203,778 research outputs found
M. Perrin, Hrabani Mauri In honorem sanctae crucis
No full textMeyers Jean. M. Perrin, Hrabani Mauri In honorem sanctae crucis. In: Vita Latina, N°152, 1998. pp. 58-60
Accurate first principles prediction of O-17 NMR parameters in SiO2: Assignment of the zeolite ferrierite spectrum
No full textO-17 NMR parameters, both the chemical shifts and the quadrupolar parameters, are calculated for SiO2 polymorphs using density functional theory with the generalized gradient-corrected PBE functional. The gauge including projector augmented wave (GIPAW) method (Pickard, C. J.; Mauri, F. Phys. Rev. B 2001, 63, 245101) ensures the reproduction of all electron results while using computationally efficient pseudopotentials. The use of plane-waves permits fully converged calculations to be performed on structures containing 144 atoms in the unit cell, without the need to resort to the cluster approximation. The calculated NMR parameters of cristobalite, quartz, coesite, and faujasite are in excellent agreement with experimental data. This demonstrates that density functional theory is able to reproduce with high accuracy the O-17 NMR parameters in SiO2 systems. This precision is used to assign the spectrum of the zeolite ferrierite. The data calculated for SiO2 are used to confirm that no simple correlation between the chemical shift and Cq NMR parameters and Si-O-Si angle exists, emphasizing the importance of predictive theories in this field
Prevention of arthritis by interleukin 10-producing B cells
Get PDFIn this study we have shown that activation of arthritogenic splenocytes with antigen and agonistic anti-CD40 gives raise to a B cell population that produce high levels of interleukin (IL)-10 and low levels of interferon (IFN)-{gamma}. Transfer of these B cells into DBA/1-TcR-ß-Tg mice, immunized with bovine collagen (CII) emulsified in complete Freund's adjuvant inhibited T helper type 1 differentiation, prevented arthritis development, and was also effective in ameliorating established disease. IL-10 is essential for the regulatory function of this subset of B cells, as the B cells population isolated from IL-10 knockout mice failed to mediate this protective function. Furthermore, B cells isolated from arthritogenic splenocytes treated in vitro with anti–IL-10/anti–IL-10R were unable to protect recipient mice from developing arthritis. Our results suggest a new role of a subset of B cells in controlling T cell differentiation and autoimmune disorders
Synthesis of photoactivable probes for the study of glycosphingolipid-protein interactions
No full textSYNTHESIS OF PHOTOACTIVABLE PROBES FOR THE STUDY OF GLYCOSPHINGOLIPID-PROTEIN INTERACTIONS
Giuseppina Brasile,1 Federica Compostella,1 Laura Mauri,2Sandro Sonnino2 and Fiamma Ronchetti1
Dipartimento di Chimica, Biochimica e Biotecnologie per la Medicina, Università di Milano
1Via Saldini 50, 20133-Milano, Italy; 2Via Fratelli Cervi 93, 20190- Segrate (Milano), Italy
E-mail:[email protected]
It is widely accepted that glycosphingolipids (GSLs) at the level of the plasma membrane can affect the biological functions of protein molecules, such as cell surface receptors or transporters. The interactions between GSLs and proteins belonging to specific membrane microdomains, called lipid rafts, could be responsible for the modulation of the functional properties of membrane proteins participating in signal transduction. GSL-protein interactions can be investigated by cell photolabelling experiments using radioactive photoactivable GSLs, which yield, when illuminated, a very reactive intermediate that covalently binds to the molecules in the environment, i.e. proteins.1,2
In this context, we have designed a fatty acid probe with two nitrophenylazide photoactivable groups, one at position 2 and the other at the end of the acyl chain. The conjugation of the fatty acid to a radioactive sphingoglycolipid generates a species to be used for photolabelling experiments. In this way, the simultaneous identification of the proteins belonging to both the leaflets of the plasma membrane, the cytoplasmatic and the extracellular one, will be realized.
Herein we describe a general synthetic strategy to obtain not commercially available α,ω-diamino acids, the synthetic precursors of the labelled fatty acids, which we have applied to the synthesis of a C-18 derivative. Furthermore, it will be described the preparation of a photolabelled radioactive GSL as a case study.
1. Aureli M., Prioni S., Mauri L. Loberto N., Casellato R., Ciampa M.G., Chigorno V., Prinetti, A.; Sonnino S. J. Lipid Res. 2010, 51, 798-808
2. Mauri L., Prioni S., Loberto N., Chigorno V., Prinetti A., Sonnino S. Glycoconj. J. 2004, 20, 11-23
Rabani Mauri Martyrologium edidit John McCulloh ; De Computo edidit Wesley M. Stevens
No full textPhilippart Guy. Rabani Mauri Martyrologium edidit John McCulloh ; De Computo edidit Wesley M. Stevens. In: Revue belge de philologie et d'histoire, tome 61, fasc. 2, 1983. Histoire médiévale, moderne et contemporaine — Middeleeuwse, moderne en hedendaagse geschiedenis. pp. 462-465
A Model-Based Method for Seamless Web and Mobile Experience
No full textConsumer-centered software applications nowadays are required to be available both as mobile and desktop versions. However, the app design is frequently made only for one of the two (i.e., mobile first or web first) while missing an appropriate design for the other (which, in turn, simply mimics the interaction of the first one). This results into poor quality of the interaction on one or the other platform. Current solutions would require different designs, to be realized through different design methods and tools, and that may require to double development and maintenance costs. In order to mitigate such an issue, this paper proposes a novel approach that supports the design of both web and mobile applications at once. Starting from a unique requirement and business specification, where web- and mobile-specific aspects are captured through tagging, we derive a platformindependent design of the system specified in IFML. This model is subsequently refined and detailed for the two platforms, and used to automatically generate both the web and mobile versions. If more precise interactions are needed for the mobile part, a blending with MobML, a mobile-specific modeling language, is devised. Full traceability of the relations between artifacts is granted
Botrychium lanceolatum Seb. et Mauri
No full textE. lanceolatum Seb. et Mauri Steinige, buschige Orte. Am Rhoneknie in denDistr. l und2, entdeckt1915von H.GAMS. l: Mehrfach im Gebiet Collonges-Dorenaz, 550-900 m (Garns). - 2: Ob Branson-Fully, 845 bis 1100m (Garns).Published as part of Becherer, 1956, Florae Vallesiacae Supplementum, pp. 1-556 in Denkschriften der Schweizerischen Naturforschenden Gesellschaft 71 on pages 1-55
Hannemania achalai Bischoff de Alzuet and Mauri 1987
No full textHannemania achalai Bischoff de Alzuet and Mauri, 1987: NEOPublished as part of Nielsen, David H., Robbins, Richard G. & Rueda, Leopoldo M., 2021, Annotated world checklist of the Trombiculidae and Leeuwenhoekiidae (1758 - 2021) (Acari: Trombiculoidea), with notes on nomenclature, taxonomy, and distribution, pp. 1-243 in Zootaxa 4967 (1) on page 12, DOI: 10.11646/zootaxa.4967.1.1, http://zenodo.org/record/474551
Depressive symptoms and mental representations in a sample of pregnant Italian women during COVID-19: primiparous and multiparous in comparison
No full textDuring the COVID-19 outbreak, the risk of depression has increased for pregnant women and especially for first-time mothers-to-be. Pre-COVID-19 literature showed that depression is negatively linked to mental representations during pregnancy. This pilot study explored the difference in depressive symptoms and maternal representations style in primiparous and multiparous pregnant women during the outbreak of COVID-19 (2020-2021). 25 women (14 primiparous, 11 multiparous) were recruited in their last trimester of pregnancy. Participants responded to the Edinburgh Postnatal Depression Scale (EPDS) and Interview for Maternal Representations during Pregnancy (Intervista sulle Rappresentazioni Materne in Gravidanza – IRMAG). Results showed that primiparous women presented higher depressive symptoms than Original article“Pediatric Psychology and Related Issues” Section (Sezione “Psicologia Pediatrica e Dintorni”) by S.I.P.Ped. (Italian Society of Pediatric Psychology, Società Italiana di Psicologia Pediatrica)
2/8Ponti • Smorti • Ionio • Mauri • CarducciJournal of Pediatric and Neonatal Individualized Medicine • vol. 12 • n. 1 • 2023www.jpnim.comOpen Accessmultiparous ones. Moreover, primiparous women reported lower richness of perception (p = 0.008), openness to change (p = 0.035) and dominance of fantasies (p = 0.000) in maternal representation and, globally, more restricted representations (71.4%) than multiparous ones (18.2%) (p = 0.020). Mental representations were related to the level of depression, with integrated representations being associated with lower depression than restricted and ambivalent ones (p = 0.001). A preventive intervention to support primiparous pregnant women during future pandemics would be necessary in particular to avoid negative repercussions also in the post-partum experience
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