22 research outputs found
Cultural appropriation and historiography in the works of Ishmael Reed
No full textThe purpose of this study is to explore the theme of cultural appropriation and its representation in Ishmael Reed's novels, while also situating this theme within his larger critiques of Western Eurocentric culture. While much critical work has been undertaken in regards to how Reed has confronted issues of Western historiography and the means by which the Western version of history is presented as unquestionably natural and orthodox, little writing has attempted to flesh out and describe the specific strategies by which such orthodoxy is constituted and legitimized. By exploring the recurrent presence of cultural appropriation and the various ways it manifests in Reed's work through satire, parody, allegory, symbolism and metaphor, this study attempts to enumerate and describe this specific effect of Western history making as cultural appropriation that Reed is bringing to light. This study undertakes a detailed analysis of Reed's novels as occasions for not only calling out cultural appropriation, but as textual mediums for expressing the strategies, forms and types of such appropriation
Cultural appropriation and historiography in the works of Ishmael Reed
No full textThe purpose of this study is to explore the theme of cultural appropriation and its representation in Ishmael Reed's novels, while also situating this theme within his larger critiques of Western Eurocentric culture. While much critical work has been undertaken in regards to how Reed has confronted issues of Western historiography and the means by which the Western version of history is presented as unquestionably natural and orthodox, little writing has attempted to flesh out and describe the specific strategies by which such orthodoxy is constituted and legitimized. By exploring the recurrent presence of cultural appropriation and the various ways it manifests in Reed's work through satire, parody, allegory, symbolism and metaphor, this study attempts to enumerate and describe this specific effect of Western history making as cultural appropriation that Reed is bringing to light. This study undertakes a detailed analysis of Reed's novels as occasions for not only calling out cultural appropriation, but as textual mediums for expressing the strategies, forms and types of such appropriation
GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology
No full textThis is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record Full summary statistics of the erectile dysfunction genome-wide meta-analysis are available at the following URL: http://www.geenivaramu.ee/tools/ED_AJHG_Bovijn_et_al_2018.gz and at the LD Hub GWAShare Center at the following URL: http://ldsc.broadinstitute.org/gwashare/.Erectile dysfunction (ED) is a common condition affecting more than 20% of men over 60 years, yet little is known about its genetic architecture. We performed a genome-wide association study of ED in 6,175 case subjects among 223,805 European men and identified one locus at 6q16.3 (lead variant rs57989773, OR 1.20 per C-allele; p = 5.71 × 10−14), located between MCHR2 and SIM1. In silico analysis suggests SIM1 to confer ED risk through hypothalamic dysregulation. Mendelian randomization provides evidence that genetic risk of type 2 diabetes mellitus is a cause of ED (OR 1.11 per 1-log unit higher risk of type 2 diabetes). These findings provide insights into the biological underpinnings and the causes of ED and may help prioritize the development of future therapies for this common disorder.Novo NordiskMedical Research CouncilBritish Heart Foundation Intermediate Clinical Research FellowshipLi Ka Shing FoundationWT-SSI/John Fell fundsOxfordWidenlifeNIHNational Institute for Health Research Oxford Biomedical Research Centr
The Response of a protandrous species to exploitation, and the implications for management: a case study with patellid limpets
No full textA zygote production model for the patellid limpet Patella vulgata has been developed to examine the effect of exploitation on the reproductive output of a protandrous (male to female sequential) hermaphrodite. Patellid limpets are broadcast spawners which can have specific implications for the effect of exploitation on reproductive output, due to sperm limitation. The combined zygote production model was made of three component sub-models; a population fecundity model, a gamete dispersal model, and a fertilisation model. The model makes explicit account of sperm limitation, and is based upon data collected through field and laboratory investigations conducted as part of this thesis.The model was used to examine the relationship between egg and zygote production, and spawning stock biomass (SSB) and fishery yield for a range of P. vulgata populations across a wave exposure gradient. The effect of different management strategies, minimum landing size or marine protected areas, on the relationship between reproductive output and yield was also examined.Protandry lead to a decoupling between SSB and zygote production as the populations were exposed to the simulated fishery. There was a five-fold variation in zygote production per unit area across a wave exposure gradient. Comparison of different management strategies indicates that the fishery yield could vary by up to three-fold depending on the management strategy used, whilst still protecting the same level of population reproductive output. The genetic population structure of the Azorean Patella candei population was also examined to determine the scale of larval dispersal to allow the management recommendations of the zygote production model to be examined in a wider ecological context. Due to evidence of a recent population bottleneck in the Azorean P. candei population no firm conclusions could be drawn from this study as to the scale of larval dispersal
The influence of training status, age, and muscle fiber type on cycling efficiency and endurance performance.
No full textThe purpose of this study was to assess the influence of age, training status, and muscle fiber-type distribution on cycling efficiency. Forty men were recruited into one of four groups: young and old trained cyclists, and young and old untrained individuals. All participants completed an incremental ramp test to measure their peak O2 uptake, maximal heart rate, and maximal minute power output; a submaximal test of cycling gross efficiency (GE) at a series of absolute and relative work rates; and, in trained participants only, a 1-h cycling time trial. Finally, all participants underwent a muscle biopsy of their right vastus lateralis muscle. At relative work rates, a general linear model found significant main effects of age and training status on GE (P 0.05). Power output in the 1-h performance trial was predicted by average O2 uptake and GE, with standardized ?-coefficients of 0.94 and 0.34, respectively, although some mathematical coupling is evident. These data demonstrate that muscle fiber type does not affect cycling efficiency and was not influenced by the aging process. Cycling efficiency and the percentage of type I muscle fibers were influenced by training status, but only GE at 120 revolutions/min was seen to predict cycling performance
A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure
No full textThis is the author accepted manuscript. The final version is available from Elsevier via the DOI in this recordFibroblast growth factor 21 (FGF21) is a hormone that has insulin-sensitizing properties. Some trials of FGF21 analogs show weight loss and lipid-lowering effects. Recent studies have shown that a common allele in the FGF21 gene alters the balance of macronutrients consumed, but there was little evidence of an effect on metabolic traits. We studied a common FGF21 allele (A:rs838133) in 451,099 people from the UK Biobank study, aiming to use the human allele to inform potential adverse and beneficial effects of targeting FGF21. We replicated the association between the A allele and higher percentage carbohydrate intake. We then showed that this allele is more strongly associated with higher blood pressure and waist-hip ratio, despite an association with lower total body-fat percentage, than it is with BMI or type 2 diabetes. These human phenotypes of variation in the FGF21 gene will inform research into FGF21’s mechanisms and therapeutic potential.A.R.W. and T.M.F. are supported by the European Research Council (grant 323195:GLUCOSEGENES-FP7-IDEAS-ERC). R.M.F. is a Sir Henry Dale Fellow (Wellcome Trust and Royal Society grant 104150/Z/14/Z). H.Y. is an RD Lawrence Fellow, funded by Diabetes UK. R.N.B. is funded by the Wellcome Trust and Royal Society grant 104150/Z/14/Z. J.T. is funded by the European Regional Development Fund (ERDF) and a Diabetes Research and Wellness Foundation fellowship. S.E.J. is funded by the Medical Research Council (grant MR/M005070/1). M.A.T., M.N.W., and A.M. are supported by the Wellcome Trust Institutional Strategic Support Award (WT097835MF). C.M.L. is supported by the Li Ka Shing Foundation, by the National Institute for Health Research (NIHR) Biomedical Research Centre (Oxford), by Widenlife, and by the NIH (CRR00070 CR00.01). The funders had no influence on study design, data collection and analysis, decision to publish, or preparation of the manuscript. The Novo Nordisk Foundation Center for Basic Metabolic Research is an independent research center at the University of Copenhagen partially funded by an unrestricted donation from the Novo Nordisk Foundation (http://cbmr.ku.dk). This research has been conducted using the UK Biobank resource. This work was carried out under UK Biobank project numbers 9072 and 9055
Data for: A Bayesian approach to modelling subnational spatial dynamics of worldwide non-state terrorism, 2010 - 2016
No full textA Bayesian Approach to Modelling Subnational Spatial Dynamics of Worldwide Non-State Terrorism, 2010 - 2016
A. Python, J. Illian, C. Jones-Todd, M. Blangiardo
J. R. Statist. Soc. A, (2018)
All results are obtained using R statistical software. We provide the R code and data needed to reproduce the research work.
For full replication, the R code listed below should be run in this order:
-first: from (1) to (2): generate input data for the statistical models;
-second: (4), (5) and (6): the L,S, and F model, respectively;
-third: (7): the results and plots of the L,S, and F model, respectively.
Since fitting the models are computationally intense, we also provide the outputs of the models as .RData files along with the R code used to produce them.
The R code and data are provided in "R_code.zip", which contains the following folders:
(1) GTD
GTD.R: extraction of terrorism data from the Global Terrorism database (GTD)
Input: GTDsource.csv (file downloaded Jan 2017 from GTD)
Output: GTDworld.csv used in R code (2):
(2) DATA
Data_paper.R: extraction of covariate data based on GTD events locations
Input: covariates data with different formats in covariate.zip
Output: paper_data.RData used in R code (4) to (9)
(3) FUNCTIONS
functions.R: functions to facilitate running the spatio-temporal models in R-INLA
used in in R code (4) to (9)
(4) L-MODEL
L_model.R: the Bernoulli space-time models of the lethality of terrorism
Inputs: paper_data.RData (2) and functions.R (3)
Outputs:
-models with different sets of covariates: L0.Rdata to L7.RData ;
-selected final model: L7.Rdata
-models for plotting: L7.Rdata
-robustness test models: Lrob1.Rdata, Lmesh2.RData, Lmesh3.RData
-predictive models with different sets of covariates: L7pred.Rdata, L0pred.Rdata
(5) S-MODEL
S_model.R: the Poisson space-time models of the severity of lethal terrorism
Inputs: paper_data.RData (2) and functions.R (3)
Outputs:
-models with different sets of covariates: S0.Rdata to S7.RData ;
-selected final model: S4.Rdata
-models for plotting: S4plot.Rdata
-robustness test models: bernrob1.Rdata, bernmesh2.RData, bernmesh3.RData
-predictive models with different sets of covariates: bern0pred.Rdata, bern4pred.Rdata
(6) F-MODEL
F_model.R: the Poisson space-time models of the frequency of lethal terrorism
Inputs: paper_data.RData (2) and functions.R (3)
Outputs:
-models with different sets of covariates: F0.Rdata to F7.RData ;
-selected final model: Ffinal.Rdata
-models for plotting: F3plot.Rdata
-robustness test models: Frob1.Rdata, Ffinalagg075.RData, Ffinalagg025.RData,Ffinalagg100.RData, Ffinalagg150.RData
-predictive models with different sets of covariates: F0pred.Rdata, F6pred.Rdata
(7) RESULTS
-Results_Lmodel.R: generate the results of the L-models and the graphics in the manuscript
Inputs: paper_data.RData (2), functions.R (3), L-model outputs (4)
Outputs: plots and figures
-Results_Smodel.R: generate the results of the S-models and the graphics in the manuscript
Inputs: paper_data.RData (2), functions.R (3), S-model outputs (5)
Outputs: plots and figures
-Results_Fmodel.R: generate the results of the F-models and the graphics in the manuscript
Inputs: paper_data.RData (2), functions.R (3), F-model outputs (6), and country.shp
Outputs: plots and figures
Contact (first author):
Dr Andre Python
Malaria Atlas Project | University of Oxford
Big Data Institute | Li Ka Shing Centre for Health Information and Discovery
Old Road Campus | Headington | Oxford | OX3 7LF | United Kingdom
E: [email protected]
W: www.map.ox.ac.uk | www.bdi.ox.ac.u
Erratum: The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma (Cell Reports (2018) 23(1) (313–326.e5) (S2211124718304364) (10.1016/j.celrep.2018.03.075))
No full text(Cell Reports 23, 313–326; April 3, 2018) In the originally published version of this article, the author list contained two errors. Specifically, David J. Kwiatkowski was misspelled as David J. Kwaitkowski, and William Y. Kim was inadvertently written as William T. Kim. Both names have been corrected online. The authors regret this error
Fresno State vs Utah, September 23, 1995
No full textFootball game statisticsAttendance: 31362; Head Coach Ron McBrideFootballFresno State 21 Utah 25NCAA OFFICIAL SCORING SUMMARY FRESNO STATE VS. UTAH Visitor Home Overall Record Now 3-1 Stadium Rice Stadium Overall Record Now 2-2 Date Sept. 23, 1995 Score by Quarters (V) FRESNO STATE (H) UTAH (Team) (Qtr. ) (Time Site Salt Lake City, Utah Attendance 31,362 (City, State) 1 2 3 4 7 0 14 0 7 0 3 15 (Scoring Play) (Conversion) (Drive Final 21 25 (Score) Left) Play-Yards) FSU 1st 9:37 Brown 1 run Lysand kick 10-87 0-7 UTAH 1st 7:48 Henry 46 pass from Dyson Pulsipher kick 4-65 7-7 FSU 3rd 12:35 Oliver 33 run Lysand kick 6-74 7-14 UTAH 3rd 6:29 Pulsipher 20 field goal 6-77 10-14 FSU 3rd 1:07 Jones 57 pass from Donati Lysand kick 6-80 10-21 UTAH 4th 2:09 Fuamatu-Ma\u27afala 3 run Pass (Dyson) 11-80 18-21 UTAH 4th 0:47 Henry 34 pass from-Pouts PulSipher kick 5-66 25-21 (Kissed Field Goals) Team Qtr Time/Player/Distance UTAH 1st 0:28/Pulsipher/41 yards FSU 4th 7:26/Lysand/47 yards UTAH 4th 6:05/Pulsipher/49 yards Time of Game: Kickoff 7:05 p.m. End of Game 10:40 p.m. Total Elapsed Time 3:35 Officials Bill McCabe. Tim Kuhlman. Jim Crittenden, David Lambros, Royce Cooley, Gordan Birk, John Lothrop , I I ~femperature 66 degrees Wind West 5 MPH Weather Su~ny NCAA FINAL TEAM STATISTICS I.U\u27J171 U ?.:: i Home Visitor i First Downs ................................. . ?q Rushing ............................... . 12 12 Passing ................................ . 15 Penalty ................................ . 2 2 Rushing Attempts ............................. . 39 Yards Gained Rushing .......................... . 188 \u2748 Yards Lost Rushing ............................ . 22 11 Net Yards Rushing ........................... . 1C:C: I .... ..,..., I Net Yards Passing ............................ . I 404 I .184 J Passes Attempted ........................ . 50 29 I Passes Completed ....................... . 28 13 Had Intercepted 3 2 j Total Offensive Plays 89 I II ! 74 Total Net Yards .............................. . 570 J I Jt:t 421 I Average Gain Per Play .................... . 6.4 5.7 Fumbles: Number-Lost ........................ . ! 1 -1 1 - 0 Penalties: Number-Yards ....................... . 5 -62 7 -65 Number of Punts-Yards ........................ . 3 -134 6 -268 Average Per Punt ........................ . 44.7 44.7 Punt Returns: Number-Yards .................... . 4 -23 0 -0 Kickoff Returns: Number-Yards .................. . 2 -40 3 -43 Interception Returns: Number-Yards .............. . 2 - 6 3 8 Fumble Returns: Number-Yards ................. . 0 - 1 -1 Possession Time ..... : ......................... . 31 : 06 28:54 r :)rd-Down Conversions ........................ . 6 of 14 7 o~ 5 Fourth-Down Conversions ....................... . 1 of 1 0 of 0 Sacks By: Number-Yards ...................... . 1 5 2 19 Copyright 1995 National Collegiate Athletic Association NCAA 10430-5195 NCAA FINAL INDIVIDUAL STATISTICS 2 9 7 6 7 1 9 123 ·18 I 6 \84 • 1 UTAH 25 Home Rushing AU. Gain Lost Net TO Long .T .T n h n !\u27:nT" .,1 IQ7 I~ Iq4 I (1 ~ J:.T""n T.ll!\u27:k 1 12 0 12 0 12 n/Wn"f-4 Fl1:=1m::.\u27i\u27:b. M;:,;:,f;:,l;:, 1 6 6 \u27T\u27llrok"",r 4 78 24 Dvson . 1 2fi 1 1 Kozlowski 1 be; ?e; -TA (,JIJ(\u27,!~ \u271- ~ .J \u27 \u27i- I Totals I 28 404 2 46 Punting No. Yds. Avg. Long 301 nol\u27,ulsiPher ,I Totals Field Goals 30E,PlllSiPher \41, 20 (49) (After player\u27s name list distances of each attempt and circle FGs Made. e.g .• 46-@ ·35) Punts, Kickoffs Int. Passes All Returns* No. Yds. ~P No. Yds. LP No. Yds. LP 5,"P Beck _1 - 9 ==="\u27--_ -4- \u2723-\u27 ..1.4... -.l. -lii... __ \u27 8 1 - 6 I Totals 5 4 o FRESNO STATE 21 Visitor Rushing AIL Gain Lost Net TO Long T f"\u27Il;uo ..... \u27)0 111"7 11 11 A ":l ~ 33 P \u27Rr ..... t.7Tl 1.1. Q1 n Q1 1 1 Q ,., T\u27\~ .... ~.j- ~ 3 \u270 7 3 0 1 U Totals I 45 248 11 ~ 2 33 Passing Alt.-Comp.-Int. Yards TO Long Sacks I 1Et~~ r -13-2 r~l] 157 ri 8 3 4 4 2 Pass Receiving :b.rn ..... lr1 Rnher!\u27:nn .T ..... n"" Klc~f~ I=~~ Ilull/~ :a, 7 12;S( • u.r~w "\u27:- i ,. " \u275 \u27~7 Kl~t=-F o 7:48 L9tc~tAltl b5 4 \u27:4\u27l I tI II t.tW- &:.ll PUJJT ~~ :t:J ·REU)~ 4~ ,1. S:t3 ~r:. I, 2JJD LrrD~ F.(~ U:2f putJT 14 5 2,\u27:33 " " ~~~ \u27t,\u2721 Wr€1U£PflD~ i=~ ~P4 LJ~ 41 12 4:\u271 u H 1AtT\u27A\u27K l\ 2~lq puur lk~ :91 P(\u27{lJ\" 3~{\ t=i{kJl LtW lD:4 FUust.£ -( 0 0 I IL h lA.W 7:21, ~frf~~ ~i! ~c6 Pll:\u27lMUW ~Pf 3~ 15 2!ug ~?S :47 NCAA 10430-5/95 UNIVERSITY OF UTAH VS. FRESNO STATE UNIVERSITY. sept. 23, 1995 7 pm Rice Stadium, Salt Lake City, UT OFFICIALS: Bill McCabe (R), Jim Crittenden (U), Royce Cooley (L), John Lothrop (LJ), Tim Kuhlman (FJ), David Lambrose (SJ), Gordan Birk (BJ) weather: 66 degrees, wind west @ 5 mph, partly cloudy. Utah wins the toss and elects toreceive; FSU defends North goal Torigian kikks off for FSU to Beck at U3, far side, returns 24 tonear side 1-10 U 27 Fouts with catchers co~ered, runs up middle and right for 0 2-10 U 27 Fouts spot pass to Hen Lusk far sideline for 14, 1st DOWWN 1-10 U 41 Johnson up the middle, breaks left for 12, 1st DOWN 1-10 F 47 Fouts pass to Hen Lusk complete for 5 (22) 2- 5 F 42Johnson on pitchout left loses 3 (57) 3- 8 ~ 45 Fouts pass complete to Henry far sideline for 11, 1st DOWN 1-10 F 34 Fouts paSS OFF Henry\u27s hands, intercepted by Wilson at 1~, J ret i 12:09 to go I · 1-10 F 27\u27 Donati pass ,"}.inc. for Nero who fell down ~ 2-10 F 27 Donati pass inc. for Roberson (20) i I 1 10 F 13 Oliver at left side for 14 t8, 26) I -:;z 3-10 F 27 Donati pass inc. for Brown. i~7·(8) ~ 4-*0 F 27 Roberts punts 45 yards to Hen Lusk at U 28, return of ~ ~ ID F 43 Donati\u27s pitch to Oliver at re for 2 ~} 13 null. by roughing kicker pen. of 1~ yards, 1st down LL 2~ 8 F 45 Donati pass inc. for Jones broken up by Beck 3- 8 F 43 Donati pass complete to Arnold for 16 (6), 1st DOWN ~F 1-10 U 39 Donati perfgectly -led pass to Roberson for 38 (20) 1- G U 1 Oliver dives 19 for no gain (50, 46) 2- G U 1 Oloiverdives rg for TD with 9:37 to go (87 in10 plays) (, ·r Lyssand kicks P.T FSU 7, UTAH 0 drive took 2:32 Torigian kicks off out of bounds near sideline; UTAH elects ball at 35 1-10 U 35 Johnson bulls off rg for 2 (91) -ie -r~ ~~g:::::~~::~~:::::~k :::s~:: f~~::: ::::~~:~:o w::n~s::T:mplete ~o---~ wide open Henry for TD with 7:48 to play 65 yuards in 4 plays in 1:49 ~ Pulsipher kicks PAT UTAH 7, FSU 7 pulsipher kicks off to Arnold at F 4, returns 19 to 23 1 -1 0 F 23 Donati fumbles snap, FSU covers for loss of 2 2-12 F 21 Donati pass complete to Jones for 5 ( 5) 3- 7 F 26 Donati pass inc. for Jones at U 25 ( 5, 26) 4- 7 F 26 Robert/s punts to Hen Lusk 45 XIl!IXRiM, 0 return 6:02 to go 1-10 U 29 Fouts swing pass compo to Johnson, loses 7 (13) 2-1\u27 U 22 Johnson delay at right side for no gain 3-17 U 22 Fouts pass complete to Hen. Lusk for 19, 1st DOWN 1-10 U 41 Johnson on the draw play, jiterbugs left for 5 (57) 2- 5 U 46 Johnson ~right up the gut for 12, 1st DOWN 1~1~ F 4~2 Johnson up the middle for 4 more 2- 6 F 38 Fouts pas compo to Hen Lusk for 2 (5) 3- 4 F 34 Fouts pass complete near sideline to F-Maafala for 4, 1st DOWN 1-10 F 30 Fouts keeps fora 0 gain 2-20 F 30 Johnson drags people thru rg for 7 (5) 3- 3 F 23 Johnson tries rg for no gain 4- 3 F 23 Pulsipher 40 FG wide to left with 28 seconds left, 48 yds, 12 1-10 Oliver sweeps re for 1 (8) 2- 9 F 24 quarter ends FSU 7 POSSESSION TIME: Utah 10:14 FSU 4:46 pSi./. /-3 STATMAN II(tm) FIRST QUARTER TEAM STATISTICS BULLDOGS UTES Firs t Downs.......................................... 4 8 r", , \ Rushing ............................................................................... .. 1 3 Passing ................................................................................ .. 2 5 Penal ty .................................................................. .............. .. 1 0 Rushing Attempts ............................ . \u27 ....................................... .. 6 12 Yards Rushing ............................................................................. .. 18 50 Tackles-Yards Lost Rushing .•...••••.•••.•••.••.••••.• 1/2 1/3 Net Yards Rushing •••.••.• \u27 ••.•••••••••..••.••.••.••••• 16 47 Net Yards Passing ..................................................................... .. 59 105 Passes Attempted ••••.••..•••.•••••••••.•••.••••• 8 10 Passes Compi eted .............................................................. .. 3 9 Had Intercepted •••••••.••.•••••••••••••••••..... 0 1 Total Offensive Plays ••.•••••••••••••••••.••••••.•••. 14 22 Total Net Yards ••.••...••.•.••..••...••.• \u27 •..••..•..•• 75 152 Avg Gain Per Play ..•..•••.•..•••.•••.•••.••••••• 5.4 6.9 RA-turn yards ............................................................................. ".8 ( \J 1 0 \ / FU"mbl es : Number-Lost .............. . \u27 .......... \u27 ............................ \u27 .......... .. 1-0 0-0 Penal ties: Number-Yards •..••..••..•...•.••••••.•.•• \u27 ••• 0-0 1-16· Interceptions:Nurnber-Yards .•...••.•...••.••..•.•.•••. 1-1 0-0 Number of Punts-yards ••.••••••.••..••••••.••.•••.•••. 1-45 0-0 Average per Pllnt ............................................. . 45.0 0.0 Punt Returns:Number-Yards .•...••..•......•••••.••.•.• 0-0\u27 . 0-0 Kickoff Returns:Number-Yards ••..•.••..••.••••••.•.•.• 1-19 1-24 Possession Time ............................................ . 4:46 10:14 Thi rd Down Conversions •..••.••...•.•.•..•..••••..•.•• ,1/;3_ .. - 33% 3/4 - 75% Fourth Down Conversions ••.•••••..•••.••..•••.•.••...• 0/0 - 0% 0/0 - 0% Sacks/Sack Yds •••••.•.•.••.•••.•••.••.•••.••.••••.•.• 0.0/0 0.0/0 STATMAN II(tm) FIRST QUARTER INDIVIDUAL STATISTICS VISITORS: BULLDOGS HOME: UTES /~~SHING \ "--------- Oliver Brown Donati TOTALS PASSING Donati TOTALS RECEIVING Arnold C.Jones Roberson TOTALS NO GRS NEG NET AVG 4 17 1 1 1 0 6 18 o 17 4.3 o 1 1.0 2 -2 -2.0 2 16 2.7 LG TD 14 0 1 1 -2 0 14 1 NO CP YDS SK/YDS LG TD I 8 3 59 0 8 3 59 0 a 380 a a 38 a a NO YDS LG TD 1 1 1 3 16 16 5 5 38 38 59 38 o a a a RUSHING Johnson Fouts TOTALS NO GRS NEG NET AVG 10 50 2 a 12 50 3 47 4.7 a a 0.0 3 47 3.9 LG TD 12 a o a 12 0 PASSING NO CP YDS SK/YDS LG TD I Fouts Dyson TOTALS 9 8 59 0 1 1 46 0 10 9 105 a o 19 a 1 o 46 1 0 a 46 1 1 RECEIVING NO YDS LG TD He. Lusk 4 Henry 3 Fua-Ma 1 afa1a 1 Johnson 1 TOTALS 9 40 19 66 46 6 6 -7 -7 105 46 a 1 a a 1 FIELD GOALS FIELD GOALS )rERCEPTS NO YDS LG TD Wilson TOTALS 1 1 1 1 1 1 a a PUNTING NO YDS AVG TB 120 LG Roberts TOTALS 1 1 45 45.0 45 45.0 a a a 45 a 45 PUNT RETURNS NO FC YDS LG TD TOTALS o o o o KICK RETURNS NO YDS LG TD Arnold TOTALS 1 1 19 19 19 19 o a a Pulsipher 41WL INTERCEPTS TOTALS PUNTING TOTALS PUNT RETURNS He. Lusk TOTALS KICK RETURNS Beck TOTALS NO YDS LG TD a a a a NO YDS AVG TB I20LG a a 0.0 a a a NO FC\u27 YDS LG TD a a 1 1 a a a a NO YDS LG TD 1 1 24 24 24 24 o o o a FUMBLES NO OWN YD LG TD OPP YD LG TD FUMBLES NO OWN YD LG TD OPP YD LG TD i ;-------- ho-nati 1 TOTALS 1 100 a 100 0 000 0 o 0 a 0 TOTALS 0 a 0 0 0 a a 0 a 2nd quarter sept. 23, 1995 UTAH 7 FRESNO STATE 7 FSU has ball for 2nd play on drive wfuich began own 23 with 0:28 left 2- 9 F 24 Donati pass comp_ to Jones for 5 (8) 3- 4 F 29 010mati swing pass far side for 11 (91), 1st DOWN 1-10 F 40 D6nati pass complete to Roberson for 12 (8.) 1-10 U 48 Olivber bursts thru rg for 5, bu FSU pen 5, ill.motion 1-17 F 47 Donati pass intercepted b .~ qar. LU\u27,\u275k at U 39, re-turns 6, out of bounds own 45, with 13:44 to go 1-10 U 45 F-Maafala at left saide for 1 2- 9 U~46 Fouts pass for Dyson broken up (face-guard?) by .22 3- 9 U 46 Fouts pass for~Dysondeep middle incomp., but FSU pen. 16 for pass interference. 1st DOWN 12:53 left 1-10 F 38 Jopnssn at left side for 3 (5, 57) 2- 7 F 35 Johnson slant-in pass over middle inc. (drop) by T*cke~rinside 20 3- 7 F 35 Fouts sacked for loss of 6 (3) 4-13 F 41 Pulsipher punts into EZ for touchback 11:21 left 1-10 F 20 Brown in the middle for for 5 (95) 2- 5 F 25 Brown off rg for 6 (50, 57) 1-10 F 31 Donati deep pass for Jones dropped at U 22 (26, 20) 2-10 F 31 Donati pass compo far sideline to Roberson for 9 3- 1 F 40 Brown drives inside rt for 4 (45), Cunninghamhurt official time at 10:06 to go 1-10 F 44 Brown sweeps left, cuts up at Ie for 11 1-10 U 45 Donati pass off Arnold1s hands, intyercp by Beck at U2~ 9:21 to play no return 1-10 U 25 Johnson high-steps way thru Ig for 12, 1st DOWN 1-10 U 37 Foiuts quixck screen pass left to Dyson £*~X for 8 2- 2 U 45Fouts, after nice fake to diving Johnson, inc.,to Dyson,drop 3- 2 U 45 FSU takes time (1) with 8:50 yo go 3- 2 U 45 F-Maafala drives thru rt for 9, 1st DOWN ) 1-10 F 46 F-Maafala off the left side for t~ 6 2- 4 F 40mF-Maafala swings wide left for ·6, 1 st DOWN 1-1~ F 34 Fouts after fake tyo diving Johnson inc. to Dyson at F 2 2~10 F 34 Fouts pass complete to Keehan for 8 3- 2 F 26F-Maafala at It forH4 1-10 F 22 F-Maafala drives off rt for 3 rf 2- 7 F 19 Fouts pass compo to Henry at F 1, but UTAH pen. at, off. interf. 2_22 F 34 Fouts pass inc. in EZ with Dyson, Kos:j.owski both ~t!here 3- 22 F 34 Fouts pass interc. by Jackson at F 2~, ret. ~ 5:04 to go 1-10 F 30 Oliver gets 3 at left side (57) 2- 7 F 33 Brown sweeps re for 6 (20,17) 3- 1 F 39 Brown gets 3 1-10 F 42 Oliver sweeps wide left for 7 (46) 2- i F 4901iver thru rg for no gain 3- 3 F 49 Donati pass compo to Jones for no gain 4- 3 F 49 Roberts punts dead at Utah 11 (4~ yards I 2:191eft 1-10 U 11 Fouts quick pass screen left to Dyson for 11, 1stDOWN 1~1~ U 22 Johnson at ;lg, spins for 3 (91,45) 2- 7 U 25 Fouts pass compo to crossing Tucker far sidelinefor 19,1stDOWN 1-10 U 44 Fouts swing pass to Johnson for 1 UTAH TINME(1) 1:18 left 2- 9 U 45 Fouts pass compo to Keehan near sideline for 4 3- 5 U 49 1:12 left Fouts pass inc. for Henry at F 32 4- 5 U 49 Pulsipher punts 51 yaRDS INTO EZ on bounce for touchback 0:59 to go 1-10 F 20 Oliver slants at It for 6 (50,17) 2- 4 F 26 Brown breaks tackle in backfield, sweeps Ie for 8 1-10 F 34 half ends with FSU in huddle FSU 7, UTAH 7 possession time: UTAH 18:14 FSU 11:46 R±d down convs. UTAH 5-9 FSU 5-8 NCAA QUICKIE STATISTICS (Circle One) Score ............................ . First Downs ....................... . Rushes-YB;rdage (Net) .•...... \u27 ...... . Passing Yardage (Net) .......•........ Passes-Att. -Camp. -I nt. _ ............. . Total Offense plays-Yards ..•••........ Fumble Returns-Yards ..... _ ....... ~ . Punt Returns-Yards " ".\u27 ....•......... Kickoff Returns-Yards ............... . Interception Returns-Yards .••.•....... Punts (Number-Average) ...•••••...... Fumbles-Lost ............••••...... Penalties-Yards Possession Time ................... . Third Home !I 7 1 c; 22 -88 156 \u27··i· -15.- l.tl\u27i -?AA 0 - 0 1 - 0 1 - 24 2 - 6 2 - 46 0 - 0 2 - 31 18: 14 INDIVIDUAL LEADERS RES I 2 I Home Visitor @ 9 7 6 Rushing Att. .T ..,..1- 13 Hen.Lusk 0 ID Fouts ~ F-Maafala 6 Passing Att. -camp: -Int. "D. Fouts ~-_2 .- 1 4.. -2 Dyson 1 - 1. 0 Net Yards 65 -- 1-6.L 29 Yards 110 4.6 1 TO long 12 -- 9 TO long 0 19··\u27; Pass Receiving No. Yards TO Long r-------------,-----,-----r---~- 9 Hen Lusk 8 25 4 10 Rushing .T nl; "tTO .... R .- B Donatj Pass Receiving In::nQ] d Roberson ones 23 Henry 18 Keehan Punting No. Avg. long Punting Att 8 8 No. i 3 3 - ~ Final FRESNO STATE Visitor I 2 11 17 16 b3 0 0 1 2 2 1 2 Net Yards 33 44 Yards 1 6 59 -75 95 -8 -2 - 120 -0 - -19 -\u278 -0 --"2.1 11 : 46 TO Long 14 1 11 TO Long 38 5 I I 30 n Plllc::inhe:>r 2 46 51 3 ,.-----------,---~--:-=-..-:-:~ Copyright 1995 National Collegiate Athletic Association NCAA 10430·5/95 ) l ) ~ 3rd quarter Sept. 23, 1995 UTAH 7 FRESNO STATE 7 FSU elects to receive to start 2nd half; Utah defends S. goal Pulsipher kicks off to Ollis at F 11, returns 15 1-10 F 2601iver off rt for 9 (measufad) (50,57) 2- 1 F 35 Brown on mia=directiOn right side for 4,1st doewn 1-10 F 39 Oliver at re for 9 (26) 2- 1 F 48 Oliver at re, cuts outside for 14 (8), 1st DOWN 1 10 U 38 Brown counter at Ig for 5 2- 5 U 33 Oliver starts at rg, cuts back left for 33 yards, TD with 12:35 to ... 74 yards, 6 plays, 2:25 Lyssand kicks PAT FSU 14 UTAH 7 Torigian kicks off 8 deep in EZ and out 1-10 U 20 Johnson at Ig for loss of 1, but FSU pen. 5 (offsides) 1- 5 U 25 Johnson up the middle for 3 (57) 2- 2 U 28 Johnson at rt for no gain 3- 2 U 28 o~F-Maafala plows thru rt for 16 (23,22) pancaking 2~ 1-10 U 44 Fouts pass compo to Tucker over the middle for 20, 1st down 1-10 F 36 Johnson at rg, spins left for 5 (50,57) 2- 5 F 31 Johnson squirts thru Ig, trips for 6, \u271st DOWN 1 1~ F 25 Johnson stymied at It for 1 2~ 9 F 24 Fouts quick pass compo to Tucker for 15, 1st DOWN 1- G F 9 F-Maafala slides off It for 4 2~ G F 5 F-Maafala on delay at 19 for 1 3- G F 4 Johnson bobbles hanfoff at rg for 1 4- G F 3 Pulsipher 20-yard field goal is good with 6:29 left 12 plays, 77 in 6:06 FSU 14 UTAH 10 Pulsipher kicks off and downed in EZ for touchback 1-10 F 20 Oliver at c, slides left for 4 ( 50) 2- 6 F 24 PQnatipass inc. for Arnold ( 1 7 ) 3- 6 F 24 Donati rolling right swing pass tyo Brown for 7,1 stDOWl\u27 1-10 F 31 Oliver gets 1 (45) 2- 9 F 32 Donati pass for Roberson broken up by Lawson 3 9 F 32 Donati pass unbderthrown, Cunningahm can\u27t hold 4 inte:r 4- 9 F 32 4:21 to go 1-10 U 37 Johnson at 1- 12 U35 Fouts pass 2-12 U 35 Fouts pass 1-10 F 34 Fouts pass 3:37 to go Roberts punt of 45 taken by Hen.Lusk at left sidefor 8~ U pen. 10 for hold for Henry inc. at F 30, (5,22) complete dowen middle 31 yards to Hen inc. for Henry, overthrown, interc by 1-10 F 20 Brogwn at Ig for ~ (17) 23, runs 14 Lusk (5),1st dov Jackson in EX 2- 6 F 24 Donati pass compo to Roberson right side for 5 (45) 3- 1 F 29 Brown strung out wide right, escapes 17 for 3,1st down 1-10 F 32 Oliver sweeps le, strung out for 3 2- 7 F 35 Oliver sweeps ;le behind 64 for 8 (8) 31362 ATTN. 1-10 F 43 Donati pass complete to Jones for 57 yds, TD,1st DOWN WITH 4:07 to go; :Lyssand kicks PAT FSU 21, UTAH 10 80 yds, 6 plays in 2:30 Torigian kicks off Hen.Lusk at U2, returns 16 to 18 1 10 U 18 Fouts pass to Tucker far side for 24, 1st DOWN 1-10 U 42 Johnson cuts up over It for 5 2- 5 U 47 Fouts spot pass right side to Henry for 12, 1st DOWN, as Q ends FSU 21, UTRR 10 3rd down conversions UTAH 6-11 FSU 6 10 possession time UTAH 26:11 FS~ 18:49 STATMAN II(tm) ~ TEAM STATISTICS BULLDOGS First Downs.......................................... 18 Rushing. . . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 Passing. . . . . . . . • . . . . . . . . . . • . . . • . . . • . . . • . • . . . . . . . 6 Penal ty. . . . • • • . . . . . . . . . . . • . . . • . . . . . . . • . . • . . . • . . . 1 Rushing Attempts.. . . • . • . . . . . • . • . . • . • • . • . . . . • • . . . . . . . . 29 Yards Rushing ..•.•.•..•.••.••....•. 0 •••••••••••• 0 • • • • 174 Tackles-Yards Lost Rushing........................... 1/2 Net Yards Rushing ••••....•••. 0 ••••• 0 ••••••••••••••••• Net Yards Passing •....•...... 0 ••••• 0 • 0 ••• 0 ••••••••••• Passes Attempted •....•.•....•..•......•..•.•..•. Passes Completed ••....••....••..•••.....•.....•.. Had Intercepted ....••...••...•.•.••.....••..•...• Total Offensive Plays .•.....•.•....••...•.••.•••..•.. Total Net yards .•.•..••.•....••••••..•••.•..••..•...• Avg Gain Per Play .••..••...•.•••...•..••.•.•..•. Return Yards ................... ....................................................... .. () FUllloles : Number-Lost .....•..•...••...••....•....•..•.. Penal ties : Number-Yards ......••.•..................... Interceptions:Number-Yards •.•...••..
Role of chemerin, a novel adipochemokine, in the human microvascular endothelial cell (HMEC)-1 line
No full textChemerin is a newly identified adipokine and exerts its functional effects by
binding to its natural GPCR, known as CMKLR1. Chemerin is highly expressed in
the adipose tissue and in lower levels in other body tissues; and is known to play an
important role in adipocyte differentiation and metabolism. Chemerin circulates at
the normal physiological concentrations of approximately 3-4nM in humans, and
circulating chemerin levels positively correlate with various facets of metabolic
abnormalities; such as insulin resistance, type 2 diabetes, high triglycerides,
hypertension, and associated risks of development of diseases of cardiovascular
system. Endothelial Cells (ECs) line the vasculature of the entire circulatory system
and form a direct contact with the bloodstream. In this project, the role of chemerin
in EC biology was proposed, and was studied in terms of activation of important
signalling Mitogen-activated Protein Kinases (MAPKs) including Extracellular
signal-regulated Kinase (ERK) 1/2, ERK5, p38, Stress-activated Protein Kinase/c-
Jun NH2-terminal Kinase (SAPK/JNK); and Akt/Protein Kinase B (PKB) and
Adenosine Monophosphate Protein Kinase (AMPK)-α in a time- and concentrationdependent
manners. These signalling kinases regulate the activity of different
transcription factors which then regulate the expression of different genes. Chemerin
increased the expression of Hypoxia-inducible Factor (HIF)-1α, a hypoxia-inducible
transcription factor which is known to regulate the Vascular Endothelial Growth
Factor (VEGF) gene expression. Interestingly, VEGF165, the most potent
angiogenic isoform of VEGF protein expression was down-regulated by chemerin in
a concentration-dependent manner; whereas, chemerin upregulated the protein
expression of VEGF165b, an opposite anti-angiogenic counterpart of VEGF165.
Chemerin mediated EC proliferation, migration and capillary tube formation; which
are the key processes implicated in the process of normal and pathological
angiogenesis. Chemerin altered the protein expression levels of Cell Adhesion
Molecules (CAMs) including E-selectin, ICAM-1 and VCAM-1 – increased the
activity of Nuclear Factor (NF)–kappa (κ) B pathway – and encouraged Endothelial-
Monocyte cell adhesion in a concentration-dependent manner. Nitric Oxide (NO),
not only keeps the vascular health in check by downregulating the expression levels
of adhesion molecules, but also acts as a potent vasodilator. Endothelial Nitric Oxide
Synthase (eNOS), an enzyme constitutively expressed in the endothelial cells
regulates the production of NO in the endothelium. Chemerin increased eNOS
activity by causing eNOS phosphorylation at Ser1177, and dephosphorylating at
Thr495 phosphorylation sites. Chemerin increased the protein expression of nonconstitutively
expressed enzyme, inducible Nitric Oxide Synthase (iNOS), which is
mainly induced during injury or inflammation and is known to produce 100- to
1000-times more NO compared to that of eNOS. However, interestingly, chemerin
failed to show any significant changes in the amounts of combined nitrite and nitrate
(NOx) levels in HMEC-1 cells; whereas, nitrite (NO2–) levels were decreased in a
concentration-dependent manner
