6 research outputs found
Spartan Daily, February 6, 1953
No full textVolume 41, Issue 84https://scholarworks.sjsu.edu/spartandaily/11831/thumbnail.jp
sj-pdf-1-gsj-10.1177_2192568220961357 – Supplemental Material for Provision and Perception of Physiotherapy in the Nonoperative Management of Degenerative Cervical Myelopathy (DCM): A Cross-Sectional Questionnaire of People Living With DCM
No full textSupplemental Material, sj-pdf-1-gsj-10.1177_2192568220961357 for Provision and Perception of Physiotherapy in the Nonoperative Management of Degenerative Cervical Myelopathy (DCM): A Cross-Sectional Questionnaire of People Living With DCM by Max B. Butler, Oliver D. Mowforth, Abdul Badran, Michelle Starkey, Timothy Boerger, Iwan Sadler, Julia Tabrah, Caroline Treanor, Lucy Cameron Grad Dip Phys, Sukhvinder Kalsi-Ryan, Rodney J. Laing, Benjamin M. Davies and Mark R. N. Kotter in Global Spine Journal</p
sj-pdf-2-gsj-10.1177_2192568220961357 – Supplemental Material for Provision and Perception of Physiotherapy in the Nonoperative Management of Degenerative Cervical Myelopathy (DCM): A Cross-Sectional Questionnaire of People Living With DCM
No full textSupplemental Material, sj-pdf-2-gsj-10.1177_2192568220961357 for Provision and Perception of Physiotherapy in the Nonoperative Management of Degenerative Cervical Myelopathy (DCM): A Cross-Sectional Questionnaire of People Living With DCM by Max B. Butler, Oliver D. Mowforth, Abdul Badran, Michelle Starkey, Timothy Boerger, Iwan Sadler, Julia Tabrah, Caroline Treanor, Lucy Cameron Grad Dip Phys, Sukhvinder Kalsi-Ryan, Rodney J. Laing, Benjamin M. Davies and Mark R. N. Kotter in Global Spine Journal</p
sj-pdf-3-gsj-10.1177_2192568220961357 – Supplemental Material for Provision and Perception of Physiotherapy in the Nonoperative Management of Degenerative Cervical Myelopathy (DCM): A Cross-Sectional Questionnaire of People Living With DCM
No full textSupplemental Material, sj-pdf-3-gsj-10.1177_2192568220961357 for Provision and Perception of Physiotherapy in the Nonoperative Management of Degenerative Cervical Myelopathy (DCM): A Cross-Sectional Questionnaire of People Living With DCM by Max B. Butler, Oliver D. Mowforth, Abdul Badran, Michelle Starkey, Timothy Boerger, Iwan Sadler, Julia Tabrah, Caroline Treanor, Lucy Cameron Grad Dip Phys, Sukhvinder Kalsi-Ryan, Rodney J. Laing, Benjamin M. Davies and Mark R. N. Kotter in Global Spine Journal</p
Simulations of a self propelled autonomous underwater vehicle
No full textThe missions being proposed for autonomous underwater vehicles (AUVs), by both marine scientists and industry, are becoming increasingly complex and challenging. In order to meet these demands the next generation of AUVs will need to be faster, operate for longer and be more manoeuvrable than existing vehicles. It is therefore vital that the hydrodynamic forces and moments acting on a self propelled manoeuvring AUV can be predicted accurately at the initial design stage. The flow around a typical AUV is both turbulent and three dimensional with significant interactions between the hull, propeller and control surfaces. An unsteady computational fluid dynamics analysis based on the Reynolds Averaged Navier Stokes (RANS) equations is too expensive for AUV design. In order to capture the action of the propeller at an acceptable computational cost, a novel method of coupling a commercial RANS solver with a body force propeller model based on blade element momentum theory has been developed. This discretises the propeller plane into a series of radial and circumferential sectors. The local axial and tangential inflow conditions at each sector of the propeller plane can then be considered. This allows analysis of non-uniform propeller inflow conditions due to the interaction of hull, propeller and control surfaces. During a manoeuvre the hull boundary layer may separate due to the adverse pressure gradient, resulting in free vortex sheets which roll up to form a pair of body vortices. An adaptive mesh strategy is required to ensure a suitable mesh structure and density to capture these flow features. Modifications to a vortex capture algorithm (VORTFIND) are proposed, optimising it as a tool for identifying the path of vortex structures. This enables it to be used as part of an iterative meshing strategy, capturing vortical flow features more accurately and consequently their influence on the pressure loading experienced by the hull. To demonstrate the pertinence of the numerical methods developed in this work a series of case studies has been analysed. These include: determining the hydrodynamic derivatives of an AUV, propeller-rudder interaction studies, steady state manoeuvring performance of the self propelled KVLCC2, and in-service straight line performance prediction of Autosub 3. These highlight the roles of the numerical methodologies in the design process for future AUVs. The techniques developed in this work enable the designer to accurately predict the hydrodynamic loading acting on a self propelled manoeuvring AU
Data_Sheet_1_The impact of phosphodiesterase inhibition on neurobehavioral outcomes in preclinical models of traumatic and non-traumatic spinal cord injury: a systematic review.PDF
No full textStudy designSystematic review.ObjectiveThe objective of this study was to evaluate the impact of phosphodiesterase (PDE) inhibitors on neurobehavioral outcomes in preclinical models of traumatic and non-traumatic spinal cord injury (SCI).MethodsA systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines and was registered with PROSPERO (CRD42019150639). Searches were performed in MEDLINE and Embase. Studies were included if they evaluated the impact of PDE inhibitors on neurobehavioral outcomes in preclinical models of traumatic or non-traumatic SCI. Data were extracted from relevant studies, including sample characteristics, injury model, and neurobehavioral assessment and outcomes. Risk of bias was assessed using the SYRCLE checklist.ResultsThe search yielded a total of 1,679 studies, of which 22 met inclusion criteria. Sample sizes ranged from 11 to 144 animals. PDE inhibitors used include rolipram (n = 16), cilostazol (n = 4), roflumilast (n = 1), and PDE4-I (n = 1). The injury models used were traumatic SCI (n = 18), spinal cord ischemia (n = 3), and degenerative cervical myelopathy (n = 1). The most commonly assessed outcome measures were Basso, Beattie, Bresnahan (BBB) locomotor score (n = 13), and grid walking (n = 7). Of the 22 papers that met the final inclusion criteria, 12 showed a significant improvement in neurobehavioral outcomes following the use of PDE inhibitors, four papers had mixed findings and six found PDE inhibitors to be ineffective in improving neurobehavioral recovery following an SCI. Notably, these findings were broadly consistent across different PDE inhibitors and spinal cord injury models.ConclusionIn preclinical models of traumatic and non-traumatic SCI, the administration of PDE inhibitors appeared to be associated with statistically significant improvements in neurobehavioral outcomes in a majority of included studies. However, the evidence was inconsistent with a high risk of bias. This review provides a foundation to aid the interpretation of subsequent clinical trials of PDE inhibitors in spinal cord injury.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=150639, identifier: CRD42019150639.</p
