly Joh Dougan Ann Smith J.Savage Seamus Sullivan Paddy McGivern Con McHugh Séamus McMahon Barry Morgan Tony O'Kane Jimmy Largey Jimmy Monagah Eamon Meehan Billy Davidson Marie Moore Terry Rooney Bobby (Moke) McMahon Frankie "Tex" Dougan Tony Lennon Tony Duffy Brendan Duffy 1980s Mary McCann (nee McClenaghan) Madeline Rosbotham Charlie McCann Patrick (Scobie) McParland Pat McCotter 1970s'.Republican
The origin, diagnosis, and prognosis of oligomannose-type diffuse large B-cell lymphoma
No full textThe acquisition of N-glycosylation sites occupied by oligomannose-type glycans in the immunoglobulin complementarity-determining region (CDR) is an early clonal tumor-specific identifier of follicular lymphoma (FL). CDR-located N-glycosylation sites are also acquired in germinal-center-B-cell-like diffuse large B-cell lymphomas (GCB-DLBCL), but their significance is less defined. We used RNA-seq immunoglobulin assembly to determine the frequency and CDR location of the acquired N-glycosylation sites (AGS) in two large independent DLBCL cohorts. Composition of the glycans occupying the AGS was determined using liquid chromatography-mass spectrometry and correlated with cell-of-origin, FL signature (defined by EZB phenotype or BCL2 translocation), transcript profile, and clinical outcome. CDR-located AGS were observed in 41-46% of GCB-DLBCL but were rare in other DLBCL. Only CDR-located AGS of DLBCL with an FL signature were occupied by oligomannose-type glycans. These DLBCL were termed Mann-type DLBCL. Conversely, the AGS of the other DLBCL were either non-glycosylated or occupied by complex-type glycans. Mann-type status was an independent marker of short progression-free survival and overall survival. In contrast, the other GCB-DLBCL cases, including those with an FL signature but without AGS, had the best outcomes. Mann-type DLBCL overexpressed gene-sets of cell growth, survival, and cycling, and underexpressed proinflammatory and apoptotic pathways, irrespective of concomitant MYC translocations. Acquisition of Mann-type glycans is a highly selective environmental pressure, identifying an aggressive GCB-DLBCL type with an origin related to FL. The detection of AGS in the CDR of GCB-DLBCLs with an FL signature defines Mann-type DLBCLs, refines prognosis and marks a precise tumor interaction to block early therapeutically
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