68 research outputs found
Eradication of Helicobacter pylori and Gastric Cancer: A Controversial Relationship
No full textWorldwide, gastric cancer (GC) represents the fifth cancer for incidence, and the third as cause of death in developed countries. Indeed, it resulted in more than 780,000 deaths in 2018. Helicobacter pylori appears to be responsible for the majority of these cancers. On the basis of recent studies, and either alone or combined with additional etiological factors, H. pylori is considered a “type I carcinogen.” Over recent decades, new insights have been obtained into the strategies that have been adopted by H. pylori to survive the acidic conditions of the gastric environment, and to result in persistent infection, and dysregulation of host functions. The multistep processes involved in the development of GC are initiated by transition of the mucosa into chronic non-atrophic gastritis, which is primarily triggered by infection with H. pylori. This gastritis then progresses into atrophic gastritis and intestinal metaplasia, and then to dysplasia, and following Correa’s cascade, to adenocarcinoma. The use of antibiotics for eradication of H. pylori can reduce the incidence of precancerous lesions only in the early stages of gastric carcinogenesis. Here, we first survey the etiology and risk factors of GC, and then we analyze the mechanisms underlying tumorigenesis induced by H. pylori, focusing attention on virulence factor CagA, inflammation, oxidative stress, and ErbB2 receptor tyrosine kinase. Moreover, we investigate the relationships between H. pylori eradication therapy and other diseases, considering not only cardia (upper stomach) cancers and Barrett’s esophagus, but also asthma and allergies, through discussion of the “hygiene hypothesis. ” This hypothesis suggests that improved hygiene and antibiotic use in early life reduces microbial exposure, such that the immune response does not become primed, and individuals are not protected against atopic disorders, asthma, and autoimmune diseases. Finally, we overview recent advances to uncover the complex interplay between H. pylori and the gut microbiota during gastric carcinogenesis, as characterized by reduced bacterial diversity and increased microbial dysbiosis. Indeed, it is of particular importance to identify the bacterial taxa of the stomach that might predict the outcome of gastric disease through the stages of Correa’s cascade, to improve prevention and therapy of gastric carcinoma. © Copyright © 2021 Piscione, Mazzone, Di Marcantonio, Muraro and Mincione
I fiori della poesia dichiarati & raccolti da don Marcantonio Mazzone i Miglionico : da tutte l'opere di Virgilio, Ovidio & Horatio ...
No full textMarca tip. na portSign.: [cruz latina]4, A-X8, Y4Texto a duas co
First year of life: the Golden Age of gut microbiota
No full textDuring the first year of life, development and balance of newborn gut microbiota
are strongly influenced by external factors such as delivery mode, breastfeeding,
duration of pregnancy, mother diet and lifestyle, siblings and pets, environment, and
antibiotics administration. Gut microbiota colonization starts with facultative anaerobes
and continues with the establishment of anaerobic genera of which Bifidobacteria
are the gold standard of a healthy gut neonatal microbiota. Scientific literature
traditionally describes the fetus as sterile in the womb and identifies the membranes
rupture as the beginning of microbial colonization. Vaginal delivery is an important
source for the onset of infant colonization which will then continue with the transfer
of a new selection of intestinal bacteria with breastfeeding. During cesarean delivery
a direct contact of the mouth of newborn with the vaginal and intestinal microbiota is
absent, and environmental bacteria play an important role for infants intestinal colonization. Nature has ensured that newborns receive other specific maternal bacteria,
through a subsequent method of transfer: breastfeeding. We present a brief and comprehensive state-of-the-art in order to encourage natural childbirth and breastfeeding whenever possible and discuss innovative directions for develop new ad hoc personalized treatments in order to restore physiological microbiota
Marcantonio Raimondi e i nordici
No full textIn this article the author proposes an overall reconsideration of the relationships of Marcantonio Raimondi with the Nordic engravers, paying constant attention to the surviving sources. Furthermore, a new analysis of some passages from the Vita di Marcantonio Bolognese, e d’altri intagliatori di stampe by Giorgio Vasari has allowed a different interpretation of the Italian reception of some prints by Lucas van Leyden as well as of the Portrait of Pietro Aretino executed by Marcantonio: one of the masterpieces of European Renaissance engraving, which, for the first time, is being read here in the light of knowledge of a genre of portraiture emerged in Norhtern Europe in the early 1500s, that combines bust portraits with elegant Latin (and Greek) epigraphs - very significative for Marcantonio has been some famous engravings by Albrecht Dürer
Le tonalità emotive nel pensiero dell'appropriazione. La formazione dell'animo nel dolore come unità delle "Stimmungen".
No full textWith this article, the author’s aim is to examine the Heidegger’s theory of pain in "Das Ereignis". Starting from a delineation of the goals of the unpublished treatises and of the concept of "Ereignis", the author will first show the crucial role played by "Stimmungen" in the other beginning, through which Heidegger wants to think the Being differently from metaphysics; the author will do this highlighting all the conceptual and linguistic sperimentalism used by the German philosopher in such writings. At this point will be displayed how in "Das Ereignis", the last treatise, the pain emerges not only as the most important "Stimmung", but also as the unity of all attunements considered by Heidegger up to that moment. Finally, the author will illustrate how with the "Ereignis-Denken" is so at stake the formation of a thought
founded on the heart and on the temperament (Gemüt), and not on a representative consciousness
THE POTENTIAL ANTICANCER ACTIVITY OF DONKEY MILK IN HUMAN GASTRIC ADENOCARCINOMA (AGS) CELL LINE
No full textLa struttura dei trattati inediti di Heidegger
No full textThe subject of this article are Heidegger’s unpublished treatises written between the second half of the 1930s and the first half of the 1940s. In particular, the author aims to show that, far from being real treatises – systematic texts with a consequential structure – these unpublished works can be regarded as conceptual laboratories, as well as the building ground of Heidegger’s mature thought. The object of this thought is the concept of "Ereignis", not surprisingly the fil rouge that links all the treatises together. The basic objective of the author’s study is to show how it is the particular essence of the event of being that calls for the speculative approach, and hence the distinctive formulation, of the texts of each of the "Abhandlungen"
Albrecht Dürer (e Marcantonio Raimondi) nella Felsina pittrice di Carlo Cesare Malvasia: biografia, autografia e collezionismo
No full textThanks to a new analysis of some passages from the Life of Marcantonio Raimondi, both in the printed version of Felsina pittrice and in the manuscript submitted by Carlo Cesare Malvasia in 1677 to the approval of the Inquisition, the author proposes a more complete evaluation of the role that Malvasia recognizes to Albrecht Dürer, with new considerations on the autography of his prints, on their importance in the artistic training of Marcantonio Raimondi, on their widespread collecting in Bologna shortly after the mid-seventeenth century
De fiori della poesia : parte seconda oue son tutte le belle et diuerse materie ...che da Virgilio, Ouidio et Horatio sono state trattate ne i loro poemi
No full textMarca tip. na portSign.: a-h8, i4Texto a duas co
Open Questions in Cold Atmospheric Plasma Treatment in Head and Neck Cancer: A Systematic Review
No full textOver the past decade, we witnessed a promising application of cold atmospheric plasma (CAP) in cancer therapy. The aim of this systematic review was to provide an exhaustive state of the art of CAP employed for the treatment of head and neck cancer (HNC), a tumor whose late diagnosis, local recurrence, distant metastases, and treatment failure are the main causes of patients’ death. Specifically, the characteristics and settings of the CAP devices and the in vitro and in vivo treatment protocols were summarized to meet the urgent need for standardization. Its molecular mechanisms of action, as well as the successes and pitfalls of current CAP applications in HNC, were discussed. Finally, the interesting emerging preclinical hypotheses that warrant further clinical investigation have risen. A total of 24 studies were included. Most studies used a plasma jet device (54.2%). Argon resulted as the mostly employed working gas (33.32%). Direct and indirect plasma application was reported in 87.5% and 20.8% of studies, respectively. In vitro investigations were 79.17%, most of them concerned with direct treatment (78.94%). Only eight (33.32%) in vivo studies were found; three were conducted in mice, and five on human beings. CAP showed pro-apoptotic effects more efficiently in tumor cells than in normal cells by altering redox balance in a way that oxidative distress leads to cell death. In preclinical studies, it exhibited efficacy and tolerability. Results from this systematic review pointed out the current limitations of translational application of CAP in the urge of standardization of the current protocols while highlighting promising effects as supporting treatment in HNC
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